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1.

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells.

Bengsch, Bertram; Ohtani, Takuya; Khan, Omar; Setty, Manu; Manne, Sasikanth; O'Brien, Shaun; Gherardini, Pier Federico; Herati, Ramin Sedaghat; Huang, Alexander C; Chang, Kyong-Mi; Newell, Evan W; Bovenschen, Niels; Pe'er, Dana; Albelda, Steven M; Wherry, E John.

Immunity ; 48(5): 1029-1045.e5, 2018 05 15.

Article in English | MEDLINE | ID: mdl-29768164

2.

Noncytotoxic functions of killer cell granzymes in viral infections.

de Jong, Lisanne C; Crnko, Sandra; Ten Broeke, Toine; Bovenschen, Niels.

PLoS Pathog ; 17(9): e1009818, 2021 09.

Article in English | MEDLINE | ID: mdl-34529743

3.

Linked research hubs train students to tackle societal challenges.

Schakelaar, Michael Y; Bassat, Quique; Comiskey, Catherine M; Felvinczi, Katalin; Haarhuis, Jan C M; Bovenschen, Niels.

Nature ; 611(7936): 449, 2022 11.

Article in English | MEDLINE | ID: mdl-36380041

4.

Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.

Shan, Liling; Li, Shuang; Meeldijk, Jan; Blijenberg, Bernadet; Hendriks, Astrid; van Boxtel, Karlijn J W M; van den Berg, Sara P H; Groves, Ian J; Potts, Martin; Svrlanska, Adriana; Stamminger, Thomas; Wills, Mark R; Bovenschen, Niels.

PLoS Pathog ; 16(4): e1008426, 2020 04.

Article in English | MEDLINE | ID: mdl-32282833

5.

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes.

Janiszewski, Tomasz; Kolt, Sonia; Kaiserman, Dion; Snipas, Scott J; Li, Shuang; Kulbacka, Julita; Saczko, Jolanta; Bovenschen, Niels; Salvesen, Guy; Drag, Marcin; Bird, Phillip I; Kasperkiewicz, Paulina.

J Biol Chem ; 295(28): 9567-9582, 2020 07 10.

Article in English | MEDLINE | ID: mdl-32439802

6.

Intracellular expression of granzymes A, B, K and M in blood lymphocyte subsets of critically ill patients with or without sepsis.

García-Laorden, M Isabel; Hoogendijk, Arie J; Wiewel, Maryse A; van Vught, Lonneke A; Schultz, Marcus J; Bovenschen, Niels; de Vos, Alex F; van der Poll, Tom.

Clin Exp Immunol ; 205(2): 222-231, 2021 08.

Article in English | MEDLINE | ID: mdl-33866542

7.

Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis.

Shan, Liling; van den Hoogen, Lucas L; Meeldijk, Jan; Kok, Helena M; Jongeneel, Lieneke H; Boes, Marianne; Wenink, Mark H; Hack, C Erik; Radstake, Timothy R D J; van Roon, Joel A G; Bovenschen, Niels.

Clin Exp Rheumatol ; 38(2): 220-226, 2020.

Article in English | MEDLINE | ID: mdl-31172927

8.

Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis.

Kinashi, Hiroshi; Falke, Lucas L; Nguyen, Tri Q; Bovenschen, Niels; Aten, Jan; Leask, Andrew; Ito, Yasuhiko; Goldschmeding, Roel.

Kidney Int ; 92(4): 850-863, 2017 10.

Article in English | MEDLINE | ID: mdl-28545716

9.

Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.

Kok, Helena M; van den Hoogen, Lucas L; van Roon, Joel A G; Adriaansen, Elisabeth J M; Fritsch-Stork, Ruth D E; Nguyen, Tri Q; Goldschmeding, Roel; Radstake, Timothy R D J; Bovenschen, Niels.

Rheumatology (Oxford) ; 56(12): 2129-2134, 2017 12 01.

Article in English | MEDLINE | ID: mdl-28968826

10.

Granzymes regulate proinflammatory cytokine responses.

Wensink, Annette C; Hack, C Erik; Bovenschen, Niels.

J Immunol ; 194(2): 491-7, 2015 Jan 15.

Article in English | MEDLINE | ID: mdl-25556251

11.

Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes.

Wensink, Annette C; Kemp, Vera; Fermie, Job; García Laorden, M Isabel; van der Poll, Tom; Hack, C Erik; Bovenschen, Niels.

Proc Natl Acad Sci U S A ; 111(16): 5974-9, 2014 Apr 22.

Article in English | MEDLINE | ID: mdl-24711407

12.

Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors.

van Kempen, Pauline M W; Noorlag, Rob; Swartz, Justin E; Bovenschen, Niels; Braunius, Weibel W; Vermeulen, Jeroen F; Van Cann, Ellen M; Grolman, Wilko; Willems, Stefan M.

Cancer Immunol Immunother ; 65(5): 575-85, 2016 May.

Article in English | MEDLINE | ID: mdl-26993499

13.

Biological responses of human solid tumor cells to X-ray irradiation within a 1.5-Tesla magnetic field generated by a magnetic resonance imaging-linear accelerator.

Wang, Li; Hoogcarspel, Stan Jelle; Wen, Zhifei; van Vulpen, Marco; Molkentine, David P; Kok, Jan; Lin, Steven H; Broekhuizen, Roel; Ang, Kie-Kian; Bovenschen, Niels; Raaymakers, Bas W; Frank, Steven J.

Bioelectromagnetics ; 37(7): 471-80, 2016 Oct.

Article in English | MEDLINE | ID: mdl-27434783

14.

Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation.

Bovenschen, Niels; Spijkers, Sanne N M; Wensink, Annette C; Schellens, Ingrid M M; van Domselaar, Robert; van Baarle, Debbie.

Clin Immunol ; 150(1): 1-11, 2014 Jan.

Article in English | MEDLINE | ID: mdl-24316590

15.

Orphan granzymes find a home.

Bovenschen, Niels; Kummer, J Alain.

Immunol Rev ; 235(1): 117-27, 2010 May.

Article in English | MEDLINE | ID: mdl-20536559

16.

A challenge-based interdisciplinary undergraduate concept fostering translational medicine.

Valentijn, Floris A; Schakelaar, Michael Y; Hegeman, Maria A; Schot, Willemijn D; Dictus, Wim J A G; Crnko, Sandra; Ten Broeke, Toine; Bovenschen, Niels.

Biochem Mol Biol Educ ; 52(2): 198-209, 2024.

Article in English | MEDLINE | ID: mdl-38009484

17.

All human granzymes target hnRNP K that is essential for tumor cell viability.

van Domselaar, Robert; Quadir, Razi; van der Made, Astrid M; Broekhuizen, Roel; Bovenschen, Niels.

J Biol Chem ; 287(27): 22854-64, 2012 Jun 29.

Article in English | MEDLINE | ID: mdl-22582387

18.

Cellular immunotherapy for medulloblastoma.

Schakelaar, Michael Y; Monnikhof, Matthijs; Crnko, Sandra; Pijnappel, Emma W; Meeldijk, Jan; Ten Broeke, Toine; Bovenschen, Niels.

Neuro Oncol ; 25(4): 617-627, 2023 04 06.

Article in English | MEDLINE | ID: mdl-36219688

19.

Temporal Dynamics of Serum Perforin and Granzymes in Three Different Clinical Stages of Virus-Induced Severe Fever with Thrombocytopenia Syndrome.

Ryu, Sukhyun; Choi, Jin Kyeong; Achangwa, Chiara; Cho, Soojung; Hwang, Joo-Hee; Hwang, Jeong-Hwan; Bovenschen, Niels; Lee, Chang-Seop.

Am J Trop Med Hyg ; 109(3): 554-558, 2023 09 06.

Article in English | MEDLINE | ID: mdl-37524330

20.

Serpin B9 controls tumor cell killing by CAR T cells.

Kimman, Thomas; Slomp, Anne; Martens, Anne; Grabherr, Sarah; Li, Shuang; van Diest, Eline; Meeldijk, Jan; Kuball, Jurgen; Minnema, Monique C; Eldering, Eric; Bovenschen, Niels; Sebestyén, Zsolt; Peperzak, Victor.

J Immunother Cancer ; 11(3)2023 03.

Article in English | MEDLINE | ID: mdl-36931661

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