ABSTRACT
The aim of the study was to evaluate pulse wave velocity (PWV) and carotid intima-media thickness (IMT) in type 2 diabetics with microalbuminuria (mualb). The study concerned 37 patients type 2 diabetics, age: 53.4 +/- 6.6, years free of cardiovascular complications. HbA1C was 7.73 +/- 1.39%, waist circumference 104.2 +/- 11.7 cm. 19 patients with BP > 130/85 mmHg were identified as mild hypertensives (17/19 under treatment). All patients underwent ABPM, PWV and IMT measurements. The study population was separated into 2 subgroups according to median of mualb (mg/24 h): 18.9. [table: see text] In patients with mualb > 18.9 mg/24, IMT and PWV were significantly increased (p = 0.06; p < 0.01). After adjustment to BP and age, there was no significant difference in IMT and PWV in the subgroups. In this selected population of type 2 diabetics, microalbuminuria appears associated to a pressure-dependant vascular remodeling.
Subject(s)
Albuminuria/etiology , Carotid Arteries/anatomy & histology , Diabetes Mellitus, Type 2/complications , Hypertension/etiology , Tunica Intima/anatomy & histology , Albuminuria/pathology , Female , Humans , Hypertension/complications , Male , Middle Aged , Tunica Intima/pathology , Ventricular RemodelingABSTRACT
Hyperthyroidism due to inappropriate secretion of TSH is rare. It may be due to either TSH-secreting pituitary adenomas (n = 15) or selective pituitary resistance to thyroid hormone action (n = 31). The recognition of these patients is of great clinical importance since they should be treated differently than patients with more common forms of hyperthyroidism (Graves' disease, autonomous thyroid nodule).