Lack of association of XRCC1 rs1799782 genetic polymorphism with risk of pancreatic cancer: a meta-analysis.

Emerging evidence suggests that genetic polymorphisms in X-ray repair cross-complementation group 1 (XRCC1) gene could be associated with pancreatic cancer risk. However, previous published studies on the association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk reported inconsistent results. For better understanding of the effects of XRCC1 rs1799782 genetic polymorphism on pancreatic cancer risk, we conducted a meta-analysis of previous published studies by calculating the pooled odds ratio (OR) with a 95% confidence interval (95% CI). A total of five eligible studies with 1,144 pancreatic cancer cases and 2,925 controls were eventually enrolled. Overall, we found that the XRCC1 rs1799782 genetic polymorphism was not associated with pancreatic cancer risk in total population under all genetic models (TT vs. CC: OR = 1.11, 95% CI 0.76-1.63, P = 0.583; CT vs. CC: OR = 1.39, 95% CI 0.92-2.10, P = 0.118; TT/CT vs. CC: OR = 1.39, 95% CI 0.92-2.10, P = 0.121; TT vs. CT/CC: OR = 1.07, 95% CI 0.73-1.55, P = 0.743; T vs. C: OR = 1.31, 95% CI 0.93-1.86, P = 0.125). In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05). No publication bias was detected in this study. Our meta-analysis suggests that the XRCC1 rs1799782 genetic polymorphism is not significantly associated with pancreatic cancer risk. Considering the limited sample size and ethnicity enrolled in this meta-analysis, further larger scaled studies are needed to provide a more precise estimation on the association.

Co nanoparticles decorated with N-doped carbon nanotubes as high-efficiency catalysts with intrinsic oxidase-like property for colorimetric sensing.

Artificial nanozymes are designed for pursuing the functions of splendid catalytic efficiency and prominent selectivity of natural enzymes, meanwhile obtaining higher stability than that of natural enzymes. This emerging technology shows widespread application in the crossing field between nanotechnology and biomedicine. In this work, we employed a universal approach to fabricate a Co@N-CNTs hybrid nanocomposite as an oxidase mimic, in which fine Co nanoparticles were wrapped in N-doped carbon nanotubes, stacking on a hollow dodecahedron carbon skeleton. The synergistic effects of nanostructure engineering, N-doping and carbon coating, as well as the derived interfacial effect contribute to the glorious oxidase-like activity, stability and reusability. It can catalytically oxidize the colorless substrate 3,3',5,5'-tetramethylbenzidine (TMB) to a blue oxidation product (ox-TMB). As a result, a colorimetric technique with excellent selectivity and sensitivity for detecting ascorbic acid (AA) with naked eyes was established, in view of specific inhibitory effects towards oxidation of TMB. Under optimal detection conditions, this method exhibits a good linearity ranging from 0.1 to 160 µM with a low limit of detection (LOD) of 0.076 µM. For practical applications, Co@N-CNTs hybrid catalyst as a mimic oxidase was used for the determination of AA in human serum, which yielded satisfactory results. This work may serve as a new research thought to guide the design of high-performance nanozymes and establish a sensing platform for the detection of AA.