Preoperative Opioid Prescription Is Associated With Major Complications in Patients With Crohn's Disease Undergoing Elective Ileocolic Resection.

BACKGROUND: Opioid use has grown exponentially over the last decade. The effect of preoperative opioid prescription in patients with Crohn's disease undergoing surgery is unknown. OBJECTIVE: The purpose of this study was to identify whether preoperative opioid prescription is associated with adverse postoperative outcomes in Crohn's disease. DESIGN: This is a single-institution retrospective observational study. SETTINGS: This study was performed at an academic tertiary care center. Details of preoperative opioid prescription were collected from the Kentucky All-Schedule Prescription Electronic Reporting database and the electronic databases of bordering states. PATIENTS: Consecutive patients undergoing ileocolic resection for Crohn's disease from 2014 to 2018 were included. MAIN OUTCOME MEASURES: The outcomes examined were major complications (Clavien-Dindo ≥3a), length of stay, and 30-day hospital readmission. RESULTS: Fifty one of 118 patients were prescribed opioids within 6 months preoperatively (range, 0-33,760 morphine milligram equivalents). Patients with preoperative opioid prescription compared with no preoperative opioid prescription required more daily opioids during hospital admission (p = 0.024). Nineteen patients had a major postoperative complication (preoperative opioid prescription: 26% (13/51) vs no preoperative opioid prescription: 9% (6/67)). On multivariable analysis, preoperative opioid prescription (OR = 2.994 (95% CI, 1.024-8.751); p = 0.045) was a significant risk factor for a major complication. Preoperative opioid prescription was associated with increased length of stay (p < 0.001) and was a risk factor for readmission (OR = 2.978 (95% CI, 1.075-8.246); p = 0.036). Twenty-four patients were readmitted. Using a cutoff for higher opioid prescription of 300 morphine milligram equivalents within 6 months preoperation (eg, 60 tablets of hydrocodone/acetaminophen 5/325), preoperative opioid prescription remained a risk factor for major postoperative complications (OR = 3.148 (95% CI, 1.110-8.928); p = 0.031). LIMITATIONS: This was a retrospective study and could not assess nonprescribed opioid use. CONCLUSIONS: Preoperative opioid prescription was a significant risk factor for adverse outcomes in patients with Crohn's disease undergoing elective ileocolic resection. See Video Abstract at http://links.lww.com/DCR/B113. LA PRESCRIPCIÓN PREOPERATORIA DE OPIOIDES SE ASOCIA CON COMPLICACIONES MAYORES EN PACIENTES CON ENFERMEDAD DE CROHN SOMETIDOS A RESECCIÓN ILEOCÓLICA ELECTIVA: El uso de opioides ha crecido exponencialmente en la última década. Se desconoce el efecto de la prescripción preoperatoria de opioides en pacientes con enfermedad de Crohn sometidos a cirugía.Identificar si la prescripción preoperatoria de opioides está asociada con resultados postoperatorios adversos en la enfermedad de Crohn.Este es un estudio observacional retrospectivo de una sola institución.Este estudio se realizó en un centro académico de atención terciaria. Los detalles de la prescripción preoperatoria de opiáceos se recopilaron de la base de datos de "Kentucky All-Schedule Prescription Electronic Reporting" y de las bases de datos electrónicas de los estados fronterizos.Pacientes consecutivos sometidos a resección ileocólica por enfermedad de Crohn entre 2014-2018.Los resultados examinados fueron complicaciones mayores (Clavien-Dindo ≥3a), duración de la estancia y el reingreso hospitalario de 30 días.A cincuenta y uno de 118 pacientes se le recetaron opioides dentro de los 6 meses preoperatorios (rango, 0 a 33,760 equivalentes de miligramos de morfina). Los pacientes con prescripción preoperatoria de opioides en comparación con ninguna prescripción preoperatoria de opioides requirieron más opioides diarios durante el ingreso hospitalario (p = 0,024). Diecinueve pacientes tuvieron una complicación postoperatoria importante (prescripción preoperatoria de opioides: 26% [13/51] frente a ninguna prescripción preoperatoria de opioides: 9% [6/67]). En el análisis multivariable, la prescripción de opioides preoperatorios (OR = 2.994, IC 95%: 1.024-8.751, p = 0.045) fueron factores de riesgo significativos para una complicación mayor. La prescripción preoperatoria de opioides se asoció con un aumento de la duración de la estadía (p <0.001) y fue un factor de riesgo para el reingreso (OR = 2.978, IC 95%: 1.075-8.246, p = 0.036). Veinticuatro pacientes fueron readmitidos. Utilizando un límite para una mayor prescripción de opioides de 300 miligramos equivalentes de morfina dentro de los 6 meses previos a la operación (p. Ej., 60 tabletas de hidrocodona / acetaminofén 5/325), la prescripción preoperatoria de opioides siguió siendo un factor de riesgo para complicaciones postoperatorias mayores (OR = 3.148 IC 95%: 1.110-8.928, p = 0.031).Este fue un estudio retrospectivo y no pudo evaluar el uso de opioides no prescritos.La prescripción preoperatoria de opioides fue un factor de riesgo significativo para los resultados adversos en pacientes con enfermedad de Crohn sometidos a resección ileocólica electiva. Consulte Video Resumen en http://links.lww.com/DCR/B113.

Repair of complex and avascular meniscal tears and meniscal transplantation.

A functional meniscus is critical to the long-term health of the knee joint. The repair of meniscal tears that extend into the central avascular region requires understanding the appropriate indications, contraindications, surgical techniques, and postoperative rehabilitation protocols. An inside-out repair technique using multiple vertical divergent sutures with an accessory posteromedial or posterolateral incision is recommended for optimal stability. In young, active patients, the risk of repair failure and the need for revision are outweighed by the benefit of meniscal preservation. Although many meniscal tears are repairable, not all are salvageable, especially if considerable tissue damage has occurred. The goals of transplantation of human menisci are to restore partial load-bearing meniscal function, decrease patient symptoms, and provide chondroprotective effects. Clinical studies have shown that meniscal transplantation decreases tibiofemoral joint pain in the short term. The procedure remains in an evolving state with an unpredictable long-term outcome; however, most meniscal transplants gradually deteriorate, tear, or shrink in size over time, thereby losing the ability to provide function. The current goal is to provide short-term benefits to the patient until a superior meniscal transplant is clinically available.

Urgent reduction, fixation, and arthrotomy for unstable slipped capital femoral epiphysis.

BACKGROUND: The management of unstable slipped capital femoral epiphysis (SCFE) is controversial. A high incidence of avascular necrosis (AVN) has been reported after unstable SCFE. METHODS: Twenty-eight consecutive patients with thirty unstable SCFE underwent urgent reduction and fixation with two 6.5-mm cannulated screws. Positional reduction was performed in 25 cases. Arthrotomy was performed percutaneously in 16 cases and as part of an open capsulotomy in 5 cases. RESULTS: Slip severity was mild in 13 patients, moderate in 9, and severe in 8. At mean duration of follow-up of 5.5 years (range: 2.0 to 11.2), 4 patients reported groin pain, and 8 patients reported a limp. Four patients developed AVN. One patient experienced slip progression and no patient developed chondrolysis. CONCLUSIONS: Treatment of unstable SCFE with urgent positional reduction with accompanying arthrotomy and fixation through 2 cannulated screws resulted in a low incidence of slip progression and AVN. LEVEL OF EVIDENCE: Therapeutic study, level 4 (case series, no or historical control group).

Interobserver and intraobserver reliability in the evaluation of mechanical axis deviation.

BACKGROUND: The lateral distal femoral angle (LDFA), the medial proximal tibial angle (MPTA), and the mechanical axis deviation (MAD) are commonly used in the evaluation of lower extremity deformities. The interobserver and intraobserver reliabilities of these measurements have not been evaluated. METHODS: Three groups of observers with different levels of experience (5 attending pediatric orthopaedic surgeons, 5 orthopaedic chief residents, and 5 interns) measured the LDFA, MPTA, and MAD on 35 full-length standing anteroposterior teleroentgenograms (56extremities). Relatively equal numbers of extremities with varus, valgus, and normal alignments were chosen to represent a spectrum of lower extremities that might be encountered clinically. Measurements were performed in random order by each observer on 2 separate occasions separated by at least 2 weeks. RESULTS: The interobserver and intraobserver reliabilities for each of the measurements regardless of the level of experience was greater than or equal to 0.90. The interobserver differences were slightly greater than the intraobserver differences for all measurements. The overall mean interobserver differences for angular and MAD measurements were within 1.6 degrees and 3.1 mm, respectively. The overall mean intraobserver differences for angular and MAD measurements were within 1.4 degrees and 1.9 mm, respectively. Reliability and mean differences were consistent regardless of the level of experience. CONCLUSIONS: Measurement of the LDFA, MPTA, and MAD demonstrated excellent intraobserver and interobserver reliabilities regardless of the experience of the observer.

Greater than 10-year results of red-white longitudinal meniscal repairs in patients 20 years of age or younger.

BACKGROUND: A prospective longitudinal investigation was conducted to determine the long-term outcome of single longitudinal meniscal repairs extending into the central avascular region in patients aged 20 years or younger. PURPOSE: To determine the long-term success rate and reoperation rate of meniscal repairs extending into the avascular zone. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Thirty-three meniscal repairs were performed using an inside-out multiple vertical divergent suture technique. A concomitant anterior cruciate ligament reconstruction was done in 18 patients. The mean follow-up was 16.8 years (range, 10.1-21.9 years). The long-term success rate was determined in 29 repairs (88%) by the presence of normal or nearly normal parameters from 2 validated knee rating systems, assessment of magnetic resonance imaging and weightbearing posteroanterior radiographs by independent physicians, and follow-up arthroscopy when required. A 3 Tesla magnetic resonance imaging scanner with cartilage-sensitive pulse sequences was used, and T2 mapping was performed. A comparison was made between the short-term (mean, 4 years) and long-term outcomes. RESULTS: Eighteen (62%) of the meniscal repairs had normal or nearly normal characteristics in all of the parameters assessed. Six repairs (21%) required partial arthroscopic resection, 2 had loss of joint space on radiographs, and 3 that were asymptomatic failed according to magnetic resonance imaging criteria, for a total of 11 documented failures (38%). There was no significant difference in the mean articular cartilage T2 scores in the healed menisci between the involved and contralateral tibiofemoral compartments in the same knee. There were no significant differences between short- and long-term evaluations for pain, swelling, jumping, patient knee condition rating, or the overall Cincinnati rating score. CONCLUSIONS: A chondroprotective joint effect was demonstrated in the healed menisci repairs, which warrants the procedure in select patients. The long-term evaluation of the anterior cruciate ligament-reconstructed knees with concurrent successful meniscal repairs demonstrated a low rate of radiographic arthritis.

Can signal enhancement ratio (SER) reduce the number of recommended biopsies without affecting cancer yield in occult MRI-detected lesions?

RATIONALE AND OBJECTIVES: We retrospectively determined if signal enhancement ratio (SER), a quantitative measure of contrast kinetics using volumetric parameters, could reduce the number of biopsy recommendations without decreasing the number of cancers detected when applied to suspicious lesions seen on breast magnetic resonance imaging (MRI). MATERIALS AND METHODS: A retrospective review of Breast Imaging Reporting and Data System (BIRADS) 4 or 5 lesions seen on breast MRI in 2008 that were clinically and mammographically occult yielded a final sample size of 73 lesions in 65 patients. Images were processed with in-house software. Parameters used to predict benignity/malignancy included SER total tumor volume (lesion volume above a 70% initial enhancement level), SER partial tumor volume (volume with "washout" and "plateau" kinetics), SER washout tumor volume, peak SER, and peak percent enhancement. Thresholds were determined to retrospectively discriminate benign from malignant histopathology. Clinical impact was assessed through the reduction in the number of biopsies recommended (by eliminating benign lesions discriminated by SER). RESULTS: Based on the original radiologist interpretations, 73 occult lesions were called suspicious and biopsied with a predictive value of biopsies (PPV(3)) of 18/73 (25%). SER parameters were found to be significantly associated with histopathology (P < .05). Biopsy recommendations could be reduced using SER parameters of SER partial tumor volume (73 to 40), SER total tumor volume (73 to 45), and peak percent enhancement (73 to 55) without removing true positives. CONCLUSION: The adjunctive use of SER parameters may reduce the number of recommended biopsies without reducing the number of cancers detected.

Is ulnar nerve transposition beneficial during open reduction internal fixation of distal humerus fractures?

OBJECTIVES: The purpose of this study was to compare the incidence of ulnar neuritis with and without ulnar nerve transposition during open reduction and internal fixation (ORIF) of distal humerus fractures. DESIGN: Multicenter retrospective cohort series. SETTING: : Two Level I trauma centers. PATIENTS: Two cohorts were identified: 89 patients (mean age, 48.6 years) who had not undergone an ulnar nerve transposition and 48 patients (mean age, 43.2 years) who had undergone a transposition during ORIF of a distal humerus fracture (Orthopaedic Trauma Association 13A or 13C). INTERVENTION: All patients underwent ORIF of a distal humerus fracture with or without anterior subcutaneous ulnar nerve transposition based on surgeon preference. MAIN OUTCOME MEASURE: Presence or absence of ulnar neuritis (ulnar-sided paresthesias, numbness, or intrinsic weakness) or reoperation related to ulnar nerve symptoms. RESULTS: : Average follow up was 9.6 months in the transposition group and 16.0 months in the nontransposition group. Transposition of the ulnar nerve was found to be an independent variable associated with ulnar neuritis (P < 0.001). The incidence of ulnar neuritis was 33% (16 of 48) with transposition and 9% (eight of 89) without transposition (P = 0.0003). Of the patients with ulnar neuritis, one patient in the nontransposition group (1%) and two patients in the transposition group (4%) required additional surgery specifically related to the ulnar nerve. One patient who had undergone transposition developed chronic motor and sensory denervation. CONCLUSION: Patients who underwent ulnar nerve transposition at the time of ORIF of distal humerus fractures had almost four times the incidence of ulnar neuritis than those without transposition. We do not recommend routine transposition of the ulnar nerve at the time of ORIF of distal humerus fractures.

A new dynamic foot abduction orthosis for clubfoot treatment.

Recurrent clubfoot deformity after successful initial correction with the use of the Ponseti method continues to be a common problem and is often caused by noncompliance with wear of the traditional foot abduction brace. The purpose of this study was to assess the results of a newly designed dynamic foot abduction orthosis in terms of (1) parental compliance and (2) effectiveness in preventing recurrent clubfoot deformities. Twenty-eight patients (49 clubfeet) who were treated with a dynamic foot abduction orthosis in accordance with the Ponseti method were included in this study. Of the 28 patients, 18 had idiopathic clubfeet (31 clubfeet), 2 had complex idiopathic clubfeet (4 clubfeet), 5 had myelodysplasia (8 clubfeet), and 3 were syndromic (6 clubfeet). The mean duration of follow-up was 29 months (range, 24-36 months). Noncompliance was reported in only 2 (7.1%) of the 28 patients in the new orthosis compared with the authors' previously reported 41% (21/51) noncompliance rate in patients treated with the use of the traditional foot abduction brace. The two patients in this study, in which parents were noncompliant with orthosis wear, developed recurrent deformities. There were 2 patients (7%) who experienced skin blistering in the new orthosis compared with 12 (23.5%) of 51 patients who experienced blistering with the use of traditional abduction brace in the authors' previously reported study. Logistic regression modeling compliance and recurrence revealed that noncompliance with the foot abduction orthosis was most predictive of recurrence of deformity (odds ratio, 27; 95% confidence interval, 2.2-326; P = 0.01). The articulating foot abduction orthosis is well tolerated by patients and parents and results in a higher compliance rate and a lower complication rate than what were observed with the traditional foot abduction orthosis.

Troublesome stress fractures of the foot and ankle.

Athletes engaged in repetitive activity with recent increases in training or competition are at risk for stress fractures of the foot and ankle. Physical and radiographic findings are often unremarkable and diagnosis may be difficult. Although many of these injuries may be managed symptomatically, certain types of stress fractures are at higher risk for delayed union, nonunion, or refracture without aggressive immobilization or surgical fixation.