ABSTRACT
Opposed to whole wheat (WWP), traditional pizza (TP) is loved by patients with type 1 diabetes mellitus (T1DM) despite causing hyperglycemia. 50 well-trained T1DM patients had higher glucose levels after TP than after WWP or mixed flour pizza, which however was tasty, digestible and metabolically appropriate to break diet monotony.
Subject(s)
Diabetes Mellitus, Type 1/diet therapy , Glycemic Index , Hypoglycemic Agents/therapeutic use , Insulin Infusion Systems , Insulin/therapeutic use , Taste , Adolescent , Adult , Blood Glucose/analysis , Diabetes Mellitus, Type 1/drug therapy , Dietary Carbohydrates , Dietary Fiber , Female , Humans , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage , Male , Middle Aged , Treatment Outcome , Young AdultABSTRACT
A case of silicosis associated with Crohn's disease is reported. Symptoms, radiological and endoscopical findings suggested Crohn's disease in a man, who had worked as ceramist and in whom silicosis was diagnosed four years earlier. The authors, after presenting the clinical and diagnostic features of the patient, discuss the similarity of some pathogenetic features of the two diseases. They hypothesize a common pathogenetic immunological defect in the two diseases, probably caused by inhalation of silica.
Subject(s)
Crohn Disease/etiology , Silicosis/complications , Humans , Male , Middle AgedABSTRACT
Three cases of secondary gastric lymphoma are presented in which diagnosis was suggested by ultrasound (US) and confirmed by endoscopy and microscopical examination. Three different US patterns are illustrated and compared with endoscopy. US findings paralleled endoscopy during follow-up under antiblastic treatment: both improvement and lack of change in the gastric lesions were reliably predicted by US.
Subject(s)
Lymphoma/diagnosis , Stomach Neoplasms/diagnosis , Ultrasonography , Aged , Aged, 80 and over , Antineoplastic Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Female , Gastroscopy , Humans , Lymphoma/drug therapy , Stomach Neoplasms/drug therapyABSTRACT
The fatty acid composition of subcutaneous tissue has been determined in a population sample of apparently healthy middle aged men from Southern Italy. Dietary appraisal has been carried out by evaluating the usual pattern of food consumption during the year preceding the interview. The whole population sample was subdivided into three tertiles on the basis of the energy intake by the different individuals. The proportion of adipose tissue polyunsaturated fatty acids was relatively low in the high energy tertile III and high in the low energy tertile reflecting parallel differences in the intake of polyunsaturated fatty acids. The percentage of monounsaturated fatty acids (mainly oleic acid) was relatively high (p less than 0.01) and that of saturated fatty acids (mainly palmitic acid) relatively low (p less than 0.05) in the high energy tertile (III) as compared to the low energy tertile (I); these differences were independent of the amount and type of dietary fatty acids. Total energy was positively correlated (r = .87, p less than 0.01) to carbohydrate intake (g/day). Dietary carbohydrates (g/day) were inversely related to adipose tissue saturated fatty acids (r = -.40, p less than 0.001) and directly correlated to adipose tissue monounsaturated fatty acids (p = .40, p less than 0.001). Carbohydrate intake was related to adipose tissue monounsaturated and saturated fatty acids independently of daily energy intake. On the other hand when the influence of dietary carbohydrates was eliminated, no correlation was detectable any longer between energy intake and adipose tissue fatty acids.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Adipose Tissue/metabolism , Dietary Carbohydrates/metabolism , Eating , Energy Metabolism , Fatty Acids, Monounsaturated/metabolism , Fatty Acids/metabolism , Adult , Antioxidants , Humans , Liver/metabolism , Male , Middle Aged , Oleic Acid , Oleic Acids/metabolism , Palmitic Acid , Palmitic Acids/metabolismABSTRACT
247 cases of patients suffering from chronic liver diseases were reviewed. These cases were divided according to "risk areas" (viral, alcoholic, viral and alcoholic, cryptogenic) and diagnosis (CAH, compensated cirrhosis, decompensated cirrhosis). Differences found in clinical and laboratory aspects of liver diseases from different risk areas are described but it is concluded that no single aetiology affects the liver functional reserve more than the others. Laboratory tests give more information in the early stages of chronic liver diseases while clinical analysis is more varied in the terminal ones. Literature on the subject is reviewed. Our data neither confirm nor disprove that HBsAg+ Alcohol+ patients display a characteristic clinical picture and this hypothesis should be further investigated.
Subject(s)
Liver Diseases/pathology , Adolescent , Adult , Aged , Chronic Disease , Female , Hepatitis, Viral, Human/pathology , Humans , Liver Cirrhosis/pathology , Liver Diseases/etiology , Liver Diseases, Alcoholic/pathology , Male , Middle Aged , Platelet Count , Prothrombin Time , Retrospective Studies , Risk , Serum Albumin/analysis , Sex Factors , gamma-Globulins/analysisABSTRACT
Of the 53 cirrhotic patients with cholelithiasis observed at our Institution from 1978 to 1991, 31 were operated on. Twenty-eight Child-Pugh class A, two class B and one class C patients underwent elective cholecystectomy with (5 cases) or without (26 cases) common bile duct exploration. Among the symptomatic patients, nine (18.7%) were refused for surgery because the risk was estimated to be too high. Symptoms ranged from mild-moderate abdominal pain to typical biliary colic. Acute biliary inflammatory complications as cholecystitis or cholangitis could be detected in the clinical history of 5 patients (16%). Although a common clinical feature, jaundice was directly related to gallbladder or common bile duct stones only in one half of the cases. A total of 18 postoperative non-lethal complications occurred in ten patients (32.2%), with haemorrhage from the gallbladder bed being the most frequent event. Bleeding was associated with increased prothrombin time more than 1.5 seconds above the control (p < 0.01) but severe haemorrhage occurred only when the platelet count was less than 100.000/ml (p < 0.05). Common bile duct explorations increased the risk of bleeding. Two of the 3 class B or C patients developed ascites (p < 0.05). It is concluded that elective cholecystectomy can be performed without mortality in selected and symptomatic patients with adequate hepatic functional reserve.
Subject(s)
Cholecystectomy , Cholelithiasis/surgery , Liver Cirrhosis, Biliary/surgery , Adult , Aged , Cholelithiasis/complications , Female , Gallstones/surgery , Humans , Liver Cirrhosis, Biliary/complications , Male , Middle Aged , Postoperative Complications/etiology , Retrospective StudiesSubject(s)
Nitrogen/metabolism , Testosterone/pharmacology , Adult , Blood Proteins/analysis , Blood Urea Nitrogen , Female , Humans , Male , Nitrogen/urine , Transferrin/bloodSubject(s)
Blood Glucose/metabolism , Fatty Acids, Nonesterified/metabolism , Insulin/blood , Physical Exertion , Adolescent , Adult , Diet , Fasting , Female , Humans , MaleSubject(s)
Chlorpropamide/therapeutic use , Diabetes Mellitus/drug therapy , Drug Synergism , Phenformin/therapeutic use , Adult , Female , Humans , Male , Middle AgedABSTRACT
The behaviour of some urinary metabolites of tryptophan/nicotinic acid pathway was studied in 7 patients with Parkinson's disease during a 24-day period of levodopa treatment. Corresponding to the appearance of side-effects (agitation, anorexia, dysphagia, glossitis, abdominal pains) in 5 patients there was an increase in urinary Ky, AA, AAG, o-AHA, and 3-HK, while 3-HAA excretion fell. Since no other drugs were given, it was presumed that this effect was due to levodopa administration.
Subject(s)
Levodopa/therapeutic use , Nicotinic Acids/metabolism , Parkinson Disease/metabolism , Tryptophan/metabolism , Adult , Aged , Female , Humans , Male , Middle Aged , Parkinson Disease/drug therapyABSTRACT
Cultures of human intestinal aerobic flora did not have any inhibiting action on the immunologic reactivity of hepatitis B antigen even after disruption of bacterial cells by freezing and thawing. This suggests that the inhibitor is elaborated by the human intestinal mucosa.
Subject(s)
Bacteria/immunology , Hepatitis B Antigens , Intestines/microbiology , Adult , Aerobiosis , Escherichia coli/immunology , Feces/immunology , Feces/microbiology , Hepatitis B Antigens/analysis , Humans , Immune Sera , MaleABSTRACT
Ultrasound appearance of intragallbladder haemorrhage in two patients with haemobilia is presented. Gallbladder lumina were occupied by non-shadowing, firm masses of mixed echogenicity representing blood clots. In both cases iatrogenic trauma following percutaneous transcholecystic cholangiography and blind hepatic biopsy caused bleeding in the biliary tree.