1.
Crit Rev Oncol Hematol
; 107: 90-99, 2016 Nov.
Article
in English
| MEDLINE
| ID: mdl-27823655
ABSTRACT
Even though the pathogenesis of myelodysplastic syndromes (MDS) is dominated by specific molecular defects involving hematopoietic precursors, also immune mechanisms seem to play a fundamental functional role. In this review we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus on studies addressing the possible influence of different immune cell subpopulations on the disease onset and evolution. We will finally consider therapeutic approaches based on immunomodulation, ranging from immunosuppressants to vaccination and transplantation strategies.
Subject(s)
Myelodysplastic Syndromes/immunology , B-Lymphocytes/immunology , Humans , Immunosuppressive Agents/therapeutic use , Mesenchymal Stem Cells/immunology , Myelodysplastic Syndromes/drug therapy , Receptors, Antigen, T-Cell/immunology , T-Lymphocytes/immunology
2.
Mediterr J Hematol Infect Dis
; 11(1): e2019032, 2019.
Article
in English
| MEDLINE
| ID: mdl-31205636