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1.
Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Anal Chem
; 95(49): 17957-17961, 2023 12 12.
Article
in English
| MEDLINE | ID: mdl-38084380
2.
Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling.
Toxicol Appl Pharmacol
; 438: 115830, 2022 03 01.
Article
in English
| MEDLINE | ID: mdl-34933053
3.
Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.
Mol Pharm
; 19(5): 1540-1547, 2022 05 02.
Article
in English
| MEDLINE | ID: mdl-35393854
4.
Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits.
Toxicol Pathol
; 49(3): 647-655, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33733956
5.
Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.
Toxicol Pathol
; 49(3): 634-646, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33349160
6.
Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics.
Bioconjug Chem
; 30(11): 2782-2789, 2019 11 20.
Article
in English
| MEDLINE | ID: mdl-31553572
7.
Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.
Mol Pharm
; 13(9): 2996-3003, 2016 09 06.
Article
in English
| MEDLINE | ID: mdl-27244474
8.
Translational research to develop a human PBPK models tool kit-volatile organic compounds (VOCs).
J Toxicol Environ Health A
; 75(1): 6-24, 2012.
Article
in English
| MEDLINE | ID: mdl-22047160
9.
Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.
Front Pharmacol
; 12: 601569, 2021.
Article
in English
| MEDLINE | ID: mdl-34025395
10.
Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules.
Transl Vis Sci Technol
; 8(6): 1, 2019 Nov.
Article
in English
| MEDLINE | ID: mdl-31695962
11.
In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes.
Toxicol Lett
; 269: 23-32, 2017 Mar 05.
Article
in English
| MEDLINE | ID: mdl-28119020
12.
Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.
MAbs
; 8(6): 1098-106, 2016.
Article
in English
| MEDLINE | ID: mdl-27216702
13.
Gender and species differences in triadimefon metabolism by rodent hepatic microsomes.
Toxicol Lett
; 193(1): 101-7, 2010 Mar 01.
Article
in English
| MEDLINE | ID: mdl-20026392
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