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1.
HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent.
J Biol Chem
; 300(2): 105638, 2024 Feb.
Article
in English
| MEDLINE | ID: mdl-38199570
2.
Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.
Circulation
; 149(18): 1419-1434, 2024 Apr 30.
Article
in English
| MEDLINE | ID: mdl-38357791
3.
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
EMBO J
; 38(10)2019 05 15.
Article
in English
| MEDLINE | ID: mdl-30902848
4.
Pharmacological inhibition of IKKß dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.
Biochem Biophys Res Commun
; 545: 177-182, 2021 03 19.
Article
in English
| MEDLINE | ID: mdl-33561652
5.
Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.
Blood
; 134(19): 1670-1682, 2019 11 07.
Article
in English
| MEDLINE | ID: mdl-31533918
6.
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
EMBO J
; 35(16): 1766-78, 2016 08 15.
Article
in English
| MEDLINE | ID: mdl-27418190
7.
Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase-1 knockout.
Biotechnol Bioeng
; 115(10): 2530-2540, 2018 10.
Article
in English
| MEDLINE | ID: mdl-29777593
8.
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg Med Chem Lett
; 28(5): 906-909, 2018 03 01.
Article
in English
| MEDLINE | ID: mdl-29433930
9.
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.
J Med Chem
; 67(2): 1544-1562, 2024 Jan 25.
Article
in English
| MEDLINE | ID: mdl-38175811
10.
IL-1ß promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Blood Adv
; 8(5): 1234-1249, 2024 Mar 12.
Article
in English
| MEDLINE | ID: mdl-38207211
11.
HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent.
bioRxiv
; 2023 Aug 15.
Article
in English
| MEDLINE | ID: mdl-37645730
12.
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Sci Signal
; 16(768): eabh1083, 2023 01 17.
Article
in English
| MEDLINE | ID: mdl-36649377
13.
Inhibition of interleukin-1ß reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Nat Commun
; 13(1): 5346, 2022 09 13.
Article
in English
| MEDLINE | ID: mdl-36100613
14.
Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation.
PLoS One
; 16(11): e0248668, 2021.
Article
in English
| MEDLINE | ID: mdl-34767572
15.
Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.
J Mol Biol
; 433(24): 167309, 2021 12 03.
Article
in English
| MEDLINE | ID: mdl-34687713
16.
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
J Biol Chem
; 284(38): 25697-703, 2009 Sep 18.
Article
in English
| MEDLINE | ID: mdl-19620707
17.
Improving the species cross-reactivity of an antibody using computational design.
Bioorg Med Chem Lett
; 19(14): 3744-7, 2009 Jul 15.
Article
in English
| MEDLINE | ID: mdl-19477127
18.
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).
J Mol Biol
; 369(4): 1041-51, 2007 Jun 15.
Article
in English
| MEDLINE | ID: mdl-17475279
19.
ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.
Neurosci Lett
; 660: 109-114, 2017 Nov 01.
Article
in English
| MEDLINE | ID: mdl-28923481
20.
Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.
ChemMedChem
; 11(8): 862-9, 2016 Apr 19.
Article
in English
| MEDLINE | ID: mdl-26822284