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1.

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

Lotta, Luca A; Mokrosinski, Jacek; Mendes de Oliveira, Edson; Li, Chen; Sharp, Stephen J; Luan, Jian'an; Brouwers, Bas; Ayinampudi, Vikram; Bowker, Nicholas; Kerrison, Nicola; Kaimakis, Vasileios; Hoult, Diana; Stewart, Isobel D; Wheeler, Eleanor; Day, Felix R; Perry, John R B; Langenberg, Claudia; Wareham, Nicholas J; Farooqi, I Sadaf.

Cell ; 177(3): 597-607.e9, 2019 04 18.

Article in English | MEDLINE | ID: mdl-31002796

2.

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.

van der Klaauw, Agatha A; Croizier, Sophie; Mendes de Oliveira, Edson; Stadler, Lukas K J; Park, Soyoung; Kong, Youxin; Banton, Matthew C; Tandon, Panna; Hendricks, Audrey E; Keogh, Julia M; Riley, Susanna E; Papadia, Sofia; Henning, Elana; Bounds, Rebecca; Bochukova, Elena G; Mistry, Vanisha; O'Rahilly, Stephen; Simerly, Richard B; Minchin, James E N; Barroso, Inês; Jones, E Yvonne; Bouret, Sebastien G; Farooqi, I Sadaf.

Cell ; 176(4): 729-742.e18, 2019 02 07.

Article in English | MEDLINE | ID: mdl-30661757

3.

A New Drug Target for Type 2 Diabetes.

Stadler, Lukas K J; Farooqi, I Sadaf.

Cell ; 170(1): 12-14, 2017 06 29.

Article in English | MEDLINE | ID: mdl-28666114

4.

Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R.

Lotta, Luca; Langenberg, Claudia; Wareham, Nicholas J; Farooqi, I Sadaf.

Cell ; 184(7): 1652-1653, 2021 04 01.

Article in English | MEDLINE | ID: mdl-33798435

5.

The hunger genes: pathways to obesity.

van der Klaauw, Agatha A; Farooqi, I Sadaf.

Cell ; 161(1): 119-132, 2015 Mar 26.

Article in English | MEDLINE | ID: mdl-25815990

6.

Leptin mediates the increase in blood pressure associated with obesity.

Simonds, Stephanie E; Pryor, Jack T; Ravussin, Eric; Greenway, Frank L; Dileone, Ralph; Allen, Andrew M; Bassi, Jaspreet; Elmquist, Joel K; Keogh, Julia M; Henning, Elana; Myers, Martin G; Licinio, Julio; Brown, Russell D; Enriori, Pablo J; O'Rahilly, Stephen; Sternson, Scott M; Grove, Kevin L; Spanswick, David C; Farooqi, I Sadaf; Cowley, Michael A.

Cell ; 159(6): 1404-16, 2014 Dec 04.

Article in English | MEDLINE | ID: mdl-25480301

7.

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.

Pearce, Laura R; Atanassova, Neli; Banton, Matthew C; Bottomley, Bill; van der Klaauw, Agatha A; Revelli, Jean-Pierre; Hendricks, Audrey; Keogh, Julia M; Henning, Elana; Doree, Deon; Jeter-Jones, Sabrina; Garg, Sumedha; Bochukova, Elena G; Bounds, Rebecca; Ashford, Sofie; Gayton, Emma; Hindmarsh, Peter C; Shield, Julian P H; Crowne, Elizabeth; Barford, David; Wareham, Nick J; O'Rahilly, Stephen; Murphy, Michael P; Powell, David R; Barroso, Ines; Farooqi, I Sadaf.

Cell ; 155(4): 765-77, 2013 Nov 07.

Article in English | MEDLINE | ID: mdl-24209692

8.

Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.

Funcke, Jan-Bernd; Moepps, Barbara; Roos, Julian; von Schnurbein, Julia; Verstraete, Kenneth; Fröhlich-Reiterer, Elke; Kohlsdorf, Katja; Nunziata, Adriana; Brandt, Stephanie; Tsirigotaki, Alexandra; Dansercoer, Ann; Suppan, Elisabeth; Haris, Basma; Debatin, Klaus-Michael; Savvides, Savvas N; Farooqi, I Sadaf; Hussain, Khalid; Gierschik, Peter; Fischer-Posovszky, Pamela; Wabitsch, Martin.

N Engl J Med ; 388(24): 2253-2261, 2023 Jun 15.

Article in English | MEDLINE | ID: mdl-37314706

9.

A Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.

Khorisantono, Putu A; Huang é»é£æ, Fei-Yang; Sutcliffe, Michael P F; Fletcher, Paul C; Farooqi, I Sadaf; Grabenhorst, Fabian.

J Neurosci ; 43(47): 8000-8017, 2023 11 22.

Article in English | MEDLINE | ID: mdl-37845034

10.

Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

Mendes de Oliveira, Edson; Keogh, Julia M; Talbot, Fleur; Henning, Elana; Ahmed, Rachel; Perdikari, Aliki; Bounds, Rebecca; Wasiluk, Natalia; Ayinampudi, Vikram; Barroso, Inês; Mokrosinski, Jacek; Jyothish, Deepthi; Lim, Sharon; Gupta, Sanjay; Kershaw, Melanie; Matei, Cristina; Partha, Praveen; Randell, Tabitha; McAulay, Antoinette; Wilson, Louise C; Cheetham, Tim; Crowne, Elizabeth C; Clayton, Peter; Farooqi, I Sadaf.

N Engl J Med ; 385(17): 1581-1592, 2021 10 21.

Article in English | MEDLINE | ID: mdl-34614324

11.

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.

Agrawal, Neha; Lawler, Katherine; Davidson, Catherine M; Keogh, Julia M; Legg, Robert; Barroso, Inês; Farooqi, I Sadaf; Brand, Andrea H.

PLoS Biol ; 19(11): e3001255, 2021 11.

Article in English | MEDLINE | ID: mdl-34748544

12.

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity.

Liang, Zhengzheng S; Cimino, Irene; Yalcin, Binnaz; Raghupathy, Narayanan; Vancollie, Valerie E; Ibarra-Soria, Ximena; Firth, Helen V; Rimmington, Debra; Farooqi, I Sadaf; Lelliott, Christopher J; Munger, Steven C; O'Rahilly, Stephen; Ferguson-Smith, Anne C; Coll, Anthony P; Logan, Darren W.

PLoS Genet ; 16(9): e1008916, 2020 09.

Article in English | MEDLINE | ID: mdl-32877400

13.

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.

Seelig, Eleonora; Henning, Elana; Keogh, Julia M; Gillett, Daniel; Shin, Evelyn; Buscombe, John; van der Klaauw, Agatha A; Farooqi, I Sadaf.

Clin Endocrinol (Oxf) ; 96(2): 270-275, 2022 02.

Article in English | MEDLINE | ID: mdl-34694010

14.

Genetic architecture of human thinness compared to severe obesity.

Riveros-McKay, Fernando; Mistry, Vanisha; Bounds, Rebecca; Hendricks, Audrey; Keogh, Julia M; Thomas, Hannah; Henning, Elana; Corbin, Laura J; O'Rahilly, Stephen; Zeggini, Eleftheria; Wheeler, Eleanor; Barroso, Inês; Farooqi, I Sadaf.

PLoS Genet ; 15(1): e1007603, 2019 01.

Article in English | MEDLINE | ID: mdl-30677029

15.

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.

Hendricks, Audrey E; Billups, Stephen C; Pike, Hamish N C; Farooqi, I Sadaf; Zeggini, Eleftheria; Santorico, Stephanie A; Barroso, Inês; Dupuis, Josée.

PLoS Genet ; 14(10): e1007591, 2018 10.

Article in English | MEDLINE | ID: mdl-30325923

16.

Obesity-Associated GNAS Mutations and the Melanocortin Pathway. Reply.

Mendes de Oliveira, Edson; Keogh, Julia M; Farooqi, I Sadaf.

N Engl J Med ; 387(3): 285-286, 2022 07 21.

Article in English | MEDLINE | ID: mdl-35857674

17.

Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.

Jiang, Lin; Su, Haoran; Keogh, Julia M; Chen, Zheng; Henning, Elana; Wilkinson, Paul; Goodyer, Ian; Farooqi, I Sadaf; Rui, Liangyou.

FASEB J ; 32(4): 1830-1840, 2018 04.

Article in English | MEDLINE | ID: mdl-29180441

18.

Energy expenditure in frontotemporal dementia: a behavioural and imaging study.

Ahmed, Rebekah M; Landin-Romero, Ramon; Collet, Tinh-Hai; van der Klaauw, Agatha A; Devenney, Emma; Henning, Elana; Kiernan, Matthew C; Piguet, Olivier; Farooqi, I Sadaf; Hodges, John R.

Brain ; 140(1): 171-183, 2017 01.

Article in English | MEDLINE | ID: mdl-27789521

19.

SnapShot: the hormonal control of food intake.

Coll, Anthony P; Yeo, Giles S H; Farooqi, I Sadaf; O'Rahilly, Stephen.

Cell ; 135(3): 572.e1-2, 2008 Oct 31.

Article in English | MEDLINE | ID: mdl-18984167

20.

Obesity and the brain: how convincing is the addiction model?

Ziauddeen, Hisham; Farooqi, I Sadaf; Fletcher, Paul C.

Nat Rev Neurosci ; 13(4): 279-86, 2012 03 14.

Article in English | MEDLINE | ID: mdl-22414944

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