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1.
J Shoulder Elbow Surg ; 28(8): 1595-1600, 2019 Aug.
Article in English | MEDLINE | ID: mdl-30982698

ABSTRACT

BACKGROUND: Shoulder arthroplasty is a reliable procedure for patients with degenerative glenohumeral disease, and reproduction of native shoulder anatomy leads to superior outcomes. The aim of this study was to compare the ability of stemmed and stemless implants to radiographically restore native glenohumeral anatomy. METHODS: Shoulder arthroplasties were performed in 79 patients, with 58 receiving a stemless implant and 21 receiving a stemmed implant. Preoperative and postoperative radiographs were assessed for humeral head height, humeral head centering, humeral head medial offset, humeral head diameter, humeral neck angle, and lateral humeral offset by 2 independent viewers. Measurements were scored and summed to identify the anatomic reconstruction index (ARI). Radiographic measurements were compared using the Student t test, and significance was set at P < .05 for all statistical analyses. Interobserver agreement of radiographic analyses was assessed using the intraclass correlation coefficient, finding excellent reliability (intraclass correlation coefficient, 0.92). RESULTS: Five of six radiographic measurements along with the calculated ARI demonstrated no differences between stemmed and stemless shoulder implants (humeral head diameter, P = .651; humeral head height, P = .813; humeral head medial offset, P = .592; lateral humeral offset, P = .311; humeral head centering, P = .414; and ARI, P = .862). Stemless implants showed improved restoration of the native humeral neck angle (0° for stemless vs. -3° for stemmed, P = .017). CONCLUSION: Radiographic restoration of anatomy is similar for stemmed and stemless shoulder arthroplasty implants.


Subject(s)
Arthroplasty, Replacement, Shoulder/methods , Humeral Head/diagnostic imaging , Osteoarthritis/surgery , Radiography/methods , Shoulder Joint/diagnostic imaging , Humans , Humeral Head/surgery , Osteoarthritis/diagnosis , Postoperative Period , Reproducibility of Results , Shoulder Joint/surgery
2.
Int Orthop ; 43(2): 367-378, 2019 02.
Article in English | MEDLINE | ID: mdl-30511283

ABSTRACT

PURPOSE: Clinical shoulder science lacks a benchmark against which the early clinical value of new glenoid components can be compared; such a benchmark may be derived from a multicenter study of patients receiving an established, internationally used design of glenoid component. METHODS: We obtained data from 11 centers on 1270 patients having total shoulder arthroplasty using an all-polyethylene component with a fluted central peg. We analyzed individual patient outcomes at 1 and 2 years after surgery. We compared the improvement for each patient to the minimal clinically important difference (MCID) and calculated each patient's improvement as a percent of maximal possible improvement (MPI). RESULTS: The preoperative scores improved from SST 3 ± 2, ASES 37 ± 15, Constant score 36 ± 16, and Penn score 30 ± 19 to SST 10 ± 2, ASES 90 ± 12, Constant 76 ± 13, and Penn 80 ± 24 (p < 0.001 for each). A high percentage of patients improved by more than the MCID (SST 96%, ASES 98%, Constant 94%, Penn 93%) and obtained improvement of at least 30% of the MPI (SST 95%, ASES 98%, Constant 91%, Penn 87%). The clinical outcomes realized with this glenoid design were not worse for the 41% of shoulders with preoperative type B glenoids or for the 30% of shoulders with more than 15 degrees of glenoid retroversion. CONCLUSIONS: Individual patients from 11 international practices having total shoulder arthroplasty using a basic glenoid component design obtained highly significant clinical outcomes, providing a benchmark against which the early outcomes of new designs can be compared to determine whether they provide increased clinical value.


Subject(s)
Arthroplasty, Replacement, Shoulder/methods , Joint Prosthesis , Scapula/surgery , Shoulder Joint/surgery , Adult , Aged , Aged, 80 and over , Biocompatible Materials , Female , Follow-Up Studies , Humans , Joint Diseases/surgery , Male , Middle Aged , Osteoarthritis/diagnostic imaging , Osteoarthritis/surgery , Polyethylene , Prosthesis Design , Retrospective Studies , Shoulder Joint/diagnostic imaging , Tomography, X-Ray Computed , Treatment Outcome , Young Adult
3.
Nanomedicine ; 14(7): 2271-2282, 2018 10.
Article in English | MEDLINE | ID: mdl-30076934

ABSTRACT

Delayed fracture union is a significant clinical challenge in orthopedic practice. There are few non-surgical therapeutic options for this pathology. To address this challenge, we have developed a bone-targeting liposome (BTL) formulation of salvianic acid A (SAA), a potent bone anabolic agent, for improved treatment of delayed fracture union. Using pyrophosphorylated cholesterol as the targeting ligand, the liposome formulation (SAA-BTL) has demonstrated strong affinity to hydroxyapatite in vitro, and to bones in vivo. Locally administered SAA-BTL was found to significantly improve fracture callus formation and micro-architecture with accelerated mineralization rate in callus when compared to the dose equivalent SAA, non-targeting SAA liposome (SAA-NTL) or no treatment on a prednisone-induced delayed fracture union mouse model. Biomechanical analyses further validated the potent therapeutic efficacy of SAA-BTL. These results support SAA-BTL formulation, as a promising therapeutic candidate, to be further developed into an effective and safe clinical treatment for delayed bone fracture union.


Subject(s)
Caffeic Acids/pharmacology , Fracture Healing/drug effects , Fractures, Bone/drug therapy , Lactates/pharmacology , Liposomes/administration & dosage , Osteogenesis , Proton Pump Inhibitors/pharmacology , Animals , Anti-Inflammatory Agents/toxicity , Caffeic Acids/chemistry , Cholesterol/metabolism , Disease Models, Animal , Drug Compounding , Female , Fractures, Bone/chemically induced , Lactates/chemistry , Liposomes/chemistry , Mice , Prednisone/toxicity , Proton Pump Inhibitors/chemistry
5.
Mol Pharm ; 14(5): 1418-1428, 2017 05 01.
Article in English | MEDLINE | ID: mdl-28343392

ABSTRACT

N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymers were previously found to represent a versatile delivery platform for the early detection and intervention of orthopedic implant loosening. In this article, we evaluated the impact of different structural parameters of the HPMA copolymeric system (e.g., molecular weight (MW), drug content) to its pharmacokinetics and biodistribution (PK/BD) profile. Using 125I, Alexa Fluor 488, and IRDye 800 CW-labeled HPMA copolymer-dexamethasone (P-Dex) conjugates with different MW and dexamethasone (Dex) contents, we found the MW to be the predominant impact factor on the PK/BD profiles of P-Dex, with Dex content as a secondary impact factor. In gamma counter-based PK/BD studies, increased MW of P-Dex reduced elimination, leading to lower clearance, longer half-life, and higher systemic exposure (AUC and MRT). In the semiquantitative live animal optical imaging evaluation, the distribution of P-Dex to the peri-implant inflammatory lesion increased when MW was increased. This result was further confirmed by FACS analyses of cells isolated from peri-implant regions after systemic administration of Alexa Fluor 488-labeled P-Dex. Since the in vitro cell culture study suggested that the internalization of P-Dex by macrophages is generally independent of P-Dex's MW and Dex content, the impact of the MW and Dex content on its PK/BD profile was most likely exerted at physiological and pathophysiological levels rather than at the cellular level. In both gamma counter-based PK/BD analyses and semiquantitative optical imaging analyses, P-Dex with 6 wt % Dex content showed fast clearance. Dynamic light scattering analyses unexpectedly revealed significant molecular aggregation of P-Dex at this Dex content level. The underlining mechanisms of the aggregation and fast in vivo clearance of the P-Dex warrant further investigation.


Subject(s)
Dexamethasone/chemistry , Methacrylates/chemistry , Polymers/chemistry , Animals , Flow Cytometry , Male , Methacrylates/pharmacokinetics , Mice , Microscopy, Fluorescence , Polymers/pharmacokinetics
6.
Pharm Res ; 33(8): 1959-71, 2016 08.
Article in English | MEDLINE | ID: mdl-27164897

ABSTRACT

PURPOSE: To evaluate the therapeutic efficiency of a micellar prodrug formulation of simvastatin (SIM/SIM-mPEG) and explore its safety in a closed femoral fracture mouse model. METHODS: The amphiphilic macromolecular prodrug of simvastatin (SIM-mPEG) was synthesized and formulated together with free simvastatin into micelles. It was also labeled with a near infrared dye for in vivo imaging purpose. A closed femoral fracture mouse model was established using a three-points bending device. The mice with established closed femoral fractures were treated with SIM/SIM-mPEG micelles, using free simvastatin and saline as controls. The therapeutic efficacy of the micelles was evaluated using a high-resolution micro-CT. Serum biochemistry and histology analyses were performed to explore the potential toxicity of the micelle formulation. RESULTS: Near Infrared Fluorescence (NIRF) imaging confirmed the passive targeting of SIM/SIM-mPEG micelles to the bone lesion of the mice with closed femoral fractures. The micelle was found to promote fracture healing with an excellent safety profile. In addition, the accelerated healing of the femoral fracture also helped to prevent disuse-associated ipsilateral tibia bone loss. CONCLUSION: SIM/SIM-mPEG micelles were found to be an effective and safe treatment for closed femoral fracture repair in mice. The evidence obtained in this study suggests that it may have the potential to be translated into a novel therapy for clinical management of skeletal fractures and non-union.


Subject(s)
Disease Models, Animal , Femoral Fractures/drug therapy , Fractures, Closed/drug therapy , Micelles , Prodrugs/administration & dosage , Simvastatin/administration & dosage , Animals , Drug Evaluation, Preclinical , Femoral Fractures/diagnostic imaging , Fractures, Closed/diagnostic imaging , Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage , Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects , Male , Mice , Prodrugs/adverse effects , Simvastatin/adverse effects , Treatment Outcome
7.
J Shoulder Elbow Surg ; 25(5): e130-8, 2016 May.
Article in English | MEDLINE | ID: mdl-26895601

ABSTRACT

Proximal humerus fractures are the third most common fracture in the elderly. Although most fractures can be treated conservatively with acceptable outcomes, certain fracture patterns are at high risk for progression to humeral malunions, nonunions, stiffness, and post-traumatic arthrosis. The goal of antegrade humeral nailing of proximal humerus fractures is to provide stability to a reduced fracture that allows early motion to optimize patient outcomes. Certain technical pearls are pivotal in managing these difficult fractures with nails; these include rotator cuff management, respect of the soft tissues, anatomic tuberosity position, blood supply maintenance, knowledge of the deforming forces on the proximal humerus, fracture reduction, and rehabilitation strategies. Modern proximal humeral nail designs and techniques assist the surgeon in adhering to these principles and have demonstrated promising outcomes. Humeral nail designs have undergone significant innovation during the past 40 years and now can provide stable fixation in the humeral shaft distally as well as improved stability in the head and tuberosity fragments, which were the common site of fixation failure with earlier generation implants. Compared with other fixation strategies, such as locking plate fixation, no compelling evidence exists to suggest one technique over another. The purpose of this review is to describe the history, results, new designs, and techniques that make modern intramedullary nailing of proximal humerus fractures a viable treatment option.


Subject(s)
Bone Nails , Fracture Fixation, Intramedullary/methods , Prosthesis Design , Shoulder Fractures/surgery , Bone Plates , Fracture Fixation , Humans
8.
J Shoulder Elbow Surg ; 25(3): 442-7, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26456426

ABSTRACT

BACKGROUND: Radiolucent lines surrounding prosthetic glenoid components are commonly seen after unconstrained total shoulder arthroplasty and can be a harbinger of subsequent glenoid component failure. Whether less than 100% glenoid seating is associated with the development of radiolucent lines around glenoid prostheses is unknown. This study investigated the association between incomplete glenoid component seating and periprosthetic glenoid radiolucencies. METHODS: Thirty-six unconstrained total shoulder arthroplasties were performed in 29 patients for primary glenohumeral osteoarthritis with a minimum 2-year follow-up. All were implanted with a partially cemented all-polyethylene glenoid prosthesis. Patients were evaluated with standardized plain films preoperatively and postoperatively and with thin-cut computed tomography (CT) scans at the latest follow-up. The Lazarus and Yian classifications were used to assess radiolucency and seating on radiographs and CT scans. Ratings were calculated for intraobserver and interobserver reliability and given κ, the Kendall coefficient, and interclass correlation coefficient values. RESULTS: At a mean of 43 months (range 24-26 months) after surgery, neither Lazarus plain film radiolucency scores (P = .78) nor Yian CT radiolucency scores (P = .68) were associated with Lazarus plain film seating scores. Neither Lazarus plain film radiolucency scores (P = .25) nor Yian CT radiolucency scores (P = .91) were associated with modified Lazarus CT scan seating scores. CT allowed for better intraobserver and interobserver reliability in all categories. CONCLUSION: Radiolucencies around a partially cemented glenoid component were not associated with the degree of component seating. Complete seating of the glenoid component is not necessary to achieve radiographic implant stability at a mean follow-up of 43 months.


Subject(s)
Arthroplasty, Replacement , Glenoid Cavity/diagnostic imaging , Shoulder Joint/diagnostic imaging , Shoulder Joint/surgery , Follow-Up Studies , Humans , Joint Prosthesis , Observer Variation , Osteoarthritis/surgery , Prosthesis Implantation , Reproducibility of Results , Shoulder/surgery , Tomography, X-Ray Computed
9.
J Shoulder Elbow Surg ; 24(8): 1212-7, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25745828

ABSTRACT

BACKGROUND: B2 glenoid morphology is challenging to address with shoulder reconstruction. Deformity often renders current techniques inadequate, necessitating compromises that limit long-term implant durability. The purpose of this study was to perform in vivo measurements of glenoid deformity to better appreciate the orientation of the B2 biconcavity demarcation and erosion that surgeons face intraoperatively. MATERIALS AND METHODS: A consecutive 106 total shoulder arthroplasty cases for primary glenohumeral osteoarthritis were studied. We classified glenoids by direct visualization and noted lines of biconcavity demarcation and erosion in B2s. We then calculated the "angle of erosion" as that between the back side of the unsupported, smooth-backed glenoid sizer disk and the neoglenoid. We obtained depth measurements throughout the reaming process and monitored subchondral bone. RESULTS: We classified 43 of 106 glenoids (41%) as B2. A biconcavity demarcation line between the paleoglenoid and the neoglenoid was present, on average, from the 1-o'clock to the 7-o'clock position for a left shoulder. Mean depth of erosion was 4.4 mm, occurring at 114° on a Cartesian coordinate system for a left shoulder. The mean angle of erosion was 18° (range, 8°-43°). Despite reaming, 20 of 43 B2 glenoids (47%) had incompletely supported components at final seating. CONCLUSIONS: Arthritic B2 glenoids are common, and their maximal erosion is usually posteroinferior. Use of standard glenoid components to reconstruct them may require significant subchondral bone removal to achieve complete bone support. Alternatively, as a compromise, maintenance of subchondral bone in these cases requires implanting components with incomplete bony support.


Subject(s)
Arthroplasty, Replacement/methods , Osteoarthritis/surgery , Shoulder Joint/pathology , Humans , Osteoarthritis/diagnosis , Scapula/pathology , Scapula/surgery , Shoulder Joint/surgery
10.
Pharm Res ; 31(8): 2086-94, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24590878

ABSTRACT

PURPOSE: To develop and evaluate diagnostic tools for early detection of wear particle-induced orthopaedic implant loosening. METHODS: N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer was tagged with a near infrared dye and used to detect the inflammation induced by polymethylmethacrylate (PMMA) particles in a murine peri-implant osteolysis model. It was established by inserting an implant into the distal femur and challenging with routine PMMA particles infusion. The osteolysis was evaluated by micro-CT and histological analysis at different time points. RESULTS: Significant peri-implant osteolysis was found 3-month post PMMA particle challenge by micro-CT and histological analysis. At 1-month post challenge, when there was no significant peri-implant bone loss, the HPMA copolymer-near infrared dye conjugate was found to specifically target the femur with PMMA particles deposition, but not the contralateral control femur with phosphate buffered saline (PBS) infusion. CONCLUSION: The results from this study demonstrate the feasibility of utilizing the macromolecular diagnostic agent to detect particle-induced peri-implant inflammation prior to the development of detectable osteolysis. Recognition of this early pathological event would provide the window of opportunity for prevention of peri-implant osteolysis and subsequent orthopaedic implant failure.


Subject(s)
Femur/diagnostic imaging , Femur/surgery , Fluorescein , Methacrylates , Prostheses and Implants/adverse effects , Prosthesis Failure , Animals , Early Diagnosis , Femur/drug effects , Macromolecular Substances , Male , Mice , Polymethyl Methacrylate/toxicity , Tomography, X-Ray Computed
11.
Pharm Res ; 29(11): 3169-79, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22733150

ABSTRACT

PURPOSE: To develop novel biomineral-binding liposomes (BBL) for the prevention of orthopedic implant associated osteomyelitis. METHODS: A biomineral-binding lipid, alendronate-tri(ethyleneglycol)-cholesterol conjugate (ALN-TEG-Chol), was synthesized through Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (a versatile click reaction). Mixing with other excipients, the new lipid was used to develop BBL. Thermodynamic behavior was studied by differential scanning calorimetry (DSC). In vitro biomineral-binding potential and kinetics were evaluated on hydroxyapatite (HA, a widely used material for orthopedic implant devices) particles. Oxacillin was encapsulated into BBL and used for in vitro evaluation in preventing Staphylococcus aureus biofilm formation. RESULTS: DSC analysis showed that ALN-TEG-Chol could inhibit the phase transition of liposomes by reducing its cooperativity, yielding liposomes with thermodynamic stability similar to liposomes containing regular cholesterol. BBL showed fast and strong binding ability to HA. Oxacillin-loading BBL demonstrated significantly better preventive efficacy against bacteria colonization when challenged with S. aureus isolate, implying its potential in preventing orthopedic implant associated osteomyelitis. CONCLUSIONS: In this proof of concept study, novel BBL has been successfully developed and validated for reducing the frequency of implantable device-related infections.


Subject(s)
Liposomes/administration & dosage , Orthopedic Fixation Devices/microbiology , Osteomyelitis/prevention & control , Oxacillin/administration & dosage , Prostheses and Implants/microbiology , Biofilms/drug effects , Calorimetry, Differential Scanning/methods , Cycloaddition Reaction/methods , Excipients/administration & dosage , Kinetics , Orthopedics/methods , Osteomyelitis/etiology , Osteomyelitis/microbiology , Phase Transition/drug effects , Staphylococcal Infections/etiology , Staphylococcal Infections/prevention & control , Staphylococcus aureus/drug effects , Staphylococcus aureus/physiology , Thermodynamics
12.
Mol Pharm ; 8(4): 1043-51, 2011 Aug 01.
Article in English | MEDLINE | ID: mdl-21438611

ABSTRACT

Wear particle-induced inflammation is considered to be the major cause of aseptic implant loosening and clinical failure after total joint replacement. Due to the frequent absence of symptoms, early detection and intervention prior to implant failure presents a significant challenge. To address this issue, a N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-based optical imaging contrast agent (P-IRDye) was developed and used for the detection of wear particle-induced inflammation employing a murine calvaria osteolysis model. The particle-induced osteolysis of calvaria was evaluated by H&E, tartrate-resistant acid phosphatase (TRAP) staining and µ-CT after necropsy. One-day post particle implantation, P-IRDye was administrated to the mice via tail vein injection. Live imaging of the animals 6 days after implantation revealed the preferential distribution and sustained retention of the macromolecular contrast agent at the site of particle implantation. Immunohistochemical staining and FACS analyses of the calvaria-associated soft tissue revealed extensive uptake of the HPMA copolymer by F4/80, Ly-6G (Gr1) and CD11c positive cells, which accounts for the retention of the macromolecular probes at the inflammatory sites. To test the potential of the system for therapeutic intervention, an acid-labile HPMA copolymer-dexamethasone conjugate (P-Dex) was prepared and shown to prevent the particle-induced inflammation and bone damage in the calvaria osteolysis model.


Subject(s)
Acrylamides , Bone Resorption/diagnosis , Bone Transplantation/adverse effects , Contrast Media , Inflammation/diagnosis , Osteolysis/diagnosis , Skull/pathology , Animals , Flow Cytometry , Immunohistochemistry , Inflammation/pathology , Male , Mice , Osteolysis/pathology , Skull/diagnostic imaging , X-Ray Microtomography
13.
J Shoulder Elbow Surg ; 20(2): 315-21, 2011 Mar.
Article in English | MEDLINE | ID: mdl-20863718

ABSTRACT

BACKGROUND: Cement penetration problems and/or cement-induced bone necrosis may contribute to glenoid component failures. An all polyethylene component was developed that promotes biologic fixation between radial fins of its central peg and utilizes minimal cement fixation for its peripheral pegs, but it has little published data. We hypothesized better bone presence between the radial fins would be associated with less overall radiolucencies. This study's purpose was to utilize computed tomography (CT) and plain films to assess for bone between the central peg's radial fins and to assess overall component radiolucencies. MATERIALS AND METHODS: Thirty-five of 48 consecutively performed total shoulder arthroplasties (TSA) for primary glenohumeral osteoarthritis were in patients able to participate a minimum 2 years after surgery. All had reamed humeral head bone packed between radial fins of the central peg and minimal cement for the peripheral pegs. Thin cut (0.625 mm) CT scans, standardized plain films, Simple Shoulder Tests (SST), and Constant scores were obtained. A musculoskeletal radiologist calculated Yian CT scores, bone presence between fins on CT, and Lazarus radiolucency scores. RESULTS: At a mean of 43 months, by CT: 1) better Yian scores correlated with more bone between fins, and 2) bone was present in 6/6 inter-fin compartments in 23/35 shoulders, averaging 4.5/6 overall. Mean Lazarus radiolucency score was 0.45. Mean SST and Constant scores were 10.3 and 81.3, respectively. CONCLUSION: TSA utilizing autologous bone in inter-fin compartments of the central peg and minimal peripheral peg cement maintained bone presence a minimum 2 years post-op. More bone imparted fewer overall component radiolucencies.


Subject(s)
Arthroplasty, Replacement , Cementation , Humeral Head/surgery , Osseointegration , Osteoarthritis/surgery , Scapula/diagnostic imaging , Aged , Aged, 80 and over , Bone Cements , Humans , Humeral Head/diagnostic imaging , Joint Prosthesis , Middle Aged , Prosthesis Design , Prosthesis Failure , Radiography , Scapula/surgery
14.
Clin Orthop Relat Res ; 468(6): 1521-5, 2010 Jun.
Article in English | MEDLINE | ID: mdl-19763715

ABSTRACT

BACKGROUND: It is unclear whether repaired rotator cuffs heal in older patients and whether the function in those shoulders compares with those of similarly aged patients with untreated tears. QUESTIONS/PURPOSE: We questioned whether, in patients 65 years of age and older, shoulders with rotator cuff repairs that remained intact would have Simple Shoulder Test (SST) scores and Constant scores similar to those of untreated individuals with intact rotator cuffs. METHODS: We retrospectively reviewed 39 patients (42 shoulders) 65 years of age and older in whom 42 full-thickness rotator cuff tears were repaired with a mini open technique. All patients completed SST and Constant scores 12 to 60 months postoperatively; all patients also had ultrasound at those times to assess the status of the repair. These findings were compared with 200 untreated similarly aged shoulders assessed in the same fashion. RESULTS: Shoulders with healed repairs (33 of 42) had similar mean SST scores and Constant scores to those in untreated shoulders with intact rotator cuffs. Those with healed repairs also had higher SST and Constant scores than those with unhealed repairs. Finally, shoulders with healed repairs had higher SST and Constant scores than those with untreated tears. CONCLUSIONS: When rotator cuffs healed the function was comparable to that of similarly-aged patients without tears and better than that of patients with untreated tears. LEVEL OF EVIDENCE: Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.


Subject(s)
Orthopedic Procedures , Rotator Cuff/surgery , Tendon Injuries/surgery , Wound Healing , Age Factors , Aged , Female , Humans , Linear Models , Male , Range of Motion, Articular , Recovery of Function , Retrospective Studies , Rotator Cuff/diagnostic imaging , Rotator Cuff/physiopathology , Rotator Cuff Injuries , Rupture , Surveys and Questionnaires , Tendon Injuries/diagnostic imaging , Tendon Injuries/physiopathology , Treatment Outcome , Ultrasonography
15.
Clin Orthop Relat Res ; 468(3): 717-22, 2010 Mar.
Article in English | MEDLINE | ID: mdl-19626383

ABSTRACT

UNLABELLED: Total shoulder arthroplasties (TSA) are being performed more commonly for treatment of arthritis, although fewer than either hip (THA) or knee (TKA) arthroplasties. Total shoulder arthroplasty also provides general health improvements that are comparable to THA. One study suggests TSAs are associated with lower morbidity and mortality than THAs and TKAs. To confirm and extend that study, we therefore examined the association of patient characteristics (sociodemographics, comorbid illness, and other risk factors) with 30-day complications for patients undergoing TSAs, THAs, or TKAs. We used data from the Veterans Administration (VA) National Surgical Quality Improvement Program (NSQIP) for fiscal years 1999 to 2006. Sociodemographics, comorbidities, health behaviors, operative factors, and complications (mortality, return to the operating room, readmission within 14 days, cardiovascular events, and infections) were available for 10,407 THAs, 23,042 TKAs, and 793 TSAs. Sociodemographic features were comparable among groups. The mean operative time was greater for TSAs (3.0 hours) than for TKAs (2.2 hours) and THAs (2.4 hours). The 30-day mortality rates were 1.2%, 1.1%, and 0.4% for THAs, TKAs, and TSAs, respectively. The corresponding postoperative complication rates were 7.6%, 6.8%, and 2.8%. Adjusting for multiple risk factors, complications, readmissions, and postoperative stays were less for TSAs versus THAs and TKAs. In a VA population, TSAs required more operative time but resulted in shorter stays, fewer complications, and fewer readmissions than THAs and TKAs. LEVEL OF EVIDENCE: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.


Subject(s)
Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Knee/adverse effects , Postoperative Complications/etiology , Shoulder Joint/surgery , Veterans , Aged , Arthroplasty, Replacement, Hip/mortality , Arthroplasty, Replacement, Knee/mortality , Databases, Factual , Female , Hospitals, Military , Humans , Male , Retrospective Studies , Risk Factors , United States/epidemiology , Veterans/statistics & numerical data
16.
J Am Acad Orthop Surg ; 28(7): e277-e287, 2020 Apr 01.
Article in English | MEDLINE | ID: mdl-31860584

ABSTRACT

Through an iteration of various advancements, both short stem and stemless options for humeral fixation have been proposed and have shown clinical promise. The proposed benefits of a stemless humeral implant include greater bone preservation, less stress shielding, less risk of a diaphyseal stress riser, decreased surgical time, and less intraoperative blood loss. Potential downsides include the dependence on proximal bone quality for fixation, increased cost, the dependence on the strength of subscapularis fixation, and pending FDA approval for multiple implants. The purpose of this article is to review the evidence behind stemless implants including the biomechanical advantages and disadvantages, surgical technique, and clinical outcomes.


Subject(s)
Arthroplasty, Replacement, Shoulder/methods , Humerus/surgery , Prosthesis Design , Shoulder Prosthesis , Biomechanical Phenomena , Humans , Treatment Outcome
17.
J Control Release ; 324: 560-573, 2020 08 10.
Article in English | MEDLINE | ID: mdl-32445658

ABSTRACT

Despite their notorious adverse effects, glucocorticoids (GC, potent anti-inflammatory drugs) are used extensively in clinical management of rheumatoid arthritis (RA) and other chronic inflammatory diseases. To achieve a sustained therapeutic efficacy and reduced toxicities, macromolecular GC prodrugs have been developed with promising outcomes for the treatment of RA. Fine-tuning the activation kinetics of these prodrugs may further improve their therapeutic efficacy and minimize the off-target adverse effects. To assess the feasibility of this strategy, five different dexamethasone (Dex, a potent GC)-containing monomers with distinctively different linker chemistries were designed, synthesized, and copolymerized with N-(2-hydroxypropyl) methacrylamide (HPMA) to obtain 5 macromolecular Dex prodrugs. Their Dex releasing rates were analyzed in vitro and shown to display a wide spectrum of activation kinetics. Their therapeutic efficacy and preliminary toxicology profiles were assessed and compared in vivo in an adjuvant-induced arthritis (AA) rat model in order to identify the ideal prodrug design for the most effective and safe treatment of inflammatory arthritis. The in vivo data demonstrated that the C3 hydrazone linker-containing prodrug design was the most effective in preserving joint structural integrity. The results from this study suggest that the design and screening of different activation mechanisms may help to identify macromolecular prodrugs with the most potent therapeutic efficacy and safety for the management of inflammatory arthritis.


Subject(s)
Arthritis, Experimental , Prodrugs , Animals , Arthritis, Experimental/drug therapy , Dexamethasone , Methacrylates , Rats
18.
J Shoulder Elbow Surg ; 18(2): 275-8, 2009.
Article in English | MEDLINE | ID: mdl-19056301

ABSTRACT

HYPOTHESIS: Radiolucencies surrounding the stems of smooth-stemmed metal radial head prostheses placed for comminuted radial head fractures are associated with proximal radial forearm pain. MATERIALS AND METHODS: Patients in whom 18 consecutive elbows that underwent metal radial head replacement with smooth stems for comminuted radial head fractures were assessed at least two years after surgery. Proximal radial forearm pain was assessed with a visual analog score (0-10) and elbow function with a Mayo index. "Mean stem radiolucency" was determined by two musculoskeletal radiologists based upon three radiographs of each elbow: a lateral in maximum extension, a lateral in maximum flexion, and an antero-posterior. RESULTS: All elbows were stable and stem radiolucencies were present in 16 of the 17 available for study. "Mean stem radiolucency" did not correlate with proximal radial forearm pain (p = 0.63) or Mayo scores (p = 0.37) using Spearman's correlation coefficients. 6/17 prostheses were in patients that rated their pain level as 0; 11/17 were in patients that rated their pain as at least 1 with 5 being the highest. Using the Signed Rank test, operative elbows had less motion for both flexion/extension (p = 0.0001) and pronation/supination (p = 0.01) compared to non-operative elbows from the same patient. DISCUSSION: "Mean stem radiolucency" did not correlate with proximal radial forearm pain. However, proximal radial forearm pain was present in 11/17 elbows based upon visual analog scores. Proximal radial forearm pain in this population may have several etiologies. CONCLUSION: "Mean stem radiolucencies" surrounding smooth-stemmed metal radial head prostheses for fractures did not correlate with proximal radial forearm pain scores. LEVEL OF EVIDENCE: Level 4; Retrospective case series, no control group.


Subject(s)
Fractures, Comminuted/surgery , Pain/diagnostic imaging , Prostheses and Implants , Radius Fractures/surgery , Radius , Adolescent , Adult , Female , Forearm , Humans , Male , Metals , Middle Aged , Pain/physiopathology , Pain Measurement , Radiography , Radius/diagnostic imaging
19.
J Shoulder Elbow Surg ; 17(6): 881-5, 2008.
Article in English | MEDLINE | ID: mdl-18774738

ABSTRACT

The purpose of this study was to determine full-thickness rotator cuff tear prevalence in patients 65 and older and to correlate tears with comfort, function, and co-morbidities. Two-hundred shoulders without prior surgery were evaluated with a Simple Shoulder Test, a Constant Score, and ultrasound. Full thickness tear prevalence was 22%. Adjusting for age and gender, those with tears had lower scores than those without (P < .001 for each). Adjusting for many potential confounders, with a 10-year age increase, the odds of a tear increased 2.69-fold (P = .005). For those with tears, scores were no different for those who had seen a physician for their shoulder compared to those who had not. Full-thickness cuff tear prevalence was 22% in those 65 and older. Tear prevalence increased with increasing age. Shoulder scores were poorer for those with tears.


Subject(s)
Rotator Cuff Injuries , Shoulder Joint/physiopathology , Aged , Comorbidity , Female , Health Status , Humans , Logistic Models , Male , Prevalence , Rupture
20.
Orthopedics ; 31(4): 365, 2008 04.
Article in English | MEDLINE | ID: mdl-19292284

ABSTRACT

Anterior shoulder instability repairs often are performed but rarely reported in community practices. This study assessed outcomes after open anterior repairs without routine capsulorraphy by a community surgeon. Repairs were performed in 64 consecutive shoulders; patient self-assessment questionnaires were mailed to all patients after a minimum follow-up of 2 years. Eighty-three percent reported excellent or good modified Rowe scores at mean follow-up of 5 years. Patients who reported 100% elevation had better outcomes than those who did not report 100% elevation, whereas patients who reported 100% external or internal rotation had comparable outcomes to patients who did not report 100% rotation. Open anterior repair without routine capsulorraphy yielded good outcomes in this community setting.


Subject(s)
Joint Instability/etiology , Joint Instability/surgery , Patient Satisfaction , Recovery of Function , Shoulder Joint/surgery , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/surgery , Adult , Female , Humans , Male , Treatment Outcome
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