ABSTRACT
Retinoids are used in the treatment of lichen planus (LP) disease, but their mechanism of action remains unknown. We studied the epidermal Langerhans' cells in four patients with chronic LP, before and after treatment with aromatic retinoids. This study uses a new technique of quantification and exploits two monoclonal antibodies-OKT 6 specific for Langerhans' cells and BL 2 specific for HLA-DR antigens. Our results show an increase in the number of dendritic epidermal cells after treatment with oral retinoids. The number of OKT 6-positive cells is greater than the number of BL 2-positive (HLA-DR) cells before and after treatment.
Subject(s)
Etretinate/therapeutic use , Langerhans Cells/drug effects , Lichen Planus/drug therapy , Tretinoin/analogs & derivatives , Adolescent , Adult , Antibodies, Monoclonal/analysis , Etretinate/pharmacology , Humans , Langerhans Cells/immunology , Lichen Planus/immunology , MaleABSTRACT
A case of cryptococcosis in a woman 46 years old, with lesions of the skin and the lung with an evolution of six years who answered satisfactory to a treatment with ketoconazole. We will discuss the duration of the lesion, the possible start of the skin aspect of the disease and the excellent response obtained with ketoconazole.
Subject(s)
Cryptococcosis/drug therapy , Foot Dermatoses/drug therapy , Ketoconazole/therapeutic use , Female , Humans , Middle AgedABSTRACT
The purpose of the present study was to examine the phenotype of the immunocompetent cells in cutaneous infiltrates and peripheral blood in Lichen Planus. 14 patients have been studied using Monoclonal Antibodies directed against T cell populations. We have used in this study the indirect immunofluorescence technique. Helper cells (OKT4+) and Suppressor/cytotoxic cells (OKT8+) have been observed in all cutaneous infiltrates, and numerous Langerhans cells identified by OKT6 in epidermis and dermis. In peripheral blood, the balance between the two major T cell subsets (OKT4+ and OKT8+) was increased by a reduction of the percentage of Suppressor/cytotoxic cells. This balance is statistically significant (P 0,02). Our results confirm the existence of a lymphocytotoxic process in Lichen Planus.
Subject(s)
Langerhans Cells/immunology , Lichen Planus/immunology , T-Lymphocytes/immunology , Adolescent , Adult , Antibodies, Monoclonal/immunology , Female , Fluorescent Antibody Technique , Humans , Male , Middle Aged , T-Lymphocytes, Helper-Inducer/immunology , T-Lymphocytes, Regulatory/immunologySubject(s)
Langerhans Cells/pathology , Lichen Planus/pathology , T-Lymphocytes/pathology , Adolescent , Adult , Cell Count , Female , Humans , Leukocyte Count , Lichen Planus/immunology , Male , Middle Aged , T-Lymphocytes, Cytotoxic/pathology , T-Lymphocytes, Helper-Inducer/pathology , T-Lymphocytes, Regulatory/pathologyABSTRACT
El embarazo es una condición que altera y provoca una serie de cambios metabólicos, endócrinos e inmunológicos que pueden incidir sobre la piel y sus anexos. Muchas de las influencias que el embarazo ejerce en la piel han de ser consideradas como fisiológicas; las enfermedades preexistentes pueden cambiar su comportamiento y además vamos a encontrar dermatosis propias de la gestación. El objetivo de esta revisión es actualizar los conceptos sobre estas entidades, su patogenia y manejo.
The pregnancy is a condition that alters and causes a series of metabolic changes, endocrines and immunological that can affect the skin and its attached ones. Many of influences that the pregnancy exerts in the skin have to be considered like physiological; the preexisting diseases can change behaviour and in addition we are going to find specific dermatoses of pregnancy. The objective of this revision is to update the concepts on these organizations, his pathogenic and handling.
Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications , Skin Diseases/etiology , Skin Diseases/classification , Skin Diseases/physiopathology , Skin Physiological PhenomenaABSTRACT
Se estudió el suero de 80 enfermos con psoriasis, de diversas formas clínicas (60 en placas, 13 en gotas y 7 atropáticas). Para ello se aplicó la técnica de microconsumo de complemento, que permitió identificar a los inmunocomplejos que contenían IgG. Los resultados obtenidos demostraron un 56,25% de positividad estadísticamente significativa, poniendo en evidencia su participación en la patogenia de esta enfermedad. Los inmunocomplejos hallados, no guardan relación con la evolución clínica de la enfermedad
Subject(s)
Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Antigen-Antibody Complex/metabolism , Psoriasis/immunology , Hemolysis , Immunoglobulin G/metabolismABSTRACT
Las Regiones de Organizacion Nucleolar (NORs), son segmentos delDNA, ubicados en el brazo corto de los cromosomas acrocentricos. En el presente estudio, evaluamos el indice de Ag NORs en las proliferaciones melanociticas benignas y en melanomas malignos cutaneos, en los distintos tipos histologicos y comparamos el contaje de Ag NORs segun la fase de crecimiento del melanoma para establecerlo como posible parametro pronostico. De acuerdo a nuestros resultados, el indice de Ag NORs es de utilidad diagnostica limitada para diferenciar lesiones benignas de malignas. La morfologia irregular y la dispersion de los puntos negros son de ayuda para diferenciar este tipo de lesiones. El grado de malignidad no es diferenciable a traves de este metodo. La diferencia existente entre losindices de Ag NORs en los estadios tempranos y tardios del melanoma, es un elemento mas en el diagnostico diferencial entre los focos de crecimiento
Subject(s)
Humans , Melanoma/diagnosis , Nucleolus Organizer Region/analysisABSTRACT
El uso de inhibidores de proteasas en el tratamiento de la infección por HIV-1, ha revolucionado la sobrevida de éstos enfermos. Pero también se lo ha asociado a diabetes mellitus de nuevo comienzo, hiperlipidemia y lipodistrofia. Presentamos tres pacientes con lipodistrofia secundaria y comentamos la fisiopatogenia y tratamiento