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Clin Infect Dis ; 69(12): 2205-2207, 2019 11 27.
Article in English | MEDLINE | ID: mdl-30959520

ABSTRACT

Smallpox vaccine is contraindicated in immunosuppression due to increased risk for adverse reactions (eg, progressive vaccinia). We describe the first-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemotherapy in an active duty service member who presented with acute leukemia and inadvertent autoinoculation after smallpox vaccination.


Subject(s)
Antiviral Agents/administration & dosage , Benzamides/administration & dosage , Isoindoles/administration & dosage , Leukemia, Myeloid, Acute/diagnosis , Military Personnel , Smallpox Vaccine/adverse effects , Smallpox Vaccine/immunology , Smallpox/prevention & control , Vaccination , Vaccinia virus/drug effects , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Humans , Immunoglobulins, Intravenous/therapeutic use , Leukemia, Myeloid, Acute/etiology , Leukemia, Myeloid, Acute/therapy , Male , Premedication , Smallpox Vaccine/administration & dosage , Symptom Assessment , Treatment Outcome , Vaccination/adverse effects , Vaccination/methods , Vaccinia virus/immunology
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