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1.

Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data.

Rhee, Chanu; Wang, Rui; Zhang, Zilu; Fram, David; Kadri, Sameer S; Klompas, Michael.

Crit Care Med ; 47(9): 1169-1176, 2019 09.

Article in English | MEDLINE | ID: mdl-31135503

2.

Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients.

Pepper, Dominique J; Demirkale, Cumhur Y; Sun, Junfeng; Rhee, Chanu; Fram, David; Eichacker, Peter; Klompas, Michael; Suffredini, Anthony F; Kadri, Sameer S.

Crit Care Med ; 47(5): 643-650, 2019 05.

Article in English | MEDLINE | ID: mdl-30789403

3.

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria.

Rhee, Chanu; Zhang, Zilu; Kadri, Sameer S; Murphy, David J; Martin, Greg S; Overton, Elizabeth; Seymour, Christopher W; Angus, Derek C; Dantes, Raymund; Epstein, Lauren; Fram, David; Schaaf, Richard; Wang, Rui; Klompas, Michael.

Crit Care Med ; 47(3): 307-314, 2019 03.

Article in English | MEDLINE | ID: mdl-30768498

4.

Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons.

Rhee, Chanu; Jentzsch, Maximilian S; Kadri, Sameer S; Seymour, Christopher W; Angus, Derek C; Murphy, David J; Martin, Greg S; Dantes, Raymund B; Epstein, Lauren; Fiore, Anthony E; Jernigan, John A; Danner, Robert L; Warren, David K; Septimus, Edward J; Hickok, Jason; Poland, Russell E; Jin, Robert; Fram, David; Schaaf, Richard; Wang, Rui; Klompas, Michael.

Crit Care Med ; 47(4): 493-500, 2019 04.

Article in English | MEDLINE | ID: mdl-30431493

5.

Development of a mother-child database for drug exposure and adverse event detection in the Military Health System.

Taylor, Lockwood G; Thelus Jean, Rosenie; Gordon, Geoff; Fram, David; Coster, Trinka.

Pharmacoepidemiol Drug Saf ; 24(5): 510-7, 2015 May.

Article in English | MEDLINE | ID: mdl-25833769

6.

Automated method for detecting increases in frequency of spontaneous adverse event reports over time.

DuMouchel, William; Yuen, Nancy; Payvandi, Nassrin; Booth, Wendy; Rut, Andrew; Fram, David.

J Biopharm Stat ; 23(1): 161-77, 2013.

Article in English | MEDLINE | ID: mdl-23331229

7.

Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals.

Rhee, Chanu; Yu, Tingting; Wang, Rui; Kadri, Sameer S; Fram, David; Chen, Huai-Chun; Klompas, Michael.

JAMA Netw Open ; 4(12): e2138596, 2021 12 01.

Article in English | MEDLINE | ID: mdl-34928358

8.

Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use.

Rhee, Chanu; Kadri, Sameer S; Dekker, John P; Danner, Robert L; Chen, Huai-Chun; Fram, David; Zhang, Fang; Wang, Rui; Klompas, Michael.

JAMA Netw Open ; 3(4): e202899, 2020 04 01.

Article in English | MEDLINE | ID: mdl-32297949

9.

Impact of Risk Adjustment Using Clinical vs Administrative Data on Hospital Sepsis Mortality Comparisons.

Rhee, Chanu; Li, Zhonghe; Wang, Rui; Song, Yue; Kadri, Sameer S; Septimus, Edward J; Chen, Huai-Chun; Fram, David; Jin, Robert; Poland, Russell; Sands, Kenneth; Klompas, Michael.

Open Forum Infect Dis ; 7(6): ofaa213, 2020 Jun.

Article in English | MEDLINE | ID: mdl-32617377

10.

A Novel Approach to Visualize Risk Minimization Effectiveness: Peeping at the 2012 UK Proton Pump Inhibitor Label Change Using a Rapid Cycle Analysis Tool.

Sobel, Rachel E; Blackwell, William; Fram, David M; Bate, Andrew.

Drug Saf ; 42(11): 1365-1376, 2019 11.

Article in English | MEDLINE | ID: mdl-31368080

11.

Risk Adjustment for Sepsis Mortality to Facilitate Hospital Comparisons Using Centers for Disease Control and Prevention's Adult Sepsis Event Criteria and Routine Electronic Clinical Data.

Rhee, Chanu; Wang, Rui; Song, Yue; Zhang, Zilu; Kadri, Sameer S; Septimus, Edward J; Fram, David; Jin, Robert; Poland, Russell E; Hickok, Jason; Sands, Kenneth; Klompas, Michael.

Crit Care Explor ; 1(10): e0049, 2019 Oct.

Article in English | MEDLINE | ID: mdl-32166230

12.

Adaptation of Bayesian data mining algorithms to longitudinal claims data: coxib safety as an example.

Curtis, Jeffrey R; Cheng, Hong; Delzell, Elizabeth; Fram, David; Kilgore, Meredith; Saag, Kenneth; Yun, Huifeng; Dumouchel, William.

Med Care ; 46(9): 969-75, 2008 Sep.

Article in English | MEDLINE | ID: mdl-18725852

13.

Antipsychotics, glycemic disorders, and life-threatening diabetic events: a Bayesian data-mining analysis of the FDA adverse event reporting system (1968-2004).

DuMouchel, William; Fram, David; Yang, Xionghu; Mahmoud, Ramy A; Grogg, Amy L; Engelhart, Luella; Ramaswamy, Krishnan.

Ann Clin Psychiatry ; 20(1): 21-31, 2008.

Article in English | MEDLINE | ID: mdl-18297583

14.

Comparative performance of two quantitative safety signalling methods: implications for use in a pharmacovigilance department.

Almenoff, June S; LaCroix, Karol K; Yuen, Nancy A; Fram, David; DuMouchel, William.

Drug Saf ; 29(10): 875-87, 2006.

Article in English | MEDLINE | ID: mdl-16970511

15.

Comparative study of electronic vs. paper VAS ratings: a randomized, crossover trial using healthy volunteers.

Jamison, Robert N; Gracely, Richard H; Raymond, Stephen A; Levine, Jonathan G; Marino, Barbara; Herrmann, Timothy J; Daly, Margaret; Fram, David; Katz, Nathaniel P.

Pain ; 99(1-2): 341-7, 2002 Sep.

Article in English | MEDLINE | ID: mdl-12237213

16.

Association of asthma therapy and Churg-Strauss syndrome: an analysis of postmarketing surveillance data.

DuMouchel, William; Smith, Eric T; Beasley, Richard; Nelson, Harold; Yang, Xionghu; Fram, David; Almenoff, June S.

Clin Ther ; 26(7): 1092-1104, 2004 Jul.

Article in English | MEDLINE | ID: mdl-15336474

17.

Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery - the GSK experience.

Vanderwall, Dana E; Yuen, Nancy; Al-Ansari, Mohammad; Bailey, James; Fram, David; Green, Darren V S; Pickett, Stephen; Vitulli, Giovanni; Luengo, Juan I; Almenoff, June S.

Drug Discov Today ; 16(15-16): 646-53, 2011 Aug.

Article in English | MEDLINE | ID: mdl-21601652

18.

Psychogenic camptocormia.

Skidmore, Frank; Anderson, Karen; Fram, David; Weiner, William.

Mov Disord ; 22(13): 1974-5, 2007 Oct 15.

Article in English | MEDLINE | ID: mdl-17712851

19.

Signal detection methodologies to support effective safety management.

van Manen, Robbert P; Fram, David; DuMouchel, William.

Expert Opin Drug Saf ; 6(4): 451-64, 2007 Jul.

Article in English | MEDLINE | ID: mdl-17688389

20.

Using simulation to assess the sensitivity and specificity of a signal detection tool for multidimensional public health surveillance data.

Rolka, Henry; Bracy, Dwayne; Russell, Channing; Fram, David; Ball, Robert.

Stat Med ; 24(4): 551-62, 2005 Feb 28.

Article in English | MEDLINE | ID: mdl-15678409

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