ABSTRACT
OBJECTIVE: To provide physicians with an understanding of the factors behind significant delays in the diagnosis of hidradenitis suppurativa (HS) in France. PATIENTS AND METHODS: This prospective multicentre national study conducted from October 2015 to March 2016 included all patients consulting for HS. Patient data were collected by means of a standardized questionnaire. Univariate and multivariate analyses were conducted to collect factors associated with a significant time to diagnosis of at least 5.5years, defined as the period between the onset of initial clinical signs and the time of formal diagnosis. RESULTS: The 16 participating centres enrolled 312 patients (62% women), of average age 35years. The average age at onset of HS was 22years. Before formal diagnosis by a dermatologist (64% of cases), 170 (54%), 114 (37%) and 45 (15%) patients had previously consulted at least 3, 5 and 10 general physicians, respectively. The average time between the initial clinical signs of HS, the first dermatology visit and the definitive diagnosis was 6.2 and 8.4 years, respectively. Active smoking (OR adjusted 1.85; P=0.027) and disease onset at a younger age (adjusted OR 0.92; P<0.001) were both associated with significant delays in diagnosis. CONCLUSION: These results emphasized misdiagnosis among HS patients but did not evidence any association between either sociodemographic or economic characteristics and the existence of significant times to diagnosis.
Subject(s)
Delayed Diagnosis , Diagnostic Errors , Hidradenitis Suppurativa/diagnosis , Adult , Age of Onset , Cross-Sectional Studies , Female , France/epidemiology , Humans , Male , Prospective Studies , Smoking/epidemiologyABSTRACT
BACKGROUND: In analogy to acne, oral isotretinoin has been considered in the treatment of hidradenitis suppurativa (HS). OBJECTIVES: To assess the efficacy of oral isotretinoin according to patients. METHODS: From 1999 to 2006, 358 consecutive HS patients were interviewed and examined. A standardized record of the data was performed for each patient during the first consultation. Patients were questioned regarding the effect of previous treatment with oral isotretinoin: patients had to grade the effect as either 'improved', 'no effect' or 'worse'. RESULTS: Fourteen patients (16.1%) declared an improvement, 67 patients (77%) no effect and 6 patients (6.9%) worsening of HS. CONCLUSION: According to our patients, oral isotretinoin is not effective in the treatment of HS.
Subject(s)
Dermatologic Agents/therapeutic use , Hidradenitis Suppurativa/drug therapy , Isotretinoin/therapeutic use , Administration, Oral , Adult , Dermatologic Agents/administration & dosage , Female , Hidradenitis Suppurativa/diagnosis , Humans , Isotretinoin/administration & dosage , Male , Retrospective Studies , Severity of Illness Index , Surveys and Questionnaires , Treatment FailureABSTRACT
BACKGROUND: Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available. OBJECTIVE: To evaluate the efficacy of a combination of systemic clindamycin (300 mg twice daily) and rifampicin (600 mg daily) in the treatment of patients with severe HS. METHODS: Patients (n = 116) who received this combination were studied retrospectively. The main outcome measure was the severity of the disease, assessed by the Sartorius score, before and after 10 weeks of treatment. RESULTS: The Sartorius score dramatically improved at the end of treatment (median = 29, interquartile range = 14.5, vs. median = 14.5, interquartile range = 11; p < 0.001), as did other parameters of severity as well as the quality of life score. Eight patients (6.9%) stopped the treatment because of side effects. CONCLUSION: The combination of clindamycin and rifampicin is effective in the treatment of severe HS.
Subject(s)
Clindamycin/administration & dosage , Hidradenitis Suppurativa/drug therapy , Rifampin/administration & dosage , Administration, Oral , Cohort Studies , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Therapy, Combination , Female , Follow-Up Studies , Hidradenitis Suppurativa/diagnosis , Humans , Male , Patient Satisfaction/statistics & numerical data , Quality of Life , Retrospective Studies , Severity of Illness Index , Treatment OutcomeABSTRACT
BACKGROUND: We report three patients (respectively 36, 52 and 52 years old) with a long history of hidradenitis suppurativa associated with pubic lymph oedema. CASE REPORT: Dramatic pubic oedema was noted, with "rugby-ball and bag-like" tumefaction associated with nodules and fistula. There was no evidence of lymph node involvement or abdominal lymphatic blockade. One patient underwent surgical excision combined with split-thickness graft and complete healing ensued. Pathological examination of the excised tissue showed telangiectasia and fibrosis. DISCUSSION: Chronic lymphedema affects patients with severe and long-lasting disease. The complication is caused by chronic and recurrent inflammation due to HS with subsequent blockade or destruction of local lymph drainage routes. Once this complication appears, no medical treatment is effective.
Subject(s)
Hidradenitis Suppurativa/complications , Lymphedema/etiology , Adult , Drainage , Female , Fibrosis , Groin , Hidradenitis Suppurativa/pathology , Hidradenitis Suppurativa/surgery , Humans , Lymph Node Excision , Lymphedema/pathology , Lymphedema/surgery , Male , Middle Aged , Scrotum , Treatment Outcome , Treatment Refusal , Wound HealingABSTRACT
We report a patient with a 17-year history of reticulated keratotic papules on the trunk and limbs, and telangiectatic eruption on the face, in whom the diagnosis of keratosis lichenoides chronica was first established. However, the biopsies showed an epidermotropic infiltrate of small irregular CD4+ lymphocytes, and detection of a T-cell clone in the lesions by polymerase chain reaction confirmed the diagnosis of mycosis fungoides. Thus, keratosis lichenoides chronica can be an unusual and potentially misleading presentation of mycosis fungoides.