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1.

Liver-restricted Type I IFN Signature Precedes Liver Damage in Chronic Hepatitis B Patients Stopping Antiviral Therapy.

Chua, Conan; Mahamed, Deeqa; Nkongolo, Shirin; Sanchez Vasquez, Juan Diego; Mehrotra, Aman; Wong, David K H; Chung, Raymond T; Feld, Jordan J; Janssen, Harry L A; Gehring, Adam J.

J Immunol ; 212(6): 1002-1011, 2024 Mar 15.

Article in English | MEDLINE | ID: mdl-38294274

2.

Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus.

Mosa, Alexander I; Campo, David S; Khudyakov, Yury; AbouHaidar, Mounir G; Gehring, Adam J; Zahoor, Atif; Ball, Jonathan K; Urbanowicz, Richard A; Feld, Jordan J.

Proc Natl Acad Sci U S A ; 120(24): e2220294120, 2023 06 13.

Article in English | MEDLINE | ID: mdl-37276424

3.

Intrahepatic plasma cells, but not atypical memory B cells, associate with clinical phases of chronic hepatitis B.

Osmani, Zgjim; Villanueva, Martin Arreola; Joseph-Chazan, Jasmin; Beudeker, Boris J; de Knegt, Robert J; Chung, Raymond T; Hacohen, Nir; Aerssens, Jeroen; Bollekens, Jacques; Janssen, Harry L A; Gehring, Adam J; Lauer, Georg M; Shalek, Alex K; van de Werken, Harmen J G; Boonstra, Andre.

Eur J Immunol ; : e2451085, 2024 May 30.

Article in English | MEDLINE | ID: mdl-38813721

4.

Neutralizing antibodies to interferon alfa arising during peginterferon therapy of chronic hepatitis B in children and adults: Results from the HBRN Trials.

Zahoor, Muhammad Atif; Feld, Joshua B; Lin, Hsing-Hua Sylvia; Mosa, Alexander I; Salimzadeh, Loghman; Perrillo, Robert P; Chung, Raymond T; Schwarz, Kathleen B; Janssen, Harry L A; Gehring, Adam J; Feld, Jordan J.

Hepatology ; 2024 Apr 17.

Article in English | MEDLINE | ID: mdl-38630448

5.

B cell activation gene signature in blood and liver of HBeAg+ immune active chronic hepatitis B patients.

Osmani, Zgjim; Beudeker, Boris J B; Groothuismink, Zwier M A; de Knegt, Robert J; Chung, Raymond T; Aerssens, Jeroen; Bollekens, Jacques; Janssen, Harry L A; Gehring, Adam J; Lauer, Georg M; Shalek, Alex K; van de Werken, Harmen J G; Boonstra, Andre.

J Infect Dis ; 2024 Jun 07.

Article in English | MEDLINE | ID: mdl-38847286

6.

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients.

Genshaft, Alex S; Subudhi, Sonu; Keo, Arlin; Sanchez Vasquez, Juan Diego; Conceição-Neto, Nádia; Mahamed, Deeqa; Boeijen, Lauke L; Alatrakchi, Nadia; Oetheimer, Chris; Vilme, Mike; Drake, Riley; Fleming, Ira; Tran, Nancy; Tzouanas, Constantine; Joseph-Chazan, Jasmin; Arreola Villanueva, Martin; van de Werken, Harmen J G; van Oord, Gertine W; Groothuismink, Zwier M A; Beudeker, Boris J; Osmani, Zgjim; Nkongolo, Shirin; Mehrotra, Aman; Spittaels, Kurt; Feld, Jordan; Chung, Raymond T; de Knegt, Robert J; Janssen, Harry L A; Aerssens, Jeroen; Bollekens, Jacques; Hacohen, Nir; Lauer, Georg M; Boonstra, Andre; Shalek, Alex K; Gehring, Adam J.

Hepatology ; 78(5): 1525-1541, 2023 11 01.

Article in English | MEDLINE | ID: mdl-37158243

7.

Hepatitis C virus-specific immune responses following direct-acting antivirals administered during recent hepatitis C virus infection.

Casey, Julia L; Dore, Gregory J; Grebely, Jason; Matthews, Gail V; Cherepanov, Vera; Martinello, Marianne; Marks, Philippa; Janssen, Harry L A; Hansen, Bettina E; Kaul, Rupert; MacParland, Sonya A; Gehring, Adam J; Feld, Jordan J.

J Viral Hepat ; 30(1): 64-72, 2023 01.

Article in English | MEDLINE | ID: mdl-36302162

8.

Immunomodulation and RNA interference alter hepatitis B virus-specific CD8 T-cell recognition of infected HepG2-NTCP.

Kuipery, Adrian; Sanchez Vasquez, Juan Diego; Mehrotra, Aman; Feld, Jordan J; Janssen, Harry L A; Gehring, Adam J.

Hepatology ; 75(6): 1539-1550, 2022 06.

Article in English | MEDLINE | ID: mdl-34743340

9.

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B.

Johnson Valiente, Alexandra; Liem, Kin Seng; Schwarz, Kathleen B; Rosenthal, Philip; Murray, Karen F; Mogul, Douglas; Teckman, Jeffery; Rodriguez-Baez, Norberto; Schwarzenberg, Sarah Jane; Feld, Jordan J; Wong, David K; Lewis-Ximenez, Lia L; Lauer, Georg; Hansen, Bettina E; Ling, Simon C; Janssen, Harry L A; Gehring, Adam J.

J Infect Dis ; 225(3): 470-475, 2022 02 01.

Article in English | MEDLINE | ID: mdl-34286845

10.

Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection.

Gehring, Adam J; Mendez, Patricia; Richter, Kirsten; Ertl, Hildegund; Donaldson, Eric F; Mishra, Poonam; Maini, Mala; Boonstra, Andre; Lauer, Georg; de Creus, An; Whitaker, Kathleen; Martinez, Sara Ferrando; Weber, Jessica; Gainor, Emily; Miller, Veronica.

J Hepatol ; 77(2): 525-538, 2022 08.

Article in English | MEDLINE | ID: mdl-35259469

11.

Effects of on-treatment ALT flares on serum HBsAg and HBV RNA in patients with chronic HBV infection.

Choi, Hannah S J; Sonneveld, Milan J; Farag, Mina S; Brouwer, Willem P; Brakenhoff, Sylvia M; Hirode, Grishma; Gehring, Adam J; de Man, Rob A; Hansen, Bettina E; Janssen, Harry L A.

J Viral Hepat ; 28(12): 1729-1737, 2021 12.

Article in English | MEDLINE | ID: mdl-34514678

12.

IFN-α Suppresses Myeloid Cytokine Production, Impairing IL-12 Production and the Ability to Support T-Cell Proliferation.

Mehrotra, Aman; D'Angelo, June Ann; Romney-Vanterpool, Amanda; Chu, Tom; Bertoletti, Antonio; Janssen, Harry L A; Gehring, Adam J.

J Infect Dis ; 222(1): 148-157, 2020 06 16.

Article in English | MEDLINE | ID: mdl-32049318

13.

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection.

Gehring, Adam J; Protzer, Ulrike.

Gastroenterology ; 156(2): 325-337, 2019 01.

Article in English | MEDLINE | ID: mdl-30367834

14.

Comment on 'End-of-treatment HBcrAg and HBsAb levels identify durable functional cure after Peg-IFN-based therapy in patients with CHB'.

Bertoletti, Antonio; Le Bert, Nina; Tan, Anthony T; Boni, Carolina; Fisicaro, Paola; Ferrari, Carlo; Chang, Kyong-Mi; Gehring, Adam J; Lauer, Georg; Maini, Mala; Thimme, Robert; Neumann-Haefelin, Christoph.

J Hepatol ; 79(5): e202-e204, 2023 Nov.

Article in English | MEDLINE | ID: mdl-37307998

15.

Intrahepatic T cells with NK-like properties: Expanding the repertoire of lymphocytes sensitive to bystander activation.

Gehring, Adam J; MacParland, Sonya A.

J Hepatol ; 77(4): 915-917, 2022 10.

Article in English | MEDLINE | ID: mdl-35970307

16.

Nucleic Acid Polymer Therapy for Hepatitis B Virus: Strong Hepatitis B Surface Antigen Decline But Many Unanswered Questions.

Sonneveld, Milan J; Gehring, Adam J; Janssen, Harry L A.

Gastroenterology ; 160(3): 966-967, 2021 02.

Article in English | MEDLINE | ID: mdl-32866506

17.

The role of innate immunity in the immunopathology and treatment of HBV infection.

Maini, Mala K; Gehring, Adam J.

J Hepatol ; 64(1 Suppl): S60-S70, 2016 Apr.

Article in English | MEDLINE | ID: mdl-27084038

18.

Reply.

Liem, K Seng; Gehring, Adam J; Janssen, Harry L A.

Gastroenterology ; 159(3): 1187-1188, 2020 09.

Article in English | MEDLINE | ID: mdl-32693187

19.

Challenges With Stopping Long-term Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B.

Liem, K Seng; Gehring, Adam J; Feld, Jordan J; Janssen, Harry L A.

Gastroenterology ; 158(5): 1185-1190, 2020 04.

Article in English | MEDLINE | ID: mdl-31809724

20.

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.

Jo, Juandy; Tan, Anthony T; Ussher, James E; Sandalova, Elena; Tang, Xin-Zi; Tan-Garcia, Alfonso; To, Natalie; Hong, Michelle; Chia, Adeline; Gill, Upkar S; Kennedy, Patrick T; Tan, Kai Chah; Lee, Kang Hoe; De Libero, Gennaro; Gehring, Adam J; Willberg, Christian B; Klenerman, Paul; Bertoletti, Antonio.

PLoS Pathog ; 10(6): e1004210, 2014 Jun.

Article in English | MEDLINE | ID: mdl-24967632

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