Search | Nursing VHL Search Portal

1.

Gene Regulatory Circuits in Innate and Adaptive Immune Cells.

Saini, Ankita; Ghoneim, Hazem E; Lio, Chan-Wang Jerry; Collins, Patrick L; Oltz, Eugene M.

Annu Rev Immunol ; 40: 387-411, 2022 04 26.

Article in English | MEDLINE | ID: mdl-35119910

2.

Rebalancing TGFß1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy.

Saadey, Abbey A; Yousif, Amir; Osborne, Nicole; Shahinfar, Roya; Chen, Yu-Lin; Laster, Brooke; Rajeev, Meera; Bauman, Parker; Webb, Amy; Ghoneim, Hazem E.

Nat Immunol ; 24(2): 280-294, 2023 02.

Article in English | MEDLINE | ID: mdl-36543960

3.

Developmental plasticity allows outside-in immune responses by resident memory T cells.

Fonseca, Raissa; Beura, Lalit K; Quarnstrom, Clare F; Ghoneim, Hazem E; Fan, Yiping; Zebley, Caitlin C; Scott, Milcah C; Fares-Frederickson, Nancy J; Wijeyesinghe, Sathi; Thompson, Emily A; Borges da Silva, Henrique; Vezys, Vaiva; Youngblood, Benjamin; Masopust, David.

Nat Immunol ; 21(4): 412-421, 2020 04.

Article in English | MEDLINE | ID: mdl-32066954

4.

Beta cell-specific CD8⁺ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.

Abdelsamed, Hossam A; Zebley, Caitlin C; Nguyen, Hai; Rutishauser, Rachel L; Fan, Yiping; Ghoneim, Hazem E; Crawford, Jeremy Chase; Alfei, Francesca; Alli, Shanta; Ribeiro, Susan Pereira; Castellaw, Ashley H; McGargill, Maureen A; Jin, Hongjian; Boi, Shannon K; Speake, Cate; Serti, Elisavet; Turka, Laurence A; Busch, Michael E; Stone, Mars; Deeks, Steven G; Sekaly, Rafick-Pierre; Zehn, Dietmar; James, Eddie A; Nepom, Gerald T; Youngblood, Ben.

Nat Immunol ; 21(5): 578-587, 2020 05.

Article in English | MEDLINE | ID: mdl-32231298

5.

De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.

Ghoneim, Hazem E; Fan, Yiping; Moustaki, Ardiana; Abdelsamed, Hossam A; Dash, Pradyot; Dogra, Pranay; Carter, Robert; Awad, Walid; Neale, Geoff; Thomas, Paul G; Youngblood, Ben.

Cell ; 170(1): 142-157.e19, 2017 Jun 29.

Article in English | MEDLINE | ID: mdl-28648661

6.

Functional T cells are capable of supernumerary cell division and longevity.

Soerens, Andrew G; Künzli, Marco; Quarnstrom, Clare F; Scott, Milcah C; Swanson, Lee; Locquiao, J J; Ghoneim, Hazem E; Zehn, Dietmar; Youngblood, Benjamin; Vezys, Vaiva; Masopust, David.

Nature ; 614(7949): 762-766, 2023 02.

Article in English | MEDLINE | ID: mdl-36653453

7.

T cell exhaustion-a memory locked behind scars.

Yousif, Amir; Ghoneim, Hazem E.

Nat Immunol ; 22(8): 938-940, 2021 08.

Article in English | MEDLINE | ID: mdl-34312546

8.

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei, Francesca; Kanev, Kristiyan; Hofmann, Maike; Wu, Ming; Ghoneim, Hazem E; Roelli, Patrick; Utzschneider, Daniel T; von Hoesslin, Madlaina; Cullen, Jolie G; Fan, Yiping; Eisenberg, Vasyl; Wohlleber, Dirk; Steiger, Katja; Merkler, Doron; Delorenzi, Mauro; Knolle, Percy A; Cohen, Cyrille J; Thimme, Robert; Youngblood, Benjamin; Zehn, Dietmar.

Nature ; 571(7764): 265-269, 2019 07.

Article in English | MEDLINE | ID: mdl-31207605

9.

Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease.

Badr, Asmaa; Daily, Kylene P; Eltobgy, Mostafa; Estfanous, Shady; Tan, Michelle H; Chun-Tien Kuo, Jimmy; Whitham, Owen; Carafice, Cierra; Gupta, Gauruv; Amer, Heba M; Shamseldin, Mohamed M; Yousif, Amir; Deems, Nicholas P; Fitzgerald, Julie; Yan, Pearlly; Webb, Amy; Zhang, Xiaoli; Pietrzak, Maciej; Ghoneim, Hazem E; Dubey, Purnima; Barrientos, Ruth M; Lee, Robert J; Kokiko-Cochran, Olga N; Amer, Amal O.

Brain Behav Immun ; 119: 919-944, 2024 May 07.

Article in English | MEDLINE | ID: mdl-38718909

10.

Effector CD8 T cells dedifferentiate into long-lived memory cells.

Youngblood, Ben; Hale, J Scott; Kissick, Haydn T; Ahn, Eunseon; Xu, Xiaojin; Wieland, Andreas; Araki, Koichi; West, Erin E; Ghoneim, Hazem E; Fan, Yiping; Dogra, Pranay; Davis, Carl W; Konieczny, Bogumila T; Antia, Rustom; Cheng, Xiaodong; Ahmed, Rafi.

Nature ; 552(7685): 404-409, 2017 12 21.

Article in English | MEDLINE | ID: mdl-29236683

11.

Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.

Dogra, Pranay; Ghoneim, Hazem E; Abdelsamed, Hossam A; Youngblood, Ben.

Eur J Immunol ; 46(7): 1548-62, 2016 07.

Article in English | MEDLINE | ID: mdl-27230488

12.

Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections.

Ghoneim, Hazem E; Thomas, Paul G; McCullers, Jonathan A.

J Immunol ; 191(3): 1250-9, 2013 Aug 01.

Article in English | MEDLINE | ID: mdl-23804714

13.

Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice.

Ghoneim, Hazem E; McCullers, Jonathan A.

J Infect Dis ; 209(9): 1459-68, 2014 May 01.

Article in English | MEDLINE | ID: mdl-24273183

14.

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

Ellebedy, Ali H; Lupfer, Christopher; Ghoneim, Hazem E; DeBeauchamp, Jennifer; Kanneganti, Thirumala-Devi; Webby, Richard J.

Proc Natl Acad Sci U S A ; 108(7): 2927-32, 2011 Feb 15.

Article in English | MEDLINE | ID: mdl-21270336

15.

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-ß deposition in Alzheimer's disease.

Daily, Kylene P; Badr, Asmaa; Eltobgy, Mostafa; Estfanous, Shady; Whitham, Owen; Tan, Michelle H; Carafice, Cierra; Krause, Kathrin; McNamara, Andrew; Hamilton, Kaitlin; Houle, Samuel; Gupta, Spandan; Gupta, Gauruv A; Madhu, Shruthi; Fitzgerald, Julie; Saadey, Abbey A; Laster, Brooke; Yan, Pearlly; Webb, Amy; Zhang, Xiaoli; Pietrzak, Maciej; Kokiko-Cochran, Olga N; Ghoneim, Hazem E; Amer, Amal O.

Alzheimers Res Ther ; 16(1): 29, 2024 02 08.

Article in English | MEDLINE | ID: mdl-38326859

16.

Aiolos represses CD4⁺ T cell cytotoxic programming via reciprocal regulation of T_FH transcription factors and IL-2 sensitivity.

Read, Kaitlin A; Jones, Devin M; Pokhrel, Srijana; Hales, Emily D S; Varkey, Aditi; Tuazon, Jasmine A; Eisele, Caprice D; Abdouni, Omar; Saadey, Abbey; Leonard, Melissa R; Warren, Robert T; Powell, Michael D; Boss, Jeremy M; Hemann, Emily A; Yount, Jacob S; Xin, Gang; Ghoneim, Hazem E; Lio, Chan-Wang J; Freud, Aharon G; Collins, Patrick L; Oestreich, Kenneth J.

Nat Commun ; 14(1): 1652, 2023 03 24.

Article in English | MEDLINE | ID: mdl-36964178

17.

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-ß deposition in Alzheimer's disease The Ohio State University College of Medicine.

Daily, Kylene P; Badr, Asmaa; Eltobgy, Mostafa; Estfanous, Shady; Whitham, Owen; Tan, Michelle H; Carafice, Cierra; Krause, Kathrin; McNamara, Andrew; Hamilton, Kaitlin; Houle, Samuel; Gupta, Spandan; Gupta, Gauruv A; Madhu, Shruthi; Fitzgerald, Julie; Saadey, Abbey A; Laster, Brooke; Yan, Pearlly; Webb, Amy; Zhang, Xiaoli; Pietrzak, Maciej; Kokiko-Cochran, Olga N; Ghoneim, Hazem E; Amer, Amal O.

bioRxiv ; 2023 Sep 01.

Article in English | MEDLINE | ID: mdl-37693600

18.

Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82.

Alymova, Irina V; Green, Amanda M; van de Velde, Nicholas; McAuley, Julie L; Boyd, Kelli L; Ghoneim, Hazem E; McCullers, Jonathan A.

J Virol ; 85(23): 12324-33, 2011 Dec.

Article in English | MEDLINE | ID: mdl-21937639

19.

Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice.

Marcelin, Glendie; Aldridge, Jerry R; Duan, Susu; Ghoneim, Hazem E; Rehg, Jerold; Marjuki, Henju; Boon, Adrianus C M; McCullers, Jonathan A; Webby, Richard J.

J Virol ; 85(21): 11208-19, 2011 Nov.

Article in English | MEDLINE | ID: mdl-21865394

20.

Epigenetic remodeling by vitamin C potentiates plasma cell differentiation.

Chen, Heng-Yi; Almonte-Loya, Ana; Lay, Fang-Yun; Hsu, Michael; Johnson, Eric; González-Avalos, Edahí; Yin, Jieyun; Bruno, Richard S; Ma, Qin; Ghoneim, Hazem E; Wozniak, Daniel J; Harrison, Fiona E; Lio, Chan-Wang Jerry.

Elife ; 112022 09 07.

Article in English | MEDLINE | ID: mdl-36069787

Nursing VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export: