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Chem Pharm Bull (Tokyo) ; 54(3): 403-5, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16508203

ABSTRACT

2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4.SiO2) or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.


Subject(s)
Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Benzoxepins/chemical synthesis , Benzoxepins/pharmacology , Bacteria/drug effects , Catalysis , Chromatography, Thin Layer , Ciprofloxacin/pharmacology , Indicators and Reagents , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Spectrophotometry, Infrared , Spectroscopy, Fourier Transform Infrared
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