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1.
Clin Radiol ; 67(8): 815-20, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22336670

ABSTRACT

Intrasphenoid internal carotid artery (ICA) pseudoaneurysm can present as and mimic a sinonasal mass. The purpose of this review is to describe the computed tomography (CT) and magnetic resonance imaging (MRI) features that should prompt the radiologist to consider this lesion in the differential diagnosis of a skull base mass. Specifically, when a sphenoid mass appears hyperdense, expansile, and destructive on CT and has mixed T1 signal and/or flow-related artefacts on MRI, the differential diagnosis should include a pseudoaneurysm. Vascular imaging is warranted to confirm the diagnosis.


Subject(s)
Aneurysm, False/diagnosis , Carotid Artery, Internal/diagnostic imaging , Magnetic Resonance Imaging/methods , Sphenoid Sinus/diagnostic imaging , Tomography, X-Ray Computed/methods , Adult , Aged , Aged, 80 and over , Aneurysm, False/diagnostic imaging , Diagnosis, Differential , Female , Humans , Male , Middle Aged
2.
AJNR Am J Neuroradiol ; 43(5): 731-735, 2022 05.
Article in English | MEDLINE | ID: mdl-35361576

ABSTRACT

BACKGROUND AND PURPOSE: Nearly 20% of patients with spontaneous SAH have no definitive source on initial DSA. The purpose of this study was to investigate the timing and yield of repeat DSA, to clarify the influence of initial CT bleed pattern, and to characterize sources of diagnostic error in this scenario. MATERIALS AND METHODS: We evaluated the yield of repeat DSA and clinical outcomes stratified by hemorrhage pattern on CT in consecutive patients with nontraumatic SAH with negative initial DSA findings at a referral center. Cases in which the culprit lesion was subsequently diagnosed were classified as physiologically occult (ie, undetectable) on the initial DSA, despite adequate technique and interpretation or misdiagnosed due to operator-dependent error. RESULTS: Two hundred forty-two of 1163 (20.8%) patients with spontaneous SAH had negative initial DSA findings between 2009 and 2018. The SAH CT pattern was nonperimesencephalic (41%), perimesencephalic (36%), sulcal (18%), and CT-negative (5%). Repeat DSA in 135/242 patients (55.8%) revealed a source in 10 patients (7.4%): 4 saccular aneurysms, 4 atypical aneurysms, and 2 arteriovenous shunts. The overall yield of repeat DSA was 11.3% with nonperimesencephalic and 2.2% for perimesencephalic patterns. The yield of the second and third DSAs with a nonperimesencephalic pattern was 7.7% and 12%, respectively. Physiologically occult lesions accounted for 6/242 (2.5%) and operator-dependent errors accounted for 7/242 (2.9%) of all angiographically occult lesions on the first DSA. CONCLUSIONS: Atypical aneurysms and small arteriovenous shunts are important causes of SAH negative on angiography. Improving DSAs technique can modestly reduce the need for repeat DSA; however, a small fraction of SAH sources remain occult despite adequate technique. These findings support the practice of repeating DSA in patients with a nonperimesencephalic SAH pattern.


Subject(s)
Subarachnoid Hemorrhage , Angiography, Digital Subtraction/methods , Cerebral Angiography/methods , Diagnostic Errors/adverse effects , Humans , Retrospective Studies , Subarachnoid Hemorrhage/diagnostic imaging , Subarachnoid Hemorrhage/etiology , Tomography, X-Ray Computed/methods
3.
AJNR Am J Neuroradiol ; 43(7): 1060-1067, 2022 07.
Article in English | MEDLINE | ID: mdl-35772802

ABSTRACT

Pediatric patients with myelopathy expressing intradural spinal vascular ectasia without arteriovenous shunting were studied at four tertiary referral neuropediatric centers. Patients were identified by retrospective review of institutional records and excluded if spinal vascular pathology could be classified into a previously described category of spinal vascular malformation. Four patients meeting the study criteria were enrolled in the study. Clinical, magnetic resonance imaging, catheter-directed angiography, laboratory, histological and genetic data were analyzed to characterize the disease process and elucidate underlying pathomechanisms. Our study revealed a highly lethal, progressive multi-segmental myelopathy associated with a unique form of non-inflammatory spinal angiopathy featuring diffuse enlargement and tortuosity of spinal cord arteries, spinal cord hyperemia, and spinal cord edema (Arterioectatic Spinal Angiopathy of Childhood). The condition was shown to mimic venous congestive myelopathy associated with pediatric spinal cord arteriovenous shunts on MRI but to have distinct pathognomonic findings on catheter-directed angiography. Clinicopathological, genetic, and neuroimaging features, which are described in detail, closely overlap with those of mitochondrial disease.


Subject(s)
Spinal Cord Diseases , Angiography , Child , Humans , Magnetic Resonance Imaging , Retrospective Studies , Spinal Cord/pathology , Spinal Cord Diseases/diagnostic imaging , Spinal Cord Diseases/genetics , Spinal Cord Diseases/pathology
4.
AJNR Am J Neuroradiol ; 42(8): 1486-1491, 2021 08.
Article in English | MEDLINE | ID: mdl-33958333

ABSTRACT

BACKGROUND AND PURPOSE: AVFs of the foramen magnum region, including fistulas of the marginal sinus and condylar veins, have complex arterial supply, venous drainage, symptoms, and risk features that are not well-defined. The purpose of this study was to present the angioarchitectural and clinical phenotypes of a foramen magnum region AVF from a large, single-center experience. MATERIALS AND METHODS: We retrospectively reviewed cases from a 10-year neurointerventional data base. Arterial and venous angioarchitectural features and clinical presentation were extracted from the medical record. Venous drainage patterns were stratified into 4 groups as follows: type 1 = unrestricted sinus drainage, type 2 = sinus reflux (including the inferior petrosal sinus), type 3 = reflux involving sinuses and cortical veins, and type 4 = restricted cortical vein outflow or perimedullary congestion. RESULTS: Twenty-eight patients (mean age, 57.9 years; 57.1% men) had 29 foramen magnum region AVFs. There were 11 (37.9%) type 1, nine (31.0%) type 2, six (20.7%) type 3, and 3 (10.3%) type 4 fistulas. Pulsatile tinnitus was the most frequent symptom (82.1%), followed by orbital symptoms (31.0%), subarachnoid hemorrhage (13.8%), cranial nerve XII palsy (10.3%), and other cranial nerve palsy (6.9%). The most frequent arterial supply was the ipsilateral ascending pharyngeal artery (93.1% ipsilateral, 55.5% contralateral), vertebral artery (89.7%), occipital artery (65.5%), and internal carotid artery branches (48.3%). CONCLUSIONS: We present the largest case series of foramen magnum region AVFs to date and show that clinical features relate to angioarchitecture. Orbital symptoms are frequent when sinus reflux is present. Hemorrhage was only observed in type 3 and 4 fistulas.


Subject(s)
Central Nervous System Vascular Malformations , Foramen Magnum , Central Nervous System Vascular Malformations/diagnostic imaging , Cerebral Angiography , Cranial Sinuses , Female , Foramen Magnum/diagnostic imaging , Humans , Male , Middle Aged , Phenotype , Retrospective Studies
5.
J Neurooncol ; 99(3): 333-40, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20809250

ABSTRACT

Steady improvements in imaging modalities have enabled a new realm of capabilities in the identification and assessment of meningiomas. The cross-sectional imaging modalities, MRI and CT, have improved in resolution and fidelity. These modalites now provide not only improved structural information but also insights into functional behavior. MRI has, in particular, proven to have powerful capabilities in evaluating meningiomas because of the ability to assess soft tissue characteristics such as diffusion and vascular supply information, such as perfusion. Recent investigational advances have also been made using a combination of X-ray fluoroscopy for selective catheterization followed by MR perfusion measurement performed with intra-arterial injection of contrast. Together all these modalities provide the radiographer with powerful capabilities for evaluating meningiomas.


Subject(s)
Diagnostic Imaging , Meningeal Neoplasms/diagnosis , Meningioma/diagnosis , Animals , Embolization, Therapeutic , Humans , Meningeal Neoplasms/therapy , Meningioma/therapy
6.
AJNR Am J Neuroradiol ; 41(6): 969-975, 2020 06.
Article in English | MEDLINE | ID: mdl-32381546

ABSTRACT

BACKGROUND AND PURPOSE: Patients with hereditary hemorrhagic telangiectasia (HHT) have a high prevalence of brain vascular malformations, putting them at risk for brain hemorrhage and other complications. Our aim was to evaluate the relative utility of MR imaging and MRA compared with DSA in detecting cerebral AVMs in the HHT population. MATERIALS AND METHODS: Of 343 consecutive patients evaluated at the University of California, San Francisco HTT Center of Excellence, 63 met the study inclusion criteria: definite or probable hereditary hemorrhagic telangiectasia defined by meeting at least 2 Curacao criteria or positive genetic testing, as well as having at least 1 brain MR imaging and 1 DSA. MRIs were retrospectively reviewed, and the number of AVMs identified was compared with the number of AVMs identified on DSA. RESULTS: Of 63 patients, 45 (71%) had AVMs on DSA with a total of 92 AVMs identified. Of those, 24 (26%) were seen only on DSA; 68 (74%), on both DSA and MR imaging; and 5 additional lesions were seen only on MR imaging. Of the 92 lesions confirmed on DSA, 49 (53.3%) were seen on the 3D-T1 postgadolinium sequence, 52 (56.5%) were seen on the 2D-T1 postgadolinium sequence, 35 (38.0%) were seen on the SWI sequence, 24 (26.1%) were seen on T2 sequence, and 25 (27.2%) were seen on MRA. The sensitivity and specificity of MR imaging as a whole in detecting AVMs then confirmed on DSA were 80.0% and 94.4%, respectively, and the positive and negative predictive values were 97.3% and 65.4%, respectively. CONCLUSIONS: This study reinforces the use of MR imaging as a primary screening tool for cerebral AVMs in patients with hereditary hemorrhagic telangiectasia and suggests that 3D-T1 postgadolinium and 2D-T1 postgadolinium performed at 3T are the highest yield sequences.


Subject(s)
Central Nervous System Vascular Malformations/diagnostic imaging , Central Nervous System Vascular Malformations/etiology , Neuroimaging/methods , Telangiectasia, Hereditary Hemorrhagic/complications , Telangiectasia, Hereditary Hemorrhagic/pathology , Adolescent , Adult , Aged , Angiography, Digital Subtraction/methods , Central Nervous System Vascular Malformations/pathology , Child , Child, Preschool , Female , Humans , Infant , Magnetic Resonance Angiography/methods , Magnetic Resonance Imaging/methods , Male , Middle Aged , Retrospective Studies , Sensitivity and Specificity , Telangiectasia, Hereditary Hemorrhagic/diagnostic imaging , Young Adult
7.
AJNR Am J Neuroradiol ; 41(12): 2303-2310, 2020 12.
Article in English | MEDLINE | ID: mdl-33122213

ABSTRACT

BACKGROUND AND PURPOSE: Hemodynamic features of brain AVMs may portend increased hemorrhage risk. Previous studies have suggested that MTT is shorter in ruptured AVMs as assessed on quantitative color-coded parametric DSA. This study assesses the interrater reliability of MTT measurements obtained using quantitative color-coded DSA. MATERIALS AND METHODS: Thirty-five color-coded parametric DSA images of 34 brain AVMs were analyzed by 4 neuroradiologists with experience in interventional neuroradiology. Hemodynamic features assessed included MTT of the AVM and TTP of the dominant feeding artery and draining vein. Agreement among the 4 raters was assessed using the intraclass correlation coefficient. RESULTS: The interrater reliability among the 4 raters was poor (intraclass correlation coefficient = 0.218; 95% CI, 0.062-0.414; P value = .002) as it related to MTT assessment. When the analysis was limited to cases in which the raters selected the same image to analyze and selected the same primary feeding artery and the same primary draining vein, interrater reliability improved to fair (intraclass correlation coefficient = 0.564; 95% CI, 0.367-0.717; P < .001). CONCLUSIONS: Interrater reliability in deriving color-coded parametric DSA measurements such as MTT is poor so minor differences among raters may result in a large variance in MTT and TTP results, partly due to the sensitivity and 2D nature of the technique. Reliability can be improved by defining a standard projection, feeding artery, and draining vein for analysis.


Subject(s)
Angiography, Digital Subtraction , Intracranial Arteriovenous Malformations/diagnostic imaging , Adult , Angiography, Digital Subtraction/methods , Female , Humans , Male , Middle Aged , Observer Variation , Reproducibility of Results
8.
AJNR Am J Neuroradiol ; 41(2): 268-273, 2020 02.
Article in English | MEDLINE | ID: mdl-32001445

ABSTRACT

BACKGROUND AND PURPOSE: Arterial access is a technical consideration of mechanical thrombectomy that may affect procedural time, but few studies exist detailing the relationship of anatomy to procedural times and patient outcomes. We sought to investigate the respective impact of aortic arch and carotid artery anatomy on endovascular procedural times in patients with large-vessel occlusion. MATERIALS AND METHODS: We retrospectively reviewed imaging and medical records of 207 patients from 2 academic institutions who underwent mechanical thrombectomy for anterior circulation large-vessel occlusion from January 2015 to July 2018. Preintervention CTAs were assessed to measure features of the aortic arch and ipsilateral great vessel anatomy. These included the cranial-to-caudal distance from the origin of the innominate artery to the top of the aortic arch and the takeoff angle of the respective great vessel from the arch. mRS scores were calculated from rehabilitation and other outpatient documentation. We performed bootstrap, stepwise regressions to model groin puncture to reperfusion time and binary mRS outcomes (good outcome, mRS ≤ 2). RESULTS: From our linear regression for groin puncture to reperfusion time, we found a significant association of the great vessel takeoff angle (P = .002) and caudal distance from the origin of the innominate artery to the top of the aortic arch (P = .05). Regression analysis for the binary mRS revealed a significant association with groin puncture to reperfusion time (P < .001). CONCLUSIONS: These results demonstrate that patients with larger takeoff angles and extreme aortic arches have an association with longer procedural times as approached from transfemoral access routes.


Subject(s)
Aorta, Thoracic/anatomy & histology , Carotid Artery, Common/anatomy & histology , Endovascular Procedures/methods , Stroke/surgery , Adult , Aged , Aged, 80 and over , Aorta, Thoracic/surgery , Brain Ischemia/surgery , Carotid Artery, Common/surgery , Female , Humans , Male , Middle Aged , Retrospective Studies , Thrombectomy/methods , Treatment Outcome
9.
AJNR Am J Neuroradiol ; 41(12): 2235-2242, 2020 12.
Article in English | MEDLINE | ID: mdl-33214184

ABSTRACT

BACKGROUND AND PURPOSE: Automated CTP software is increasingly used for extended window emergent large-vessel occlusion to quantify core infarct. We aimed to assess whether RAPID software underestimates core infarct in patients with an extended window recently receiving IV iodinated contrast. MATERIALS AND METHODS: We reviewed a prospective, single-center data base of 271 consecutive patients who underwent CTA ± CTP for acute ischemic stroke from May 2018 through January 2019. Patients with emergent large-vessel occlusion confirmed by CTA in the extended window (>6 hours since last known well) and CTP with RAPID postprocessing were included. Two blinded raters independently assessed CT ASPECTS on NCCT performed at the time of CTP. RAPID software used relative cerebral blood flow of <30% as a surrogate for irreversible core infarct. Patients were dichotomized on the basis of receiving recent IV iodinated contrast (<8 hours before CTP) for a separate imaging study. RESULTS: The recent IV contrast and contrast-naïve cohorts comprised 23 and 15 patients, respectively. Multivariate linear regression analysis demonstrated that recent IV contrast administration was independently associated with a decrease in the RAPID core infarct estimate (proportional increase = 0.34; 95% CI, 0.12-0.96; P = .04). CONCLUSIONS: Patients who received IV iodinated contrast in proximity (<8 hours) to CTA/CTP as part of a separate imaging study had a much higher likelihood of core infarct underestimation with RAPID compared with contrast-naïve patients. Over-reliance on RAPID postprocessing for treatment disposition of patients with extended window emergent large-vessel occlusion should be avoided, particularly with recent IV contrast administration.


Subject(s)
Brain Infarction/diagnostic imaging , Contrast Media , Image Interpretation, Computer-Assisted , Iodine Compounds , Neuroimaging/methods , Software , Aged , Aged, 80 and over , Computed Tomography Angiography/methods , Female , Humans , Male , Middle Aged , Perfusion Imaging/methods , Retrospective Studies
10.
AJNR Am J Neuroradiol ; 28(3): 581-3, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17353341

ABSTRACT

SUMMARY: We report 3 patients with previously undiagnosed spinal dural arteriovenous fistulas (SDAVFs), who developed acute paraparesis following lumbar epidural steroid injection. MR imaging demonstrated spinal cord T2 hyperintensity, edema and/or enhancement of the conus, and intradural enlarged vascular flow voids. Spinal angiography confirmed SDAVFs arising from pedicles remote from the sites of the epidural steroid injection. Fistulas were eliminated with either endovascular or combination endovascular and open surgical approaches, with subsequent partial resolution of paraparesis.


Subject(s)
Adrenal Cortex Hormones/administration & dosage , Central Nervous System Vascular Malformations/drug therapy , Injections, Epidural/adverse effects , Paraparesis/etiology , Spinal Puncture/adverse effects , Acute Disease , Aged , Angiography , Central Nervous System Vascular Malformations/pathology , Central Nervous System Vascular Malformations/surgery , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Paraparesis/surgery
11.
Interv Neuroradiol ; 23(1): 47-51, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27798327

ABSTRACT

Introduction/Purpose To achieve aneurysm occlusion, flow diverters (FDs) must be accurately sized to maximize coverage over the neck and induce thrombosis. Catheterization for diagnostic angiography can cause vasospasm that may affect vessel measurements. This study evaluates impacts of intra-arterial infusion of a calcium channel blocker (CCB) on angiographic measurements in patients treated with FDs to determine effects on final diameter of the FD and subsequent occlusion. Materials and methods Pre-treatment measurements were recorded for diameter of the distal and proximal landing zones and maximum and minimum diameters between these segments. Post-treatment measurements of the stent following deployment were recorded at these locations. When CCB was infused, post-infusion pre-treatment measurements were recorded. Rates of occlusion were noted for all patients. T-tests were performed to assess for differences in pre- and post-treatment measurements and rates of occlusion between groups with and without CCB infusion. Results Twenty-eight FDs were deployed to treat 25 aneurysms in 24 patients. CCB infusion was performed prior to deployment of 12 (42.9%) devices. No significant difference was noted between groups for pre- and post-treatment measurement changes. Confirmed aneurysm occlusion was more likely to occur in the CCB infusion group (88.9% vs. 36.4%, p = 0.009). Conclusion Optimization of device sizing is important to increase FD density over the aneurysm neck and promote thrombosis. To improve measurement accuracy, CCB infusion can reduce effects of mild vasospasm. Subsequent aneurysm occlusion was more likely to occur following FD treatment when device size selection was based on measurements performed following CCB infusion.


Subject(s)
Calcium Channel Blockers/therapeutic use , Embolization, Therapeutic/instrumentation , Intracranial Aneurysm/therapy , Angiography, Digital Subtraction , Cerebral Angiography , Chemotherapy, Adjuvant , Combined Modality Therapy , Female , Humans , Infusions, Intra-Arterial , Intracranial Aneurysm/diagnostic imaging , Male , Middle Aged , Retrospective Studies , Stents , Treatment Outcome , Vasospasm, Intracranial/prevention & control
12.
AJNR Am J Neuroradiol ; 38(12): 2315-2320, 2017 Dec.
Article in English | MEDLINE | ID: mdl-28970244

ABSTRACT

BACKGROUND AND PURPOSE: Although intracranial dural arteriovenous fistulas are principally supplied by dural branches of the external carotid, internal carotid, and vertebral arteries, they can also be fed by pial arteries that supply the brain. We sought to determine the frequency of neurologic deficits following treatment of intracranial dural arteriovenous fistulas with and without pial artery supply. MATERIALS AND METHODS: One hundred twenty-two consecutive patients who underwent treatment for intracranial dural arteriovenous fistulas at our hospital from 2008 to 2015 were retrospectively reviewed. Patient data were examined for posttreatment neurologic deficits; patients with such deficits were evaluated for imaging evidence of cerebral infarction. Data were analyzed with multivariable logistic regression. RESULTS: Of 122 treated patients, 29 (23.8%) had dural arteriovenous fistulas with pial artery supply and 93 (76.2%) had dural arteriovenous fistulas without pial arterial supply. Of patients with pial artery supply, 4 (13.8%) had posttreatment neurologic deficits, compared with 2 patients (2.2%) without pial artery supply (P = .04). Imaging confirmed that 3 patients with pial artery supply (10.3%) had cerebral infarcts, compared with only 1 patient without pial artery supply (1.1%, P = .03). Increasing patient age was also positively associated with pial supply and treatment-related complications. CONCLUSIONS: Patients with dural arteriovenous fistulas supplied by the pial arteries were more likely to experience posttreatment complications, including ischemic strokes, than patients with no pial artery supply. The approach to dural arteriovenous fistula treatment should be made on a case-by-case basis so that the risk of complications can be minimized.


Subject(s)
Brain Ischemia , Brain/blood supply , Stroke , Adult , Aged , Arteries , Central Nervous System Vascular Malformations/therapy , Embolization, Therapeutic/methods , Female , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors
13.
J Neurointerv Surg ; 8(1): 19-23, 2016 Jan.
Article in English | MEDLINE | ID: mdl-25416828

ABSTRACT

BACKGROUND: Intracranial atherosclerotic disease (ICAD) causes substantial morbidity and mortality. Treatment decisions have most commonly been driven by the degree of luminal stenosis. This study compares ICAD lesion stability features with percentage stenosis for associations with adverse outcomes following treatment with stents. MATERIALS AND METHODS: Retrospective analysis was performed of prospectively maintained procedure logs. Lesions were classified by symptom type as hypoperfusion, non-hypoperfusion, or indeterminate, and pretreatment asymptomatic intervals were noted. Hypoperfusion lesions and indeterminate or non-hypoperfusion lesions with ≥14 days of asymptomatic interval were classified as stable. Percentage stenosis was calculated and compared against these other symptom features for value in predicting technical complication, ischemic stroke, disability, or death at 90 days and 2 years using univariate and multivariate analysis. RESULTS: 130 lesions were treated in 124 patients. The only statistically significant percent stenosis finding was lesions with 60-99% stenosis were less likely to have technical complications. In univariate analysis, stroke at 2 years was less common with hypoperfusion and stable lesions. In multivariate analysis, only hypoperfusion status was associated with lower stroke rates at 2 years. CONCLUSIONS: Lesion stability features, particularly non-hypoperfusion symptomatology, outperform percentage stenosis in predicting outcomes following treatment of ICAD with stents. Further examination is needed to better classify the natural history of ICAD and more precisely classify lesion stability.


Subject(s)
Cerebrovascular Circulation/physiology , Intracranial Arteriosclerosis/diagnosis , Intracranial Arteriosclerosis/therapy , Outcome Assessment, Health Care , Stents , Aged , Aged, 80 and over , Constriction, Pathologic/diagnosis , Constriction, Pathologic/therapy , Female , Humans , Male , Middle Aged , Prognosis , Retrospective Studies
14.
AJNR Am J Neuroradiol ; 37(4): 692-7, 2016 Apr.
Article in English | MEDLINE | ID: mdl-26564434

ABSTRACT

In the endovascular treatment of cerebral arteriovenous malformations, ethanol sclerotherapy is seldom used due to safety concerns. However, when limited reflux of an embolic agent is permissible or when there is a long distance to the target, ethanol may be preferable. We reviewed 10 patients with 14 cerebral AVM feeding artery aneurysms or intranidal aneurysms treated with intra-arterial ethanol sclerotherapy at our institution between 2005 and 2014. All patients presented with acute intracranial hemorrhage. Thirteen of 14 aneurysms were treated primarily with 60%-80% ethanol into the feeding artery. Complete target feeding artery and aneurysm occlusion was seen in all cases; 8/13 (62%) were occluded by using ethanol alone. No retreatments or recurrences were seen. One permanent neurologic deficit (1/13, 7.7%) and no deaths occurred. In a subset of ruptured cerebral AVMs, ethanol sclerotherapy of feeding artery aneurysms and intranidal aneurysms can be performed with a high degree of technical success and a low rate of complication.


Subject(s)
Ethanol/administration & dosage , Ethanol/therapeutic use , Intracranial Aneurysm/therapy , Intracranial Arteriovenous Malformations/therapy , Sclerotherapy/methods , Adolescent , Adult , Cerebral Angiography , Cerebral Arteries/diagnostic imaging , Endovascular Procedures/methods , Ethanol/adverse effects , Female , Humans , Infant , Injections, Intra-Arterial , Intracranial Aneurysm/diagnostic imaging , Intracranial Arteriovenous Malformations/diagnostic imaging , Male , Middle Aged , Nervous System Diseases/chemically induced , Nervous System Diseases/etiology , Recurrence , Rupture/drug therapy , Sclerotherapy/adverse effects , Subarachnoid Hemorrhage/drug therapy , Subarachnoid Hemorrhage/therapy
15.
AJNR Am J Neuroradiol ; 37(11): 2055-2059, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27390314

ABSTRACT

BACKGROUND AND PURPOSE: Comparing outcomes between endovascular aneurysm coiling trials can be difficult because of heterogeneity in patients and end points. We sought to understand the impact of geography on aneurysm retreatment in patients enrolled in the Matrix and Platinum Science Trial. MATERIALS AND METHODS: Post hoc analysis was performed on data from the Matrix and Platinum Science trial. Patients were stratified as either North American or international. Baseline patient demographics, comorbidities, aneurysm characteristics, procedural complications, and clinical and angiographic outcomes were compared. RESULTS: We evaluated 407 patients from 28 North American sites and 219 patients from 15 international sites. Patient demographics differed significantly between North American and international sites. Aneurysms were well occluded postprocedure more often at international than North American sites (P < .001). Stents were used significantly more often at North American sites (32.7% [133 of 407]) compared with international sites (10.0% [22 of 219]; P < .001). At 455 days, there was no difference in the proportion of patients alive and free of disability (P = .56) or with residual aneurysm filling (P = .10). Ruptured aneurysms were significantly more likely to have been retreated at North American sites within the first year (P < .001) and at 2 years (P < .001). Among all patients for whom the treating physician believed there to be Raymond 3 aneurysm filling at follow-up, absolute rates of retreatment at international and North American sites were similar by 2-year follow-up. CONCLUSIONS: Data from the Matrix and Platinum Science Trial demonstrate that aneurysm retreatment occurs with different frequency and at different times in different regions of the world. This trend has critical value when interpreting trials reporting short-term outcomes, especially when judgment-based metrics such as retreatment are primary end points that may or may not take place within the defined study follow-up period. Though these variations can be controlled for and balanced within a given randomized trial, such differences in practice patterns must be accounted for in any attempt to compare outcomes between different trials. Despite these differences, endovascular-treated intracranial aneurysms around the world have similar clinical outcomes.

17.
AJNR Am J Neuroradiol ; 36(5): 949-52, 2015 May.
Article in English | MEDLINE | ID: mdl-25634722

ABSTRACT

BACKGROUND AND PURPOSE: Intracranial hemorrhage is the most serious outcome for brain arteriovenous malformations. This study examines associations between venous characteristics of these lesions and intracranial hemorrhage. MATERIALS AND METHODS: Statistical analysis was performed on a prospectively maintained data base of brain AVMs evaluated at an academic medical center. DSA, CT, and MR imaging studies were evaluated to classify lesion side, drainage pattern, venous stenosis, number of draining veins, venous ectasia, and venous reflux. Logistic regression analyses were performed to identify the association of these angiographic features with intracranial hemorrhage of any age at initial presentation. RESULTS: Exclusively deep drainage (OR, 3.42; 95% CI, 1.87-6.26; P < .001) and a single draining vein (OR, 1.98; 95% CI, 1.26-3.08; P = .002) were associated with hemorrhage, whereas venous ectasia (OR, 0.52; 95% CI, 0.34-0.78; P = .002) was inversely associated with hemorrhage. CONCLUSIONS: Analysis of venous characteristics of brain AVMs may help determine their prognosis and thereby identify lesions most appropriate for treatment.


Subject(s)
Cerebral Hemorrhage/etiology , Cerebral Hemorrhage/pathology , Intracranial Arteriovenous Malformations/complications , Intracranial Arteriovenous Malformations/pathology , Aged , Female , Humans , Male , Middle Aged , Multimodal Imaging , Prognosis , Veins/pathology
18.
AJNR Am J Neuroradiol ; 36(10): 1912-9, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26206813

ABSTRACT

BACKGROUND AND PURPOSE: A minority of intracranial dural arteriovenous fistulas progress with time. We sought to determine features that predict progression and define outcomes of patients with progressive dural arteriovenous fistulas. MATERIALS AND METHODS: We performed a retrospective imaging and clinical record review of patients with intracranial dural arteriovenous fistula evaluated at our hospital. RESULTS: Of 579 patients with intracranial dural arteriovenous fistulas, 545 had 1 fistula (mean age, 45 ± 23 years) and 34 (5.9%) had enlarging, de novo, multiple, or recurrent fistulas (mean age, 53 ± 20 years; P = .11). Among these 34 patients, 19 had progressive dural arteriovenous fistulas with de novo fistulas or fistula enlargement with time (mean age, 36 ± 25 years; progressive group) and 15 had multiple or recurrent but nonprogressive fistulas (mean age, 57 ± 13 years; P = .0059, nonprogressive group). Whereas all 6 children had fistula progression, only 13/28 adults (P = .020) progressed. Angioarchitectural correlates to chronically elevated intracranial venous pressures, including venous sinus dilation (41% versus 7%, P = .045) and pseudophlebitic cortical venous pattern (P = .048), were more common in patients with progressive disease than in those without progression. Patients with progressive disease received more treatments than those without progression (median, 5 versus 3; P = .0068), but as a group, they did not demonstrate worse clinical outcomes (median mRS, 1 and 1; P = .39). However, 3 young patients died from intracranial venous hypertension and intracranial hemorrhage related to progression of their fistulas despite extensive endovascular, surgical, and radiosurgical treatments. CONCLUSIONS: Few patients with dural arteriovenous fistulas follow an aggressive, progressive clinical course despite treatment. Younger age at initial presentation and angioarchitectural correlates to venous hypertension may help identify these patients prospectively.


Subject(s)
Central Nervous System Vascular Malformations/diagnosis , Central Nervous System Vascular Malformations/therapy , Intracranial Hypertension/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Cerebral Angiography , Child , Child, Preschool , Disease Progression , Female , Humans , Infant , Infant, Newborn , Intracranial Hemorrhages/diagnosis , Intracranial Hemorrhages/surgery , Intracranial Hypertension/surgery , Male , Middle Aged , Radiosurgery , Retrospective Studies , Statistics as Topic , Treatment Outcome , Venous Pressure/physiology , Young Adult
19.
Vet Clin North Am Small Anim Pract ; 21(2): 369-87, 1991 Mar.
Article in English | MEDLINE | ID: mdl-2053257

ABSTRACT

The best means of providing for the physical and psychologic well-being of animals maintained in captive environments for research, teaching, testing, and exhibition is a problem being debated by scientists, veterinarians, animal rights and welfare groups, zoos, and others. Even a cursory examination of this question reveals its complexity and the inherited difficulties not only in assessing an animal's well-being but also in designing housing environments and implementing enforceable regulations. Assessment of well-being should not be based on a single category of measures but rather on a variety of physiologic and behavioral parameters. Most behavioral (and physiologic) methods used to assess well-being have problems of quantitation and interpretation. Preference tests and the application of economic demand theory to welfare assessment are examples of improved behavioral methodology, but much more research is needed on dogs and other species so that animal care and use guidelines can be based on objective data rather than on controversial opinions.


Subject(s)
Animal Welfare , Animals, Laboratory/psychology , Behavior, Animal , Dogs/psychology , Animals , Species Specificity
20.
Vet Clin North Am Small Anim Pract ; 20(4): 879-96, 1990 Jul.
Article in English | MEDLINE | ID: mdl-2196736

ABSTRACT

Cancer is an emotionally charged disease. During treatment, it is not uncommon for pet owners to engage veterinarians in frank discussions and emotional confrontations based on their fears and anxieties about cancer. Pet loss counseling skills are invaluable when dealing with clients after the death of their companion animal. Incorporating pet loss counseling into a veterinary practice is pragmatic as well as compassionate because clients who feel that they have received good emotional care in addition to medical care return to the veterinarian with new pets and recommend the practice to others.


Subject(s)
Bereavement , Counseling , Human-Animal Bond , Neoplasms/veterinary , Object Attachment , Veterinary Medicine , Animals , Cat Diseases/psychology , Cats , Dog Diseases/psychology , Dogs , Euthanasia/veterinary , Humans , Neoplasms/psychology
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