Luminosity-independent measurement of the proton-proton total cross section at √s=8 TeV.

The TOTEM collaboration has measured the proton-proton total cross section at √s=8 TeV using a luminosity-independent method. In LHC fills with dedicated beam optics, the Roman pots have been inserted very close to the beam allowing the detection of ~90% of the nuclear elastic scattering events. Simultaneously the inelastic scattering rate has been measured by the T1 and T2 telescopes. By applying the optical theorem, the total proton-proton cross section of (101.7±2.9) mb has been determined, well in agreement with the extrapolation from lower energies. This method also allows one to derive the luminosity-independent elastic and inelastic cross sections: σ(el)=(27.1±1.4) mb; σ(inel)=(74.7±1.7) mb.

Double diffractive cross-section measurement in the forward region at the LHC.

The first double diffractive cross-section measurement in the very forward region has been carried out by the TOTEM experiment at the LHC with a center-of-mass energy of sqrt[s]=7 TeV. By utilizing the very forward TOTEM tracking detectors T1 and T2, which extend up to |η|=6.5, a clean sample of double diffractive pp events was extracted. From these events, we determined the cross section σDD=(116±25) µb for events where both diffractive systems have 4.7<|η|min<6.5.

[S3-Check--evaluation and generation of normal values of a test for balance ability and postural stability]. / S3-Check--Evaluierung und Normwerteerhebung eines Tests zur Erfassung der Gleichgewichtsfähigkeit und Körperstabilität.

INTRODUCTION: Balance is very important in daily living, but there are practically no balance evaluation methods which fulfill scientific criteria and are available to the fitness community and other groups. The aims of this paper are to determine if the MFT-S3-Check, a system to measure balance, is scientifically objective, valid and reliable; and to establish norms for the MFT S 3-Check system. METHODS: Reliability was evaluated with 30 subjects in two testing sessions on two different days. Objectivity was determined by having two different test administrators test 10 subjects. Norms were generated from the data of over 5000 subjects (8 - 70 years of age). Validity was checked by comparing norms to data collected from 758 tests performed on ski racers (10 - 18 years of age). RESULTS: The objectivity and reliability tests for the sensor motor and stability indexes produced correlations which were moderate to very high. Norms were created for all age groups (female, male). The ski racers had significantly better values than the norms. DISCUSSION: The MFT S 3-Check fulfills the scientific criteria and is in use in fitness settings and in physiotherapy.

Effects of natural oestrogen therapy on blood pressure and renin-angiotensin system in normotensive and hypertensive menopausal women.

The blood pressure level and the renin-angiotensin system were investigated in 24 menopausal women (12 normotensive and 12 hypertensive) before, during and after six months of treatment with either oestradiol or trisekvens (sequential preparation containing oestradiol, oestriol and norethisterone acetate). In the normotensive women no significant alterations in systolic or diastolic blood pressure were found during treatment for six months. In the hypertensive women systolic blood pressure fell significantly during treatment with oestradiol as well as with trisekvens, while diastolic pressure did not change. All individual variations of blood pressure were small. The plasma concentrations of renin, angiotensin II and aldosterone remained unchanged during the treatments. A statistically significant increase in plasma renin substrate concentration was observed in all groups with the exception of the normotensive women treated with oestradiol. Menopausal symptoms in hypertensive women may safely be treated with natural oestrogens on the same indications as used for normotensive women.

The influence of arterial compliance on diastolic blood pressure and its relation to cardiovascular events.

Reduction of arterial compliance leads to a higher systolic (SBP) and a lower diastolic blood pressure (DBP). The increasing occurrence of reduced arterial compliance is responsible for the steep increase in SBP after the age of 50 years and also for the constancy and later decline in DBP. Reduced arterial compliance will blur the relationship between mean arterial pressure and DBP. This may change the relationships between cardiovascular events and DBP. The possibility of non-causal co-existence of reduced compliance and atherosclerosis is discussed. Such a co-existence would markedly influence the relationship between cardiovascular events and DBP. Finally, the influence that reduced compliance might have on the shape of the relation between cardiovascular episodes and diastolic and systolic blood pressure is discussed.

Leukocyte adhesion--an integrated molecular process at the leukocyte plasma membrane.

Leukocyte adhesion is of pivotal functional importance, because most leukocyte functions depend on cell-cell contact. It must be strictly controlled, both at the level of specificity and strength of interaction, and therefore several molecular systems are involved. The most important leukocyte adhesion molecules are the selectins, the leukocyte-specific beta2-integrins and the intercellular adhesion molecules. The selectins induce an initial weak contact between cells, whereas firm adhesion is achieved through integrin intercellular adhesion molecular binding. Although studies during the past twenty years have revealed several important features of leukocyte adhesion much is still poorly understood, and further work dealing with several aspects of adhesion is urgently needed. In this short essay, we review some recent developments in the field.

Leukocyte adhesion--a fundamental process in leukocyte physiology.

Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte beta 2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.