Chirality Engineering of Nanostructured Copper Oxide for Enhancing Oxygen Evolution from Water Electrolysis.

The exploration of a new conceptual strategy for improving the oxygen evolution reaction (OER) of earth-abundant electrocatalysts is critical. In this study, chiral copper oxide nanoflower is explored by a self-assembly method. The characterization suggests the chiral structure originates from the crystal plane-level helical stack of the secondary nanosheets. Of note, the assembly illustrates a record-high degree of spin polarization of 96%, indicating the ideal alignment of electron spin. Moreover, density function theory calculations show the chiral structure reducing the reaction energy barrier (REB) while switching the potential-determining step from *O→*OOH to *OH→*O. Together with the enhanced electrochemical active surface area and accelerated charge transfer, the production of ground-state triplet O2 is improved via a spin-forbidden route that involves the singlet H2O/OH•. Consequently, the chiral nanoflower shows a overpotential of 308 mV at 10 mA cm-2 and a Tafel slope of 93.5 mV dec-1, which is even superior to the commercial RuO2 (310 mV, 101 mV dec-1). This study presents a new strategy for improving the OER activity by simultaneously enhancing electronic properties and lowering the REB of an non-noble electrocatalyst via chirality engineering.

An explainable CNN approach for medical codes prediction from clinical text.

BACKGROUND: Clinical notes are unstructured text documents generated by clinicians during patient encounters, generally are annotated with International Classification of Diseases (ICD) codes, which give formatted information about the diagnosis and treatment. ICD code has shown its potentials in many fields, but manual coding is labor-intensive and error-prone, lead to researches of automatic coding. Two specific challenges of this task are (1) given an annotated clinical notes, the reasons behind specific diagnoses and treatments are  implicit; (2) explainability is important for practical automatic coding method, the method should not only explain its prediction output but also have explainable internal mechanics. This study aims to develop an explainable CNN approach to address these two challenges. METHOD: Our key idea is that for the automatic ICD coding task, the presence of informative snippets in the clinical text that correlated with each code plays an important role in the prediction of codes, and an informative snippet can be considered as a local and low-level feature. We infer that there exists a correspondence between a convolution filter and a local and low-level feature. Base on the inference, we come up with the Shallow and Wide Attention convolutional Mechanism (SWAM) to improve the CNN-based models' ability to learn local and low-level features for each label. RESULTS: We evaluate our approach on MIMIC-III, an open-access dataset of ICU medical records. Our approach substantially outperforms previous results on top-50 medical code prediction on MIMIC-III dataset, the precision of the worst-performing 10% labels in previous works is increased from 0% to 53% on average. We attribute this improvement to SWAM, by which the wide architecture with attention mechanism gives the model ability to more extensively learn the unique features of different codes, and we prove it by an ablation experiment. Besides, we perform manual analysis of the performance imbalance between different codes, and preliminary conclude the characteristics that determine the difficulty of learning specific codes. CONCLUSIONS: Our main contributions can be summarized into the following three: (1) We present local and low-level features, a.k.a. informative snippets play an important role in the automatic ICD coding task, and the informative snippets extracted from the clinical text provide explanations for each code. (2) We propose that there exists a correspondence between a convolution filter and a local and low-level feature. A combination of wide and shallow convolutional layer and attention layer can help the CNN-based models better learn local and low-level features. (3) We improved the precision of the worst-performing 10% labels from 0 to 53% on average.

Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients.

Breast cancer heterogeneity demands that prognostic models must be biologically driven and recent clinical evidence indicates that future prognostic signatures need evaluation in the context of early compared with late metastatic risk prediction. In pre-clinical studies, we and others have shown that various protein-protein interactions, pertaining to the actin microfilament-associated proteins, ezrin and cofilin, mediate breast cancer cell migration, a prerequisite for cancer metastasis. Moreover, as a direct substrate for protein kinase Cα, ezrin has been shown to be a determinant of cancer metastasis for a variety of tumour types, besides breast cancer; and has been described as a pivotal regulator of metastasis by linking the plasma membrane to the actin cytoskeleton. In the present article, we demonstrate that our tissue imaging-derived parameters that pertain to or are a consequence of the PKC-ezrin interaction can be used for breast cancer prognostication, with inter-cohort reproducibility. The application of fluorescence lifetime imaging microscopy (FLIM) in formalin-fixed paraffin-embedded patient samples to probe protein proximity within the typically <10 nm range to address the oncological challenge of tumour heterogeneity, is discussed.

Evolutionary Game Analysis of the Social Co-governance of E-Commerce Intellectual Property Protection.

By introducing the theory of social co-governance into the field of e-commerce intellectual property protection, this paper builds an evolutionary game model among the government, e-commerce platforms, and rights holders, and studies the conditions under the stakeholders form a stable equilibrium state under different constraints. Combined with numerical simulation, the influence of individual factors and factor combinations on the system stability is analyzed. Results shows that: Strictly controlling the action costs and response costs of all parties can enhance their willingness to actively deal with infringement issues; reasonable adjustment of the reward and punishment measures of government supervisory agencies can produce sufficient reverse shock and positive guidance to platform and operators; penalties should be imposed on government supervisory agencies that are not sufficiently supervised; strengthen the construction of the social environment for intellectual property protection, improve the social benefits of actively responding to infringement issues, and increase the sense of acquisition by the government, platforms and rights holders. And it provides certain positive references and suggestions for the government to formulate relevant policies.

Automatic Medical Code Assignment via Deep Learning Approach for Intelligent Healthcare.

With the development of healthcare 4.0, there has been an explosion in the amount of data such as image, medical text, physiological signals, lab tests, etc. Among them, medical records provide a complete picture of the associated clinical events. However, the processing of medical texts is difficult because they are structurally free, diverse in style, and have subjective factors. Assigning metadata codes from the International Classification of Diseases (ICD) presents a standardized way of indicating diagnoses and procedures, so it becomes a mandatory process for understanding medical records to make better clinical and financial decisions. Such a manual encoding task is time-consuming, error-prone and expensive. In this paper, we proposed a deep learning approach and a medical topic mining method to automatically predict ICD codes from text-free medical records. The result of the F1 score on Medical Information Mart for Intensive Care (MIMIC-III) dataset increases by 5% over the state of art. It also suitable for multiple ICD versions and languages. For the specific disease, atrial fibrillation, the F1 score is up to 96% and 93.3% using in-house ICD-10 datasets and MIMIC-III datasets, respectively. We developed an Artificial Intelligence based coding system, which can greatly improve the efficiency and accuracy of human coders, and meanwhile accelerate the secondary use for clinical informatics.

Explainable Prediction of Medical Codes With Knowledge Graphs.

International Classification of Diseases (ICD) is an authoritative health care classification system of different diseases. It is widely used for disease and health records, assisted medical reimbursement decisions, and collecting morbidity and mortality statistics. The most existing ICD coding models only translate the simple diagnosis descriptions into ICD codes. And it obscures the reasons and details behind specific diagnoses. Besides, the label (code) distribution is uneven. And there is a dependency between labels. Based on the above considerations, the knowledge graph and attention mechanism were expanded into medical code prediction to improve interpretability. In this study, a new method called G_Coder was presented, which mainly consists of Multi-CNN, graph presentation, attentional matching, and adversarial learning. The medical knowledge graph was constructed by extracting entities related to ICD-9 from freebase. Ontology contains 5 entity classes, which are disease, symptom, medicine, surgery, and examination. The result of G_Coder on the MIMIC-III dataset showed that the micro-F1 score is 69.2% surpassing the state of art. The following conclusions can be obtained through the experiment: G_Coder integrates information across medical records using Multi-CNN and embeds knowledge into ICD codes. Adversarial learning is used to generate the adversarial samples to reconcile the writing styles of doctor. With the knowledge graph and attention mechanism, most relevant segments of medical codes can be explained. This suggests that the knowledge graph significantly improves the precision of code prediction and reduces the working pressure of the human coders.