ABSTRACT
A new guaianolide, 3-deacetyl-9-O-acetylsalograviolide A, along with four known closely related lactones, salograviolide A, 9-O-acetylsalograviolide A, kandavanolide and salograviolide B were detected in the aerial parts of the flowering plant Centaurea nicolai. Antifungal tests performed on salograviolide A and its 9-O-acetyl and 3-O-deacetyl-9-O-acetyl derivatives revealed inhibitory activity against Aspergillus niger, A. ochraceus, Penicillium ochrochloron, Cladosporium cladosporoides, Fusarium tricinctum and Phomopsis helianthi. Neither of them was active against Trichoderma viride.
Subject(s)
Antifungal Agents/isolation & purification , Asteraceae/chemistry , Sesquiterpenes/isolation & purification , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Fungi/drug effects , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Molecular Structure , Sesquiterpenes/chemistry , Sesquiterpenes/pharmacology , Species SpecificityABSTRACT
The essential oils and an ethanol extract of Phlomis fruticosa L. were evaluated for antibacterial and antifungal activities. Seven bacterial and seven fungal species were used. Among them were human, animal and plant pathogens, food poisoning bacteria and fungi which are known as potential mycotoxin producers. The essential oils showed antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae and Micrococcus luteus. The essential oils extracted from the plants collected from two different localities showed similar antibacterial activities. The antifungal activity of the essential oils was positive against Aspergillus niger, A. ochraceus, Cladosporium cladosporioides, Fusarium tricinctum and Phomopsis helianthi. The ethanol extract showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis and antifungal activity against Aspergillus niger, A. ochraceus, Cladosporium cladosporioides, Fusarium tricinctum and Phomopsis helianthi.