Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase.

tRNA synthetase deficiency leads to unfolded protein responses in neuronal disorders; however, its function in embryonic neurogenesis remains unclear. This study identified an aars1cq71/cq71 mutant zebrafish allele that showed increased neuronal apoptosis and compromised neurogenesis. aars1 transcripts were highly expressed in primary neural progenitor cells, and their aberration resulted in protein overloading and activated Perk. nfe2l2b, a paralog of mammalian Nfe2l2, which encodes Nrf2, is a pivotal executor of Perk signaling that regulates neuronal phenotypes in aars1cq71/cq71 mutants. Interference of nfe2l2b in nfe2l2bΔ1/Δ1 mutants did not affect global larval development. However, aars1cq71/cq71;nfe2l2bΔ1/Δ1 mutant embryos exhibited increased neuronal cell survival and neurogenesis compared with their aars1cq71/cq71 siblings. nfe2l2b was harnessed by Perk at two levels. Its transcript was regulated by Chop, an implementer of Perk. It was also phosphorylated by Perk. Both pathways synergistically assured the nuclear functions of nfe2l2b to control cell survival by targeting p53. Our study extends the understanding of tRNA synthetase in neurogenesis and implies that Nrf2 is a cue to mitigate neurodegenerative pathogenesis.

The AalNix3&4 isoform is required and sufficient to convert Aedes albopictus females into males.

Aedes albopictus is one of the most invasive insect species in the world and an effective vector for many important arboviruses. We reported previously that Ae. albopictus Nix (AalNix) is the male-determining factor of this species. However, whether AalNix alone is sufficient to initiate male development is unknown. Transgenic lines that express each of the three AalNix isoforms from the native promoter were obtained using piggyBac transformation. We verified the stable expression of AalNix isoforms in the transgenic lines and confirm that one isoform, AalNix3&4, is sufficient to convert females into fertile males (pseudo-males) that are indistinguishable from wild-type males. We also established a stable sex-converted female mosquito strain, AalNix3&4-♂4-pseudo-male. The pseudo-male mosquitoes can fly and mate normally with wild-type female, although their mating competitiveness is lower than wild-type. This work further clarifies the role of AalNix in the sex determination pathway and will facilitate the development of Ae. albopictus control strategies that rely on male-only releases such as SIT and sex-ratio distortion.

Cryogenic Electron-Beam Writing for Perovskite Metasurface.

Halide perovskites (HPs) metasurfaces have recently attracted significant interest due to their potential to not only further enhance device performance but also reveal the unprecedented functionalities and novel photophysical properties of HPs. However, nanopatterning on HPs is critically challenging as they are readily destructed by the organic solvents in the standard lithographic processes. Here, we present a novel, subtle, and fully nondestructive HPs metasurface fabrication strategy based on cryogenic electron-beam writing. This technique allows for high-precision patterning and in situ imaging of HPs with excellent compatibility. As a proof-of-concept, broadband absorption enhanced metasurfaces were realized by patterning nanopillar arrays on CH3NH3PbI3 film, which results in photodetectors with approximately 14-times improvement on responsivity and excellent stability. Our findings highlight the great feasibility of cryogenic electron-beam writing for producing perovskite metasurface and unlocking the unprecedented photoelectronic properties of HPs.

Risk Factors of Contrast Agent Intravasation With Sulfur Hexafluoride Microbubble During Hysterosalpingo-Contrast Sonography.

OBJECTIVES: To analyze the risk factors of sulfur hexafluoride microbubble contrast agent intravasation during hysterosalpingo-contrast sonography (HyCoSy), and to explore a simple prediction model by the obvious clinical history. METHODS: This was a retrospective study included 299 infertility women who had undergone HyCoSy examination from July 1, 2018 to June 31, 2019. The factors were recorded, including age, endometrial thickness, balloon length, infertility type, history of intrauterine surgery, history of pelvic surgery, and tubal patency. The method of multivariate logistic regression analysis was adopted to analyze the risk factors affecting the contrast agent intravasation, and the receiver operating characteristic curves were plotted to test their efficacy. RESULTS: Secondary infertility, a history of intrauterine surgery, thin endometrial thickness, and tubal obstruction were all risk factors of the occurrence of intravasation (P < .05). And the area under the receiver operating characteristic curves of the multifactor-combined prediction model of the intravasation was significantly larger than that of single-factor. CONCLUSIONS: Sonographers and gynecologists should be familiar with the risk factors of intravasation and select the appropriate timing of HyCoSy toward reducing the occurrence of intravasation and other complications after thoroughly explaining and communicating with the patients.

Suppression of Phase Transitions in Perovskite Thin Films through Cryogenic Electron Beam Irradiation.

Organic-inorganic hybrid perovskites (OIHPs) with superior optoelectronic properties have emerged as revolutionary semiconductor materials for diverse applications. A fundamental understanding of the interplay between the microscopic molecular-level structure and the macroscopic optoelectronic properties is essential to boost device performance toward theoretical limits. Here, we reveal the critical role of CH3NH3+ (MA) in the regulation of the physicochemical and optoelectronic properties of a MAPbI3 film irradiated by an electron beam at 130 K. The order-to-disorder transformation of the MA cation not only leads to a notably enhanced photoluminescence emission but also results in the suppression of the orthorhombic phase down to 85 K. Taking advantage of the regulation of MA cation dynamics, we demonstrate a perovskite photodetector with 100% photocurrent enhancement and long-term stability exceeding one month. Our study provides a powerful tool for regulating the optoelectronic properties and stabilities of perovskites and highlights potential opportunities related to the organic cation in OIHPs.

Ultrasound-based radiomics for predicting different pathological subtypes of epithelial ovarian cancer before surgery.

OBJECTIVE: To evaluate the value of ultrasound-based radiomics in the preoperative prediction of type I and type II epithelial ovarian cancer. METHODS: A total of 154 patients with epithelial ovarian cancer were enrolled retrospectively. There were 102 unilateral lesions and 52 bilateral lesions among a total of 206 lesions. The data for the 206 lesions were randomly divided into a training set (53 type I + 71 type II) and a test set (36 type I + 46 type II) by random sampling. ITK-SNAP software was used to manually outline the boundary of the tumor, that is, the region of interest, and 4976 features were extracted. The quantitative expression values of the radiomics features were normalized by the Z-score method, and the 7 features with the most differences were screened by using the Lasso regression tenfold cross-validation method. The radiomics model was established by logistic regression. The training set was used to construct the model, and the test set was used to evaluate the predictive efficiency of the model. On the basis of multifactor logistic regression analysis, combined with the radiomics score of each patient, a comprehensive prediction model was established, the nomogram was drawn, and the prediction effect was evaluated by analyzing the area under the receiver operating characteristic curve (AUC), calibration curve and decision curve. RESULTS: The AUCs of the training set and test set in the radiomics model and comprehensive model were 0.817 and 0.731 and 0.982 and 0.886, respectively. The calibration curve showed that the two models were in good agreement. The clinical decision curve showed that both methods had good clinical practicability. CONCLUSION: The radiomics model based on ultrasound images has a good predictive effect for the preoperative differential diagnosis of type I and type II epithelial ovarian cancer. The comprehensive model has higher prediction efficiency.

Synthesis of Co@CoO/C by micro-tube method and their electrochemical performances.

Lithium-ion batteries (LIBs) are promising secondary batteries that are widely used in portable electronic devices, electric vehicles and smart grids. The design and synthesis of high-performance electrode materials play a crucial role in achieving lithium-ion batteries with high energy density, prolonged cycle life, and superior safety. CoO has attracted significant attention as a negative electrode material for lithium-ion batteries due to its high theoretical capacity and abundant resources. However, its limited conductivity and suboptimal cycling performance impede its potential applications. The study proposes a novel micro-tube reaction method for the synthesis of Co@CoO/C, utilizing Kapok fiber as a template with a special hollow structure. The microstructure and composition of the samples were characterized using X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). After conducting electrochemical performance tests, it was discovered that at a current density of 100 mA/g and within the range of 0.01-3.0 V for 50 charge and discharge cycles. Co@CoO/C composite negative electrode exhibits a reversible lithium insertion specific capacity of 499.8 mAh/g and keep a discharge capacity retention rate of 97.6 %. The greatly improved lithium storage and stability performance of Co@CoO/C composite anode is mainly attributed to the synergistic effect between Co@CoO nanoparticles and the kapok carbon microtubule structure.

Production and Patterning of Fluorescent Quantum Dots by Cryogenic Electron-Beam Writing.

Graphene quantum dots (GQDs) have emerged as a promising type of functional material with distinguished properties. Although tremendous effort was devoted to the preparation of GQDs, their applications are still limited due to a lack of methods for processing GQDs from synthesis to patterning smoothly. Here, we demonstrate that aromatic molecules, e.g., anisole, can be directly converted into GQD-containing nanostructures by cryogenic electron-beam writing. Such an electron-beam irradiation product exhibits evenly red fluorescence emission under laser excitation at 473 nm, and its photoluminescence intensity can be easily tuned with the electron-beam exposure dose. Experimental characterizations on the chemical composition of the product reveal that anisole undergoes a carbonization and further graphitization process during e-beam irradiation. With conformal coating of anisole, our approach can create arbitrary fluorescent patterns on both planar and curved surfaces for concealing information or anticounterfeiting applications. This study provides a one-step method for production and patterning of GQDs, facilitating their applications in highly integrated and compact optoelectronic devices.

Plate-on-plate structured MoS2/Cd0.6Zn0.4S Z-scheme heterostructure with enhanced photocatalytic hydrogen production activity via hole sacrificial agent synchronously strengthen half-reactions.

The practicable technology for producing hydrogen energy was mainly photocatalytic water splitting. Recently, heterostructural photocatalysts have attracted much attention due to its unique band structures and interfacial interactions. Herein, plate-on-plate MoS2/Cd0.6Zn0.4S heterostructure was rationally designed and fabricated by a simple strategy. It was revealed that Zn-doping content in the Cd0.6Zn0.4S solid solution as well as the mass ratio of MoS2 in the MoS2/Cd0.6Zn0.4S heterostructure can significantly affect the photocatalytic hydrogen evolution reaction (HER) activity. Especially, when Zn doping content is 40 % and the mass ratio of MoS2 is approximately 0.8 % (0.8 % MoS2/Cd0.6Zn0.4S), it exhibits the highest hydrogen production (47.68 µmol·g-1 at 2.5 h) without sacrificial agents. When Na2S/Na2SO3 is employed as sacrificial agent, its HER activity reaches 13466.50 µmol·g-1·h-1, 1.3 folds higher than Cd0.6Zn0.4S. The boosted HER activity of the Z-scheme MoS2/Cd0.6Zn0.4S heterostructure was ascribed to the greatly improved separation efficiency of photogenerated carriers. Most importantly, studies have revealed that the existence of sacrificial agents (Na2S/Na2SO3) can not only accelerate the kinetics of oxidation half reaction, but also synchronously strengthen HER half-reactions. The present work reveals a facile strategy for construction of Z-scheme heterostructures for efficient hydrogen evolution via hole sacrificial agent synchronously strengthen half-reactions.

A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus.

The initial signals governing sex determination vary widely among insects. Here we show that Armigeres subalbatus M factor (AsuMf), a male-specific duplication of an autosomal gene of the Drosophila behaviour/human splicing (DBHS) gene family, is the potential primary signal for sex determination in the human filariasis vector mosquito, Ar. subalbatus. Our results show that AsuMf satisfies two fundamental requirements of an M factor: male-specific expression and early embryonic expression. Ablations of AsuMf result in a shift from male- to female-specific splicing of doublesex and fruitless, leading to feminization of males both in morphology and general transcription profile. These data support the conclusion that AsuMf is essential for male development in Ar. subalbatus and reveal a male-determining factor that is derived from duplication and subsequent neofunctionalization of a member of the conserved DBHS family.

Operator's Influence on Contrast Agent Intravasation During Hysterosalpingo-Contrast Sonography: Explanation Based on a Physics Model.

Objective: To analyze the risk factors of the operators on contrast agent intravasation during hysterosalpingo-contrast sonography (HyCoSy). Methods: We retrospectively collected 399 infertile women who underwent HyCoSy by the same sonographer. These patients were divided into two groups according to the way how the assistants connected the syringe to the uterus radiography catheter to inject the contrast agent. We analyzed whether the use of different contrast bolus injection methods had any influence on the incidence of intravasation during HyCoSy. Results: There was no significant difference between the two groups with different cross-sectional areas of the syringe outflow tract in the risk variables for intravasation, but the intravasation rates of the two groups were different, 26.4% in group A and 17.1% in group B, P <0.05. The primary manifestation was that when both fallopian tubes were unobstructed, the intravasation rate of group B with smaller cross-sectional area of the outflow tract of the syringe was lower, and the difference was statistically significant. The inferences drawn from our physics model were also in line with the clinical results. Conclusion: The influence of different operators on the contrast agent intravasation rate of HyCoSy cannot be ignored. The assistants of HyCoSy examination should inject the contrast agent slowly and steady, and a needle can be used as a flow restrictor to control the flow into the uterine cavity per unit time, slow down the rising speed of intrauterine pressure, and avoid the accumulation of contrast agent in the uterine cavity, so as to reduce the intravasation caused by operator factors.

B, O and N Codoped Biomass-Derived Hierarchical Porous Carbon for High-Performance Electrochemical Energy Storage.

High specific surface area, reasonable pore structure and heteroatom doping are beneficial to enhance charge storage, which all depend on the selection of precursors, activators and reasonable preparation methods. Here, B, O and N codoped biomass-derived hierarchical porous carbon was synthesized by using KCl/ZnCl2 as a combined activator and porogen and H3BO3 as both boron source and porogen. Moreover, the cheap, environmentally friendly and heteroatom-rich laver was used as a precursor, and impregnation and freeze-drying methods were used to make the biological cells of laver have sufficient contact with the activator so that the layer was deeply activated. The as-prepared carbon materials exhibit high surface area (1514.3 m2 g-1), three-dimensional (3D) interconnected hierarchical porous structure and abundant heteroatom doping. The synergistic effects of these properties promote the obtained carbon materials with excellent specific capacitance (382.5 F g-1 at 1 A g-1). The symmetric supercapacitor exhibits a maximum energy density of 29.2 W h kg-1 at a power density of 250 W kg-1 in 1 M Na2SO4, and the maximum energy density can reach to 51.3 W h kg-1 at a power density of 250 W kg-1 in 1 M BMIMBF4/AN. Moreover, the as-prepared carbon materials as anode for lithium-ion batteries possess high reversible capacity of 1497 mA h g-1 at 1 A g-1 and outstanding cycling stability (no decay after 2000 cycles).

Enhanced catalytic activity of layered double hydroxides via in-situ reconstruction for conversion of glucose/food waste to methyl lactate in biorefinery.

Conversion of food waste into valuable chemicals under mild conditions has attracted increasing attention. Herein, a series of nano-sized MgAl layered double hydroxides (LDHs) were firstly developed as solid base catalyst for the methyl lactate (MLA) production directly from glucose/food waste. Glucose, which could be easily obtained from cellulose or starch-rich food waste via hydrolysis, was thus selected as the model compound. It is inspiring to find that the metal hydroxide layer in prepared LDHs was highly stable and suitable enlarged interlayer distance was reconstructed owing to in-situ intercalation of formed aromatics during the reaction, which was demonstrated by 27Al magic angle spinning nuclear magnetic resonance and time-of-flight secondary ion mass spectrometry analysis. As a result, in-situ activation of the catalysts along with gradually enhanced catalytic activity was obtained in the recycling runs and the highest MLA yield of 47.6% from glucose was achieved over LDHs (5:1) after 5 runs at 150 °C. Most importantly, the scope was further extended to other typical substrates (e.g. Chinese cabbage and rice) and the results demonstrated the effectiveness of present conversion system for real food waste.

Pathways and Kinetics for Autocatalytic Reduction of CO2 into Formic Acid with Fe under Hydrothermal Conditions.

The utilization of CO2, as a cheap and abundant carbon source to produce useful chemicals or fuels, has been regarded as one of the promising ways to reduce CO2 emissions and minimize the green-house effect. Previous studies have demonstrated that CO2 (or HCO3 -) can be efficiently reduced to formic acid with metal Fe under hydrothermal conditions without additional hydrogen and any catalyst. However, the pathways and kinetics of the autocatalytic CO2 reduction remain unknown. In the present work, the reaction kinetics were carefully investigated according to the proposed reaction pathways, and a phenomenological kinetic model was developed for the first time. The results showed that the hydrothermal conversion of HCO3 - into formic acid with Fe can be expressed as the first-order reaction, and the activation energy of HCO3 - is 28 kJ/mol under hydrothermal conditions.

Formation of Formic Acid from Glucose with Simultaneous Conversion of Ag2O to Ag under Mild Hydrothermal Conditions.

Formation of formic acid from renewable biomass resources is of great interest since formic acid is a widely used platform chemical and has recently been regarded as an important liquid hydrogen carrier. Herein, a novel approach is reported for the conversion of glucose, the constituent carbohydrate from the cellulose fraction of biomass, to formic acid under mild hydrothermal conditions with simultaneous reduction of Ag2O to Ag. Results showed that glucose was selectively converted to formic acid with an optimum yield of 40.7% and glycolic acid with a yield of 6.1% with 53.2% glucose converting to carbon dioxide (CO2) immediately at a mild reaction temperature of 135 °C for 30 min. In addition, Ag2O was used as a solid oxidant for glucose oxidation, which avoids the use of traditionally dangerous liquid oxidant H2O2. Furthermore, complete conversion of Ag2O to Ag can be achieved. This study not only developed a new method for value-added chemical production from renewable biomass but also explored an alternative low-carbon and energy-saving route for silver extraction and recovery.

Natural mineral bentonite as catalyst for efficient isomerization of biomass-derived glucose to fructose in water.

The development of inexpensive and efficient heterogeneous catalyst for the conversion of biomass including food and winery processing waste to value-added products is crucial in biorefinery. Glucose could be obtained via the hydrolysis of waste cellulose or starch-rich material, and the isomerization of glucose to fructose using either Lewis acid or Brønsted base catalysts is an important route in biorefinery. As a natural clay mineral, bentonite (Bt) is widely used as adsorption material and catalyst support, but how its intrinsic acid-base properties can impact the biomass conversion chemistry is still rarely reported. In this study, we investigated the influence of the textural and acid-base properties of Bt on the glucose isomerization reaction. The reaction kinetics and mechanism, and the effect of Al3+-exchange were explored. The results showed that the activation energy of Bt-catalyzed glucose conversion was 59.0 kJ mol-1, and the in-situ Fourier transform infrared spectrometer (FT-IR) characterization proved that Brønsted base was responsible for the isomerization. The highest fructose yield of 39.2% with 86.3% selectivity could be obtained at 110 °C for 60 min in water. Alkaline rinse and calcination can recover most of the catalytic activity of the spent catalyst.

Controllable Design of Bifunctional VO2 Coatings with Superhydrophobic and Thermochromic Performances.

The structure and functions of natural organisms provide great inspirational sources for designing and manufacturing bionic coatings, which hold a distinguished scientific promise to tackle challenges facing humans. In this work, we report a facile and controllable approach to prepare various hexagonal periodic array VO2 thin films by simply manipulating the speed of the dip-coating operation. The hexagonal cellular-structured VO2 surface delivered the best thermochromic performance with a Tlum of 79.34% and a ΔTsol of 9.87%. Impressively, superhydrophobic and thermochromic properties could be integrated into hexagonal semi-dome thin films (with a Tlum of 70.9%, a ΔTsol of 9.3%, and a water contact angle of 150°) without any post-treatment by low-surface-energy chemicals, which hold considerable potential for application in multifunctional smart windows. Moreover, based on the Cassie-Baxter mode and finite-difference time-domain calculations, the dependence of the thermochromic and wettability performances on the VO2 structure has been investigated in this study.

Electron-Beam Irradiation Induced Regulation of Surface Defects in Lead Halide Perovskite Thin Films.

Organic-inorganic hybrid perovskites (OIHPs) have been intensively studied due to their fascinating optoelectronic performance. Electron microscopy and related characterization techniques are powerful to figure out their structure-property relationships at the nanoscale. However, electron beam irradiation usually causes damage to these beam-sensitive materials and thus deteriorates the associated devices. Taking a widely used CH3NH3PbI3 film as an example, here, we carry out a comprehensive study on how electron beam irradiation affects its properties. Interestingly, our results reveal that photoluminescence (PL) intensity of the film can be significantly improved along with blue-shift of emission peak at a specific electron beam dose interval. This improvement stems from the reduction of trap density at the CH3NH3PbI3 surface. The knock-on effect helps expose a fresh surface assisted by the surface defect-induced lowering of displacement threshold energy. Meanwhile, the radiolysis process consistently degrades the crystal structure and weaken the PL emission with the increase of electron beam dose. Consequently, the final PL emission comes from a balance between knock-on and radiolysis effects. Taking advantage of the defect regulation, we successfully demonstrate a patterned CH3NH3PbI3 film with controllable PL emission and a photodetector with enhanced photocurrent. This work will trigger the application of electron beam irradiation as a powerful tool for perovskite materials processing in micro-LEDs and other optoelectronic applications.

Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis.

ETHNOPHARMACOLOGICAL RELEVANCE: Salvia miltiorrhiza and ligustrazine injection is a compound injection composed of the extract from Salvia miltiorrhiza and Ligusticum striatum (Ligusticum striatum DC.), has been frequently used for the adjuvant treatment of early-stage diabetic kidney disease (DKD) in China. Safety and efficacy studies in terms of evidence-based medical practice have become more prevalent in application to Chinese Herbal Medicine. It is necessary to assess the efficacy and safety of Salvia miltiorrhiza and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease by conducting a systematic review and meta-analysis of available clinical data. AIM OF THE STUDY: The aim of this systematic review and meta-analysis was to evaluate the efficacy and safety of Salvia miltiorrhiza and ligustrazine injection as an adjunctive therapy to conventional therapies for early-stage DKD. MATERIALS AND METHODS: The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) checklist was used to structure this study. We searched the English databases PubMed, Cochrane library, and Chinese databases including Chinese journal full text database (CNKI), China Biomedical Documentation Service System (SinoMed), Wanfang digital periodical full text database and Chinese Scientific Journal Database (VIP). Relevant studies were selected based on the inclusion and exclusion criteria. Meta-analysis was performed with RevMan 5.3 software after data extraction and the quality of studies assessment. The quality of the evidence was assessed with the Cochrane risk of bias tool. Sensitivity analysis and Egger's test were performed using Stata 15.0 software. RESULTS: A total of 22 trials were included with 1939 patients. Meta-analysis showed that compared with the control group of conventional western medicine alone, Salvia miltiorrhiza and ligustrazine injection combined with conventional western medicine can achieve better efficacy in the treatment of early-stage DKD, reduce urinary albumin excretion rate (12RCTs, 1181 participants; SMD = -1.82, 95% CI [-2.62, -1.01], P < 0.00001), serum creatinine (13RCTs, 1228 participants; MD = -13.21 µmol/L, 95% CI [-19.58, -6.83], P < 0.0001), ß2-microglobulin (9RCTs, 669 participants; SMD = -1.45, 95% CI [-2.43, -0.48], P = 0.003) and reduce interleukin-6 (4RCTs, 331 participants; MD = -6.38 ng/L, 95% CI [-9.03, -3.78], P < 0.00001), interleukin-18 (2RCTs, 177 participants; MD = -29.78 ng/L, 95% CI [-41.51, -18.05], P < 0.00001), tumor necrosis factor-α (4RCTs, 331 participants; MD = -18.03 ng/L, 95% CI [-22.96, -13.09], P < 0.00001), with statistical differences and alleviate the body inflammatory response effectively. CONCLUSION: Based on the existing evidence, that Salvia miltiorrhiza and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease is safe and effective. However, due to the limitation of the quality of the included studies, the above conclusions need to be further verified by more relevant randomized controlled trials with high-quality large samples.

Coupling of Immobilized Photosynthetic Bacteria with a Graphene Oxides/PSF Composite Membrane for Textile Wastewater Treatment: Biodegradation Performance and Membrane Anti-Fouling Behavior.

The membrane bioreactor (MBR), as one of the promising technologies, has been widely applied for treatments of wastewater. However, serious membrane fouling and low microbial activity have been reported as major problems hindering the development of the MBR. To overcome these drawbacks, we intend to improve the MBR process in the view of membrane surface modification and efficient granular bacteria cultivation. In the present study, immobilized photosynthetic bacteria integration with graphene oxide (GO)/polysulfone (PSF) composite membrane separation (IPMBR) was first applied for textile wastewater treatment. Due to the high activity of immobilized cells, the IPMBR system exhibited higher efficiency on the removal of color, ammonia-nitrogen, and chemical oxygen demand than the conventional MBR system. In comparison with a pure PSF membrane, GO/PSF composite membrane presented the higher hydrophilicity (water contact angles of 62.9°) and more attractive permeability (178.5 L/m2h) by reducing the adhesion of hydrophobic foulants. During the whole operation, the immobilized photobioreactor exhibited approximately seven times higher membrane permeability that that of the conventional MBR. Meanwhile, the effect of the structure and character of immobilized photosynthetic bacteria on the membrane fouling reduction was investigated in detail. The change of extracellular polymeric substance concentration, settleability and particle size of flocs was very beneficial to alleviate membrane fouling. As a result, this research will open a new avenue for developing efficient and anti-fouling MBR technology in the future.