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1.

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection.

Schober, Kilian; Voit, Florian; Grassmann, Simon; Müller, Thomas R; Eggert, Joel; Jarosch, Sebastian; Weißbrich, Bianca; Hoffmann, Patrick; Borkner, Lisa; Nio, Enzo; Fanchi, Lorenzo; Clouser, Christopher R; Radhakrishnan, Aditya; Mihatsch, Lorenz; Lückemeier, Philipp; Leube, Justin; Dössinger, Georg; Klein, Ludger; Neuenhahn, Michael; Oduro, Jennifer D; Cicin-Sain, Luka; Buchholz, Veit R; Busch, Dirk H.

Nat Immunol ; 21(4): 434-441, 2020 04.

Article in English | MEDLINE | ID: mdl-32205883

2.

Aire Gets Company for Immune Tolerance.

Klein, Ludger.

Cell ; 163(4): 794-5, 2015 Nov 05.

Article in English | MEDLINE | ID: mdl-26544932

3.

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

Afzali, Ali Maisam; Nirschl, Lucy; Sie, Christopher; Pfaller, Monika; Ulianov, Oleksii; Hassler, Tobias; Federle, Christine; Petrozziello, Elisabetta; Kalluri, Sudhakar Reddy; Chen, Hsin Hsiang; Tyystjärvi, Sofia; Muschaweckh, Andreas; Lammens, Katja; Delbridge, Claire; Büttner, Andreas; Steiger, Katja; Seyhan, Gönül; Ottersen, Ole Petter; Öllinger, Rupert; Rad, Roland; Jarosch, Sebastian; Straub, Adrian; Mühlbauer, Anton; Grassmann, Simon; Hemmer, Bernhard; Böttcher, Jan P; Wagner, Ingrid; Kreutzfeldt, Mario; Merkler, Doron; Pardàs, Irene Bonafonte; Schmidt Supprian, Marc; Buchholz, Veit R; Heink, Sylvia; Busch, Dirk H; Klein, Ludger; Korn, Thomas.

Nature ; 627(8003): 407-415, 2024 Mar.

Article in English | MEDLINE | ID: mdl-38383779

4.

Recollections of the discovery of promiscuous antigen expression in mTECs.

Klein, Ludger.

Nat Immunol ; 21(11): 1303-1305, 2020 11.

Article in English | MEDLINE | ID: mdl-32820273

5.

Bruno Kyewski 1950-2018.

Klein, Ludger.

Nat Immunol ; 19(6): 509, 2018 06.

Article in English | MEDLINE | ID: mdl-29643481

6.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Yamano, Tomoyoshi; Nedjic, Jelena; Hinterberger, Maria; Steinert, Madlen; Koser, Sandra; Pinto, Sheena; Gerdes, Norbert; Lutgens, Esther; Ishimaru, Naozumi; Busslinger, Meinrad; Brors, Benedikt; Kyewski, Bruno; Klein, Ludger.

Immunity ; 42(6): 1048-61, 2015 Jun 16.

Article in English | MEDLINE | ID: mdl-26070482

7.

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

Vahl, J Christoph; Drees, Christoph; Heger, Klaus; Heink, Sylvia; Fischer, Julius C; Nedjic, Jelena; Ohkura, Naganari; Morikawa, Hiromasa; Poeck, Hendrik; Schallenberg, Sonja; Rieß, David; Hein, Marco Y; Buch, Thorsten; Polic, Bojan; Schönle, Anne; Zeiser, Robert; Schmitt-Gräff, Annette; Kretschmer, Karsten; Klein, Ludger; Korn, Thomas; Sakaguchi, Shimon; Schmidt-Supprian, Marc.

Immunity ; 41(5): 722-36, 2014 Nov 20.

Article in English | MEDLINE | ID: mdl-25464853

8.

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance.

Hinterberger, Maria; Aichinger, Martin; Prazeres da Costa, Olivia; Voehringer, David; Hoffmann, Reinhard; Klein, Ludger.

Nat Immunol ; 11(6): 512-9, 2010 Jun.

Article in English | MEDLINE | ID: mdl-20431619

9.

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.

Hassler, Tobias; Urmann, Emanuel; Teschner, Sebastian; Federle, Christine; Dileepan, Thamotharampillai; Schober, Kilian; Jenkins, Marc K; Busch, Dirk H; Hinterberger, Maria; Klein, Ludger.

Proc Natl Acad Sci U S A ; 116(37): 18537-18543, 2019 09 10.

Article in English | MEDLINE | ID: mdl-31451631

10.

Regulatory T cell differentiation: turning harmful into useful.

Klein, Ludger; Jovanovic, Ksenija.

Immunity ; 37(3): 441-3, 2012 Sep 21.

Article in English | MEDLINE | ID: mdl-22999949

11.

B cells latently infected with murine gammaherpesvirus 68 (MHV-68) are present in the mouse thymus-A step toward immune evasion?

Yamano, Tomoyoshi; Steinert, Madlen; Steer, Beatrix; Klein, Ludger; Hammerschmidt, Wolfgang; Adler, Heiko.

Eur J Immunol ; 49(2): 351-352, 2019 02.

Article in English | MEDLINE | ID: mdl-30488950

12.

Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation.

Warth, Sebastian C; Hoefig, Kai P; Hiekel, Anian; Schallenberg, Sonja; Jovanovic, Ksenija; Klein, Ludger; Kretschmer, Karsten; Ansel, K Mark; Heissmeyer, Vigo.

EMBO J ; 34(9): 1195-213, 2015 May 05.

Article in English | MEDLINE | ID: mdl-25712478

13.

A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

Dobes, Jan; Edenhofer, Frank; Voboril, Matous; Brabec, Tomás; Dobesová, Martina; Cepková, Adéla; Klein, Ludger; Rajewsky, Klaus; Filipp, Dominik.

Eur J Immunol ; 48(3): 546-548, 2018 03.

Article in English | MEDLINE | ID: mdl-29193031

14.

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.

Pasquarella, Alessandra; Ebert, Anja; Pereira de Almeida, Gustavo; Hinterberger, Maria; Kazerani, Maryam; Nuber, Alexander; Ellwart, Joachim; Klein, Ludger; Busslinger, Meinrad; Schotta, Gunnar.

Development ; 143(10): 1788-99, 2016 05 15.

Article in English | MEDLINE | ID: mdl-27013243

15.

Dead man walking: how thymocytes scan the medulla.

Klein, Ludger.

Nat Immunol ; 10(8): 809-11, 2009 Aug.

Article in English | MEDLINE | ID: mdl-19621041

16.

Regulatory T cell lineage commitment in the thymus.

Klein, Ludger; Jovanovic, Ksenija.

Semin Immunol ; 23(6): 401-9, 2011 Dec.

Article in English | MEDLINE | ID: mdl-21733719

17.

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance.

Klein, Ludger; Hinterberger, Maria; von Rohrscheidt, Julia; Aichinger, Martin.

Trends Immunol ; 32(5): 188-93, 2011 May.

Article in English | MEDLINE | ID: mdl-21493141

18.

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

Nedjic, Jelena; Aichinger, Martin; Emmerich, Jan; Mizushima, Noboru; Klein, Ludger.

Nature ; 455(7211): 396-400, 2008 Sep 18.

Article in English | MEDLINE | ID: mdl-18701890

19.

Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032-1039.

Derbinski, Jens; Schulte, Antje; Kyewski, Bruno; Klein, Ludger.

J Immunol ; 196(7): 2915-22, 2016 Apr 01.

Article in English | MEDLINE | ID: mdl-26994303

20.

LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.

Rodrigues, Pedro M; Sousa, Laura G; Perrod, Chiara; Maceiras, Ana R; Ferreirinha, Pedro; Pombinho, Rita; Romera-Cárdenas, Gema; Gomez-Lazaro, María; Senkara, Meryem; Pistolic, Jelena; Cabanes, Didier; Klein, Ludger; Saftig, Paul; Alves, Nuno L.

Autophagy ; 19(2): 426-439, 2023 02.

Article in English | MEDLINE | ID: mdl-35535798

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Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection.

Aire Gets Company for Immune Tolerance.

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

Recollections of the discovery of promiscuous antigen expression in mTECs.

Bruno Kyewski 1950-2018.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance.

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.

Regulatory T cell differentiation: turning harmful into useful.

B cells latently infected with murine gammaherpesvirus 68 (MHV-68) are present in the mouse thymus-A step toward immune evasion?

Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation.

A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.

Dead man walking: how thymocytes scan the medulla.

Regulatory T cell lineage commitment in the thymus.

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance.

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032-1039.

LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.