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1.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.

Stewart-Jones, Guillaume B E; Soto, Cinque; Lemmin, Thomas; Chuang, Gwo-Yu; Druz, Aliaksandr; Kong, Rui; Thomas, Paul V; Wagh, Kshitij; Zhou, Tongqing; Behrens, Anna-Janina; Bylund, Tatsiana; Choi, Chang W; Davison, Jack R; Georgiev, Ivelin S; Joyce, M Gordon; Kwon, Young Do; Pancera, Marie; Taft, Justin; Yang, Yongping; Zhang, Baoshan; Shivatare, Sachin S; Shivatare, Vidya S; Lee, Chang-Chun D; Wu, Chung-Yi; Bewley, Carole A; Burton, Dennis R; Koff, Wayne C; Connors, Mark; Crispin, Max; Baxa, Ulrich; Korber, Bette T; Wong, Chi-Huey; Mascola, John R; Kwong, Peter D.

Cell ; 165(4): 813-26, 2016 May 05.

Article in English | MEDLINE | ID: mdl-27114034

2.

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.

de Taeye, Steven W; Ozorowski, Gabriel; Torrents de la Peña, Alba; Guttman, Miklos; Julien, Jean-Philippe; van den Kerkhof, Tom L G M; Burger, Judith A; Pritchard, Laura K; Pugach, Pavel; Yasmeen, Anila; Crampton, Jordan; Hu, Joyce; Bontjer, Ilja; Torres, Jonathan L; Arendt, Heather; DeStefano, Joanne; Koff, Wayne C; Schuitemaker, Hanneke; Eggink, Dirk; Berkhout, Ben; Dean, Hansi; LaBranche, Celia; Crotty, Shane; Crispin, Max; Montefiori, David C; Klasse, P J; Lee, Kelly K; Moore, John P; Wilson, Ian A; Ward, Andrew B; Sanders, Rogier W.

Cell ; 163(7): 1702-15, 2015 Dec 17.

Article in English | MEDLINE | ID: mdl-26687358

3.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.

Zhou, Tongqing; Lynch, Rebecca M; Chen, Lei; Acharya, Priyamvada; Wu, Xueling; Doria-Rose, Nicole A; Joyce, M Gordon; Lingwood, Daniel; Soto, Cinque; Bailer, Robert T; Ernandes, Michael J; Kong, Rui; Longo, Nancy S; Louder, Mark K; McKee, Krisha; O'Dell, Sijy; Schmidt, Stephen D; Tran, Lillian; Yang, Zhongjia; Druz, Aliaksandr; Luongo, Timothy S; Moquin, Stephanie; Srivatsan, Sanjay; Yang, Yongping; Zhang, Baoshan; Zheng, Anqi; Pancera, Marie; Kirys, Tatsiana; Georgiev, Ivelin S; Gindin, Tatyana; Peng, Hung-Pin; Yang, An-Suei; Mullikin, James C; Gray, Matthew D; Stamatatos, Leonidas; Burton, Dennis R; Koff, Wayne C; Cohen, Myron S; Haynes, Barton F; Casazza, Joseph P; Connors, Mark; Corti, Davide; Lanzavecchia, Antonio; Sattentau, Quentin J; Weiss, Robin A; West, Anthony P; Bjorkman, Pamela J; Scheid, Johannes F; Nussenzweig, Michel C; Shapiro, Lawrence.

Cell ; 161(6): 1280-92, 2015 Jun 04.

Article in English | MEDLINE | ID: mdl-26004070

4.

Vaccines that stimulate T cell immunity to HIV-1: the next step.

McMichael, Andrew J; Koff, Wayne C.

Nat Immunol ; 15(4): 319-22, 2014 Apr.

Article in English | MEDLINE | ID: mdl-24646598

5.

Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

Tsang, John S; Dobaño, Carlota; VanDamme, Pierre; Moncunill, Gemma; Marchant, Arnaud; Othman, Rym Ben; Sadarangani, Manish; Koff, Wayne C; Kollmann, Tobias R.

Trends Immunol ; 41(6): 457-465, 2020 06.

Article in English | MEDLINE | ID: mdl-32340868

6.

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Falkowska, Emilia; Le, Khoa M; Ramos, Alejandra; Doores, Katie J; Lee, Jeong Hyun; Blattner, Claudia; Ramirez, Alejandro; Derking, Ronald; van Gils, Marit J; Liang, Chi-Hui; Mcbride, Ryan; von Bredow, Benjamin; Shivatare, Sachin S; Wu, Chung-Yi; Chan-Hui, Po-Ying; Liu, Yan; Feizi, Ten; Zwick, Michael B; Koff, Wayne C; Seaman, Michael S; Swiderek, Kristine; Moore, John P; Evans, David; Paulson, James C; Wong, Chi-Huey; Ward, Andrew B; Wilson, Ian A; Sanders, Rogier W; Poignard, Pascal; Burton, Dennis R.

Immunity ; 40(5): 657-68, 2014 May 15.

Article in English | MEDLINE | ID: mdl-24768347

7.

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

Zhou, Tongqing; Zhu, Jiang; Wu, Xueling; Moquin, Stephanie; Zhang, Baoshan; Acharya, Priyamvada; Georgiev, Ivelin S; Altae-Tran, Han R; Chuang, Gwo-Yu; Joyce, M Gordon; Kwon, Young Do; Longo, Nancy S; Louder, Mark K; Luongo, Timothy; McKee, Krisha; Schramm, Chaim A; Skinner, Jeff; Yang, Yongping; Yang, Zhongjia; Zhang, Zhenhai; Zheng, Anqi; Bonsignori, Mattia; Haynes, Barton F; Scheid, Johannes F; Nussenzweig, Michel C; Simek, Melissa; Burton, Dennis R; Koff, Wayne C; Mullikin, James C; Connors, Mark; Shapiro, Lawrence; Nabel, Gary J; Mascola, John R; Kwong, Peter D.

Immunity ; 39(2): 245-58, 2013 Aug 22.

Article in English | MEDLINE | ID: mdl-23911655

8.

Toward a human vaccines project.

Koff, Wayne C; Gust, Ian D; Plotkin, Stanley A.

Nat Immunol ; 15(7): 589-92, 2014 Jul.

Article in English | MEDLINE | ID: mdl-24940943

9.

Covid-19 and Immunity in Aging Populations - A New Research Agenda.

Koff, Wayne C; Williams, Michelle A.

N Engl J Med ; 383(9): 804-805, 2020 Aug 27.

Article in English | MEDLINE | ID: mdl-32302079

10.

Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop.

Patil, Shilpa; Kumar, Rajesh; Deshpande, Suprit; Samal, Sweety; Shrivastava, Tripti; Boliar, Saikat; Bansal, Manish; Chaudhary, Nakul Kumar; Srikrishnan, Aylur K; Murugavel, Kailapuri G; Solomon, Suniti; Simek, Melissa; Koff, Wayne C; Goyal, Rajat; Chakrabarti, Bimal K; Bhattacharya, Jayanta.

J Virol ; 90(7): 3446-57, 2016 Jan 13.

Article in English | MEDLINE | ID: mdl-26763999

11.

Broad neutralization coverage of HIV by multiple highly potent antibodies.

Walker, Laura M; Huber, Michael; Doores, Katie J; Falkowska, Emilia; Pejchal, Robert; Julien, Jean-Philippe; Wang, Sheng-Kai; Ramos, Alejandra; Chan-Hui, Po-Ying; Moyle, Matthew; Mitcham, Jennifer L; Hammond, Phillip W; Olsen, Ole A; Phung, Pham; Fling, Steven; Wong, Chi-Huey; Phogat, Sanjay; Wrin, Terri; Simek, Melissa D; Koff, Wayne C; Wilson, Ian A; Burton, Dennis R; Poignard, Pascal.

Nature ; 477(7365): 466-70, 2011 Sep 22.

Article in English | MEDLINE | ID: mdl-21849977

12.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.

McLellan, Jason S; Pancera, Marie; Carrico, Chris; Gorman, Jason; Julien, Jean-Philippe; Khayat, Reza; Louder, Robert; Pejchal, Robert; Sastry, Mallika; Dai, Kaifan; O'Dell, Sijy; Patel, Nikita; Shahzad-ul-Hussan, Syed; Yang, Yongping; Zhang, Baoshan; Zhou, Tongqing; Zhu, Jiang; Boyington, Jeffrey C; Chuang, Gwo-Yu; Diwanji, Devan; Georgiev, Ivelin; Kwon, Young Do; Lee, Doyung; Louder, Mark K; Moquin, Stephanie; Schmidt, Stephen D; Yang, Zhi-Yong; Bonsignori, Mattia; Crump, John A; Kapiga, Saidi H; Sam, Noel E; Haynes, Barton F; Burton, Dennis R; Koff, Wayne C; Walker, Laura M; Phogat, Sanjay; Wyatt, Richard; Orwenyo, Jared; Wang, Lai-Xi; Arthos, James; Bewley, Carole A; Mascola, John R; Nabel, Gary J; Schief, William R; Ward, Andrew B; Wilson, Ian A; Kwong, Peter D.

Nature ; 480(7377): 336-43, 2011 Nov 23.

Article in English | MEDLINE | ID: mdl-22113616

13.

Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes.

Das, Supratik; Boliar, Saikat; Mitra, Nivedita; Samal, Sweety; Bansal, Manish; Koff, Wayne C; Chakrabarti, Bimal K.

Retrovirology ; 13(1): 81, 2016 Nov 21.

Article in English | MEDLINE | ID: mdl-27871328

14.

Association of mutations in V3/C3 domain with enhanced sensitivity of HIV-1 clade C primary envelopes to autologous broadly neutralizing plasma antibodies.

Deshpande, Suprit; Patil, Shilpa; Kumar, Rajesh; Shrivastava, Tripti; Srikrishnan, Aylur K; Murugavel, Kailapuri G; Koff, Wayne C; Chakrabarti, Bimal K; Bhattacharya, Jayanta.

Retrovirology ; 13(1): 41, 2016 06 15.

Article in English | MEDLINE | ID: mdl-27307004

15.

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.

Zhu, Jiang; Ofek, Gilad; Yang, Yongping; Zhang, Baoshan; Louder, Mark K; Lu, Gabriel; McKee, Krisha; Pancera, Marie; Skinner, Jeff; Zhang, Zhenhai; Parks, Robert; Eudailey, Joshua; Lloyd, Krissey E; Blinn, Julie; Alam, S Munir; Haynes, Barton F; Simek, Melissa; Burton, Dennis R; Koff, Wayne C; Mullikin, James C; Mascola, John R; Shapiro, Lawrence; Kwong, Peter D.

Proc Natl Acad Sci U S A ; 110(16): 6470-5, 2013 Apr 16.

Article in English | MEDLINE | ID: mdl-23536288

16.

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.

Amin, Mohammed N; McLellan, Jason S; Huang, Wei; Orwenyo, Jared; Burton, Dennis R; Koff, Wayne C; Kwong, Peter D; Wang, Lai-Xi.

Nat Chem Biol ; 9(8): 521-6, 2013 Aug.

Article in English | MEDLINE | ID: mdl-23831758

17.

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.

Doria-Rose, Nicole A; Georgiev, Ivelin; O'Dell, Sijy; Chuang, Gwo-Yu; Staupe, Ryan P; McLellan, Jason S; Gorman, Jason; Pancera, Marie; Bonsignori, Mattia; Haynes, Barton F; Burton, Dennis R; Koff, Wayne C; Kwong, Peter D; Mascola, John R.

J Virol ; 86(15): 8319-23, 2012 Aug.

Article in English | MEDLINE | ID: mdl-22623764

18.

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.

Pejchal, Robert; Walker, Laura M; Stanfield, Robyn L; Phogat, Sanjay K; Koff, Wayne C; Poignard, Pascal; Burton, Dennis R; Wilson, Ian A.

Proc Natl Acad Sci U S A ; 107(25): 11483-8, 2010 Jun 22.

Article in English | MEDLINE | ID: mdl-20534513

19.

Historical Advances in Structural and Molecular Biology and How They Impacted Vaccine Development.

Koff, Wayne C; Rappuoli, Rino; Plotkin, Stanley A.

J Mol Biol ; 435(13): 168113, 2023 07 01.

Article in English | MEDLINE | ID: mdl-37080423

20.

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.

Reynolds, Matthew R; Sacha, Jonah B; Weiler, Andrea M; Borchardt, Gretta J; Glidden, Chrystal E; Sheppard, Neil C; Norante, Francesca A; Castrovinci, Philip A; Harris, Jacqueline J; Robertson, Henry T; Friedrich, Thomas C; McDermott, Adrian B; Wilson, Nancy A; Allison, David B; Koff, Wayne C; Johnson, Welkin E; Watkins, David I.

J Virol ; 85(18): 9637-40, 2011 Sep.

Article in English | MEDLINE | ID: mdl-21734037

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