Prognostic Factors for Japanese Adults With Acute Community-Acquired Bacterial Meningitis: A Retrospective Study.

Background This study aimed to determine if the cerebrospinal fluid (CSF) cell count is useful for predicting the infection severity or prognosis in Japanese adults with community-acquired bacterial meningitis. Methodology This study retrospectively evaluated the prognosis of patients diagnosed with community-acquired bacterial meningitis at our hospital from January 2004 to December 2021 using the modified Rankin scale (mRs) (Showa General Hospital; N = 39). Patients were classified into the following two groups: (i) favorable (mRs: 0-3) and (ii) unfavorable (mRs: 4-6). Eight factors were selected and compared with outcomes, and then two factors were evaluated from those, and a multivariate logistic regression was used to determine the significant variables. Results CSF cell count was observed to be associated with poor prognoses (odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.99995-0.99999, p = 0.0012). Glasgow coma scale (GCS) score on admission was also observed to be associated with poor prognoses (OR = 0.93, 95% CI = 0.89145-0.97290, p = 0.0029). Conclusions Low CSF cell count and low GCS on admission were observed as risk factors for poor prognoses in patients with bacterial meningitis.

Community-acquired Pseudomonas aeruginosa Osteomyelitis Caused by an Injury from a Dishwasher.

A 70-year-old healthy woman came to our hospital with right index finger pain and swelling after an injury incurred due to a commercial dishwasher. X-ray of the hand showed osteolysis around the distal interphalangeal joint. A further examination revealed Pseudomonas aeruginosa in the unexposed pus, so the patient was treated with a total of 10 weeks of cefepime, followed by levofloxacin and debridement twice. While this may have been a case of bacterial replacement, we should still consider P. aeruginosa infection in healthy adults when faced with an episode of waterborne injury.

Hyperbolic band theory under magnetic field and Dirac cones on a higher genus surface.

We explore the hyperbolic band theory under a magnetic field for the first time. Our theory is a general extension of the conventional band theory defined on a Euclidean lattice into the band theory on a general hyperbolic lattice/Riemann surface. Our methods and results can be confirmed experimentally by circuit quantum electrodynamics, which enables us to create novel materials in a hyperbolic space. To investigate the band structures, we construct directly the hyperbolic magnetic Bloch states and find that they form Dirac cones on a coordinate neighborhood. They can be regarded as a global quantum gravity solution detectable in a laboratory. Besides this is the first explicit example of a massless Dirac state on a higher genus surface. Moreover we show that the energy spectrum exhibits an unusual fractal structure refracting the negative curvature, when plotted as a function of a magnetic flux.