1.
Cancer Res
; 84(13): 2043-2045, 2024 Jul 02.
Article
in English
| MEDLINE
| ID: mdl-38657107
ABSTRACT
Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition, the metabolic shift modulates the immunogenicity of the tumor cells. Recently, Mahmood and colleagues reported a connection between mitochondrial DNA mutations in cancer cells and their response to immunotherapy in a mouse model of melanoma.
Subject(s)
Warburg Effect, Oncologic , Animals , Humans , Mice , Neoplasms/immunology , Neoplasms/pathology , Neoplasms/metabolism , Neoplasms/genetics , DNA, Mitochondrial/immunology , DNA, Mitochondrial/genetics , Mutation , Melanoma/immunology , Melanoma/pathology , Melanoma/metabolism , Immunotherapy/methods , Mitochondria/metabolism , Mitochondria/immunology , Energy Metabolism/immunology
2.
Cancer Commun (Lond)
; 44(4): 508-513, 2024 Apr.
Article
in English
| MEDLINE
| ID: mdl-38512765