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1.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell, Brent R; Friedmann Angeli, José Pedro; Bayir, Hülya; Bush, Ashley I; Conrad, Marcus; Dixon, Scott J; Fulda, Simone; Gascón, Sergio; Hatzios, Stavroula K; Kagan, Valerian E; Noel, Kay; Jiang, Xuejun; Linkermann, Andreas; Murphy, Maureen E; Overholtzer, Michael; Oyagi, Atsushi; Pagnussat, Gabriela C; Park, Jason; Ran, Qitao; Rosenfeld, Craig S; Salnikow, Konstantin; Tang, Daolin; Torti, Frank M; Torti, Suzy V; Toyokuni, Shinya; Woerpel, K A; Zhang, Donna D.

Cell ; 171(2): 273-285, 2017 Oct 05.

Article in English | MEDLINE | ID: mdl-28985560

2.

Mutant p53 regulates Survivin to foster lung metastasis.

Tang, Qiaosi; Efe, Gizem; Chiarella, Anna M; Leung, Jessica; Chen, Maoting; Yamazoe, Taiji; Su, Zhenyi; Pitarresi, Jason R; Li, Jinyang; Islam, Mirazul; Karakasheva, Tatiana; Klein-Szanto, Andres J; Pan, Samuel; Hu, Jianhua; Natsugoe, Shoji; Gu, Wei; Stanger, Ben Z; Wong, Kwok-K; Diehl, J Alan; Bass, Adam J; Nakagawa, Hiroshi; Murphy, Maureen E; Rustgi, Anil K.

Genes Dev ; 35(7-8): 528-541, 2021 04 01.

Article in English | MEDLINE | ID: mdl-33737385

3.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Webster, Marie R; Fane, Mitchell E; Alicea, Gretchen M; Basu, Subhasree; Kossenkov, Andrew V; Marino, Gloria E; Douglass, Stephen M; Kaur, Amanpreet; Ecker, Brett L; Gnanapradeepan, Keerthana; Ndoye, Abibatou; Kugel, Curtis; Valiga, Alexander; Palmer, Jessica; Liu, Qin; Xu, Xiaowei; Morris, Jessicamarie; Yin, Xiangfan; Wu, Hong; Xu, Wei; Zheng, Cathy; Karakousis, Giorgos C; Amaravadi, Ravi K; Mitchell, Tara C; Almeida, Filipe V; Xiao, Min; Rebecca, Vito W; Wang, Ying-Jie; Schuchter, Lynn M; Herlyn, Meenhard; Murphy, Maureen E; Weeraratna, Ashani T.

Mol Cell ; 77(3): 633-644.e5, 2020 02 06.

Article in English | MEDLINE | ID: mdl-31836388

4.

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Singh, Kumar Sachin; Sharma, Rishabh; Reddy, Poli Adi Narayana; Vonteddu, Prashanthi; Good, Madeline; Sundarrajan, Anjana; Choi, Hyeree; Muthumani, Kar; Kossenkov, Andrew; Goldman, Aaron R; Tang, Hsin-Yao; Totrov, Maxim; Cassel, Joel; Murphy, Maureen E; Somasundaram, Rajasekharan; Herlyn, Meenhard; Salvino, Joseph M; Dotiwala, Farokh.

Nature ; 589(7843): 597-602, 2021 01.

Article in English | MEDLINE | ID: mdl-33361818

5.

Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression.

Indeglia, Alexandra; Murphy, Maureen E.

Crit Rev Biochem Mol Biol ; : 1-11, 2024 Apr 25.

Article in English | MEDLINE | ID: mdl-38661126

6.

Common activities and predictive gene signature identified for genetic hypomorphs of TP53.

Leung, Jessica C; Leu, Julia I-Ju; Indeglia, Alexandra; Kannan, Toshitha; Clarke, Nicole L; Kirven, Nicole A; Dweep, Harsh; Garlick, David; Barnoud, Thibaut; Kossenkov, Andrew V; George, Donna L; Murphy, Maureen E.

Proc Natl Acad Sci U S A ; 120(7): e2212940120, 2023 02 14.

Article in English | MEDLINE | ID: mdl-36749725

7.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Basu, Subhasree; Gnanapradeepan, Keerthana; Barnoud, Thibaut; Kung, Che-Pei; Tavecchio, Michele; Scott, Jeremy; Watters, Andrea; Chen, Qing; Kossenkov, Andrew V; Murphy, Maureen E.

Genes Dev ; 32(3-4): 230-243, 2018 02 01.

Article in English | MEDLINE | ID: mdl-29463573

8.

Fatty acid transport protein 2 reprograms neutrophils in cancer.

Veglia, Filippo; Tyurin, Vladimir A; Blasi, Maria; De Leo, Alessandra; Kossenkov, Andrew V; Donthireddy, Laxminarasimha; To, Tsun Ki Jerrick; Schug, Zach; Basu, Subhasree; Wang, Fang; Ricciotti, Emanuela; DiRusso, Concetta; Murphy, Maureen E; Vonderheide, Robert H; Lieberman, Paul M; Mulligan, Charles; Nam, Brian; Hockstein, Neil; Masters, Gregory; Guarino, Michael; Lin, Cindy; Nefedova, Yulia; Black, Paul; Kagan, Valerian E; Gabrilovich, Dmitry I.

Nature ; 569(7754): 73-78, 2019 05.

Article in English | MEDLINE | ID: mdl-30996346

9.

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.

Jennis, Matthew; Kung, Che-Pei; Basu, Subhasree; Budina-Kolomets, Anna; Leu, Julia I-Ju; Khaku, Sakina; Scott, Jeremy P; Cai, Kathy Q; Campbell, Michelle R; Porter, Devin K; Wang, Xuting; Bell, Douglas A; Li, Xiaoxian; Garlick, David S; Liu, Qin; Hollstein, Monica; George, Donna L; Murphy, Maureen E.

Genes Dev ; 30(8): 918-30, 2016 Apr 15.

Article in English | MEDLINE | ID: mdl-27034505

10.

PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis.

Gnanapradeepan, Keerthana; Indeglia, Alexandra; Stieg, David C; Clarke, Nicole; Shao, Chunlei; Dougherty, James F; Murali, Nivitha; Murphy, Maureen E.

J Biol Chem ; 298(12): 102637, 2022 12.

Article in English | MEDLINE | ID: mdl-36309086

11.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Webster, Marie R; Fane, Mitchell E; Alicea, Gretchen M; Basu, Subhasree; Kossenkov, Andrew V; Marino, Gloria E; Douglass, Stephen M; Kaur, Amanpreet; Ecker, Brett L; Gnanapradeepan, Keerthana; Ndoye, Abibatou; Kugel, Curtis; Valiga, Alexander; Palmer, Jessica; Liu, Qin; Xu, Xiaowei; Morris, Jessicamarie; Yin, Xiangfan; Wu, Hong; Xu, Wei; Zheng, Cathy; Karakousis, Giorgos C; Amaravadi, Ravi K; Mitchell, Tara C; Almeida, Filipe V; Xiao, Min; Rebecca, Vito W; Wang, Ying-Jie; Schuchter, Lynn M; Herlyn, Meenhard; Murphy, Maureen E; Weeraratna, Ashani T.

Mol Cell ; 77(3): 681, 2020 Feb 06.

Article in English | MEDLINE | ID: mdl-32032511

12.

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

Leu, Julia I-Ju; Murphy, Maureen E; George, Donna L.

Proc Natl Acad Sci U S A ; 117(43): 26804-26811, 2020 10 27.

Article in English | MEDLINE | ID: mdl-33055209

13.

Retraction Note: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Singh, Kumar Sachin; Sharma, Rishabh; Reddy, Poli Adi Narayana; Vonteddu, Prashanthi; Good, Madeline; Sundarrajan, Anjana; Choi, Hyeree; Muthumani, Kar; Kossenkov, Andrew; Goldman, Aaron R; Tang, Hsin-Yao; Totrov, Maxim; Cassel, Joel; Murphy, Maureen E; Somasundaram, Rajasekharan; Herlyn, Meenhard; Salvino, Joseph M; Dotiwala, Farokh.

Nature ; 599(7885): 518, 2021 11.

Article in English | MEDLINE | ID: mdl-34580487

14.

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

Leu, Julia I-Ju; Murphy, Maureen E; George, Donna L.

Proc Natl Acad Sci U S A ; 116(17): 8390-8396, 2019 04 23.

Article in English | MEDLINE | ID: mdl-30962386

15.

A small molecule inhibitor of inducible heat shock protein 70.

Leu, J I-Ju; Pimkina, Julia; Frank, Amanda; Murphy, Maureen E; George, Donna L.

Mol Cell ; 36(1): 15-27, 2009 Oct 09.

Article in English | MEDLINE | ID: mdl-19818706

16.

PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric ß-carboline.

Chatwichien, Jaruwan; Basu, Subhasree; Budina-Kolomets, Anna; Murphy, Maureen E; Winkler, Jeffrey D.

Bioorg Med Chem Lett ; 26(20): 4884-4887, 2016 10 15.

Article in English | MEDLINE | ID: mdl-27650927

17.

Design, Synthesis and Biological Evaluation of ß-Carboline Dimers Based on the Structure of Neokauluamine.

Chatwichien, Jaruwan; Basu, Subhasree; Murphy, Maureen E; Hamann, Mark T; Winkler, Jeffrey D.

Tetrahedron Lett ; 56(23): 3515-3517, 2015 Jun 03.

Article in English | MEDLINE | ID: mdl-26257442

18.

Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.

Lum, Michelle A; Balaburski, Gregor M; Murphy, Maureen E; Black, Adrian R; Black, Jennifer D.

J Biol Chem ; 288(38): 27112-27127, 2013 Sep 20.

Article in English | MEDLINE | ID: mdl-23900841

19.

Ironing out how p53 regulates ferroptosis.

Murphy, Maureen E.

Proc Natl Acad Sci U S A ; 113(44): 12350-12352, 2016 11 01.

Article in English | MEDLINE | ID: mdl-27791175

20.

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors.

Hill, Connor M; Indeglia, Alexandra; Picone, Francis; Murphy, Maureen E; Cipriano, Cara; Maki, Robert G; Gardini, Alessandro.

bioRxiv ; 2024 Apr 20.

Article in English | MEDLINE | ID: mdl-38659891

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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Mutant p53 regulates Survivin to foster lung metastasis.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression.

Common activities and predictive gene signature identified for genetic hypomorphs of TP53.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Fatty acid transport protein 2 reprograms neutrophils in cancer.

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.

PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

Retraction Note: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

A small molecule inhibitor of inducible heat shock protein 70.

PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric ß-carboline.

Design, Synthesis and Biological Evaluation of ß-Carboline Dimers Based on the Structure of Neokauluamine.

Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.

Ironing out how p53 regulates ferroptosis.

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors.