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1.

Biosynthesis of strychnine.

Hong, Benke; Grzech, Dagny; Caputi, Lorenzo; Sonawane, Prashant; López, Carlos E Rodríguez; Kamileen, Mohamed Omar; Hernández Lozada, Néstor J; Grabe, Veit; O'Connor, Sarah E.

Nature ; 607(7919): 617-622, 2022 07.

Article in English | MEDLINE | ID: mdl-35794473

2.

A microbial supply chain for production of the anti-cancer drug vinblastine.

Zhang, Jie; Hansen, Lea G; Gudich, Olga; Viehrig, Konrad; Lassen, Lærke M M; Schrübbers, Lars; Adhikari, Khem B; Rubaszka, Paulina; Carrasquer-Alvarez, Elena; Chen, Ling; D'Ambrosio, Vasil; Lehka, Beata; Haidar, Ahmad K; Nallapareddy, Saranya; Giannakou, Konstantina; Laloux, Marcos; Arsovska, Dushica; Jørgensen, Marcus A K; Chan, Leanne Jade G; Kristensen, Mette; Christensen, Hanne B; Sudarsan, Suresh; Stander, Emily A; Baidoo, Edward; Petzold, Christopher J; Wulff, Tune; O'Connor, Sarah E; Courdavault, Vincent; Jensen, Michael K; Keasling, Jay D.

Nature ; 609(7926): 341-347, 2022 09.

Article in English | MEDLINE | ID: mdl-36045295

3.

Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis.

DeMars, Matthew D; O'Connor, Sarah E.

Proc Natl Acad Sci U S A ; 121(7): e2318586121, 2024 Feb 13.

Article in English | MEDLINE | ID: mdl-38319969

4.

Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.

Florean, Matilde; Luck, Katrin; Hong, Benke; Nakamura, Yoko; O'Connor, Sarah E; Köllner, Tobias G.

Proc Natl Acad Sci U S A ; 120(42): e2307981120, 2023 10 17.

Article in English | MEDLINE | ID: mdl-37812727

5.

OXIDOSQUALENE CYCLASE 1 and 2 influence triterpene biosynthesis and defense in Nicotiana attenuata.

Yang, Caiqiong; Halitschke, Rayko; O'Connor, Sarah E.

Plant Physiol ; 194(4): 2580-2599, 2024 Mar 29.

Article in English | MEDLINE | ID: mdl-38101922

6.

Single-cell multi-omics in the medicinal plant Catharanthus roseus.

Li, Chenxin; Wood, Joshua C; Vu, Anh Hai; Hamilton, John P; Rodriguez Lopez, Carlos Eduardo; Payne, Richard M E; Serna Guerrero, Delia Ayled; Gase, Klaus; Yamamoto, Kotaro; Vaillancourt, Brieanne; Caputi, Lorenzo; O'Connor, Sarah E; Robin Buell, C.

Nat Chem Biol ; 19(8): 1031-1041, 2023 08.

Article in English | MEDLINE | ID: mdl-37188960

7.

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast.

Bradley, Samuel A; Lehka, Beata J; Hansson, Frederik G; Adhikari, Khem B; Rago, Daniela; Rubaszka, Paulina; Haidar, Ahmad K; Chen, Ling; Hansen, Lea G; Gudich, Olga; Giannakou, Konstantina; Lengger, Bettina; Gill, Ryan T; Nakamura, Yoko; de Bernonville, Thomas Dugé; Koudounas, Konstantinos; Romero-Suarez, David; Ding, Ling; Qiao, Yijun; Frimurer, Thomas M; Petersen, Anja A; Besseau, Sébastien; Kumar, Sandeep; Gautron, Nicolas; Melin, Celine; Marc, Jillian; Jeanneau, Remi; O'Connor, Sarah E; Courdavault, Vincent; Keasling, Jay D; Zhang, Jie; Jensen, Michael K.

Nat Chem Biol ; 19(12): 1551-1560, 2023 Dec.

Article in English | MEDLINE | ID: mdl-37932529

8.

Biosynthesis of iridoid sex pheromones in aphids.

Köllner, Tobias G; David, Anja; Luck, Katrin; Beran, Franziska; Kunert, Grit; Zhou, Jing-Jiang; Caputi, Lorenzo; O'Connor, Sarah E.

Proc Natl Acad Sci U S A ; 119(42): e2211254119, 2022 10 18.

Article in English | MEDLINE | ID: mdl-36227916

9.

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus.

Uzaki, Mai; Mori, Tetsuya; Sato, Mayuko; Wakazaki, Mayumi; Takeda-Kamiya, Noriko; Yamamoto, Kotaro; Murakami, Akio; Guerrero, Delia Ayled Serna; Shichijo, Chizuko; Ohnishi, Miwa; Ishizaki, Kimitsune; Fukaki, Hidehiro; O'Connor, Sarah E; Toyooka, Kiminori; Mimura, Tetsuro; Hirai, Masami Yokota.

New Phytol ; 242(3): 1156-1171, 2024 May.

Article in English | MEDLINE | ID: mdl-38513692

10.

Engineered biosynthesis of plant heteroyohimbine and corynantheine alkaloids in Saccharomyces cerevisiae.

Dror, Moriel J; Misa, Joshua; Yee, Danielle A; Chu, Angela M; Yu, Rachel K; Chan, Bradley B; Aoyama, Lauren S; Chaparala, Anjali P; O'Connor, Sarah E; Tang, Yi.

J Ind Microbiol Biotechnol ; 512024 Jan 09.

Article in English | MEDLINE | ID: mdl-38140980

11.

Directed Biosynthesis of Mitragynine Stereoisomers.

Schotte, Carsten; Jiang, Yindi; Grzech, Dagny; Dang, Thu-Thuy T; Laforest, Larissa C; León, Francisco; Mottinelli, Marco; Nadakuduti, Satya Swathi; McCurdy, Christopher R; O'Connor, Sarah E.

J Am Chem Soc ; 145(9): 4957-4963, 2023 03 08.

Article in English | MEDLINE | ID: mdl-36883326

12.

Phylogeny-Aware Chemoinformatic Analysis of Chemical Diversity in Lamiaceae Enables Iridoid Pathway Assembly and Discovery of Aucubin Synthase.

Rodríguez-López, Carlos E; Jiang, Yindi; Kamileen, Mohamed O; Lichman, Benjamin R; Hong, Benke; Vaillancourt, Brieanne; Buell, C Robin; O'Connor, Sarah E.

Mol Biol Evol ; 39(4)2022 04 10.

Article in English | MEDLINE | ID: mdl-35298643

13.

Engineering of Secondary Metabolism.

O'Connor, Sarah E.

Annu Rev Genet ; 49: 71-94, 2015.

Article in English | MEDLINE | ID: mdl-26393965

14.

A "Magic Mushroom" Multi-Product Sesquiterpene Synthase.

Schäfer, Eike; Seibold, Paula S; Bartram, Stefan; Trottmann, Felix; Haensch, Veit G; Gressler, Markus; Chadeayne, Andrew R; Hertweck, Christian; O'Connor, Sarah E; Hoffmeister, Dirk.

Chembiochem ; 24(21): e202300511, 2023 11 02.

Article in English | MEDLINE | ID: mdl-37614035

15.

Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.

Laforest, Larissa C; Kuntz, Michelle A; Kanumuri, Siva Rama Raju; Mukhopadhyay, Sushobhan; Sharma, Abhisheak; O'Connor, Sarah E; McCurdy, Christopher R; Nadakuduti, Satya Swathi.

J Nat Prod ; 86(4): 1042-1052, 2023 04 28.

Article in English | MEDLINE | ID: mdl-36913648

16.

Publisher Correction: Biosynthesis of strychnine.

Hong, Benke; Grzech, Dagny; Caputi, Lorenzo; Sonawane, Prashant; López, Carlos E Rodríguez; Kamileen, Mohamed Omar; Hernández Lozada, Néstor J; Grabe, Veit; O'Connor, Sarah E.

Nature ; 608(7924): E37, 2022 Aug.

Article in English | MEDLINE | ID: mdl-35931767

17.

Directed Evolution of Piperazic Acid Incorporation by a Nonribosomal Peptide Synthetase.

Stephan, Philipp; Langley, Chloe; Winkler, Daniela; Basquin, Jérôme; Caputi, Lorenzo; O'Connor, Sarah E; Kries, Hajo.

Angew Chem Int Ed Engl ; 62(35): e202304843, 2023 08 28.

Article in English | MEDLINE | ID: mdl-37326625

18.

Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis.

Kamileen, Mohamed O; DeMars, Matthew D; Hong, Benke; Nakamura, Yoko; Paetz, Christian; Lichman, Benjamin R; Sonawane, Prashant D; Caputi, Lorenzo; O'Connor, Sarah E.

J Am Chem Soc ; 144(43): 19673-19679, 2022 11 02.

Article in English | MEDLINE | ID: mdl-36240425

19.

Tonoplast and Peroxisome Targeting of Î³-tocopherol N-methyltransferase Homologs Involved in the Synthesis of Monoterpene Indole Alkaloids.

Koudounas, Konstantinos; Guirimand, Gregory; Hoyos, Luisa Fernanda Rojas; Carqueijeiro, Ines; Cruz, Pamela Lemos; Stander, Emily; Kulagina, Natalja; Perrin, Jennifer; Oudin, Audrey; Besseau, Sébastien; Lanoue, Arnaud; Atehortùa, Lucia; St-Pierre, Benoit; Giglioli-Guivarc'h, Nathalie; Papon, Nicolas; O'Connor, Sarah E; Courdavault, Vincent.

Plant Cell Physiol ; 63(2): 200-216, 2022 Feb 15.

Article in English | MEDLINE | ID: mdl-35166361

20.

In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria).

Palmer, Lira; Chuang, Ling; Siegmund, Marlen; Kunert, Maritta; Yamamoto, Kotaro; Sonawane, Prashant; O'Connor, Sarah E.

Planta ; 256(5): 99, 2022 Oct 12.

Article in English | MEDLINE | ID: mdl-36222913

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