ABSTRACT
BACKGROUND: Multicystic peritoneal mesothelioma (MPM) and well-differentiated papillary peritoneal mesothelioma (WDPPM) are exceedingly uncommon lesions with uncertain malignant potential and no uniform treatment strategy. The aim of the current study was to review our experience with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) in these clinical settings. METHODS: Four women with MPM and eight with WDPPM underwent 13 procedures of cytoreduction and close-abdomen HIPEC with cis-platin and doxorubicin. Seven patients had recurrent disease after previous debulking (one operation in five patients, two in one, four in one). Potential clinicopathological prognostic factors were assessed. RESULTS: Optimal cytoreduction (residual tumor nodules Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
, Chemotherapy, Cancer, Regional Perfusion
, Hyperthermia, Induced
, Mesothelioma, Cystic/drug therapy
, Mesothelioma, Cystic/surgery
, Peritoneal Neoplasms/drug therapy
, Peritoneal Neoplasms/surgery
, Adult
, Aged
, Chemotherapy, Adjuvant
, Cisplatin/administration & dosage
, Combined Modality Therapy
, Disease-Free Survival
, Doxorubicin/administration & dosage
, Female
, Follow-Up Studies
, Humans
, Infusions, Parenteral
, Mesothelioma, Cystic/mortality
, Mesothelioma, Cystic/pathology
, Middle Aged
, Neoplasm Recurrence, Local/drug therapy
, Neoplasm Recurrence, Local/mortality
, Neoplasm Recurrence, Local/pathology
, Neoplasm Recurrence, Local/surgery
, Neoplasm, Residual/drug therapy
, Neoplasm, Residual/mortality
, Neoplasm, Residual/pathology
, Neoplasm, Residual/surgery
, Peritoneal Neoplasms/mortality
, Peritoneal Neoplasms/pathology
, Reoperation