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1.
Toxicol Ind Health ; 31(2): 188-92, 2015 Feb.
Article in English | MEDLINE | ID: mdl-23299192

ABSTRACT

Snakebites are relatively rare medical emergency cases that might lead to serious consequences. This study aims to evaluate snakebite cases in terms of medical follow-up, antivenom therapy and antivenom reactions. Medical records of patients admitted to emergency department between January 1, 2006 and December 31, 2010 were retrospectively investigated. Snakebite-related cases of a total of 125 patients were included in the scope of the study. Of the total 125 cases, 54.4% were male and 45.6% were female. Most of cases (n: 65, 52%) were aged over 30 years, while the mean age was 34.87 ± 19.29 years. Snakebite-related applications to the emergency department were mostly seen in June with 27 cases. Upon admitting, all patients were recorded to be conscious and showing good general conditions; however, they suffered from pain and edema at the site of bite. Of all, 25 patients only suffered from bite injury and ecchymosis due to snakebite. The site of bite was upper extremities in 66 patients (52.8%), whereas it was lower extremities in 58 (46.4%). Of all, antivenom was unnecessary in 25 (20%) patients, while four antivenoms were administered to each of the 23 (18.4%) patients. Furthermore, six (4.8%) patients needed nine antivenom administrations for each. Anaphylaxis (n: 2, 1.6%), compartment syndrome (n: 2, 1.6%) and serum sickness (n: 1, 0.8%) encountered in remaining cases. Of all, 86 (68.8%) patients were hospitalized in the emergency department, while 25 (20.0%) patients were followed up by observation in emergency service. Only one patient was treated and followed up in intensive care unit. Implementation of antivenom therapy is considered unnecessary for the treatment of all snakebite cases. Antivenom reactions and number of related cases might be reduced by continuous close monitoring, appropriate prophylaxis and controlled slow infusion administration of medications.


Subject(s)
Snake Bites/epidemiology , Adolescent , Adult , Antivenins/administration & dosage , Antivenins/therapeutic use , Child , Child, Preschool , Emergency Service, Hospital , Female , Humans , Male , Middle Aged , Retrospective Studies , Snake Bites/therapy , Turkey/epidemiology , Young Adult
2.
Arthroscopy ; 30(1): 16-21, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24183107

ABSTRACT

PURPOSE: The aim of this study was to test a simple technique to augment the pullout resistance of an anchor in an over-drilled sheep humerus model. METHODS: Sixty-four paired sheep humeri were harvested from 32 male sheep aged 18 months. Specimens were divided into an augmented group and non-augmented group. FASTIN RC 5-mm titanium screw anchors (DePuy Mitek, Raynham, MA) double loaded with suture material (braided polyester, nonabsorbable USP No. 2) were used in both groups. Osteoporosis was simulated by over-drilling with a 4.5-mm drill. Augmentation was performed by fixing 1 of the sutures 1.5 cm inferior to the anchor insertion site with a washer screw. This was followed by a pull-to-failure test at 50 mm/min. The ultimate load (the highest value of strength before anchor pullout) was recorded. A paired t test was used to compare the biomechanical properties of the augmented and non-augmented groups. RESULTS: In all specimens the failure mode was pullout of the anchor. The ultimate failure loads were statistically significantly higher in the augmented group (P < .0001). The mean pullout strength was 121.1 ± 10.17 N in the non-augmented group and 176.1 ± 10.34 N in the augmented group. CONCLUSIONS: The described augmentation technique, which is achieved by inferior-lateral fixation of 1 of the sutures of the double-loaded anchor to a fully threaded 6.5-mm cancellous screw with a washer, significantly increases the ultimate failure loads in the over-drilled sheep humerus model. CLINICAL RELEVANCE: Our technique is simple, safe, and inexpensive. It can be easily used in all osteoporotic patients and will contribute to the reduction of anchor failure. This technique might be difficult to apply arthroscopically. Cannulated smaller screws would probably be more practical for arthroscopic use. Further clinical studies are needed.


Subject(s)
Bone Screws , Humerus/physiopathology , Osteoporosis/complications , Rotator Cuff/surgery , Aged , Animals , Biomechanical Phenomena , Disease Models, Animal , Equipment Design , Humans , In Vitro Techniques , Lacerations/etiology , Lacerations/surgery , Male , Rotator Cuff Injuries , Sheep , Sheep, Domestic , Suture Techniques
3.
Arch Orthop Trauma Surg ; 134(7): 1031-5, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24853959

ABSTRACT

INTRODUCTION: The side-to-side (SS) tenorrhaphy technique has been used in tendon transfer surgery. The mechanical properties of SS tendon suture have been studied previously. However, the histo-pathological healing of the SS tenorrhaphy of the tendons is unknown. The aim of this study was to assess the gross and histological effects of SS tenorrhaphy in a rabbit model. MATERIALS AND METHODS: Twenty New Zealand rabbits were used. The extensor hallucis longus and tibialis anterior tendon were sewed SS at the level distal to the ankle joint. The patellar tendon (PT) at the same side was used as control group. A unilateral midline incision was made and repaired with a single suture. The animals were killed at the 12th week postoperatively. The histological sections were obtained from the side of surgery from each group. Each sample was stained with hematoxylene and eosin (H&E). Gross and microscopic healing was compared between the two groups. RESULTS: Gross examination of the control group showed complete healing with a thin peri-tendinous sheath formation around the suture site, whereas in the study group, a thick peri-tendinous sheath was formed around the area of the tendon-tendon anastomosis. In the control group, at the 12th week after surgery, the healing was almost completed in all samples. In the study group, a thick fibro vascular sheath has formed around the side of anastomosis. In all specimens few inter-digitations were observed between the tendons;however, the trough was still present. CONCLUSION: The result of the current study showed that histological healing and union of SS tenorrhaphy differ from that in primary tendon injury and healing. Further studies are required to clarify the healing stages at the tenorrhaphy site.


Subject(s)
Tendons/surgery , Tenodesis/methods , Wound Healing/physiology , Anastomosis, Surgical/methods , Animals , Biomechanical Phenomena , Disease Models, Animal , Female , Male , Rabbits , Suture Techniques , Tendons/pathology
4.
Arthroscopy ; 28(5): 681-7, 2012 May.
Article in English | MEDLINE | ID: mdl-22284410

ABSTRACT

PURPOSE: To biomechanically compare anterior cruciate ligament (ACL) tibial bony avulsion fixation by suture anchors, EndoButtons (Smith & Nephew, Andover, MA), and high-strength sutures subjected to cyclic loading. METHODS: Type III tibial eminence fractures were created in 49 ovine knees, and 7 different types of repairs were performed. Each repair group contained 7 specimens. The repair groups were as follows: No. 2 FiberWire (Arthrex, Naples, FL); No. 2 UltraBraid (Smith & Nephew); No. 2 MaxBraid (Arthrotek, Warsaw, IN); No. 2 Hi-Fi (ConMed Linvatec, Largo, FL); No. 2 OrthoCord (DePuy Mitek, Raynham, MA); Ti-Screw suture anchor (Arthrotek); and titanium EndoButton. These constructs were cyclically loaded (500 cycles, 0 to 100 N, 1 Hz) in the direction of the native ACL and loaded to failure (100 mm/min). Endpoints included ultimate failure load (in Newtons); pullout stiffness (in Newtons per millimeter); cyclic displacement (in millimeters) after 100 cycles, between 100 and 500 cycles, and after 500 cycles; and mode of failure. Bone density testing was performed in all knees. RESULTS: Bone density was not different among the groups. The EndoButton group had a higher ultimate failure load than the FiberWire, UltraBraid, Hi-Fi, and suture anchor groups (P < .05). The MaxBraid and OrthoCord groups had higher failure loads than the suture anchor group (P < .05). The MaxBraid group also had a higher failure load than the Hi-Fi group (P < .05). Stiffness was not statistically different for the various tested constructs. After 100 cycles, the EndoButton group had less displacement than the FiberWire, UltraBraid, MaxBraid, and Hi-Fi groups (P < .05). The suture anchor group had less displacement than the Hi-Fi and FiberWire groups (P < .05). The displacements of the different tested constructs between 100 and 500 cycles and total displacements after 500 cycles were not statistically different. The predominant failure mode was suture rupture. CONCLUSIONS: Under cyclic loading conditions in an ovine model, EndoButton fixation of tibial eminence fractures provided greater initial fixation strength than suture anchor fixation or fixation with various high-strength sutures except for OrthoCord. CLINICAL RELEVANCE: During initial cyclic loading of ACL tibial eminence fractures, the strength of the repair construct should be taken into consideration because conventional suture repair even with ultrahigh-molecular-weight polyethylene sutures may not provide enough strength.


Subject(s)
Arthroscopy , Fracture Fixation, Internal/instrumentation , Suture Anchors , Sutures , Tibial Fractures/surgery , Animals , Anterior Cruciate Ligament/physiology , Anterior Cruciate Ligament/surgery , Biomechanical Phenomena , Female , Fracture Fixation, Internal/methods , Random Allocation , Sheep , Treatment Outcome , Weight-Bearing
5.
Knee Surg Sports Traumatol Arthrosc ; 20(2): 322-6, 2012 Feb.
Article in English | MEDLINE | ID: mdl-21678092

ABSTRACT

PURPOSE: Medial patellofemoral ligament (MPFL) reconstruction is an effective option for the treatment of recurrent patellar instability. Most techniques utilize the passage of a tendon graft through tunnels at the patella with the risk of patellar fracture. The purpose of this study was to investigate the strength of the recent MPFL reconstruction techniques (transverse tunnel, interference screw, anchor, and docking technique). METHODS: Thirty-six saw bones were divided into four groups (transverse tunnel, interference screw, anchor fixation, and docking technique) with nine patellae in each. Patella-tendon constructs were pre-loaded to 10 N and cyclically loaded for 20 cycles from 2 to 30 N under load control at a rate of 5 N/sec. The construct was then tested to failure at a constant displacement rate of 6 mm/sec. Ultimate load (N), stiffness (N/mm), and failure mode were recorded for each specimen. RESULTS: The docking group had lower ultimate load [106 (SD 41) N] and stiffness [14 (SD 2) N/mm] values than the other groups tested (P = 0.007). The anchor group had lower stiffness [21 (SD 6) N/mm] values than the tunnel group [28 (SD 3) N/mm (P = 0.01)] and the interference screw group [31 (SD 6) N/mm, (P = 0.004)]. There was no significant difference in the ultimate load between anchor [299 (SD 116) N], tunnel [304 (SD 140) N], and interference screw groups [241 (SD 103) N] (n.s.). CONCLUSION: Aperture fixation techniques, especially interference screw fixation, were as strong as the technique utilizing tunnels in the patella for MPFL reconstruction.


Subject(s)
Ligaments, Articular/surgery , Patella/surgery , Patellofemoral Joint/surgery , Tendons/transplantation , Tenodesis/methods , Animals , Biomechanical Phenomena , Cattle , Joint Instability/etiology , Joint Instability/surgery , Ligaments, Articular/injuries , Patella/physiology , Patellar Dislocation/complications , Patellofemoral Joint/injuries , Patellofemoral Joint/physiology , Tendons/physiology , Tendons/surgery , Tenodesis/instrumentation , Weight-Bearing
6.
J Orthop Surg Res ; 15(1): 464, 2020 Oct 08.
Article in English | MEDLINE | ID: mdl-33032647

ABSTRACT

BACKGROUND: In gunshot and shell fragment injuries to the hip joint, orthopedic intervention includes wound assessment and care, osteosynthesis of fractures, and avoiding of infection and osteoarthritis. Individuals injured in the Syrian civil war were frequently transferred to the authors' institution in neighboring city. Orthopedic trauma exposures were determined in approximately 30% of these patients. The aim of this study was to evaluate the outcomes of the patients with secondary hip arthritis due to prior gunshot and shell fragment (shrapnel) injuries who underwent primary total hip arthroplasty. METHODS: This retrospective study reviewed 26 patients (24 males, 2 females) who underwent hip arthroplasty due to prior gunshot and shell fragment injuries from November 2013 to January 2019. For all patients, the Harris Hip Score (HHS) was evaluated preoperatively and after surgery. RESULTS: Mean age was 31.5 (range, 19-48) years. The mean preoperative HHS was 52.95 points, and the mean postoperative HHS was 79.92 points at the final follow-up after surgery. Patients with shell fragment injuries to the hip joint had higher infection rates, but it is not statistically significant. CONCLUSIONS: An anatomic reduction of the fracture may not be possible in these cases as a result of significant bone and/or cartilage loss. Total hip arthroplasty can be done after gunshot- and shell fragment-related posttraumatic arthritis. It is an effective treatment choice to reduce pain and improve function, but the surgeon must be very careful because of high rate of infection.


Subject(s)
Armed Conflicts , Arthroplasty, Replacement, Hip , Osteoarthritis, Hip/etiology , Osteoarthritis, Hip/therapy , War-Related Injuries/complications , Wounds, Gunshot/complications , Adult , Female , Humans , Male , Middle Aged , Osteoarthritis, Hip/diagnosis , Retrospective Studies , Severity of Illness Index , Surgical Wound Infection/epidemiology , Surgical Wound Infection/prevention & control , Young Adult
7.
Acta Orthop Traumatol Turc ; 51(2): 172-176, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28236546

ABSTRACT

Bipolar hemiarthroplasty is frequently used in the treatment of intracapsular hip fractures. Dissociation of the bipolar components can happen during the hip dislocation, the reduction maneuvers, or spontaneously without any dislocation. Here we report early dissociation between bipolar components in two cases during the attempt of closed reduction maneuvers and three cases with spontaneous dissociation without any trauma. To prevent or minimize this complication; the reduction of dislocated hips must be achieved very gently under general anesthesia with fluoroscopic control. During the initial operation the surgeons must be sure that the bipolar components are locked to each other and after final reduction, especially in osteoarthritic acetabulums, that the cup position is not in varus position.


Subject(s)
Acetabulum/surgery , Arthroplasty, Replacement, Hip/adverse effects , Hip Dislocation/etiology , Hip Prosthesis/adverse effects , Joint Dislocations/surgery , Adult , Aged , Female , Fluoroscopy , Hip Dislocation/diagnosis , Hip Dislocation/surgery , Humans , Joint Dislocations/diagnosis , Male , Prosthesis Failure , Reoperation
8.
Acta Orthop Traumatol Turc ; 49(5): 522-9, 2015.
Article in English | MEDLINE | ID: mdl-26422348

ABSTRACT

OBJECTIVE: The use of intralaminar screws (ILS) in spinal surgery has experienced a recent increase in popularity. The aim of this study is to define the morphological parameters of the lumbar laminas so that guidance may be defined for ILS placement. METHODS: The study involved the evaluation of lumbar computed tomography (CT) images of patients. Two hundred thirty-five patients (127 male, 108 female) were included in the study. The mean patient age was 44.2 years (19-78 years). The measured parameters of the lamina were the transverse inner diameter, transverse outer diameter (lamina width), lamina length, subdural space (safe zone), and spinolaminar angle for each lumbar level (L1-L5). RESULTS: The mean transverse outer diameter (L1-L5) ranged from 7.2-7.8 mm, and mean transverse inner diameter ranged from 2.5-3.0 mm. The lamina of L3 had the largest width and the lamina of L1 and L5 the smallest. The mean lamina length was 26.6 mm, ranging from 21.0-34.0 mm, and the mean spinolaminar angle was 124.7°, ranging from 111-135°. The L1 level had the shortest mean lamina length and L4 the lowest spinolaminar angle. Mean subdural space (safe zone), which was narrowest at the L5 level, was 2.4 mm, ranging from 1.3-3.6 mm. CONCLUSION: ILS of the appropriate size (3.5-4.5 mm) and length (20 and 25 mm) can be used safely in the lumbar spine. However, further biomechanical studies should be performed to measure strength of the fixation.


Subject(s)
Bone Screws/adverse effects , Lumbar Vertebrae/pathology , Lumbar Vertebrae/surgery , Spinal Fusion/methods , Adult , Age Distribution , Aged , Cross-Sectional Studies , Feasibility Studies , Female , Humans , Imaging, Three-Dimensional , Male , Middle Aged , Salvage Therapy , Tomography, X-Ray Computed , Young Adult
9.
Biol Trace Elem Res ; 167(1): 77-83, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25728510

ABSTRACT

Spinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible positive effects if the local administration of BA on posterolateral spinal fusion. Thirty-two rats were randomly divided into four independent groups: no material was added at the fusion area for group 1; an autogenous morselized corticocancellous bone graft was used for group 2; an autogenous morselized corticocancellous bone graft with boric acid (8.7 mg/kg) for group 3; and only boric acid was placed into the fusion area for group 4. The L4-L6 spinal segments were collected at week 6, and the assessments included radiography, manual palpation, and histomorphometry. A statistically significant difference was determined between the groups with regard to the mean histopathological scores (p = 0.002), and a paired comparison was made with the Mann-Whitney U test to detect the group/groups from which the difference originated. It was determined that only the graft + BA practice increased the histopathological score significantly with regard to the control group (p = 0.002). Whereas, there was no statistically significant difference between the groups in terms of the manual assessment of fusion and radiographic analysis (respectively p = 0.328 and p = 0.196). This preliminary study suggests that BA may clearly be useful as a therapeutic agent in spinal fusion. However, further research is required to show the most effective dosage of BA on spinal fusion, and should indicate whether BA effects spinal fusion in the human body.


Subject(s)
Bone Transplantation/methods , Boric Acids/pharmacology , Lumbar Vertebrae/drug effects , Lumbar Vertebrae/surgery , Spinal Fusion/methods , Animals , Boric Acids/administration & dosage , Lumbar Vertebrae/diagnostic imaging , Male , Radiography , Random Allocation , Rats, Sprague-Dawley , Treatment Outcome
10.
Acta Orthop Traumatol Turc ; 48(2): 175-80, 2014.
Article in English | MEDLINE | ID: mdl-24747626

ABSTRACT

OBJECTIVE: The aim of this study was to evaluate the treatment results of the application of nitric oxide (NO) in the form of topical glyceryl trinitrate (GTN) for the treatment of lateral epicondylitis (LE). METHODS: The study included 40 patients with LE randomized into 2 equal groups. Selection criteria included the presence of pain, tenderness, and positive pain stimulating maneuvers. Glyceryl trinitrate patches were applied to the area of maximal tenderness once a day in the treatment group and placebo patches in the control group. Outcomes in terms of pain relief was assessed using the visual analog scale (VAS) and were evaluated according to the criteria of Verhaar et al. Excellent or good results were considered successful. Differences in VAS scores between the two groups were calculated using the Mann-Whitney U-test and the chi-square test was used to investigate distributions of categorical variables (sex, affected side) and good and excellent results among groups. RESULTS: There were no significant differences in any of the baseline clinical parameters between groups. At the 3rd week follow-up, there were statistically significant differences in the pain measured using VAS between groups (mean VAS score of the control and treatment groups were 6.45 and 3.15, respectively) (p=0.001). Patients in the GTN group and control group had lower VAS pain scores and reduced elbow pain at 3 weeks (3.15 vs 8.05 in the GTN and 6.45 vs 8.80 in the control group). In the control group, no patient had excellent or good results while 18 (90%) patients in treatment group reported successful treatment. There was statistically significant difference in the VAS measured at 6 months between groups (mean VAS score of the control and treatment groups were 4.85 and 0.70, respectively) (p=0.001). CONCLUSION: The administration of NO directly over an area of tendinopathy through a GTN patch reduces pain and other symptoms in chronic LE.


Subject(s)
Arthralgia , Nitroglycerin , Tennis Elbow , Administration, Topical , Adult , Arthralgia/diagnosis , Arthralgia/drug therapy , Arthralgia/physiopathology , Female , Hand Strength , Humans , Male , Nitroglycerin/administration & dosage , Nitroglycerin/adverse effects , Pain Management/methods , Pain Measurement/methods , Tennis Elbow/diagnosis , Tennis Elbow/drug therapy , Tennis Elbow/physiopathology , Transdermal Patch , Treatment Outcome , Vasodilator Agents/administration & dosage , Vasodilator Agents/adverse effects
11.
Turk J Med Sci ; 44(2): 330-6, 2014.
Article in English | MEDLINE | ID: mdl-25536745

ABSTRACT

AIM: Cardiac toxicity due to the administration of local anesthetics may be fatal. In this study, we evaluated the efficacy of a 20% lipid solution combined with epinephrine in a levobupivacaine-induced cardiac arrest model. MATERIALS AND METHODS: A total of 14 New Zealand rabbits were sedated and mechanically ventilated. Asystole was induced with intravenous levobupivacaine injection. The rabbits were randomized into groups receiving the same volume of either 0.9% saline (CR group) or a 20% lipid solution (LE group) along with a 100 µg/kg epinephrine bolus, which were administered immediately upon asystole. Standard advanced cardiac life support protocols were performed. RESULTS: Four subjects in the LE group as well as 3 subjects in the CR group had a spontaneous recovery (P = 0.592). In the 20th minute after arrest, 3 subjects in the LE group had maintained spontaneous circulation, while there was only 1 subject from the CR group with the same outcome. CONCLUSION: We found that adding a lipid solution to epinephrine for the resuscitation of rabbits that underwent levobupivacaine- induced cardiac arrest increased recovery rates of circulation and therefore the likelihood of survival. Further studies are needed to develop clinical therapies for the systemic toxicity of local anesthetics.


Subject(s)
Epinephrine/administration & dosage , Fat Emulsions, Intravenous/administration & dosage , Heart Arrest/drug therapy , Phospholipids/administration & dosage , Resuscitation/methods , Soybean Oil/administration & dosage , Vasoconstrictor Agents/administration & dosage , Anesthetics, Local/adverse effects , Animals , Bupivacaine/adverse effects , Bupivacaine/analogs & derivatives , Coronary Circulation , Disease Models, Animal , Drug Therapy, Combination , Emulsions/administration & dosage , Heart Arrest/chemically induced , Levobupivacaine , Rabbits , Random Allocation
12.
Ulus Travma Acil Cerrahi Derg ; 20(5): 328-32, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25541843

ABSTRACT

BACKGROUND: Spinal cord injury (SCI) is one of the most devastating conditions leading to neurological impairment and disabilities. The aim of the study was to investigate the potential neuroprotective effect of thymoquinone (TQ) histopathologically in an experimental model of traumatic spinal cord injury (SCI). METHODS: Twenty-four male Wistar albino rats were randomly divided into 4 groups: control group; SCI group; SCI-induced and 10 mg/kg/day TQ administered group; SCI-induced and 30 mg/kg/day TQ administered group. TQ was given as intraperitoneal for three days prior to injury and four days following injury. Spinal cord segment between T8 and T10 were taken for histopathologic examination. Hemorrhage, spongiosis and liquefactive necrosis were analyzed semiquantatively for histopathological changes. RESULTS: Administration of TQ at a dose of 10 mg/kg did not cause any significant change on the histological features of neuronal degeneration as compared to the SCI group (p=0.269); however, 30 mg/kg TQ significantly decreased the histological features of spinal cord damage below that of the SCI group (p=0.011). CONCLUSION: Data from this study suggest that TQ supplementation attenuates trauma induced spinal cord damage. Thus, TQ needs to be taken into consideration, for it may have a neuroprotective effect in trauma induced spinal cord damage.


Subject(s)
Benzoquinones/therapeutic use , Neuroprotective Agents/therapeutic use , Spinal Cord Injuries/prevention & control , Animals , Benzoquinones/administration & dosage , Injections, Intraperitoneal , Male , Models, Animal , Neuroprotective Agents/administration & dosage , Random Allocation , Rats , Rats, Wistar , Spinal Cord Injuries/pathology
13.
Arch Trauma Res ; 3(2): e17610, 2014 Jun.
Article in English | MEDLINE | ID: mdl-25147776

ABSTRACT

INTRODUCTION: Diabetic foot is a clinical disorder, which is commonly seen in patients with diabetes mellitus. It is also the major cause of below knee amputation in the world. There are many underlying causes such as neuropathic, ischemic, and infectious causes for diabetic foot. Local or systemic complications may develop after snake bite. CASE PRESENTATION: We reported a very rare case, involving a 78-year-old male admitted to the Emergency Department, who developed anaphylactic shock and diabetic foot after the snake bite. CONCLUSIONS: Reviewing the literature, this is the second reported case of snake bite associated with diabetic foot.

14.
Peptides ; 54: 159-61, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24468547

ABSTRACT

Synovial fibrosis is one of the main outcomes of osteoarthritis. Some authors have reported that urotensin-II (U-II) may cause pathologic fibrosis in cardiovascular system, lung and liver. However there are no previous reports available in the literature about its relationship with the synovial fibrosis in osteoarthritis. The aim of this study was to compare the U-II levels in knee synovial fluids obtained from osteoarthritic and non-osteoarthritic patients. Two groups were created, the osteoarthritis group and non-osteoarthritic control group. The control group was consisted of patients who underwent arthroscopic surgery for other reasons than cartilage disorders. In the osteoarthritis group all patients had grade 4 primer degenerative osteoarthritis and were treated with total knee arthroplasty. Minimum 1 mL knee synovial fluids were obtained during operation. Levels of U-II were measured by using ELISA kit U-II levels were significantly higher in the osteoarthritic group than that in the control group. No correlation was found between U-II levels and age. In conclusion, the significantly high U-II levels in the knee synovial fluid of osteoarthritic patients supported our hypothesis that "U-II may be associated with the synovial fibrosis in osteoarthritis".


Subject(s)
Synovial Fluid/metabolism , Urotensins/metabolism , Adult , Case-Control Studies , Female , Humans , Male , Middle Aged , Osteoarthritis, Knee/metabolism , Osteoarthritis, Knee/physiopathology
15.
Acta Orthop Traumatol Turc ; 48(1): 37-42, 2014.
Article in English | MEDLINE | ID: mdl-24643098

ABSTRACT

OBJECTIVE: The aim of this study was to ascertain the effect of gender and cultural habits on hip, knee and ankle range of motion (ROM) and to determine the differences between the ROM of right and left side symmetric joints of the lower extremities. METHODS: The study included 987 (513 males and 474 females) healthy volunteers. Individuals with a history of illness, prior surgery or trauma involving any joint of either lower extremity were excluded from the study. The terminology and techniques of measurements used were those suggested by the American Academy of Orthopedic Surgeons. RESULTS: Left side passive hip flexion and active internal rotation was higher than the right side. Passive flexion of the hip joint was higher in male subjects and internal and external rotation was higher in female subjects. In the knee joint, passive extension was higher in males. Plantarflexion and inversion of the ankle joint were higher in male subjects and dorsiflexion and eversion were higher in female subjects. The differences were considered insignificant in clinical terms as all were less than 3 degrees. CONCLUSION: There is no clinically significantly difference between right and left side hip, knee and ankle joints ROM. Gender and cultural habits do not appear to have clinically significantly effects on lower extremity joint ROM.


Subject(s)
Ankle Joint/physiology , Hip Joint/physiology , Knee Joint/physiology , Range of Motion, Articular/physiology , Adult , Female , Humans , Male , Reference Values , Rotation , Sex Factors , Turkey , Young Adult
16.
J Brachial Plex Peripher Nerve Inj ; 8(1): 5, 2013 May 30.
Article in English | MEDLINE | ID: mdl-23721086

ABSTRACT

Peripheral neuropathies caused by ganglion cysts are rare. They seldom cause serious complications especially in the lower extremities. The case was a 51-year-old woman referred by her physician to the vascular surgeon with diagnosis including intermittent (vascular) claudication and deep venous thrombosis. Primarily vascular surgeon performed a doppler ultrasound of the lower extremity and calculation of the ankle-brachial index. There were no abnormal pathological findings. Careful physical examination revealed soft swelling and tenderness around the fibular head and neck. Weakness was observed in foot eversion and dorsiflexion. There was pain and tingling in the distribution of the peroneal nerve. and referring the patient to orthopedic surgeon owing to concern for a potential compressive lesion at the right proximal tibiofibular region. Electromyogram studies and physical examination confirmed a diagnosis of compression neuropathy of common peroneal nerve. Magnetic resonance imaging revealed a fluid-filled, lobulated mass indicating a ganglion cyst. One months after decompression, the patient had no complaint. Fast diagnosis and immediate management are essential to regain best possible recovery.

17.
Injury ; 44(6): 863-6, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23298756

ABSTRACT

INTRODUCTION: In locking intramedullary nails, the most important problem is to put the distal interlocking screw accurately and quickly with minimum radiation exposure. The purpose of this clinical study was to compare the fluoroscopic time and surgical time required for distal locking with either free-hand fluoroscopic guidance or with an electromagnetic navigation system. MATERIALS AND METHODS: The study comprised 54 patients with 58 fractures of the lower extremity. The patients were divided in two groups: distal locking with freehand fluoroscopic guidance (group I) and distal locking with electromagnetic navigation (group II). The primary outcome in this study was fluoroscopy time. The secondary outcome was the operative time in distal interlocking. RESULTS: In group I, the mean operation time was 108 (81-135) min, the mean time for distal interlocking was 18.35 (9-27) min, the total fluoroscopy time was 47.77 (19-74) s, the mean fluoroscopy time during distal interlocking was 18.29 (2-29) s and the mean attempt at number of distal locking for two screws was 9.96 (2-18) times. In group II, the mean operation time was 80.96 (63-100) min, the mean time for distal interlocking was 7.85 (6.5-10) min, the total fluoroscopy time was 22.59 (15-32) s, the mean fluoroscopy time during distal interlocking was 1.62 (0-2) s and the mean attempt number of distal interlocking was 2 (2-2). CONCLUSION: Fluoroscopy time to achieve equivalent precision is significantly reduced with electromagnetism-based surgical navigation compared with free hand fluoroscopic guidance. Also the operative time is significantly reduced with electromagnetic based navigation.


Subject(s)
Electromagnetic Fields , Fluoroscopy , Fracture Fixation, Intramedullary/methods , Fractures, Bone/surgery , Fractures, Closed/surgery , Fractures, Open/surgery , Lower Extremity/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Bone Nails , Female , Fluoroscopy/methods , Fractures, Bone/diagnostic imaging , Fractures, Bone/epidemiology , Fractures, Closed/diagnostic imaging , Fractures, Closed/epidemiology , Fractures, Open/diagnostic imaging , Fractures, Open/epidemiology , Humans , Image Processing, Computer-Assisted , Lower Extremity/diagnostic imaging , Lower Extremity/injuries , Male , Middle Aged , Reproducibility of Results , Retrospective Studies , Surgery, Computer-Assisted , Time Factors , Treatment Outcome , Turkey/epidemiology
18.
J Int Med Res ; 41(5): 1639-47, 2013 Oct.
Article in English | MEDLINE | ID: mdl-24029022

ABSTRACT

OBJECTIVE: To compare unilateral spinal anaesthesia (USA) and ultrasound-guided combined sciatic-femoral nerve block (USFB) in ambulatory arthroscopic knee surgeries in terms of haemodynamic stability, nerve block quality, bladder function, adverse events and time-to-readiness for discharge (TRD). METHODS: Patients undergoing ambulatory arthroscopic knee surgery were randomly assigned to one of two groups. The USA group received 2 ml (10 mg) of 0.5% levobupivacaine and the USFB group received a 25 ml mixture consisting of 10 ml of 2.0% lidocaine, 10 ml of 0.5% levobupivacaine and 5 ml of saline (15 ml for the femoral and 10 ml for the sciatic nerve block). Preparation time (PT), surgical anaesthesia time (SAT), operation time, total anaesthesia time, time-to-first spontaneous urination, time-to-first analgesia, TRD, adverse events and patient satisfaction were recorded. RESULTS: A total of 40 patients were enrolled in the study (n = 20 per group). PT, SAT, total anaesthesia time and time-to-first analgesia were significantly shorter in the USA group than the USFB group; time-to-first spontaneous urination and TRD were significantly longer in the USA group than the USFB group. CONCLUSIONS: USFB provided sufficient duration of sensory blockade and it reduced the TRD and the rate of adverse events.


Subject(s)
Anesthesia, Spinal/methods , Anesthetics, Local , Arthroscopy , Bupivacaine/analogs & derivatives , Knee Joint/surgery , Lidocaine , Nerve Block/methods , Adult , Ambulatory Surgical Procedures , Female , Femoral Nerve/drug effects , Hemodynamics/physiology , Humans , Knee Joint/diagnostic imaging , Knee Joint/pathology , Levobupivacaine , Male , Middle Aged , Nerve Block/instrumentation , Outpatients , Sciatic Nerve/drug effects , Ultrasonography , Urinary Bladder/physiology
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