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1.
Article in English | MEDLINE | ID: mdl-37917912

ABSTRACT

Objective: The the intensive care unit (ICU), also known as intensive care medicine department and intensive intensive care unit, is a medical place for centralized treatment of critical diseases and continuous monitoring and treatment. To investigate the relationship between the length of intensive care unit (ICU) admission and long-term mortality in elderly critically ill patients. Methods: A total of 2694 critically ill ICU patients admitted to Xianning First People's Hospital from April 2017 to April 2021 were selected. Inclusion criteria including: age ≥ 60 years; meet the diagnostic criteria for critical illness; admission to ICU ≥ 24h. According to admission time, patients were divided into 1684 patients admitted during working hours and 1010 patients admitted during non-working hours. The relationship between the admission time of ICU patients and long-term mortality was taken as the dependent variable. The evaluation was performed using the Acute Physiology and Chronic Health Status Assessment Scale (APACHE II score). Epidemiological questionnaire was used to investigate the status of time to hospital and mortality, and the independent risk factors affecting time to hospital and mortality were analyzed by univariate and multivariate analysis. SPSS 26.0 statistical software was used for analysis and processing. Results: Among 2694 critically ill patients in ICU, 1010 patients were hospitalized during non-working hours, with an admission rate of 37.49%. The acute physiology and chronic health evaluation (APACHE) II score of non-working hours was 19.91±6.62, which is significantly higher than that of working hours (18.21±6.42) (P < .05). The mortality rates of ICU patients hospitalized during non-working hours and during working hours accounted for 30.10 % and 19.71% of all patients, respectively, with statistical significance (P < .05). Comparing the mortality rates of the two groups at different time periods, there was a significant difference between the two groups (P < .05). In order to influence the independent variables of ICU mortality (non-occurrence = 0, occurrence = 1), the significant factors of univariate analysis were included in the logistic regression equation. Time of admission, combined cardiopulmonary disease, APACHE II score, nurse workload and other factors were independent risk factors for ICU mortality. Conclusion: Out-of-hours admission is associated with an increased risk of death and is associated with changes in ICU organizational structure. Therefore, sending patients to ICU in time migh help improve their life.

2.
J Nanosci Nanotechnol ; 18(6): 4255-4263, 2018 Jun 01.
Article in English | MEDLINE | ID: mdl-29442771

ABSTRACT

In this paper, polyacrylonitrile/graphene composite nanofiber filaments were manufactured continuously by a homemade eight-needle electrospinning device with an auxiliary electrode. The polyacrylonitrile/graphene composite nanofiber yarns were obtained continuously by plying and twisting the composite nanofiber filaments. The structures and properties of the composite nanofiber filaments with different GP mass fractions and yarns were investigated. The results demonstrated that the maximum alignment degree of the composite nanofibers along the filament axis could reach 74.3% with 1%, and the alignment degree decreased with increasing graphene mass fraction. The diameters of the composite nanofibers were considerably smaller than those of the pure polyacrylonitrile nanofiber, and the minimum diameter was 156 nm for 1%. The conductivity of the composite nanofiber filaments was significantly enhanced by seven orders of magnitude compared with that of the pure polyacrylonitrile nanofiber filament, and the maximum value was 3.73×10-7 S/cm for 1.5%. Due to graphene agglomeration, the conductivity decreased when the mass fraction was more than 1.5%. The different number of filaments and twists were examined in detail to improve the poor mechanical properties of the nanofiber filaments. With an increase in twists, the breaking stress and strain increased initially and later decreased, and the maximum breaking stress and strain were 16.54 MPa and 26.42%, respectively. This study demonstrates the possibility of continuously and stably manufacturing polyacrylonitrile/graphene composite nanofiber yarns.

3.
Biol Blood Marrow Transplant ; 22(1): 86-95, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26283096

ABSTRACT

The National Marrow Donor Program and Center for International Blood and Marrow Transplant Research provided guidelines for the use of anti-HLA antibodies and HLA-DP-mismatched loci in unrelated donor hematopoietic stem cell transplantation (HSCT). However, a deeper understanding of other potentially useful biomarkers for predicting clinical outcomes in HLA-A, -B, -C, -DRB1, -DQB1, and -DQA1 (12/12)-matched unrelated donor HSCT is needed to further improve clinical outcomes. We tested HLA genotyping for 123 pairs of patients and donors. Anti-HLA antibodies using the Luminex method was applied to 123, 117, and 106 serum samples collected before and 1 month and 3 months after transplantation. The presences of anti-HLA antibodies at the 3 time points were 37.4% (46 of 123), 40.2% (47 of 117), and 22.6% (24 of 106). Mismatch of HLA-DPB1 and/or DPA1 allele between patient-donor pairs was 83.6% (92 of 110). Patients with anti-HLA antibodies had delayed platelet recovery. The presence of anti-HLA antibodies and their dynamic changes after transplantation were associated with increased occurrence of grades II to IV acute and chronic graft-versus-host disease (GVHD), higher treatment-related mortality, and reduced overall survival (OS) and disease-free survival, especially in acute myeloid leukemia and myelodysplastic syndrome patients. Multivariate analysis showed that presence of anti-HLA antibodies before transplantation was a risk factor for GVHD and OS. Furthermore, HLA-DP loci-matched subgroup showed a trend towards a lower rate of acute GVHD and a higher OS in the anti-HLA Abs-negative group. Our results suggest that dynamic changes of anti-HLA antibodies independently predict for a negative outcome of HSCT, independent of HLA-DP loci mismatches. Routine monitoring for anti-HLA antibody dynamics should be conducted before and after HSCT.


Subject(s)
HLA-DP Antigens , Isoantibodies/blood , Unrelated Donors , Acute Disease , Adolescent , Adult , Child , Disease-Free Survival , Female , Follow-Up Studies , Hematologic Neoplasms/blood , Hematologic Neoplasms/mortality , Hematologic Neoplasms/therapy , Humans , Male , Middle Aged , Predictive Value of Tests , Survival Rate
4.
Clin Transplant ; 28(11): 1225-33, 2014 Nov.
Article in English | MEDLINE | ID: mdl-25123053

ABSTRACT

Graft failure and survival are the major problems for patients with aplastic anemia undergoing hematopoietic stem cell transplantation (HSCT). Previous studies showed that anti-HLA antibodies negatively impact engraftment in HSCT. This retrospective study of 51 pediatric patients with acquired aplastic anemia who underwent allogeneic HSCT at a single institution between 2006 and 2012 investigated the influence of anti-HLA antibodies on the outcome of HSCT. Serum samples collected before HSCT were tested for the presence of anti-HLA antibodies. Pre-existing anti-HLA antibodies were detected in 54.9% (28/51) of patients, among whom 39.2% (20/51) had anti-HLA class I antibodies. Anti-HLA antibodies were associated with worse five-yr survival (78.6% vs. 100%, p = 0.021) and higher treatment-related mortality (21.4% vs. 0%, p = 0.028) compared with antibody-negative patients. Anti-HLA class I antibody-positive patients had poorer five-yr survival (75.0%) than anti-HLA class I&II antibody-positive and antibody-negative patients (87.5% and 100.0%, respectively, p = 0.039). Presence of anti-HLA class I antibodies (p = 0.024) and older age (10 yr or more; p = 0.027) significantly increased the risk of post-HSCT mortality. Pre-existing anti-HLA antibodies negatively affect the outcome of HSCT in pediatric patients with aplastic anemia. Routine testing for anti-HLA antibodies concurrent with efficient treatment should be conducted prior to HSCT.


Subject(s)
Anemia, Aplastic/blood , Anemia, Aplastic/therapy , Antibodies/blood , HLA Antigens/immunology , Hematopoietic Stem Cell Transplantation , Adolescent , Anemia, Aplastic/mortality , Child , Child, Preschool , Female , Histocompatibility Testing , Humans , Male , Retrospective Studies , Survival Rate , Treatment Outcome
5.
ACS Appl Mater Interfaces ; 15(5): 7392-7404, 2023 Feb 08.
Article in English | MEDLINE | ID: mdl-36693331

ABSTRACT

Conductive polymer composite-based strain sensors are essential components of flexible wearable devices. However, nonmonotonic responses with shoulder peaks limit their practical application. Herein, we innovatively optimized the shoulder-peak phenomenon in a strain-sensing composite nanofiber filament by regulating carbon nanomaterial dispersion. Further, the preparation methods, characteristics, and performances of the filament strain sensors were systematically introduced. On this basis, transmission electron microscopy, finite element analysis, and mathematic and structural evolution models were used to explore the origin of shoulder peaks and explain the sensing mechanism of conductive networks. Results confirmed that the beacon tower-shaped conductive network designed by constructing nanofiller agglomerates could cause strain concentration and resist the Poisson transverse contraction of nanofibers, considerably improving the monotonicity and sensitivity of the sensor. The strain-sensing performance was optimal when the nanofillers were dispersed using 2.5 wt % of an anionic dispersant. The sensor exhibited a maximum detective strain of 120%, an ultralow detection limit of 0.01%, and high sensitivity and linearity of 9.66 and 0.996 within 20% strain, respectively. Moreover, it showed the advantages of a fast response time (120 ms), excellent durability (3000 cycles), anti-interference, washability, and antibacterial capability. Finally, a smart Kinesio tape was developed for protecting/treating the human body and detecting joint/muscle movement via simple sewing.


Subject(s)
Nanofibers , Nanostructures , Wearable Electronic Devices , Humans , Nanofibers/chemistry , Carbon , Shoulder
6.
ACS Appl Mater Interfaces ; 15(25): 29971-29981, 2023 Jun 28.
Article in English | MEDLINE | ID: mdl-37318121

ABSTRACT

The current antibacterial treatment methods of silk sutures can only be finished by surface modification, leading to problems of short antibacterial effects, easy slow-release consumption, prominent toxicity, and susceptibility to drug resistance. Speculatively, surgical sutures combining antibacterial material internally will possess a more promising efficacy. Hence, we extracted recycled regenerated silk fibroin (RRSF) from waste silk resources to make RRSF solutions. Internally combining with inorganic titanium dioxide (TiO2) nanoparticles, we fabricated antibacterial RRSF-based surgical sutures. The morphologies, mechanical and antibacterial properties, biocompatibility tests, and in vivo experiments were carried out. The results showed that the surgical sutures with 1.25 wt % TiO2 acquired 2.40 N knot strength (143 µm diameter) and achieved a sustainable antibacterial effect of 93.58%. Surprisingly, the sutures significantly reduced inflammatory reactions and promoted wound healing. Surgical sutures in this paper realize high-value recovery of waste silk fibers and provide a novel approach to preparing multifunctional sutures.


Subject(s)
Fibroins , Nanostructures , Silk , Sutures , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use
7.
ACS Nano ; 17(9): 8622-8633, 2023 May 09.
Article in English | MEDLINE | ID: mdl-37129379

ABSTRACT

We have achieved the synthesis of dual-metal single atoms and atomic clusters that co-anchor on a highly graphitic carbon support. The catalyst comprises Ni4 (and Fe4) nanoclusters located adjacent to the corresponding NiN4 (and FeN4) single-atom sites, which is verified by systematic X-ray absorption characterization and density functional theory calculations. A distinct cooperation between Fe4 (Ni4) nanoclusters and the corresponding FeN4 (NiN4) atomic sites optimizes the adsorption energy of reaction intermediates and reduces the energy barrier of the potential-determining steps. This catalyst exhibits enhanced oxygen reduction and evolution activity and long-cycle stability compared to counterparts without nanoclusters and commercial Pt/C. The fabricated Zn-air batteries deliver a high power density and long-term cyclability, demonstrating their prospects in energy storage device applications.

8.
iScience ; 25(10): 105162, 2022 Oct 21.
Article in English | MEDLINE | ID: mdl-36212024

ABSTRACT

Recently, various strain-sensing yarns have been developed without ideal stitchability. Herein, we used spherical carbon black particles (CBs), linear carbon nanotubes (CNTs), and lamellar graphene flakes (GRs) as conductive nanofillers to construct multi-element conductive networks inside a thermoplastic polyurethane (TPU) matrix. First, a highly stretchable and conductive multidimensional carbon-based nanomaterial/TPU composite nanofiber yarn was fabricated using electrospinning, which could be used as a flexible strain sensor without post-processing. Accordingly, the effects of nanomaterials' dimensionality and synergy on yarns' conductivity, mechanical properties, and strain sensing performances were explored. The yarn containing multiple networks formed by CB/CNT/GR ternary hybrid networks, CNT and GR auxiliary networks exhibited the best performances. Subsequently, the structural evolution of the ternary conductive network under stretching was revealed to further analyze the sensing mechanism. Finally, the yarn endowed a medicated plaster with an intelligent function to detect motions in the rehabilitation of joint pain by simple sewing.

9.
J Nanosci Nanotechnol ; 11(9): 7813-9, 2011 Sep.
Article in English | MEDLINE | ID: mdl-22097492

ABSTRACT

Poly(lactic acid) (PLA)/graphene nanocomposites were prepared by direct solution blending of PLA with graphene using chloroform as a mutual solvent. Graphene was prepared by a solution-phase processing followed by thermal reduction, which can be dispersed stably in chloroform for more than one month. Transmission electron microscopy (TEM) was used to examine the quality of the dispersion of graphene in the PLA matrix. The thermal properties and crystallization behavior of the nanocomposites were investigated by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and polar optical microscopy (POM). The results showed that the thermal stability of PLA was significantly improved with a very low loading of graphene and the addition of graphene had a great effect on spherulite morphology of PLA.

10.
RSC Adv ; 11(58): 36596-36606, 2021 Nov 10.
Article in English | MEDLINE | ID: mdl-35494358

ABSTRACT

Due to unique anti-erosion properties and excellent thermal stability, polytetrafluoroethylene (PTFE) fibers are regarded as an ideal material to manufacture filters for industrial dust purification. Based on weak interactions between PTFE molecular chains, we applied a high-pressure waterjet to cause normal PTFE split-film fibers to split fibers again. Four kinds of PTFE split-film fibers and sintered films with different molecular weights were produced. Afterward, waterjets were introduced to impact PTFE sintered films and split-film fibers under different pressures and jets, and we analyzed variations in the sintered film morphology and fiber diameter. When the molecular weight was increased, the visible light transmittance of four different PTFE sintered films at the wavelength of 382 nm decreased from 85.7% to 77.6% and then increased to 95.1%, which was consistent with light-dark characteristics in light micrographs of sintered films. The four PTFE sintered films split into fibers under the waterjet impact force. In particular, MW49 PTFE sintered film was split into microscale fibers using waterjets at 110 bar and 5 jets. Finally, waterjets were applied to impact normal PTFE split-film fibers to force the original fibers to split into fine fibers. Different PTFE split-film fibers exhibited a significant decrease in the average diameter. In particular, in the case of MW49 PTFE split-film fibers, the average diameter of fibers impacted by 5 jets at 110 bar decreased from 27.4 to 15.7 µm, confirming the suitability of high-pressure waterjets for the splitting of PTFE split-film fibers into microscale fibers.

11.
Polymers (Basel) ; 11(10)2019 Oct 08.
Article in English | MEDLINE | ID: mdl-31597253

ABSTRACT

With excellent biocompatibility and biodegradability, silk fibroin has been developed into many protein materials. For producing regenerated silk fibroin (RSF) fibers, the conformation transition of silk fibroin needs to be thoroughly studied during the spinning process. Since the many silk fabrics that are discarded comprise an increasing waste of resources and increase the pressure on the environment, in this paper, waste silk fiber was recycled in an attempt to prepare regenerated fibroin fiber by dry-wet spinning. Ethanol was the coagulation bath. The rheological properties of all the RSF solutions were investigated to acquire rheology curves and non-Newtonian indexes for spinnability analysis. Four stages of the spinning process were carried out to obtain RSF samples and study their conformation transitions, crystallization, and thermal properties by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, and differential scanning calorimetry. Quantitative analysis of the FTIR results was performed to obtain specific data regarding the contents of the secondary structures. The results showed that higher concentration spinning solutions had better spinnability. As the spinning process progressed, random coils were gradually converted into ß-sheets and crystallization increased. Among the different influencing factors, the ethanol coagulation bath played a leading role in the conformation transitions of silk fibroin.

12.
Polymers (Basel) ; 10(4)2018 Mar 22.
Article in English | MEDLINE | ID: mdl-30966386

ABSTRACT

In this paper, a simple method to prepare PANI-coated conductive PET yarn is reported, which involves pre-applying aniline and HCl vapors on PET surface and subsequent dielectric-barrier discharge (DBD) plasma treatment of the coated yarn under atmospheric pressure. The volume resistivity of the optimal sample was about 1.8 × 105 times lower than that of the control. Moreover, with the increase of coating amount of PANI, the air drag of PET yarns improved gradually. The surface chemistry of the treated yarn was analyzed by Fourier transform-infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS), while the morphology was observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). This study offers a new method to prepare conductive fabric via air-jet loom and is expected to increase the weaving efficiency of air-jet loom.

13.
Polymers (Basel) ; 10(10)2018 Sep 30.
Article in English | MEDLINE | ID: mdl-30961010

ABSTRACT

Particulate matter (PM) pollution, which usually carries viruses and bacteria, has drawn considerable attention as a major threat to public health. In this present study, an environment-friendly antibacterial Poly(lactic acid)(PLA)/chitosan composite air filter was fabricated using the one-step electrospinning technique. The composite PLA/chitosan fibres show a highly porous structure, in which chitosan nanoparticles (NPs) were found to be uniformly distributed throughout the entire fibre. The morphologies, through-pore size and distribution, air filtration and anti-microbial properties of these filter media were studied. The results showed that it was not the chitosan content but instead the concentration of the spinning solutions that had the greatest effect on the morphologies of the porous fibres. The relative humidity influenced the nanometre-scale pores on the surface of PLA/chitosan fibres. The PLA/chitosan fibrous membranes with a chitosan to PLA mass ratio of 2.5:8 exhibited a high filtration efficiency of 98.99% and a relatively low pressure drop (147.60 Pa) when the air flow rate was 14 cm/s, while these also had high antibacterial activity of 99.4% and 99.5% against Escherichia coli and Staphylococcus aureus, respectively. It took 33 min for the PM2.5 concentration to decrease to 0 µg/m³ from 999 µg/m³ using the PLA/chitosan fibrous membranes, which demonstrates obviously effective air purification performance.

14.
RSC Adv ; 8(3): 1378-1384, 2018 Jan 02.
Article in English | MEDLINE | ID: mdl-35540923

ABSTRACT

Tailoring the wetting properties of nanofibrous membranes and endowing them with expected wettability provides new ways in extending the application field of these materials. In this study, we first performed the in situ fabrication of poly(butylenes succinate-co-terephthalate) (PBST) composite nanofibrous membrane with cyclodextrin polymer (CDP) using a combination of electrospinning and heating processes. Then, the morphologies, crystallization and mechanical properties of the PBST composite membrane were investigated. It was found that the CDP was uniformly dispersed on the PBST nanofibers instead of merely covering the surface of the membrane. Moreover, the introduction of additives brought about a decreased crystallinity and tensile strength of the resultant membrane due to its restraining role in the crystallization of PBST. Furthermore, the wettability of the PBST composite membranes with various amounts of additives was explored and the evolution of water spread on top of the membranes was also recorded. The membrane became superhydrophilic from hydrophobic upon increasing the amount of additives and the water droplet could completely spread within 0.2 s, which was attributed to the enlarged roughness and increased contact area of CDP on the nanofibers. A comparison between the two fabrication methods used for PBST composite nanofibrous membranes is also presented and studies on the preparation and wetting properties may shed light on polymer composite membranes that exhibit potential application in more fields.

15.
Polymers (Basel) ; 10(12)2018 Dec 14.
Article in English | MEDLINE | ID: mdl-30961311

ABSTRACT

Metal-organic frameworks (MOFs) have been regarded as an ideal material for the development of functional textiles with filtration function. Such functional textiles with filtration function can be further used to develop personal protective equipment, such as protective masks. This paper focuses on the comparisons of different processes when applying MOFs to conventional textiles. Two different processes existing in the literature, namely the electrospinning method and hot-pressing method, are discussed in this paper. Materials loaded with MOFs developed with these two processes are evaluated and compared, regarding the adsorption of dyes in water and the removal of pollutants. Experiment results indicate that the hot-pressing method is more advantageous when applying MOF to textiles, in terms of adsorption and removal efficiency.

16.
J Colloid Interface Sci ; 441: 121-9, 2015 Mar 01.
Article in English | MEDLINE | ID: mdl-25499733

ABSTRACT

Porous bead-on-string poly(lactic acid) (PLA) nanofibrous membranes (NMs) were fabricated by electrospinning, and the formation mechanism of the membranes was determined in this study. The PLA fibrous morphology, including the fiber diameter, bead size, number of beads, and surface structure of the beads, could be closely controlled by regulating the solvent compositions and the concentrations of the PLA solutions. The filtration performance, which was evaluated by measuring the penetration of sodium chloride (NaCl) aerosol particles with an average diameter of 260nm, indicated that the filtration efficiency and pressure drop for the resultant PLA membranes could be manipulated by modifying the morphology of the fibers. Moderate bead size and quantity contribute to the low pressure drop, and small fiber diameters and nanopores on the beads were conducive to high filtration efficiency. Furthermore, the NM formed from a 5 wt% solution and a solvent mixture containing dichloromethane (DCM)/N,N-dimethylacetamide (DMAC) in a 10/1 ratio of PLA by weight exhibited excellent filtration efficiency (99.997%) and a low pressure drop (165.3 Pa), which are promising characteristics for the membranes' application as filters for respiratory protection, indoor air purification, and other filtration applications.

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