ABSTRACT
A 3-year-old black male child with X-linked chronic granulomatous disease and red cells of the rare McLeod phenotype is presented. The red cells showed acanthocytosis and did not react with anti-KL. Similarly the leukocytes were nonreactive with anti-Kx. The Xk and Xg linkage could not be investigated since all members of his family were Xg (a+).
Subject(s)
Blood Group Antigens/genetics , Granulomatous Disease, Chronic/blood , Kell Blood-Group System/genetics , Acanthocytes/pathology , Black or African American , Child, Preschool , Erythrocytes/pathology , Female , Granulomatous Disease, Chronic/genetics , Granulomatous Disease, Chronic/pathology , Humans , Male , Syndrome , X ChromosomeABSTRACT
Twenty-three normal subjects and 19 patients with nephrotic syndrome were vaccinated with tridecavalent pneumococcal capsular polysaccharide vaccine of Streptococcus pneumoniae. The antibody response of the nephrotic patients to pneumococcal capsular antigens was equal to that of the control subjects. These findings indicate that patients with nephrotic syndrome, despite hypogammaglobulinemia, can mount an adequate antibody response to pneumococcal polysaccharides and that there is no evidence of suppressor thymus-derived (T) cells of dysfunctioning bone marrow-derived (B) cells in these patients.