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1.

Regulation of immune responses by mTOR.

Powell, Jonathan D; Pollizzi, Kristen N; Heikamp, Emily B; Horton, Maureen R.

Annu Rev Immunol ; 30: 39-68, 2012.

Article in English | MEDLINE | ID: mdl-22136167

2.

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Walton, Zandra E; Patel, Chirag H; Brooks, Rebekah C; Yu, Yongjun; Ibrahim-Hashim, Arig; Riddle, Malini; Porcu, Alessandra; Jiang, Tianying; Ecker, Brett L; Tameire, Feven; Koumenis, Constantinos; Weeraratna, Ashani T; Welsh, David K; Gillies, Robert; Alwine, James C; Zhang, Lin; Powell, Jonathan D; Dang, Chi V.

Cell ; 174(1): 72-87.e32, 2018 06 28.

Article in English | MEDLINE | ID: mdl-29861175

3.

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Pollizzi, Kristen N; Sun, Im-Hong; Patel, Chirag H; Lo, Ying-Chun; Oh, Min-Hee; Waickman, Adam T; Tam, Ada J; Blosser, Richard L; Wen, Jiayu; Delgoffe, Greg M; Powell, Jonathan D.

Nat Immunol ; 17(6): 704-11, 2016 06.

Article in English | MEDLINE | ID: mdl-27064374

4.

An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.

Mo, Fei; Yu, Zhiya; Li, Peng; Oh, Jangsuk; Spolski, Rosanne; Zhao, Liang; Glassman, Caleb R; Yamamoto, Tori N; Chen, Yun; Golebiowski, Filip M; Hermans, Dalton; Majri-Morrison, Sonia; Picton, Lora K; Liao, Wei; Ren, Min; Zhuang, Xiaoxuan; Mitra, Suman; Lin, Jian-Xin; Gattinoni, Luca; Powell, Jonathan D; Restifo, Nicholas P; Garcia, K Christopher; Leonard, Warren J.

Nature ; 597(7877): 544-548, 2021 09.

Article in English | MEDLINE | ID: mdl-34526724

5.

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.

Heikamp, Emily B; Patel, Chirag H; Collins, Sam; Waickman, Adam; Oh, Min-Hee; Sun, Im-Hong; Illei, Peter; Sharma, Archna; Naray-Fejes-Toth, Aniko; Fejes-Toth, Geza; Misra-Sen, Jyoti; Horton, Maureen R; Powell, Jonathan D.

Nat Immunol ; 15(5): 457-64, 2014 May.

Article in English | MEDLINE | ID: mdl-24705297

6.

Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.

Kim, Jiyeon S; Sklarz, Tammarah; Banks, Lauren B; Gohil, Mercy; Waickman, Adam T; Skuli, Nicolas; Krock, Bryan L; Luo, Chong T; Hu, Weihong; Pollizzi, Kristin N; Li, Ming O; Rathmell, Jeffrey C; Birnbaum, Morris J; Powell, Jonathan D; Jordan, Martha S; Koretzky, Gary A.

Nat Immunol ; 14(6): 611-8, 2013 Jun.

Article in English | MEDLINE | ID: mdl-23644504

7.

SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.

Helms, Rachel S; Marin-Gonzalez, Alberto; Patel, Chirag H; Sun, Im-Hong; Wen, Jiayu; Leone, Robert D; Duvall, Bridget; Gao, Run-Duo; Ha, Taekjip; Tsukamoto, Takashi; Slusher, Barbara S; Pomerantz, Joel L; Powell, Jonathan D.

J Immunol ; 211(12): 1767-1782, 2023 12 15.

Article in English | MEDLINE | ID: mdl-37947442

8.

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.

Ranek, Mark J; Kokkonen-Simon, Kristen M; Chen, Anna; Dunkerly-Eyring, Brittany L; Vera, Miguel Pinilla; Oeing, Christian U; Patel, Chirag H; Nakamura, Taishi; Zhu, Guangshuo; Bedja, Djahida; Sasaki, Masayuki; Holewinski, Ronald J; Van Eyk, Jennifer E; Powell, Jonathan D; Lee, Dong Ik; Kass, David A.

Nature ; 566(7743): 264-269, 2019 02.

Article in English | MEDLINE | ID: mdl-30700906

9.

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.

McCurdy, Shannon R; Radojcic, Vedran; Tsai, Hua-Ling; Vulic, Ante; Thompson, Elizabeth; Ivcevic, Sanja; Kanakry, Christopher G; Powell, Jonathan D; Lohman, Brian; Adom, Djamilatou; Paczesny, Sophie; Cooke, Kenneth R; Jones, Richard J; Varadhan, Ravi; Symons, Heather J; Luznik, Leo.

Blood ; 139(4): 608-623, 2022 01 27.

Article in English | MEDLINE | ID: mdl-34657151

10.

Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1.

Patel, Chirag H; Heikamp, Emily B; Xu, Wei; Sun, Im-Hong; Oh, Min-Hee; Sun, Im-Meng; Wen, Jiayu; Tam, Ada J; Blosser, Richard L; Powell, Jonathan D.

J Immunol ; 209(12): 2287-2291, 2022 12 15.

Article in English | MEDLINE | ID: mdl-36469844

11.

GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation.

Xu, Wei; Patel, Chirag H; Alt, Jesse; Zhao, Liang; Sun, Im-Hong; Oh, Min-Hee; Sun, Im-Meng; Wen, Jiayu; Blosser, Richard L; Tam, Ada J; Powell, Jonathan D.

Nature ; 614(7946): E1-E11, 2023 02.

Article in English | MEDLINE | ID: mdl-36726001

12.

Inhibition of the Adenosine Pathway to Potentiate Cancer Immunotherapy: Potential for Combinatorial Approaches.

Thompson, Elizabeth A; Powell, Jonathan D.

Annu Rev Med ; 72: 331-348, 2021 01 27.

Article in English | MEDLINE | ID: mdl-32903139

13.

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Delgoffe, Greg M; Pollizzi, Kristen N; Waickman, Adam T; Heikamp, Emily; Meyers, David J; Horton, Maureen R; Xiao, Bo; Worley, Paul F; Powell, Jonathan D.

Nat Immunol ; 12(4): 295-303, 2011 Apr.

Article in English | MEDLINE | ID: mdl-21358638

14.

mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism.

Collins, Samuel L; Oh, Min-Hee; Sun, Im-Hong; Chan-Li, Yee; Zhao, Liang; Powell, Jonathan D; Horton, Maureen R.

J Immunol ; 207(3): 913-922, 2021 08 01.

Article in English | MEDLINE | ID: mdl-34290107

15.

Fueling memories.

Powell, Jonathan D; Pollizzi, Kristen.

Immunity ; 36(1): 3-5, 2012 Jan 27.

Article in English | MEDLINE | ID: mdl-22284413

16.

MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.

Riggle, Brittany A; Sinharay, Sanhita; Schreiber-Stainthorp, William; Munasinghe, Jeeva P; Maric, Dragan; Prchalova, Eva; Slusher, Barbara S; Powell, Jonathan D; Miller, Louis H; Pierce, Susan K; Hammoud, Dima A.

Proc Natl Acad Sci U S A ; 115(51): E12024-E12033, 2018 12 18.

Article in English | MEDLINE | ID: mdl-30514812

17.

Slc7a5 helps T cells get with the program.

Powell, Jonathan D.

Nat Immunol ; 14(5): 422-4, 2013 May.

Article in English | MEDLINE | ID: mdl-23598390

18.

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.

Li, Qingsheng; Rao, Rajesh R; Araki, Koichi; Pollizzi, Kristen; Odunsi, Kunle; Powell, Jonathan D; Shrikant, Protul A.

Immunity ; 34(4): 541-53, 2011 Apr 22.

Article in English | MEDLINE | ID: mdl-21511183

19.

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3⁺ Regulatory T Cells.

Sun, Im-Hong; Oh, Min-Hee; Zhao, Liang; Patel, Chirag H; Arwood, Matthew L; Xu, Wei; Tam, Ada J; Blosser, Richard L; Wen, Jiayu; Powell, Jonathan D.

J Immunol ; 201(2): 481-492, 2018 07 15.

Article in English | MEDLINE | ID: mdl-29884702

20.

Manipulation of Metabolic Pathways and Its Consequences for Anti-Tumor Immunity: A Clinical Perspective.

Yang, Huang-Yu; Wu, Chao-Yi; Powell, Jonathan D; Lu, Kun-Lin.

Int J Mol Sci ; 21(11)2020 Jun 04.

Article in English | MEDLINE | ID: mdl-32512898

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