Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
1.
J Neuroophthalmol ; 39(1): 8-13, 2019 Mar.
Article in English | MEDLINE | ID: mdl-29697441

ABSTRACT

BACKGROUND: Although giant cell arteritis (GCA) is a well-known cause of transient and permanent vision loss, diplopia as a presenting symptom of this condition is uncommon. We compared symptoms and signs of patients presenting with diplopia from GCA to those from other causes. METHODS: This was a multicenter, retrospective study comparing the clinical characteristics of patients presenting with diplopia from GCA with age-matched controls. Demographic information, review of symptoms, ophthalmic examination, and laboratory data of biopsy-proven patients with GCA were compared with those of age-matched controls presenting with diplopia. RESULTS: A total of 27 patients presented with diplopia from GCA, 19 with constant diplopia, and 8 with transient diplopia. All patients with constant diplopia from GCA were matched with 67 control subjects who had diplopia from other etiologies. Patients with GCA were more likely to describe other accompanying visual symptoms (58% vs 25%, P = 0.008), a greater number of systemic GCA symptoms (3.5, GCA vs 0.6, controls, P < 0.001) such as headache (94% [17/18] vs 39% [23/67]; P < 0.001), jaw claudication (80% [12/15] vs 0% [0/36]; P < 0.001), and scalp tenderness (44% [7/16] vs 7% [3/43]; P < 0.001). Ocular ischemic lesions (26% vs 1%, P < 0.001) were also common in patients with diplopia from GCA. Inflammatory markers were elevated significantly in patients with GCA vs controls (erythrocyte sedimentation rate: 91% [10/11] vs 12% [3/25], P < 0.001; C-reactive protein: 89% [8/9] vs 11% [2/19], P < 0.001). CONCLUSIONS: GCA is a rare but serious cause of diplopia among older adults and must be differentiated from other more common benign etiologies. Our study suggests that most patients with diplopia from GCA have concerning systemic symptoms and/or elevated inflammatory markers that should trigger further work-up. Moreover, careful ophthalmoscopic examination should be performed to look for presence of ocular ischemic lesions in older patients presenting with acute diplopia.


Subject(s)
Diplopia/etiology , Giant Cell Arteritis/complications , Temporal Arteries/pathology , Vision, Binocular/physiology , Visual Acuity/physiology , Aged , Biopsy , Blood Sedimentation , C-Reactive Protein/metabolism , Diplopia/diagnosis , Diplopia/physiopathology , Female , Follow-Up Studies , Giant Cell Arteritis/diagnosis , Giant Cell Arteritis/metabolism , Humans , Male , Prognosis , Retrospective Studies
2.
Opt Lett ; 37(4): 659-61, 2012 Feb 15.
Article in English | MEDLINE | ID: mdl-22344139

ABSTRACT

Recent developments of optical-resolution photoacoustic microscopy (OR-PAM) have improved its spatial resolution and imaging speed. However, the penetration depth of OR-PAM is still limited to ~1 mm in tissue, owing to the strong tissue scattering. Here, we have developed double-illumination PAM (DI-PAM), which illuminates the sample from both top and bottom sides simultaneously. Through phantom and in vivo experiments, we have demonstrated for thin targets that DI-PAM has a penetration depth of ~2 mm in tissue at 532 nm and a focal zone of 260 µm, both significant improvements over traditional reflection or transmission-mode OR-PAM.


Subject(s)
Microscopy, Acoustic/instrumentation , Microscopy, Acoustic/methods , Animals , Chickens , Ear/anatomy & histology , Humans , Light , Mice , Mice, Inbred C57BL , Phantoms, Imaging
3.
Sports Health ; 9(5): 474-476, 2017.
Article in English | MEDLINE | ID: mdl-28610536

ABSTRACT

Rupture of the triceps brachii tendon is exceedingly rare, and surgical repair is generally indicated. Fluoroquinolone antibiotics have been implicated in tendon pathology, including tendon ruptures. Triceps rupture has not been previously reported in the setting of fluoroquinolone antibiotic therapy. We present 2 cases of triceps tendon rupture after treatment with fluoroquinolones. In both cases, triceps repair was performed with good outcomes. These cases highlight a risk of fluoroquinolone-induced tendinopathy to athletes. The sports medicine team should be aware of this risk and consider it when choosing antibiotics to treat athletes.


Subject(s)
Anti-Bacterial Agents/adverse effects , Bicycling/injuries , Ciprofloxacin/adverse effects , Levofloxacin/adverse effects , Martial Arts/injuries , Tendon Injuries/etiology , Humans , Male , Middle Aged , Rupture/etiology , Tendon Injuries/surgery
SELECTION OF CITATIONS
SEARCH DETAIL