Cohesion of Cortical Language Networks During Word Processing Is Predicted by a Common Polymorphism in the SETBP1 Gene.

The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome-wide association study of DLD in a geographically isolated population, and brain network-based endophenotypes of functional intracortical coherence between major language-related brain areas. We analyzed electroencephalogram (EEG) data from thirty-nine children (twenty-three with, sixteen without DLD) aged 7.17-15.83 years acquired during an auditory picture-word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the SETBP1 gene, rs8085464, explained 19% of the variance in intracortical network cohesion (p = .00478). This suggests that the development of these brain networks might be partially associated with the variation in SETBP1.

Lexical processing deficits in children with developmental language disorder: An event-related potentials study.

Lexical processing deficits in children with developmental language disorder (DLD) have been postulated to arise as sequelae of their grammatical deficits (either directly or via compensatory mechanisms) and vice versa. We examined event-related potential indices of lexical processing in children with DLD (n = 23) and their typically developing peers (n = 16) using a picture-word matching paradigm. We found that children with DLD showed markedly reduced N400 amplitudes in response both to auditorily presented words that had initial phonological overlap with the name of the pictured object and to words that were not semantically or phonologically related to the pictured object. Moreover, this reduction was related to behavioral indices of phonological and lexical but not grammatical development. We also found that children with DLD showed a depressed phonological mapping negativity component in the early time window, suggesting deficits in phonological processing or early lexical access. The results are partially consistent with the overactivation account of lexical processing deficits in DLD and point to the relative functional independence of lexical/phonological and grammatical deficits in DLD, supporting a multidimensional view of the disorder. The results also, although indirectly, support the neuroplasticity account of DLD, according to which language impairment affects brain development and shapes the specific patterns of brain responses to language stimuli.

Phonemic awareness is a more important predictor of orthographic processing than rapid serial naming: Evidence from Russian.

We studied the relationship between rapid serial naming (RSN) and orthographic processing in Russian, an asymmetrically transparent orthography. Ninety-six students (mean age = 13.73) completed tests of word and pseudoword reading fluency, spelling, orthographic choice, phonological choice, PA and RSN. PA was a better predictor of orthographic skills and pseudoword reading accuracy than RSN, which accounted for more variance in word and pseudoword reading fluency. Controlling for pseudoword reading fluency washed out RSN's contribution to word reading fluency. These results extend previous findings questioning the role of RSN as an index of orthographic processing skills and support the idea that RSN taps into automaticity/efficiency of processing print-sound mappings.

Gender and agreement processing in children with developmental language disorder.

Two experiments tested whether Russian-speaking children with Developmental Language Disorder (DLD) are sensitive to gender agreement when performing a gender decision task. In Experiment 1, the presence of overt gender agreement between verbs and/or adjectival modifiers and postverbal subject nouns memory was varied. In Experiment 2, agreement violations were introduced and the targets varied between words, pseudo-words, or pseudo-words with derivational suffixes. In both experiments, children with DLD did not differ from typically developing children in their reaction time or sensitivity to agreement features. In both groups, trials with feminine gender resulted in a higher error rate. Children with DLD displayed lower overall accuracy, which was related to differences in phonological memory in both experiments. Furthermore, in Experiment 1 group differences were not maintained after phonological memory was entered as a covariate. The results are discussed with respect to various processing and linguistic theories of DLD.

"Speech Is Golden": The Importance of Colloquial Arabic for Reading Standard Arabic for Beginning Readers.

PURPOSE: We investigated the role of spoken language in the acquisition of literacy in the context of Arabic diglossia, where the written language, Standard Arabic, deviates substantially from the spoken language, Colloquial Arabic, children acquire naturally from birth. METHOD: The participants (N = 110; 40 girls) were Saudi Arabic-speaking children in Grades 2-4. Children completed assessments of oral paragraph reading and word decoding using a vowelized script. They also completed three spoken assessments of Colloquial Arabic, which include sentence comprehension, sentence completion, and pragmatic knowledge, as well as a test of phonological awareness. We used path analysis to investigate the contributions of each of the spoken language indicators, decoding, and phonological awareness to reading comprehension (RC) in single and multiple serial mediator models. RESULTS: We found that spoken language (i.e., sentence comprehension, sentence completion, and pragmatic knowledge) and word decoding uniquely contributed to RC. Moreover, word decoding mediated the association between spoken language and RC. The path from spoken language to phonological awareness, then to word decoding, and finally to RC was inconclusive. CONCLUSIONS: While most studies on literacy acquisition in the context of Arabic diglossia focus on the linguistic distance between the colloquial (spoken) and the standard (written) language varieties, our results highlight the important contribution of spoken language skills to reading skills in Arabic despite this linguistic gap. The important implication of these findings is that spoken language interventions aimed at boosting children's narrative language skills in their home language (Colloquial Arabic) are an important tool for building a foundation for literacy in diglossia contexts.

Assessing language development in Arabic: The Arabic language: Evaluation of function (ALEF).

Arabic is characterized by extensive dialectal variation, diglossia, and substantial morphological complexity. Arabic lacks comprehensive diagnostic tools that would allow for a systematic evaluation of its development, critical for the early identification of language difficulties in the spoken and written domains. To address this gap, we have developed an assessment battery called Arabic Language: Evaluation of Function (ALEF), aimed at children aged 3 to 11 years. ALEF consists of 17 subtests indexing different language domains, modalities, and associated skills and representational systems. We administered the ALEF battery to native Gulf Arabic-speaking children (n = 467; ages 2.5 to 10.92; 55% boys; 20 children in each 6-month age band) in Saudi Arabia in two data collection waves. Analyses examining the psychometric properties of the instrument indicated that after the removal of misfitting items, the ALEF subtests had reliability coefficients in the range from 0.78 to 0.98, and resulting subtest scores displayed a consistent profile of positive intercorrelations and age effects. Taken together, the results indicate that the ALEF battery has good psychometric properties, and can be used for the purpose of evaluating early language development in Gulf Arabic speaking children, pending further refinement of the test structure, examination of gender-related differential item functioning, and norming.

Narrative Language Markers of Arabic Language Development and Impairment.

Purpose We examined indices of narrative microstructure as metrics of language development and impairment in Arabic-speaking children. We examined their age sensitivity, correlations with standardized measures, and ability to differentiate children with average language and language impairment. Method We collected story narratives from 177 children (54.2% boys) between 3.08 and 10.92 years old (M = 6.25, SD = 1.67) divided into six age bands. Each child also received standardized measures of spoken language (Receptive and Expressive Vocabulary, Sentence Imitation, and Pseudoword Repetition). Several narrative indices of microstructure were examined in each age band. Children were divided into (suspected) developmental language disorder and typical language groups using the standardized test scores and compared on the narrative indicators. Sensitivity and specificity of the narrative indicators that showed group differences were calculated. Results The measures that showed age sensitivity included subject omission error rate, number of object clitics, correct use of subject-verb agreement, and mean length of utterance in words. The developmental language disorder group scored higher on subject omission errors (Cohen's d = 0.55) and lower on correct use of subject-verb agreement (Cohen's d = 0.48) than the typical language group. The threshold for impaired performance with the highest combination of specificity and sensitivity was 35th percentile. Conclusions Several indices of narrative microstructure appear to be valid metrics for documenting language development in children acquiring Gulf Arabic. Subject omission errors and correct use of subject-verb agreement differentiate children with typical and atypical levels of language development.

Orthographic processing is a key predictor of reading fluency in good and poor readers in a transparent orthography.

We used structural equation modeling to investigate sources of individual differences in oral reading fluency in a transparent orthography, Russian. Phonological processing, orthographic processing, and rapid automatized naming were used as independent variables, each derived from a combination of two scores: phonological awareness and pseudoword repetition, spelling and orthographic choice, and rapid serial naming of letters and digits, respectively. The contribution of these to oral text-reading fluency was evaluated as a direct relationship and via two mediators, decoding accuracy and unitized reading, measured with a single-word oral reading test. The participants were "good" and "poor" readers, i.e., those with reading skills above the 90th and below the 10th percentiles (n = 1,344, grades 2-6, St. Petersburg, Russia). In both groups, orthographic processing skills significantly contributed to fluency and unitized reading, but not to decoding accuracy. Phonological processing skills did not contribute directly to reading fluency in either group, while contributing to decoding accuracy and, to a lesser extent, to unitized reading. With respect to the roles of decoding accuracy and unitized reading, the results for good and poor readers diverged: in good readers, unitized reading, but not decoding accuracy, was significantly related to reading fluency. For poor readers, decoding accuracy (measured as pseudoword decoding) was related to reading fluency, but unitized reading was not. These results underscore the importance of orthographic skills for reading fluency even in an orthography with consistent phonology-to-orthography correspondences. They also point to a qualitative difference in the reading strategies of good and poor readers.

Diversity of Grammars and Their Diverging Evolutionary and Processing Paths: Evidence From Functional MRI Study of Serbian.

We address the puzzle of "unity in diversity" in human languages by advocating the (minimal) common denominator for the diverse expressions of transitivity across human languages, consistent with the view that early in language evolution there was a modest beginning for syntax and that this beginning provided the foundation for the further elaboration of syntactic complexity. This study reports the results of a functional MRI experiment investigating differential patterns of brain activation during processing of sentences with minimal versus fuller syntactic structures. These structural layers have been postulated to represent different stages in the evolution of syntax, potentially engaging different brain networks. We focused on the Serbian "middles," analyzed as lacking the transitivity (vP) layer, contrasted with matched transitives, containing the transitivity layer. Our main hypothesis was that transitives will produce more activation in the syntactic (Broca's-Basal Ganglia) brain network, in comparison to more rudimentary middles. The participants (n = 14) were healthy adults (Mean age = 33.36; SD = 12.23), native speakers of Serbo-Croatian. The task consisted of reading a series of sentences (middles and transitives; n = 64) presented in blocks of 8, while being engaged in a detection of repetition task. We found that the processing of transitives, compared to middles, was associated with an increase in activation in the basal ganglia bilaterally. Although we did not find an effect in Broca's area, transitives, compared to middles, evoked greater activation in the precentral gyrus (BA 6), proposed to be part of the "Broca's complex." Our results add to the previous findings that Broca's area is not the sole center for syntactic processing, but rather is part of a larger circuit that involves subcortical structures. We discuss our results in the context of the recent findings concerning the gene-brain-language pathway involving mutations in FOXP2 that likely contributed to the enhancement of the frontal-striatal brain network, facilitating human capacity for complex syntax.

Neural Correlates of Syntax and Proto-Syntax: Evolutionary Dimension.

The present fMRI study tested predictions of the evolution-of-syntax framework which analyzes certain structures as remnants ("fossils") of a non-hierarchical (non-recursive) proto-syntactic stage in the evolution of language (Progovac, 2015, 2016). We hypothesized that processing of these structures, in comparison to more modern hierarchical structures, will show less activation in the brain regions that are part of the syntactic network, including Broca's area (BA 44 and 45) and the basal ganglia, i.e., the network bolstered in the line of descent of humans through genetic mutations that contributed to present-day dense neuronal connectivity among these regions. Fourteen healthy native English-speaking adults viewed written stimuli consisting of: (1) full sentences (FullS; e.g., The case is closed); (2) Small Clauses (SC; e.g., Case closed); (3) Complex hierarchical compounds (e.g., joy-killer); and (4) Simple flat compounds (e.g., kill-joy). SC (compared to FullS) resulted in reduced activation in the left BA 44 and right basal ganglia. Simple (relative to complex) compounds resulted in increased activation in the inferior temporal gyrus and the fusiform gyrus (BA 37/19), areas implicated in visual and semantic processing. We discuss our findings in the context of current theories regarding the co-evolution of language and the brain.

Sources of heterogeneity in developmental outcomes of children with past and current experiences of institutionalization in Russia: A four-group comparison.

The present study sought to compare 4 groups of age- and gender-matched children-(a) those reared in institutions for children without parental care in Russia; (b) those raised by their biological parents in Russia; (c) those adopted to the United States from Russian institutions; and (d) those born in the United States and raised by their biological parents-on indicators of cognition, language, and early learning. In addition, we aimed to compare the effects of the length of time spent in an institution, the age of initial placement in an institution, the age at adoption, and pre-institutional risk factors (i.e., prenatal substance exposure and prematurity and low birth weight) on the above-mentioned outcomes in the 2 groups of children with institutionalization experiences. Our results confirm previous reports demonstrating negative consequences of institutionalization and substantial ameliorating effects of adoption. They also underscore the complexity of the effects of institutionalization and adoption, showing that they are intertwined with the effects of pre-institutional risk factors. (PsycINFO Database Record

Syntactic Complexity Effects of Russian Relative Clause Sentences in Children with and without Developmental Language Disorder.

We investigated relative clause (RC) comprehension in 44 Russian-speaking children with typical language (TD) and developmental language disorder (DLD); M age = 10.67, SD = 2.84, and 22 adults. Flexible word order and morphological case in Russian allowed us to isolate factors that are obscured in English, helping us to identify sources of syntactic complexity and evaluate their roles in RC comprehension by children with typical language and their peers with DLD. We administered a working memory and an RC comprehension (picture-choice) task, which contained subject- and object-gap center-embedded and right branching RCs. The TD group, but not adults, demonstrated the effects of gap, embedding, and case. Their lower accuracy relative to adults was not fully attributable to differences in working memory. The DLD group displayed lower than TD children overall accuracy, accounted for by their lower working memory scores. While the effect of gap and embedding on their performance was not different from what was found for the TD group, children with DLD exhibited a diminished effect of case, suggesting reduced sensitivity to morphological case markers as processing cues. The implications of these results to theories of syntactic complexity and core deficits in DLD are discussed.

Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population.

BACKGROUND AND OBJECTIVE: Developmental language disorder (DLD) is a highly prevalent neurodevelopmental disorder associated with negative outcomes in different domains; the etiology of DLD is unknown. To investigate the genetic underpinnings of DLD, we performed genome-wide association and whole exome sequencing studies in a geographically isolated population with a substantially elevated prevalence of the disorder (ie, the AZ sample). METHODS: DNA samples were collected from 359 individuals for the genome-wide association study and from 12 severely affected individuals for whole exome sequencing. Multifaceted phenotypes, representing major domains of expressive language functioning, were derived from collected speech samples. RESULTS: Gene-based analyses revealed a significant association between SETBP1 and complexity of linguistic output (P = 5.47 × 10(-7)). The analysis of exome variants revealed coding sequence variants in 14 genes, most of which play a role in neural development. Targeted enrichment analysis implicated myocyte enhancer factor-2 (MEF2)-regulated genes in DLD in the AZ population. The main findings were successfully replicated in an independent cohort of children at risk for related disorders (n = 372). CONCLUSIONS: MEF2-regulated pathways were identified as potential candidate pathways in the etiology of DLD. Several genes (including the candidate SETBP1 and other MEF2-related genes) seem to jointly influence certain, but not all, facets of the DLD phenotype. Even when genetic and environmental diversity is reduced, DLD is best conceptualized as etiologically complex. Future research should establish whether the signals detected in the AZ population can be replicated in other samples and languages and provide further characterization of the identified pathway.

Interpretation of Anaphoric Dependencies in Russian-speaking Children with and without Developmental Language Disorder.

We examined anaphora resolution in children with and without Developmental Language Disorder (DLD) to clarify whether 1) DLD is best understood as missing knowledge of certain linguistic operations/elements or as unreliable performance and 2) if comprehension of sentences with anaphoric expressions as objects and exceptionally case marked (ECM) subjects supports a particular theoretical account of anaphora. Fifty-four native-Russian-speaking children (age M = 7;6, SD = 1;9) were tested on a picture selection task. Children with DLD (n=18) underperformed overall, but displayed similar patterns to the typically developing (TD) group with respect to the extra difficulty of the ECM relative to the transitive and ECM pronouns relative to all other conditions. However, whereas pronouns were more difficult than reflexives for the TD children, this effect was not significant for the DLD group, whose reduced accuracy on reflexives washed out the effect of pronouns in that group. These results are consistent with performance-level vulnerability in DLD, arguably related to weaknesses in lexical processing and with the Reflexivity framework of Binding phenomena.

Language development of internationally adopted children: Adverse early experiences outweigh the age of acquisition effect.

UNLABELLED: We compared English language and cognitive skills between internationally adopted children (IA; mean age at adoption=2.24, SD=1.8) and their non-adopted peers from the US reared in biological families (BF) at two time points. We also examined the relationships between outcome measures and age at initial institutionalization, length of institutionalization, and age at adoption. On measures of general language, early literacy, and non-verbal IQ, the IA group performed significantly below their age-peers reared in biological families at both time points, but the group differences disappeared on receptive vocabulary and kindergarten concept knowledge at the second time point. Furthermore, the majority of children reached normative age expectations between 1 and 2 years post-adoption on all standardized measures. Although the age at adoption, age of institutionalization, length of institutionalization, and time in the adoptive family all demonstrated significant correlations with one or more outcome measures, the negative relationship between length of institutionalization and child outcomes remained most robust after controlling for the other variables. Results point to much flexibility and resilience in children's capacity for language acquisition as well as the potential primacy of length of institutionalization in explaining individual variation in IA children's outcomes. LEARNING OUTCOMES: (1) Readers will be able to understand the importance of pre-adoption environment on language and early literacy development in internationally adopted children. (2) Readers will be able to compare the strength of the association between the length of institutionalization and language outcomes with the strength of the association between the latter and the age at adoption. (3) Readers will be able to understand that internationally adopted children are able to reach age expectations on expressive and receptive language measures despite adverse early experiences and a replacement of their first language with an adoptive language.

Attentional but not pre-attentive neural measures of auditory discrimination are atypical in children with developmental language disorder.

We examined neural indices of pre-attentive phonological and attentional auditory discrimination in children with developmental language disorder (DLD, n = 23) and typically developing (n = 16) peers from a geographically isolated Russian-speaking population with an elevated prevalence of DLD. Pre-attentive phonological MMN components were robust and did not differ in two groups. Children with DLD showed attenuated P3 and atypically distributed P2 components in the attentional auditory discrimination task; P2 and P3 amplitudes were linked to working memory capacity, development of complex syntax, and vocabulary. The results corroborate findings of reduced processing capacity in DLD and support a multifactorial view of the disorder.

Spelling well despite developmental language disorder: what makes it possible?

The goal of the study was to investigate the overlap between developmental language disorder (DLD) and developmental dyslexia, identified through spelling difficulties (SD), in Russian-speaking children. In particular, we studied the role of phoneme awareness (PA), rapid automatized naming (RAN), pseudoword repetition (PWR), morphological (MA), and orthographic awareness (OA) in differentiating between children with DLD who have SD from children with DLD who are average spellers by comparing the two groups to each other, to typically developing children as well as children with SD but without spoken language deficits. One hundred forty-nine children, aged 10.40 to 14.00 years, participated in the study. The results indicated that the SD, DLD, and DLD/SD groups did not differ from each other on PA and RAN Letters and underperformed in comparison to the control groups. However, whereas the children with written language deficits (SD and DLD/SD groups) underperformed on RAN Objects and Digits, PWR, OA, and MA, the children with DLD and no SD performed similarly to the children from the control groups on these measures. In contrast, the two groups with spoken language deficits (DLD and DLD/SD) underperformed on RAN Colors in comparison to the control groups and the group of children with SD only. The results support the notion that those children with DLD who have unimpaired PWR and RAN skills are able to overcome their weaknesses in spoken language and PA and acquire basic literacy on a par with their age peers with typical language. We also argue that our findings support a multifactorial model of DLD.