1.
Org Lett
; 7(14): 2989-91, 2005 Jul 07.
Article
in English
| MEDLINE
| ID: mdl-15987187
ABSTRACT
[reaction: see text] A novel and efficient synthesis of racemic camptothecin, starting from a readily accessible hydroxy pyridone, is presented. Key steps include a Claisen rearrangement of a functionalized allylic ether, a hindered Heck coupling, and a Friedländer condensation.
Subject(s)
Antineoplastic Agents, Phytogenic/chemical synthesis , Camptothecin/chemical synthesis , Antineoplastic Agents, Phytogenic/chemistry , Camptotheca/chemistry , Camptothecin/chemistry , Catalysis , Molecular Structure , Stereoisomerism
2.
Angew Chem Int Ed Engl
; 42(41): 5059-61, 2003 Oct 27.
Article
in English
| MEDLINE
| ID: mdl-14595631