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Trends Biochem Sci
; 44(12): 993-995, 2019 12.
Article
in English
| MEDLINE
| ID: mdl-31668600
ABSTRACT
Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid-liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration.