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Chem Commun (Camb)
; 50(62): 8593-6, 2014 Aug 11.
Article
in English
| MEDLINE
| ID: mdl-24956071
ABSTRACT
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.