ABSTRACT
Characterization of HLA-DQB1*02:02:01:18, -DQB1*02:02:01:19, -DQB1*03:02:01:20 and -DQB1*05:03:01:10 alleles in Spanish individuals.
Subject(s)
High-Throughput Nucleotide Sequencing , Humans , Alleles , HLA-DQ beta-Chains/genetics , MutationABSTRACT
Characterization of HLA-B*40:01:02:61, -B*48:01:01:14, and -C*01:02:01:69 alleles in Spanish individuals.
Subject(s)
Genes, MHC Class I , HLA-B Antigens , Humans , Alleles , HLA-B Antigens/genetics , Genomics , High-Throughput Nucleotide SequencingABSTRACT
Characterisation of HLA-DQA1*01:02:01:30, HLA-DQA1*01:03:01:14, HLA-DQA1*03:03:01:20, HLA-DQA1*04:01:01:13, HLA-DQA1*05:05:01:40 alleles in Spanish individuals.
Subject(s)
Alleles , HLA-DQ alpha-Chains , Humans , HLA-DQ alpha-Chains/genetics , Histocompatibility Testing , Spain , Sequence Analysis, DNA/methods , Exons , Base SequenceABSTRACT
Genomic sequence of HLA-DPA1*01:03:01:73, -DPA1*01:03:01:80, DPA1*01:03:01:82, -DPA1*01:155:01:02, -DPA1*02:02:02:16 alleles in Spanish individuals.
Subject(s)
Alleles , HLA-DP alpha-Chains , Humans , HLA-DP alpha-Chains/genetics , Exons , Spain , Histocompatibility Testing , Sequence Analysis, DNA , Base Sequence , Sequence AlignmentABSTRACT
Genomic sequence of HLA-DQB1*03:01:01:60, -DQB1*03:01:01:61, -DQB1*03:01:01:62, -DQB1*03:01:01:63, -DQB1*03:02:01:23, -DQB1*03:02:01:24, -DQB1*03:02:01:25 and -DQB1*03:03:02:14 alleles in Spanish individuals.
Subject(s)
Alleles , HLA-DQ beta-Chains , High-Throughput Nucleotide Sequencing , Humans , HLA-DQ beta-Chains/genetics , High-Throughput Nucleotide Sequencing/methods , Histocompatibility Testing/methods , Exons , Spain , Sequence Analysis, DNA/methods , Genetic VariationABSTRACT
El progreso de la ciencia y en especial el de los trasplantes de riñón amerita muchas reflexiones éticas, pues no todos los dilemas que se presentan se han solucionado y algunos no han sido tomados como tales. Los donantes vivos pueden ser sujetos a coacción, pues adquieren un compromiso con la familia, la sociedad y el equipo de salud para donar su riñón. Muchos en realidad no lo quieren hacer, aunque en los libros aparezca la donación como el mayor acto de amor y solidaridad. No todos los hijos quieren a sus padres y viceversa, ni todos los hermanos se quieren entre sí. Son muy importantes los conceptos de solidaridad y amor, que no suelen aparecer de manera espontánea en la vida de los individuos. Amor es un arte que implica dar pero de una forma madura. ¿Tendrán todos los donantes esta capacidad de dar? Si no la tienen es probable que estén siendo víctima de una coacción. Como existen tantos dilemas éticos con el trasplante de riñón, la bioética ayuda a dar respuesta a tantas inquietudes para poder colaborar con más efectividad a los involucrados en él.
Scientific breakthroughs, especially kidney transplantation, deserve serious ethical reflections for not all dilemmas that arise have been addressed and some have not been contemplated as such. Live donors could be subject to coercion in favor of donating their kidney for they have acquired a commitment with their relatives, society and health teams. Although donation appears in literature as the greatest act of love and solidarity not all live donors are actually willing to give up their kidney. Not all sons and daughters love their parents or parents love their children, nor all siblings love each other. Such important concepts as solidarity and love are not commonly manifest spontaneously in the life of individuals. Love is considered an art which implies giving in a mature manner. Will all donors have this ability? If they lack this ability they are more likely being victims of coercion. As various ethical dilemmas on kidney transplantation exist, bioethics has helped answer many questions in order to furnish an effective support to all who are involved.