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1.
Can J Diet Pract Res ; 77(4): 203-205, 2016 12.
Article in English | MEDLINE | ID: mdl-27763768

ABSTRACT

PURPOSE: To understand how and where parents of infants and young children (children ≤5 years old) prefer to receive nutrition information. METHODS: A 1-page survey was developed and pilot tested at 2 community agencies. The final survey was distributed at 18 community health centres (CHCs) in Calgary and surrounding rural areas. Any parent attending a well-child visit (child ≤5 years old) was able to participate. RESULTS: Five hundred and twenty-nine surveys were completed. The majority of respondents at every CHC identified online reading (79.2%) in their home (86.0%) as the preferred method and location to receive nutrition information. Almost all (99.4%) participants had internet access. Handouts (38.6%) were the second most popular way to receive nutrition information. In-person and online classes were only a preferred method by a small percentage of respondents, 10.6% and 8.1%, respectively. CONCLUSIONS: Appropriate, evidence-based nutrition websites should be promoted to parents with young children. Health professionals should be aware that parents likely access nutrition information online, and they need to provide an opportunity for parents to discuss what they found. Future research is needed to understand which websites parents access for online nutrition information and how they discern whether it is credible.


Subject(s)
Consumer Health Information , Health Knowledge, Attitudes, Practice , Information Dissemination/methods , Child, Preschool , Female , Humans , Infant , Internet , Male , Parents , Pilot Projects , Surveys and Questionnaires
2.
Am J Epidemiol ; 182(1): 67-79, 2015 Jul 01.
Article in English | MEDLINE | ID: mdl-25921649

ABSTRACT

This study applied socioecological and cumulative risk exposure frameworks to test the hypotheses that 1) the experience of poverty is associated with feeling less safe at school, and 2) feeling less safe is associated with engaging in poorer weight-related behaviors, as well as an increased probability of being overweight or obese. Data were from the ongoing Québec Longitudinal Study of Child Development, initiated in 1998 with a population-based cohort of 2,120 Québec (Canada) infants 5 months of age and their parent or primary caregiver. Measures of youths' (age, 13 years) self-reported feelings of safety, screen time, physical activity, and objectively assessed not overweight/obese (70%), overweight (22%), and obese (8%) weight status were collected in 2011. Family poverty trajectory from birth was assessed by using latent growth modeling. As hypothesized, exposure to poverty was associated with feeling less safe at school and, in turn, with an increased probability of being overweight or obese. The association was most pronounced for youths who experienced chronic poverty. Compared with youths who experienced no poverty and felt unsafe, those who experienced chronic poverty and felt unsafe were nearly 18% more likely to be obese (9.2% vs. 11.2%). Although feeling unsafe was associated with screen time, screen time did not predict weight status.


Subject(s)
Exercise/psychology , Obesity/etiology , Poverty/statistics & numerical data , Sedentary Behavior , Stress, Psychological/complications , Adolescent , Cohort Studies , Female , Humans , Internet , Male , Safety , Schools , Television
3.
Prev Med ; 75: 18-22, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25797329

ABSTRACT

BACKGROUND: Parents play a critical role in their children's lifestyle habits. The objective was to assess the effect of parenting style on the risk of childhood obesity, and to determine whether poverty was a moderator of the association. METHODS: Participants were from the 1994-2008 cross-sectional samples of the National Longitudinal Survey of Children and Youth (NLSCY), a nationally representative survey of Canadian youth. Factor and cluster analyses identified four parenting styles consistent with Baumrind's parenting style prototypes. Multivariable logistic regression assessed the risk of obesity based on parenting style after adjusting for covariates. Analyses were stratified by age (preschool: 2-5years of age, n=19,026; school-age: 6-11years of age, n=18,551) and the moderating effect of poverty (household income

Subject(s)
Parent-Child Relations , Parenting , Pediatric Obesity , Body Mass Index , Canada , Child , Child, Preschool , Cross-Sectional Studies , Eating/psychology , Female , Humans , Logistic Models , Longitudinal Studies , Male , Multivariate Analysis , Poverty , Risk Factors
4.
Pediatr Cardiol ; 36(1): 41-8, 2015 Jan.
Article in English | MEDLINE | ID: mdl-25056158

ABSTRACT

Heart rate variability (HRV) is a non-invasive quantitative marker of cardiac autonomic function derived from continuous electrocardiogram (ECG) recordings. Normative HRV values and development factors have not been established in pediatric populations. The objective was to derive referent time- and frequency-domain HRV values for a population-based sample of children. Children aged 9-11 years (N = 1,036) participated in the Québec Longitudinal Study of Child Development cohort cardiovascular health screening. Registered nurses measured anthropometrics (height, weight) and children wore an ambulatory Holter monitor to continuously record an ECG signal. HRV variables included time (SDNN, pNN50, RMSSD, SDANN) and frequency (HF, LF, LF/HF ratio) domain variables. Normative HRV values, stratified by age, sex, and heart rate, are presented. Greater heart rate (ß avg  = -0.60, R avg (2)  = 0.39), pubertal maturation (ß avg = -0.11, R avg (2)  = 0.01), later ECG recording times (ß avg = -0.19, R avg (2)  = 0.07), and higher diastolic blood pressure (ß avg = -0.11, R avg (2)  = 0.01) were significantly associated with reduced HRV in 10-year-old children. The normative HRV values permit clinicians to monitor, describe, and establish pediatric nosologies in primary care and research settings, which may improve treatment of diseases associated with HRV in children. By better understanding existing values, the practical applicability of HRV among clinicians will be enhanced. Lastly, developmental (e.g., puberty) and procedural (e.g., recording time) factors were identified that will improve recording procedures and interpretation of results.


Subject(s)
Autonomic Nervous System/physiology , Heart Rate/physiology , Anthropometry , Blood Pressure Determination , Caffeine/administration & dosage , Child , Cross-Sectional Studies , Electrocardiography , Electrocardiography, Ambulatory , Female , Gestational Age , Humans , Longitudinal Studies , Male , Motor Activity , Puberty , Quebec , Reference Values , Registries , Sleep/physiology , Surveys and Questionnaires
5.
J Youth Adolesc ; 44(6): 1194-207, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25388832

ABSTRACT

Although disadvantaged youth are more likely to be victimized at school, victimization only partly explains their decreased feelings of safety at school. We applied a socioecological approach to test the hypotheses that the experience of poverty is associated with decreased feelings of safety at school, and that residential neighborhood features partly mediate the relationship between poverty and feeling less safe at school. This study draws on the Québec Longitudinal Study of Child Development (QLSCD) which began in 1998 with a representative population-based cohort of 2,120 5-month old infants (49.1% female) and their primary caregiver. The study also includes measures of ego-centred residential neighborhood exposures (based on a 500 m circular buffer zone surrounding the family's residential postal code) derived from a spatial data infrastructure. We used latent growth modeling to estimate youth's family poverty trajectory from age 5 months to 13 years, and structural equation modeling to test our hypotheses. The results suggest that youth experiencing chronic and later-childhood poverty felt less safe at school in part because they lived in neighborhoods that their parents described as being disorderly (e.g., demarked by the presence of garbage, drug use and groups of trouble-makers). These neighborhoods also tended to have less greenery (e.g., trees, parks) and more lone-parent households. Neighborhood features did not help explain the relationship between early-childhood poverty and feeling less safe at school. The findings suggest that targeting residential neighborhood features such as greenery and disorder could improve youth's felt safety at school, particularly for those experiencing chronic and later-childhood poverty.


Subject(s)
Adolescent Behavior/psychology , Family Characteristics , Poverty/statistics & numerical data , Residence Characteristics , Safety/statistics & numerical data , Adolescent , Attitude to Health , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Longitudinal Studies , Male , Quebec , Social Environment
6.
Paediatr Perinat Epidemiol ; 27(3): 237-46, 2013 May.
Article in English | MEDLINE | ID: mdl-23574411

ABSTRACT

BACKGROUND: Although second-trimester blood corticotrophin-releasing hormone (CRH) levels are robustly associated with preterm birth, the findings with respect to cortisol have been inconsistent, as have been those relating stress hormones to measured stressors and maternal distress. METHODS: We measured plasma CRH, adrenocorticotrophic hormone (ACTH), cortisol, cortisol-binding globulin, oestradiol and progesterone at 24-26 weeks in a nested case-control study of 206 women who experienced spontaneous preterm birth and 442 term controls. We also related the hormonal levels to measures of environmental stressors, perceived stress and maternal distress (also assessed at 24-26 weeks) and to placental histopathology. RESULTS: With the exception of an unexpectedly low oestradiol:progesterone ratio among cases (adjusted odds ratio = 0.5 [95% confidence interval 0.3, 0.8] for ratios above the median in controls), none of the hormonal measures was independently associated with spontaneous preterm birth; placental histopathological evidence of infection/inflammation, infarction or decidual vasculopathy; or measures of maternal stress or distress. CRH levels were positively associated with cortisol, but not with ACTH, whereas ACTH was also positively associated with cortisol. CONCLUSIONS: Our findings suggest an intact pituitary-adrenal axis and confirm the positive feedback effect of cortisol on (placental) CRH. Neither of these hormonal pathways, however, was strongly linked to maternal stress/distress or to the risk of spontaneous preterm birth.


Subject(s)
Adrenocorticotropic Hormone/blood , Corticotropin-Releasing Hormone/blood , Hydrocortisone/blood , Pituitary-Adrenal System/physiology , Premature Birth/blood , Progesterone/blood , Stress, Psychological/blood , Adolescent , Adult , Case-Control Studies , Estradiol/blood , Female , Humans , Infant, Newborn , Middle Aged , Odds Ratio , Placenta/physiology , Pregnancy , Pregnancy Trimester, Second , Stress, Physiological , Young Adult
7.
Ann Hum Biol ; 39(4): 322-6, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22716236

ABSTRACT

BACKGROUND: The impact of the obesity epidemic on cardiovascular health in young people is of increasing concern. However, data on secular trends in CVD indicators are outdated and mixed. METHODS: This study compared lipid profiles and insulin of 9-10 year olds in 2008 (n = 605) and 1999 (n = 779). Data were drawn from two population-based samples of youth: the 1999 Québec Child and Adolescent Health and Social Survey and the 2008 Québec Longitudinal Study of Child Development. RESULTS: Mean body mass index (BMI) Z-scores were higher in 2008 than in 1999 in both boys (0.37 vs 0.12, p = 0.004) and girls (0.32 vs 0.05, p = 0.0004). After adjusting for maturity stage, height, BMI Z-score, age and household income, high-density lipoprotein cholesterol was 0.12 mmol/L (p < 0.05) and 0.10 mmol/L (p < 0.05) higher in 2008 than 1999 in boys and girls, respectively. Total cholesterol, low density lipoprotein cholesterol and insulin were not significantly different between 2008 and 1999. CONCLUSIONS: Despite higher BMI Z-scores in 2008, differences in cardiometabolic indicators between 1999 and 2008 were small and may not be clinically meaningful. Surveillance to closely monitor trends in cardiometabolic indicators in Canadian youth is needed.


Subject(s)
Cardiovascular Diseases/complications , Cardiovascular Diseases/epidemiology , Epidemics/statistics & numerical data , Obesity/complications , Obesity/epidemiology , Child , Female , Humans , Logistic Models , Male , Multivariate Analysis , Quebec/epidemiology , Risk Factors
8.
Ethn Health ; 16(3): 185-200, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21491286

ABSTRACT

OBJECTIVE: Poverty and low social support are common among minority migrant families. Little is known about their impact on the health of children of minority migrants to Canada. This study examined the associations between maternal perception of child's health and migration status, and examined the specific role of poverty and low social support in these associations. DESIGN: Data from the first two rounds of the Quebec Longitudinal Study of Child Development (QLSCD) were analysed. The sample included 1990 children at 17 months of age, classified according to their mother's migration status: children of minority migrant mothers (n=165) and Canadian-born mothers (n=1825). Maternal perception of child's health status and social support were measured at 17 months, household income was measured at 5 and 17 months. Multivariable logistic regressions were performed; interactions of migration status with poverty and social support were tested. RESULTS: Poverty and low social support were more common among minority migrant mothers than among Canadian-born mothers. Children of minority migrant mothers who were 'never poor' and reported high levels of social support were perceived in better health (OR 0.42; 95% confidence interval (CI): 0.19-0.91) than children of Canadian-born mothers (reference group). In contrast, children of minority migrant mothers who were 'always poor' and reported low social support were perceived in worse health (OR 6.32; 95% CI: 1.69-23.71) compared to the reference group. CONCLUSION: In Quebec, economic hardship and lack of social support are common realities among minority migrants with young children. Combined exposure to poverty and low social support is most detrimental to the perceived health of children of minority migrants.


Subject(s)
Child Welfare/statistics & numerical data , Minority Health , Poverty/statistics & numerical data , Social Support , Transients and Migrants/statistics & numerical data , Adolescent , Child , Child Development , Cohort Studies , Confidence Intervals , Female , Health Surveys , Humans , Infant , Logistic Models , Male , Maternal Welfare , Multivariate Analysis , Odds Ratio , Quebec/ethnology , Risk Assessment , Time Factors
9.
Women Health ; 51(5): 461-81, 2011 Jul 22.
Article in English | MEDLINE | ID: mdl-21797679

ABSTRACT

The authors examined the association between maternal reports of child asthma attacks since birth and occurrence of elevated maternal depressive symptoms at seventeen months postpartum in the present study. The modifying role of poverty in this association was also examined. Data from n = 1,696 mother-child dyads from the Quebec Longitudinal Study of Child Development, a birth cohort of children born in 1998, were used. Maternal depressive symptoms were measured with an abridged and validated twelve-item version of the Center for Epidemiologic Studies Depression Scale. Maternal reports of child asthma attacks since birth in relation to the occurrence of maternal depressive symptoms at 17 months postpartum and the potential modifying role of poverty were tested using multiple logistic regression models. When mothers reported child asthma attacks, those without elevated depressive symptoms at 5 months postpartum had lower odds of elevated depressive symptoms one year later (OR = 0.2, 95% CI: 0.1-0.7). Poverty was associated with increased odds of elevated maternal depressive symptoms (OR = 2.4, 95% CI: 1.5-3.9), without interacting with child asthma. Through this study, the authors suggest that in mothers without elevated symptoms at 5 months, reported child asthma attacks since birth did not contribute one year later to new occurrence of depressive symptoms.


Subject(s)
Asthma/psychology , Depression, Postpartum/etiology , Depression/etiology , Poverty , Adolescent , Adult , Child , Cohort Studies , Female , Humans , Logistic Models , Longitudinal Studies , Odds Ratio , Pregnancy , Quebec , Surveys and Questionnaires , Young Adult
10.
Psychol Health ; 36(4): 461-477, 2021 04.
Article in English | MEDLINE | ID: mdl-32449394

ABSTRACT

OBJECTIVE: Major life transitions, such as the arrival of a new baby, can be stressful, and therefore, costly to one's health. Being in a satisfying romantic relationship has been previously linked with better health, perhaps because it provides access to a bank of psychosocial resources. The objective of the present research was two-fold. First, we examined whether prenatal relationship satisfaction benefitted mothers' postpartum health. Second, we examined whether this association was mediated by reduced postpartum stress. Design: Pregnant women (N = 431) were drawn from a larger prospective pregnancy and birth cohort study. Main Outcome Measures: Participants reported on their relationship satisfaction, perceived stress, and perceived health at two time points: 24-26 weeks of gestation and 6 months postpartum. Results: Greater prenatal romantic satisfaction predicted enhanced perceived postpartum health, and reduced perceived postpartum stress appeared to mediate this link. Conclusion: This research demonstrates that greater prenatal relationship satisfaction is associated with better postpartum health and provides evidence for one potential mechanism for this link: the reduction of perceived postpartum stress. Thus, assessments of women's prenatal relationship satisfaction may help identify those who are at higher risk of experiencing poor postpartum health. Implications for interventions are discussed.


Subject(s)
Health Status , Interpersonal Relations , Mothers , Personal Satisfaction , Postpartum Period , Stress, Psychological , Cohort Studies , Female , Humans , Mothers/psychology , Mothers/statistics & numerical data , Postpartum Period/psychology , Pregnancy , Prospective Studies , Stress, Psychological/psychology
11.
Cytokine ; 49(1): 10-4, 2010 Jan.
Article in English | MEDLINE | ID: mdl-19783155

ABSTRACT

Most previous studies of maternal cytokines and preterm birth have analyzed immunologic biomarkers after the onset of labor or membrane rupture; fewer have examined the systemic (blood) immune response prior to labor onset. We carried out a case-control study nested in a large (n=5337) prospective, multi-center cohort. Cohort women had an interview, examination, and venipuncture at 24-26 weeks. Frozen plasma samples in women with spontaneous preterm birth (n=207) and approximately 2 term controls per case (n=444) were analyzed using Luminex multianalyte profiling technology. Fresh placentas were fixed, stained, and blindly assessed for histologic evidence of infection/inflammation, decidual vasculopathy, and infarction, and vaginal swabs were analyzed for bacterial vaginosis and fetal fibronectin concentration. High maternal matrix metalloproteinase-9 (MMP-9) concentration, but none of the other cytokines or C-reactive protein (CRP), was significantly associated with spontaneous preterm birth [adjusted OR=1.7 (1.1-2.4)] and showed a dose-response relation across quartiles. No association was observed, however, between maternal MMP-9 and placental infection/inflammation, bacterial vaginosis, or vaginal fetal fibronectin concentration. Our results require confirmation in future studies but suggest that a systemic immune response implicating MMP-9 may have an etiologic role in spontaneous preterm birth.


Subject(s)
Biomarkers/blood , C-Reactive Protein/metabolism , Cytokines/blood , Premature Birth , Adult , Case-Control Studies , Cytokines/immunology , Female , Fibronectins/metabolism , Gestational Age , Humans , Labor Onset , Matrix Metalloproteinase 9/blood , Odds Ratio , Placenta/immunology , Placenta/pathology , Pregnancy , Pregnancy Trimesters , Premature Birth/blood , Premature Birth/immunology , Prospective Studies , Vagina/chemistry , Vagina/microbiology , Young Adult
12.
Prev Med ; 50 Suppl 1: S59-64, 2010 Jan.
Article in English | MEDLINE | ID: mdl-19769996

ABSTRACT

OBJECTIVE: To determine the extent to which active transportation (AT) to and from school is associated with changes in body mass index (BMI) from kindergarten (6-year-olds) through grade 2 (8-year-olds). METHODS: The sample included 1170 children (50.4% of baseline participants) who were part of the Quebec Longitudinal Study of Child Development (QLSCD), a birth cohort established in 1998 in Quebec, Canada. Data were collected by trained interviewers using structured interviews and measuring height and weight in the home with the person most knowledgeable about the child's health. Relative weight was operationalized as age- and sex-adjusted BMI Z-scores. RESULTS: Growth curve analyses showed that using AT to and from school both when in kindergarten and in grade 1 was predictive of a lower BMI Z-score (coeff=-0.18, SE=0.09, p=0.05) in grade 1. Using AT to and from school in kindergarten, grade 1, and grade 2 was predictive of a lower BMI Z-score (coeff=-0.30, SE=0.098, p=0.003) in grade 2. No other covariates were predictive of relative weight across time, although having an overweight or obese mother was associated with a BMI Z-score of 0.39 (SE=0.07, p<0.001) across all time points. CONCLUSION: Sustained AT is associated with more healthful trajectories of BMI across the early school years.


Subject(s)
Body Mass Index , Motor Activity , Transportation/methods , Bicycling/statistics & numerical data , Child , Female , Health Status , Humans , Longitudinal Studies , Male , Motor Vehicles/statistics & numerical data , Multivariate Analysis , Overweight/epidemiology , Quebec/epidemiology , Schools/statistics & numerical data , Socioeconomic Factors , Transportation/statistics & numerical data , Walking/statistics & numerical data
13.
Paediatr Perinat Epidemiol ; 24(4): 390-7, 2010 Jul 01.
Article in English | MEDLINE | ID: mdl-20618729

ABSTRACT

During pregnancy, most maternal corticotrophin-releasing hormone (CRH) is secreted by the placenta, not the hypothalamus. Second trimester maternal CRH concentration is robustly associated with the subsequent risk of preterm birth, and it is often assumed that physiological and/or psychological stress stimulates placental CRH release. Evidence supporting the latter assumption is weak, however, and other factors affecting maternal CRH have received little attention from investigators. We carried out a case-control study nested within a large, multicentre prospective cohort of pregnant women to examine potential 'upstream' factors associated with maternal CRH concentration measured at 24-26 weeks of gestation. The predictors studied included maternal age, parity, birthplace (as a proxy for ethnic origin), pre-pregnancy body mass index, height, smoking, bacterial vaginosis and vaginal fetal fibronectin (FFN) concentration. Women with high (above the median) plasma CRH concentration were significantly less likely to have been born in Sub-Saharan Africa or the Caribbean, less likely to be overweight or obese, and more likely to be smokers. Associations with maternal birthplace and BMI persisted in logistic regression analyses controlling for potential confounding variables and when restricted to term controls. A strong (but imprecise and statistically non-significant) association was also observed with high vaginal FFN concentration. Further studies are indicated both in animal models and human populations to better understand the biochemical and physiological pathways to CRH secretion and their aetiological role, if any, in preterm birth.


Subject(s)
Corticotropin-Releasing Hormone/blood , Pregnancy Trimester, Second/blood , Adolescent , Adult , Body Height , Body Mass Index , Case-Control Studies , Ethnicity , Female , Fibronectins/analysis , Humans , Maternal Age , Parity , Pregnancy , Risk Factors , Smoking , Vaginosis, Bacterial/epidemiology , Young Adult
14.
J Obstet Gynaecol Can ; 32(4): 313-320, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20500937

ABSTRACT

OBJECTIVE: Vaginal douching and bacterial vaginosis (BV) are independently associated with spontaneous preterm birth. Because the interrelationships among these variables remain unclear, we sought to examine the associations in a prospective study. METHODS: We conducted a nested case-control study within a prospectively recruited cohort of pregnant women. We prospectively collected demographic and health status data, data on pre-pregnancy vaginal douching, vaginal smears for bacterial vaginosis as defined by Nugent's criteria, fetal fibronectin at 26 weeks of pregnancy, and placental pathology at delivery. Spontaneous preterm births before 37 weeks' gestation were selected as cases. All spontaneous births occurring after 37 weeks were potential control subjects. To limit costs, some tests were performed only in selected control subjects. RESULTS: Preterm birth occurred in 207 of 5092 women (4.1%). In bivariate analysis, BV was not associated with preterm birth (OR 1.2; 95% CI 0.5 to 2.4). Vaginal douching was significantly associated with bacterial vaginosis (P < 0.05) and preterm birth (P < 0.05). On multivariate analysis, vaginal douching was no longer associated with preterm birth, but a significant association with early preterm birth < 34 weeks (OR, 6.9; 95% CI 1.7 to 28.2) and preterm birth due to preterm labour (OR 3.0; 95% CI 1.1 to 8.5) persisted after controlling for the presence of bacterial vaginosis and placental inflammation. CONCLUSION: Vaginal douching and bacterial vaginosis were not associated with spontaneous preterm birth overall. However, vaginal douching appears to be an independent and potentially modifiable risk factor for early preterm birth (32-34 weeks), although the mechanism remains unclear.


Subject(s)
Premature Birth/epidemiology , Vaginal Douching/adverse effects , Vaginosis, Bacterial/epidemiology , Adult , Case-Control Studies , Female , Humans , Multivariate Analysis , Obstetric Labor, Premature/epidemiology , Pregnancy , Prospective Studies , Risk Factors
15.
Am J Epidemiol ; 169(11): 1319-26, 2009 Jun 01.
Article in English | MEDLINE | ID: mdl-19363098

ABSTRACT

The authors investigated a large number of stressors and measures of psychological distress in a multicenter, prospective cohort study of spontaneous preterm birth among 5,337 Montreal (Canada)-area women who delivered from October 1999 to April 2004. In addition, a nested case-control analysis (207 cases, 444 controls) was used to explore potential biologic pathways by analyzing maternal plasma corticotrophin-releasing hormone (CRH), placental histopathology, and (in a subset) maternal hair cortisol. Among the large number of stress and distress measures studied, only pregnancy-related anxiety was consistently and independently associated with spontaneous preterm birth (for values above the median, adjusted odds ratio = 1.8 (95% confidence interval: 1.3, 2.4)), with a dose-response relation across quartiles. The maternal plasma CRH concentration was significantly higher in cases than in controls in crude analyses but not after adjustment (for concentrations above the median, adjusted odds ratio = 1.1 (95% confidence interval: 0.8, 1.6)). In the subgroup (n = 117) of participants with a sufficient maternal hair sample, hair cortisol was positively associated with gestational age. Neither maternal plasma CRH, hair cortisol, nor placental histopathologic features of infection/inflammation, infarction, or maternal vasculopathy were significantly associated with pregnancy-related anxiety or any other stress or distress measure. The biologic pathways underlying stress-induced preterm birth remain poorly understood.


Subject(s)
Corticotropin-Releasing Hormone/blood , Premature Birth/metabolism , Premature Birth/psychology , Stress, Psychological/complications , Adult , Biomarkers/blood , Case-Control Studies , Female , Fetal Membranes, Premature Rupture/blood , Fetal Membranes, Premature Rupture/psychology , Humans , Hydrocortisone/metabolism , Pregnancy , Principal Component Analysis , Prospective Studies , Risk Factors , Social Support , Socioeconomic Factors , Stress, Psychological/epidemiology , Ultrasonography, Prenatal
16.
Epidemiology ; 20(5): 707-13, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19568173

ABSTRACT

BACKGROUND: Neither macro- nor micronutrient supplements have been clearly demonstrated to reduce the risk of preterm birth. However, there has been little attention to carotenoids, tocopherols, and long-chain fatty acids other than n-3 polyunsaturates. METHODS: We conducted a case-control study nested in a large (n = 5337) prospective, multicenter cohort. All cohort women had an interview, examination, and venipuncture at 24-26 weeks' gestation. Frozen plasma samples in spontaneous preterm births (n = 207) and approximately 2-term controls per case (n = 443) were analyzed for carotenoids, retinol, tocopherols, and long-chain fatty acids. Fresh placentas were fixed, stained, and assessed (without knowledge of pregnancy outcome) for histologic evidence of infection or inflammation, decidual vasculopathy, and infarction. RESULTS: High (above the median) plasma concentrations of alpha- and beta-carotene, alpha- and beta-cryptoxanthin, and lycopene were all associated with reductions in risk of spontaneous preterm birth, with evidence of dose-response effects across quartiles. Modest increases in risk were observed with elevated total monounsaturated, total polyunsaturated, and total n-6 polyunsaturated long-chain fatty acids concentrations. Paradoxically, a high gamma-tocopherol concentration was associated with increased preterm birth risk (adjusted odds ratio = 1.8 [95% confidence interval = 1.2-2.6]). Only one of the studied micronutrients (lutein) was independently associated with a reduced risk of decidual vasculopathy (0.5 [0.3-0.9]). CONCLUSIONS: Carotenoids and long-chain fatty acids warrant further investigation in in vitro, animal, and human studies of preterm birth.


Subject(s)
Antioxidants/analysis , Fatty Acids/blood , Pregnancy Complications/epidemiology , Premature Birth/epidemiology , Vitamins/blood , Adult , Case-Control Studies , Female , Humans , Pregnancy , Prospective Studies , Quebec/epidemiology , Young Adult
17.
Am J Obstet Gynecol ; 200(2): 151.e1-9; discussion e1-5, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19070828

ABSTRACT

OBJECTIVE: We sought to evaluate the association between inherited thrombophilia and preeclampsia. STUDY DESIGN: From a multicenter cohort of 5337 pregnant women, we prospectively identified 113 women who developed preeclampsia and selected 443 control subjects who did not have preeclampsia or nonproteinuric gestational hypertension. Blood samples were tested for DNA polymorphisms affecting thrombophilia (factor V Leiden mutation, prothrombin G20210A mutation, methylenetetrahydrofolate reductase C677T polymorphism), homocysteine, and folate levels, and placentae underwent pathological evaluation. RESULTS: Thrombophilia was present in 14% of patients and 21% of control subjects (adjusted logistic regression odds ratio, 0.6; 95% confidence interval, 0.3-1.3). Placental underperfusion was present in 63% of patients vs 46% of control subjects (P < .001) and was more frequent in women with folate levels in the lowest quartile (P = .04), but was not associated with thrombophilia. CONCLUSION: We did not find evidence to support an association between inherited thrombophilia and increased risk of preeclampsia. Placental underperfusion is associated with preeclampsia, but this does not appear to be consequent to thrombophilia.


Subject(s)
Pre-Eclampsia/etiology , Thrombophilia/complications , Adult , Case-Control Studies , Cohort Studies , Female , Humans , Placenta/blood supply , Placenta Diseases/etiology , Pregnancy , Prospective Studies , Quebec , Thrombophilia/genetics , Young Adult
18.
Paediatr Perinat Epidemiol ; 23(4): 301-9, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19523077

ABSTRACT

Selective study participation can theoretically lead to selection bias. We explored this issue in the context of a multicentre cohort study of socio-economic disparities in preterm birth. Women with singleton pregnancies were recruited from four large Montreal maternity hospitals and invited to return for an interview, vaginal examination and venepuncture at 24-26 weeks of gestation. We compared the observed preterm birth rate (ultrasound confirmed) among the 5146 cohort women to that expected based on all 108 724 Montreal Census Metropolitan Area (CMA) singleton births for 1998-2000. The observed preterm birth rate in the study cohort was 5.1%, compared with 6.3% in the CMA (P < 0.001) (unadjusted morbidity ratio [95% CI] = 0.80 [0.71, 0.90]). Within each stratum of maternal education and neighbourhood income (the latter based on postal code matched links to the 2001 Canadian census), cohort women had substantially lower rates of preterm birth than women from the CMA. No significant association between socio-economic status (SES) and preterm birth was observed in the study cohort, except among 'indicated' (non-spontaneous) cases. The association between neighbourhood income and preterm birth was biased to the null in the study cohort, with adjusted odds ratios in the poorest vs. richest quintiles of 1.01 [0.63, 1.64] in the cohort vs. 1.28 [1.18, 1.39] in the CMA, although no such bias was observed for the association with maternal education assessed at the individual level. We speculate that the lower-than-expected preterm birth rate and attenuated association between neighbourhood income and preterm birth may be related to selective participation by women more psychologically invested in their pregnancies. Investigators should consider the potential for biased associations in pregnancy/birth cohort studies, especially associations based on SES or race/ethnicity, and carry out sensitivity analyses to gauge their effects.


Subject(s)
Pregnancy Outcome/epidemiology , Premature Birth/epidemiology , Adolescent , Adult , Cohort Studies , Female , Gestational Age , Humans , Infant, Newborn , Infant, Premature , Patient Selection/ethics , Pregnancy , Selection Bias , Socioeconomic Factors , Young Adult
19.
BMJ Paediatr Open ; 3(1): e000568, 2019.
Article in English | MEDLINE | ID: mdl-31909223

ABSTRACT

BACKGROUND: Health and well-being are better, on average, in countries that are more equal, but less is known about how this benefit is distributed across society. Height is a widely used, objective indicator of child health and predictor of lifelong well-being. We compared the level and slope of social gradients in children's height in high-income countries with different levels of income inequality, in order to investigate whether children growing up in all socioeconomic circumstances are healthier in more equal countries. METHODS: We conducted a coordinated analysis of data from five cohort studies from countries selected to represent different levels of income inequality (the USA, UK, Australia, the Netherlands and Sweden). We used standardised methods to compare social gradients in children's height at age 4-6 years, by parent education status and household income. We used linear regression models and predicted height for children with the same age, sex and socioeconomic circumstances in each cohort. RESULTS: The total analytic sample was 37 063 children aged 4-6 years. Gradients by parent education and household income varied between cohorts and outcomes. After adjusting for differences in age and sex, children in more equal countries (Sweden, the Netherlands) were taller at all levels of parent education and household income than children in less equal countries (USA, UK and Australia), with the greatest between-country differences among children with less educated parents and lowest household incomes. CONCLUSIONS: The study provides preliminary evidence that children across society do better in more equal countries, with greatest benefit among children from the most disadvantaged socioeconomic groups.

20.
J Epidemiol Community Health ; 59(1): 42-8, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15598725

ABSTRACT

STUDY OBJECTIVES: To examine the unique impact of financial difficulties as measured by a lack of money for basic needs on the occurrence of health problems between the ages of 17 and 29 months, controlling for mother's level of education and neonatal health problems. DESIGN AND PARTICIPANTS: Analyses were performed on the 29 month data of the Quebec longitudinal study of child development. This longitudinal study followed up a birth cohort annually. Interviews were conducted in the home with the mother in 98.8% of cases. This information was supplemented with data from birth records. At 29 months, the response rate was 94.2% of the initial sample (n = 1946). The main outcome measures were mothers' report of acute health problems, asthma episodes, and hospitalisation as well as growth delay and a composite index of health problems (acute problems, asthma attack, growth delay). MAIN RESULTS: Children raised in a family experiencing a serious lack of money for basic needs during the preceding year were more likely to be reported by their mothers as presenting acute health problems, a growth delay, two or more health problems, and to have been hospitalised for the first time within the past few months as compared with babies living in a family not experiencing a lack of money for basic needs regardless of the mother's level of education and of neonatal health problems. CONCLUSION: Financial difficulties as measured by a lack of money for basic needs have a significant and unique impact on toddlers' health.


Subject(s)
Health Status , Income/statistics & numerical data , Infant Mortality , Acute Disease , Asthma/epidemiology , Child Development , Child, Preschool , Educational Status , Epidemiologic Methods , Female , Hospitalization/statistics & numerical data , Humans , Infant , Male , Morbidity , Mothers , Quebec/epidemiology
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