ABSTRACT
While online working seems to have become more common since the start of the Covid-19 pandemic, social media has the potential to offer greater interactivity and networking capacities. Thus it seems relevant for the IRPA Young Generation Network to investigate the use of social media by members of the young generation in radiation protection (RP) through an online survey. It was also the opportunity to collect early feedback about on-line learning. The survey received 89 answers from 15 countries. The most commonly used social media platforms were first Facebook, then LinkedIn and Twitter, but other social media were reported. The respondents have a multi-objectives approach while on social media, using it for different purposes (chiefly for sharing news and RP related information/educational material) and different audiences (e.g. public, professional). Yet, they are making a very moderate use based on the frequencies of publication and consultation and the challenges they see in social media. The survey also collected the view of the young generation about their practical experience in learning in a virtual setting and its advantages and disadvantages vs. in-person learning. Most participants expressed mixed-feelings about on-line learning. The results show that the young generation can play a role in supporting the extra- and intra-communication activities of the RP community.
Subject(s)
COVID-19 , Education, Distance , Radiation Protection , Social Media , COVID-19/epidemiology , Dreams , Humans , PandemicsABSTRACT
This study was conducted to find out characteristics of trace element levels and those impacts to organisms at a former uranium (U) mining site. Concentrations of trace elements (Li, Mg, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, Cs, Ba, Pb, Bi, and U) were determined in sediments, water, and three organism types (insects, frogs, and newts) from three zones in the former U mining site, Ningyo-toge in Japan. Concentrations of As and U in the sediments and water samples were the highest at the mill tailings pond (MP) site, where post-U extraction remnants have been accumulated. Additionally, among the organisms analyzed the highest concentrations of these elements/isotopes were found in newts from MP. Considering data analyses of the whole-body element concentrations, bioaccumulation factors, and δ15N values for the organisms, it was concluded that newts might be the most vulnerable species in this location. Further monitoring and more accurate evaluation of the ecological impacts are preferred for this former U mining site.
Subject(s)
Trace Elements , Uranium , Environment , Environmental Monitoring , Japan , Mining , Trace Elements/analysis , Uranium/analysis , Water/analysisABSTRACT
The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000â Bq/m3 for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000â Bq/m3 for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function.
ABSTRACT
Following the Fukushima Daiichi Nuclear Power Plant accident in 2011, many radiation experts directly experienced a vast gap between ideal and real public understanding (PU) of radiation in risk communication. Therefore, this study collated and reviewed information about PU activities for radiation and its risk that six Japanese academic societies-which seem to be socially neutral expert communities-related to radiation and radiation risk conducted before and after the accident. Activities these radiation-related societies provided to the general public were discussed from the following perspectives: (a) difficulties in two-way communication due to resources, motivation and public interest and concerns; (b) balance between academic research and PU activities; (c) academic societies' building trust with the public while ensuring member experts' neutrality and independence; and (d) discussions among academic societies to prepare for public engagement. We hope that this paper encourages experts and academic societies in radiation protection to hold more national and international discussions about their roles in public communication and outreach.
Subject(s)
Fukushima Nuclear Accident , Radiation Protection , Communication , Japan , Nuclear Power PlantsABSTRACT
Potentially higher cancer risk due to exposure from natural background radiation was indicated for the Bangladeshi population by estimations based on the countrywide study. Several regions with elevated natural background exhibited higher soil radium and thorium contents than the world average. Being the decay products of these radioactive elements, natural radon isotopes could constitute environmental risk factors for internal radiation exposure to the lungs of people living in these areas. Although lung cancer is one of the most prevalent types of cancer in Bangladesh, its status and features are still unclear. To clarify the present status of one of the potential risk factors for lung cancer in the country, this review intends to ascertain the countrywide radon exposure, and its pathways by types of local dwelling and by regions, which would provide an indication of the internal exposures in areas of elevated natural background radiation and radionuclides of soil as well as an understanding of the preliminary contribution of environmental radon on the country's lung cancer prevalence. In this review, countrywide monitored air radon exposures for Bangladeshi dwellings and workplaces are organized from peer-reviewed published papers. Radon has been identified as one of influential sources of radiation dose in Bangladesh with its higher radon exhalation and emanation rate from soil. A novel nationwide depiction of the overall assessed indoor and soil radon levels for Bangladesh has been made through radiation maps. This would be helpful for designing future systematic radon/radiological monitoring and research on the country's lung cancer prevalence.
Subject(s)
Air Pollutants, Radioactive , Air Pollution, Indoor , Radiation Monitoring , Radon , Air Pollutants, Radioactive/analysis , Air Pollution, Indoor/analysis , Background Radiation , Humans , Radon/analysisABSTRACT
Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.
Subject(s)
Radon/administration & dosage , Administration, Inhalation , Animals , Brain/metabolism , Brain/radiation effects , Glutathione/blood , Glutathione/metabolism , Kidney/metabolism , Kidney/radiation effects , Lipid Peroxides/blood , Lipid Peroxides/metabolism , Liver/metabolism , Liver/radiation effects , Lung/metabolism , Lung/radiation effects , Male , Mice, Inbred BALB C , Oxidative Stress , Pancreas/metabolism , Pancreas/radiation effects , Superoxide Dismutase/blood , Superoxide Dismutase/metabolismABSTRACT
The purpose of this study is to investigate the biokinetics of inhaled radon, radon activity concentrations in mouse tissues and organs were determined after mice had been exposed to about 1 MBq/m3 of radon in air. Radon activity concentrations in mouse blood and in other tissues and organs were measured with a liquid scintillation counter and with a well-type HP Ge detector, respectively. Radon activity concentration in mouse blood was 0.410 ± 0.016 Bq/g when saturated with 1 MBq/m3 of radon activity concentration in air. In addition, average partition coefficients obtained were 0.74 ± 0.19 for liver, 0.46 ± 0.13 for muscle, 9.09 ± 0.49 for adipose tissue, and 0.22 ± 0.04 for other organs. With these results, a value of 0.414 for the blood-to-air partition coefficient was calculated by means of our physiologically based pharmacokinetic model. The time variation of radon activity concentration in mouse blood during exposure to radon was also calculated. All results are compared in detail with those found in the literature.
Subject(s)
Air Pollutants, Radioactive/metabolism , Radiation Monitoring , Radon/metabolism , Air Pollutants, Radioactive/blood , Animals , Kinetics , Mice , Radon/bloodABSTRACT
The impacts of mathematical models and associated parameters on radon (222Rn) and thoron (220Rn) exhalation rates based on in-situ testing at building interior solid walls were demonstrated to improve data analysis techniques. The results showed that the heterogeneity of their activity concentrations within the measurement system was more significant for thoron than radon. The diurnal variation in indoor radon should be considered for better data quality. In conclusion, a model should be appropriately made and selected under the purposes and accuracy requirements of the exhalation test.
ABSTRACT
Beryllium-7 activity concentrations in the atmosphere and precipitation were continuously measured every day between April 2011 and December 2015 in Dazaifu, western Japan. The measured data were quantitatively analyzed to determine the precipitation-induced variation in 7Be activity concentrations. The average concentrations on nonprecipitation and precipitation days were 5.5 and 3.8 mBq/m3, respectively. This difference of 31% (1.7 mBq/m3) on average, was attributable to the washout effect, which was more significant in the summer. Regarding the association between 7Be activity concentration and precipitation, the concentration remained at a similar level for the small precipitation amount of <5.0 mm/day and showed a decreasing trend (but was insignificant) for the precipitation of 5.0-10.0 mm/day. A significant decrease in the concentration was observed for ≥10 mm/day. Furthermore, when precipitation occurred on two successive days, the 7Be activity concentrations on the second day significantly decreased regardless of precipitation.
Subject(s)
Air Pollutants, Radioactive , Atmosphere , Beryllium , Radiation Monitoring , Beryllium/analysis , Japan , Radiation Monitoring/methods , Air Pollutants, Radioactive/analysis , Atmosphere/chemistry , Radioisotopes/analysis , Rain/chemistry , SeasonsABSTRACT
This paper provides absorbed doses arising from radon gas in air retained in lung airway lumens. Because radon gas exposure experiments often use small animals, the calculation was performed for mice and rats. For reference, the corresponding computations were also done for humans. Assuming that radon concentration in airway lumens is the same as that in the environment, its progeny's production in and clearance from airways were simulated. Absorbed dose rates were obtained for three lung regions and the whole lung, considering that secretory and basal cells are sensitive to radiation. The results showed that absorbed dose rates for all lung regions and whole lung generally increase from mice to rats to humans. For example, the dose rates for the whole lung were 25.4 in mice, 41.7 in rats, and 59.9 pGy (Bq m⻳)⻹ h⻹ in humans. Furthermore, these values were also compared with lung dose rates from two other types of exposures, that is, due to inhalation of radon or its progeny, which were already reported. It was confirmed that the direct inhalation of radon progeny in the natural environment, which is known as a cause of lung cancer, results in the highest dose rates for all species. Based on the present calculations, absorbed dose rates of the whole lung from radon gas were lower by a factor of about 550 (mice), 200 (rats), or 70 (humans) than those from radon progeny inhalation. The calculated dose rate values are comparatively small. Nevertheless, the present study is considered to contribute to our understanding of doses from inhalation of radon and its progeny.
Subject(s)
Lung/metabolism , Models, Biological , Radon/pharmacokinetics , Absorption , Administration, Inhalation , Animals , Humans , Mice , Radiation Dosage , Radon/administration & dosage , RatsABSTRACT
Biological response of exposure to radon progeny has long been investigated, but there are only few studies in which absorbed doses in lungs of laboratory animals were estimated. The present study is the first attempt to calculate the doses of inhaled radon progeny for mice. For reference, the doses for rats and humans were also computed with the corresponding models. Lung deposition of particles, their clearance, and energy deposition of alpha particles to sensitive tissues were systematically simulated. Absorbed doses to trachea and bronchi, bronchioles and terminal bronchioles, alveolar-interstitial regions, and whole lung were first provided as a function of monodisperse radon progeny particles with an equilibrium equivalent radon concentration of 1 Bq m(-3) (equilibrium factor, 0.4 and unattached fraction, 0.01). Based on the results, absorbed doses were then calculated for (1) a reference mine condition and (2) a condition previously used for animal experiments. It was found that the whole lung doses for mice, rats, and humans were 34.8, 20.7, and 10.7 nGy (Bq m(-3))(-1) h(-1) for the mine condition, respectively, while they were 16.9, 9.9, and 6.5 nGy (Bq m(-3))(-1) h(-1) for the animal experimental condition. In both cases, the values for mice are about 2 times higher than those for rats, and about 3 times higher than those for humans. Comparison of our data on rats and humans with those published in the literature shows an acceptable agreement, suggesting the validity of the present modeling for mice. In the future, a more sophisticated dosimetric study of inhaled radon progeny in mice would be desirable to demonstrate how anatomical, physiological, and environmental parameters can influence absorbed doses.
Subject(s)
Lung/metabolism , Models, Biological , Radiation Dosage , Radon/pharmacokinetics , Animals , Female , Humans , Inhalation , Male , Mice, Inbred BALB C , Middle Aged , Particle Size , Rats, Long-EvansABSTRACT
Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
Subject(s)
Acute Kidney Injury/prevention & control , Carbon Tetrachloride Poisoning/complications , Kidney/pathology , Radon/therapeutic use , alpha-Tocopherol/therapeutic use , Acute Kidney Injury/etiology , Acute Kidney Injury/pathology , Animals , Antioxidants/therapeutic use , Carbon Tetrachloride/toxicity , Carbon Tetrachloride Poisoning/drug therapy , Carbon Tetrachloride Poisoning/pathology , Disease Models, Animal , Female , Glomerular Filtration Rate/drug effects , Kidney/drug effects , Kidney/physiopathology , Mice , Mice, Inbred ICR , Treatment OutcomeABSTRACT
In March 2013, increased 7Be activity concentrations in the atmosphere were observed for successive days in Dazaifu, western Japan. The daily 7Be activity concentration ranged from 0.93 to 14 mBq/m3, with a monthly average of 8.3 mBq/m3. This average was the highest among the monthly averages observed between 1999 and 2015, and higher than the monthly average over this period (4.7 mBq/m3) plus twice the standard deviation. Also, this exceeded the monthly average (6.0 mBq/m3) only for March 1999-2015 (excluding 2013, when the cosmic-ray intensity, a component producing 7Be, decreased). Based on the backward trajectory analysis etc. results, the inflow of air from the stratosphere and upper troposphere at high latitudes that frequently occurred in March 2013 was considered the reason for the 7Be activity concentration increase.
Subject(s)
Atmosphere , Beryllium , Beryllium/analysis , JapanABSTRACT
Therapy using hot springs, including the high-level radioactive gas "radon", is traditionally conducted as an alternative treatment for various diseases. Oxidative-stress-related diseases are inhibited by the enhancement of antioxidative functions following radon inhalation. We have reported that radon inhalation increased the level of anti-oxidants, such as glutathione (G-SH), in the brain and had a protective antioxidative effect against transient global cerebral ischemic injury. However, no studies have yet revealed the changes in G-SH associated substances after radon inhalation. In this study, we comprehensively analyzed several metabolites, focusing on G-SH. Mice were exposed to radon at concentrations of 200, 2000, or 20,000 Bq/m3 for 1, 3, or 10 days. We detected 27 metabolites in the mouse brains. The result showed that the L-methionine levels increased, whereas the levels of urea, glutathione, and sulfite ion decreased under any condition. Although the ratio of G-SH to oxidized glutathione (GS-SG) decreased, glutathione monosulfide (G-S-SH) and cysteine monosulfide (Cys-S-SH) increased after radon inhalation. G-S-SH and Cys-S-SH can produce a biological defense against the imbalance of the redox state at very low-dose irradiation following radon inhalation because they are strong scavengers of reactive oxygen species. Additionally, we performed an overall assessment of high-dimensional data and showed some specific characteristics. We showed the changes in metabolites after radon inhalation using partial least squares-discriminant analysis and self-organizing maps. The results showed the health effects of radon, especially the state of sulfur-related metabolites in mouse brains under the exposure conditions for radon therapy.
Subject(s)
Brain , Radon , Sulfur , Administration, Inhalation , Animals , Antioxidants/metabolism , Brain/metabolism , Glutathione/metabolism , Mice , Radon/metabolism , Radon/therapeutic use , Sulfur/metabolismABSTRACT
In specific situations such as bathing in a radon spa, where the radon activity concentration in thermal water is far higher than that in air, it has been revealed that radon uptake via skin can occur and should be considered for more precise dose evaluation. The primary aim of the present study was to numerically demonstrate the distribution as well as the degree of diffusion of radon in the skin, with a focus on its surface layer (i.e., stratum corneum). We developed a biokinetic model that included diffusion theory at the stratum corneum, and measured radon solubility in that tissue layer as a crucial parameter. The implementation of the model suggested that the diffusion coefficient in the stratum corneum was as low as general radon-proof sheets. After a 20-min immersion in water, the simulated depth profile of radon in the skin showed that the radon activity concentration at the top surface skin layer was approximately 103 times higher than that at the viable skin layer. The information on the position of radon as a radiation source would contribute to special dose evaluation where specific target cell layers are assumed for the skin.
Subject(s)
Radon , Diffusion , Skin , Skin Absorption , Solubility , WaterABSTRACT
Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m3 thoron inhalation was lower than that after 500 Bq/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m3 was more effective than that at 2000 Bq/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.
Subject(s)
Antioxidants , Ascorbic Acid , Liver Diseases, Alcoholic , Radon , Administration, Inhalation , Alanine Transaminase/metabolism , Animals , Antioxidants/administration & dosage , Antioxidants/pharmacology , Ascorbic Acid/administration & dosage , Ascorbic Acid/pharmacology , Aspartate Aminotransferases , Catalase/metabolism , Ethanol/toxicity , Glutathione/metabolism , Liver Diseases, Alcoholic/prevention & control , Mice , Radon/administration & dosageABSTRACT
No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
Subject(s)
Lead Radioisotopes/analysis , Nicotiana/chemistry , Potassium Radioisotopes/analysis , Smoking , Alcohol Drinking , Humans , Inhalation Exposure , Monte Carlo MethodABSTRACT
The particle size distributions of airborne aerosols with 7Be were measured using cascade impactors at Dazaifu, a city in western Japan, in 2018 to observe their seasonal variation. Beryllium-7 was found to be adsorbed to aerosols with a particle size of less than 2.1 µm; in general, particles sized 0.43-0.65 µm had the highest 7Be activity concentrations. The activity median aerodynamic diameter (AMAD) of 7Be fluctuated less over the year within the range of 0.40-0.52 µm, which is the size range of particles that can reach human alveoli, and had an annual mean of 0.43 ± 0.034 µm. The activity concentrations of 7Be were significantly lower in summer, which affected 7Be activity concentration for each particle size fraction. The particle size distribution of 7Be-carrying aerosols was also affected by that of the aerosol particles in the atmosphere. Finally, findings suggest that 7Be was mainly adsorbed to sulfate aerosols (particularly ammonium sulfate aerosols).
Subject(s)
Air Pollutants, Radioactive , Radiation Monitoring , Aerosols/analysis , Air Pollutants, Radioactive/analysis , Atmosphere , Humans , Japan , Particle SizeABSTRACT
It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances as there are a number of uncertainties in terms of related parameters such as activity concentrations in air and water, target cells in skin, skin covering materials, and deposition velocities. An interesting proposal has emerged in that skin exposure to natural radon-rich thermal water as part of balneotherapy can produce an immune response to induce beneficial health effects. The goal of this study was to obtain generic dose coefficients with a focus on the radon progeny deposited on the skin in air or water in relation to risk or treatment assessments. We thus first estimated the skin deposition velocities of radon progeny in air and thermal water based on data from the latest human studies. Skin dosimetry was then performed under different assumptions regarding alpha-emitting source position and target cell (i.e. basal cells or Langerhans cells). Furthermore, the impact of the radon progeny deposition on effective doses from all exposure pathways relating to 'radon exposure' was assessed using various possible scenarios. It was found that in both exposure media, effective doses from radon progeny inhalation are one to four orders of magnitude higher than those from the other pathways. In addition, absorbed doses on the skin can be the highest among all pathways when the radon activity concentrations in water are two or more orders of magnitude higher than those in air.
Subject(s)
Air , Radiometry , Radon Daughters/analysis , Skin/radiation effects , Temperature , Water , Alpha Particles , Dose-Response Relationship, Radiation , Epidermis/radiation effects , Radiation ExposureABSTRACT
Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.