ABSTRACT
OBJECTIVE/AIM: The aim of this report was to investigate the effect of ventriculoperitoneal shunt insertion for the treatment of hydrocephalus on thyroid hormones in the first 3 months of life. METHODS: Thyroid-stimulating hormone (TSH), free T3 (fT3), and free T4 (fT4) levels were compared at 7 days (preoperatively) and at 30 and 90 days (postoperatively) after birth between 25 ventriculoperitoneal shunt-inserted hydrocephalic newborns and 20 healthy newborns. RESULTS: The TSH level at 7 days was higher in the hydrocephalic patient group (6.33 µIU) compared to the control group (3.76 µIU). This value was significantly decreased at 90 days in the ventriculoperitoneal shunt-inserted newborns (2.35 µIU) compared to the control group (3.33 µIU; p < 0.05). There were no significant differences between time points for fT4 and fT3 values in the patient group or for TSH, fT4, and fT3 values in the control group. CONCLUSION: We propose that a ventriculoperitoneal shunt inserted in the early period of life may have beneficial effects on thyroid hormones.
Subject(s)
Hydrocephalus/blood , Hydrocephalus/surgery , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/blood , Ventriculoperitoneal Shunt/trends , Female , Follow-Up Studies , Humans , Hydrocephalus/diagnosis , Infant , Infant, Newborn , Male , Thyroid Hormones/bloodABSTRACT
The aim of this study is to determine the effects of L-asparaginase (L-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the L-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the L-ASP-only groups. CSs and L-ASP were significantly effective in liver necrosis, L-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or L-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered.
Subject(s)
Antineoplastic Agents/adverse effects , Hypolipidemic Agents/pharmacology , Lipids/blood , Liver/drug effects , Pancrelipase/drug effects , Adrenal Cortex Hormones/adverse effects , Animals , Asparaginase/adverse effects , Drug Combinations , Female , Gemfibrozil/pharmacology , Male , Mice , Mice, Inbred BALB C , Models, Animal , Prednisolone/adverse effectsABSTRACT
Deep venous thrombosis is an extremely rare cause of acute abdomen and is often difficult to diagnose. Protein C and protein S deficiencies are rare genetic abnormalities that predispose the patient to thrombophilia and lead to thrombosis. We report the case of a previously healthy 7-year-old boy with iliofemoral thrombosis due to protein C and protein S deficiencies mimicking acute abdomen.
Subject(s)
Abdomen, Acute/etiology , Protein C Deficiency/diagnosis , Protein S Deficiency/diagnosis , Venous Thrombosis/diagnosis , Child , Diagnosis, Differential , Humans , Male , Protein C Deficiency/complications , Protein S Deficiency/complications , Ultrasonography, Doppler, Color , Venous Thrombosis/etiologyABSTRACT
OBJECTIVE: The peptide hormones ghrelin and leptin have been found in blood and breast milk. This study was undertaken to investigate whether breast milk also contains obestatin, which is derived from the same gene as ghrelin but has opposite actions, and to characterize the relations among serum and milk ghrelin, obestatin, and leptin levels in lactating mothers. METHODS: Venous blood, colostrum, and mature milk were obtained from healthy lactating women (n = 31) just before suckling. The ghrelin and obestatin concentrations were determined by radioimmunoassay. Leptin levels were measured by enzyme-amplified sensitivity immunoassay. RESULTS: Obestatin levels in colostrum (538.9 pg/mL) and mature milk (528.5 pg/mL) were more than twice the corresponding blood levels (270.3 and 289.4 pg/mL, respectively). In contrast, leptin levels in colostrum (2.01 ng/mL) and mature milk (2.04 ng/mL) were more than five-fold lower than the corresponding blood levels (11.54 ng/mL). There was no correlation between breast milk ghrelin levels and leptin (r = -0.18, P > 0.05). However, there was a positive correlation between leptin levels in breast milk and blood (r = 0.369, P < 0.05). CONCLUSION: The origin of milk obestatin is not currently known, but it comes from the blood or breast and may drain through the mammary glands into the milk. Ghrelin, obestatin, and leptin in the milk may directly affect appetite and their levels may be related to the regulation of energy balance and the pathogenesis of obesity.
Subject(s)
Ghrelin/analysis , Lactation/metabolism , Leptin/analysis , Milk, Human/chemistry , Peptide Hormones/analysis , Adult , Colostrum/chemistry , Female , Ghrelin/blood , Humans , Lactation/blood , Leptin/blood , Peptide Hormones/blood , Postpartum PeriodABSTRACT
The present study was performed to determine the prevalence of metabolic syndrome (MS) and its risk factors in obese children and adolescents. The study included 352 obese children and adolescents (body mass index [BMI] > or = 95th percentile) aged between 2 and 19 years. The diagnosis of MS was made according to the criteria adapted from the World Health Organization (WHO) and the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. BMI z-scores were calculated to assess the degree of obesity. The prevalence of MS and risk factors were determined. Determinants of MS were examined using regression analysis. The prevalence of MS was 41.8%. The age at onset of obesity, sedentary life-span, fasting blood levels of glucose, insulin, triglyceride, very-low-density lipoprotein (VLDL) cholesterol, and alanine aminotransferase (ALT) were higher, while levels of high-density lipoprotein (HDL) cholesterol and the number of actively spent hours were lower in cases with MS (p < 0.05). The most important determinant of MS was BMI z-score (r = 0.31, p < 0.0001). A one-point increase in BMI z-score yielded a 2-fold increase in the prevalence of MS. The prevalence of MS increased from 27.6% to 60.7% when the BMI z-score increased from 2.3 to 3.3. The risk of developing MS was 2.6-fold higher in cases with BMI z-score > 3 when compared to those with z-scores between 2 and 3. The results from this study indicate that, although the correlation between MS and the BMI z-score was weak, the BMI z-score may be an effective parameter in identifying obese children and adolescents at risk for MS. Screening the cases with BMI z-scores > or = 2 for MS is important for establishing an early diagnosis.
Subject(s)
Metabolic Syndrome/epidemiology , Metabolic Syndrome/etiology , Obesity/complications , Adolescent , Body Mass Index , Cardiovascular Diseases/etiology , Child , Child, Preschool , Diabetes Mellitus, Type 2/complications , Female , Humans , Male , Prevalence , Risk Factors , Young AdultABSTRACT
OBJECTIVES: The aim of this study was to investigate the relationship between the varying degrees of obesity and blood glucocorticoid levels in obese children and adolescents with and without metabolic syndrome features. METHODS: We studied 241 obese children and adolescents aged between 2 and 17.6 years; 127 boys and 114 girls. All children underwent an oral glucose tolerance test. Measurements included blood pressure, cortisol, ACTH, and lipid profiles. The diagnosis of metabolic syndrome was defined according to the criteria adapted from World Health Organisation and National Cholesterol Education Program Adult Treatment Panel-III guidelines. RESULTS: Blood cortisol and ACTH levels were higher in patients with MS than without MS (p = 0.02). ACTH levels increased with weight (r = 0.13, p = 0.02), systolic blood pressure (r = 0.21, p = 0.002), diastolic blood pressure (r = 0.17, p = 0.01), fasting glucose (r = 0.17, p = 0.01). Cortisol production was only correlated with systolic blood pressure (r = 0.12, p = 0.05). CONCLUSIONS: Results from the present study indicates that there may be a link between cortisol production and the metabolic syndrome in obese children and adolescents.
Subject(s)
Hydrocortisone/blood , Metabolic Syndrome/blood , Obesity/blood , Adolescent , Adrenocorticotropic Hormone/blood , Blood Pressure/physiology , Child , Child, Preschool , Female , Humans , Lipids/blood , Male , Metabolic Syndrome/physiopathology , Obesity/physiopathology , Risk FactorsABSTRACT
BACKGROUND/AIM: Ghrelin has effects on nutrient intake and growth. The cause of growth retardation in congenital heart disease is multifactorial. The aim of the present study is to investigate the ghrelin in congenital heart disease and the association of ghrelin with TNF-alpha and IL-6. Materials and methods. We measured serum ghrelin, TNF-alpha, and IL-6 levels using specific immunoassay in 68 patients (47 acyanotic, 21 cyanotic with congenital heart disease) and in 25 control subjects. Results. In comparison to controls, serum ghrelin, TNF-alpha levels were significantly higher in acyanotic patients and cyanotic patients with congenital heart disease (P<.0001). In acyanotic and cyanotic patients with congenital heart disease, there was a positive correlation between ghrelin and TNF-alpha (r=.485, P<.05 and r=.573, P<.01, resp.). CONCLUSION: Serum ghrelin levels is elevated in acyanotic and cyanotic patients with congenital heart disease. Increased ghrelin levels represents malnutrition and growth retardation in these patients. The relation of ghrelin with cytokines may be explained by the possible effect of chronic congestive heart failure and chronic shunt hypoxemia.
Subject(s)
Cyanosis/metabolism , Gene Expression Regulation , Ghrelin/blood , Heart Diseases/metabolism , Immunoassay/methods , Interleukin-6/blood , Tumor Necrosis Factor-alpha/blood , Case-Control Studies , Child, Preschool , Cyanosis/blood , Female , Heart Failure , Humans , Hypoxia , Infant , MaleABSTRACT
Topical therapy with glucocorticoids (GCs) is used commonly in chronic dermatoses. Side effects are less common compared to systemic use; however, newer potent preparations may have serious side effects. A potential danger is their inappropriate use. Three infants who developed iatrogenic Cushing's syndrome and prolonged adrenal suppression in the course of GC therapy for simple diaper dermatitis are described. One patient also developed steatohepatitis which is uncommon with local GCs.
Subject(s)
Cushing Syndrome/chemically induced , Dermatitis/drug therapy , Glucocorticoids/adverse effects , Administration, Topical , Contraindications , Cushing Syndrome/diagnosis , Diagnosis, Differential , Fatty Liver/chemically induced , Fatty Liver/diagnosis , Female , Glucocorticoids/administration & dosage , Humans , Hypothalamo-Hypophyseal System/drug effects , Hypothalamo-Hypophyseal System/physiopathology , Iatrogenic Disease , Infant , Obesity/diagnosis , Pituitary-Adrenal System/drug effects , Pituitary-Adrenal System/physiopathologyABSTRACT
BACKGROUND: The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders. METHODS: A PT group aged 1-8 years (n = 40), a PA group aged 1-9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning. RESULTS: When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups. CONCLUSIONS: Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.
Subject(s)
Adrenarche/blood , Biomarkers/blood , Ghrelin/blood , Kisspeptins/blood , Puberty, Precocious/diagnosis , Sexual Maturation/physiology , Case-Control Studies , Child , Child, Preschool , Female , Humans , Infant , Male , Puberty, Precocious/bloodABSTRACT
OBJECTIVE: This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia. METHODS: This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group. H-FABP values were measured again after acidosis correction in the DKA patients. RESULTS: No statistically significant differences were found with respect to troponin I and CK-MB within the groups. The H-FABP values of DKA patients at presentation were found to be significantly higher than those of DK patients and the control group (p=0.015). The H-FABP value of the DKA group was also found to be significantly higher than the value at hour 36 after acidosis correction (p=0.0001). CONCLUSION: We would like to propose H-FABP as a potential marker for indicating myocardial ischemia.
Subject(s)
Biomarkers/blood , Diabetic Ketoacidosis/blood , Fatty Acid Binding Protein 3/blood , Myocardial Ischemia/blood , Adolescent , Child , Child, Preschool , Creatine Kinase, MB Form/blood , Diabetic Ketoacidosis/diagnosis , Diabetic Ketoacidosis/etiology , Early Diagnosis , Female , Humans , Male , Myocardial Ischemia/complications , Myocardial Ischemia/diagnosis , Prospective Studies , Troponin I/bloodABSTRACT
Malignant infantile osteopetrosis is a rare autosomal recessive disorder characterized by presentation in the first few months of life with manifestations relating to an underlying defect in osteoclastic bone resorption. This report describes a 10 day-old boy in whom neonatal hypocalcemia was present and whose brother had died with the diagnosis of osteopetrosis.
Subject(s)
Hypocalcemia/etiology , Osteopetrosis/complications , Calcium Gluconate/therapeutic use , Humans , Hypocalcemia/diagnostic imaging , Hypocalcemia/drug therapy , Infant, Newborn , Male , Osteopetrosis/diagnostic imaging , Osteopetrosis/drug therapy , Radiography , Seizures/etiology , Seizures/therapy , Treatment OutcomeABSTRACT
Idiopathic Juvenile Osteoporosis (IJO) is a very rare disease, self restrictive and shows marked, spontaneous improvement during adolescence. The major clinical features were pain with difficulty walking, growth retardation, oral and dental abnormalities with radiographically porous bone structure. A 13-year-old male referred to paediatric dentistry clinic for toothache. The observations made with extra-intraoral clinic examination that one revealed short and skinny stature, diffuse caries in deciduous teeth, abraded lower incisor, deep bite and dysmorphic appearance in permanent incisor. This report emphasizes the recognized features of IJO as well as describes facio-dental findings that could aid in the diagnosis and management of these patients.
ABSTRACT
Calcium pyrophosphate dehydrate (CPPD) crystal deposition disease (also known as chondrocalcinosis, CC) is a rare metabolic arthropathy mostly seen in elderly patients. Chondrocalcinosis may be associated with metabolic diseases such as hypomagnesemia when it occurs in young people. We report here a case with hypomagnesemia due to familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) who developed CC during clinical follow-up. To our best knowledge this is the first case of a young patient with CPPD associated with FHHNC.
Subject(s)
Chondrocalcinosis/complications , Hypercalciuria/complications , Nephrocalcinosis/complications , Renal Tubular Transport, Inborn Errors/complications , Adolescent , Chondrocalcinosis/diagnostic imaging , Humans , Hypercalciuria/diagnostic imaging , Male , Nephrocalcinosis/diagnostic imaging , Radiography , Renal Tubular Transport, Inborn Errors/diagnostic imagingABSTRACT
Association of Kocher-Debré-Semelaigne syndrome-a myopathy of hypothyroidism in childhood characterized by muscular hypertrophy, with rhabdomyolysis is very rare. We present a case of Kocher-Debré-Semelaigne syndrome with rhabdomyolysis secondary to Hashimoto's thyroiditis. He had muscular symptoms simulating poly/dermatomyositis, massively elevated creatine kinase (CK) levels and high creatinine levels. All of the findings reversed on treatment of hypothyroidism. The response to the therapy strongly suggested that Kocher-Debré-Semelaigne (KDS) syndrome was the underlying etiology. Serum thyroid- stimulating hormone levels should be routinely determined in all patients with muscular symptoms and/or elevation of CK and creatinine, keeping KDS syndrome in mind.
Subject(s)
Congenital Hypothyroidism/complications , Creatinine/blood , Hashimoto Disease/complications , Hypertrophy/complications , Muscle, Skeletal/pathology , Muscular Diseases/complications , Rhabdomyolysis/etiology , Adolescent , Congenital Hypothyroidism/blood , Creatine Kinase/blood , Hashimoto Disease/blood , Hashimoto Disease/drug therapy , Humans , Hypertrophy/blood , Male , Muscular Diseases/blood , Rhabdomyolysis/blood , Thyroxine/therapeutic use , Treatment OutcomeABSTRACT
To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients with CPHD were included in this study. Based on clinical, hormonal, and neuro-radiological data, relevant transcription factor genes were evaluated by Sanger sequencing and multiplex ligation-dependent probe amplification. Total frequency of mutations was 30.9 % in patients with CPHD. Frequency was significantly higher in familial patients (p = 0.001). Three different types of mutations in PROP1 gene (complete gene deletion, c.301-302delAG, a novel mutation; IVS1+2T>G) were found in 12 unrelated patients (21.8 %). Mutations in PROP1 gene were markedly higher in familial than in sporadic cases (58.8 vs. 5.3 %, p < 0.001). Homozygous complete gene deletion was the most common mutation in PROP1 gene (8/12) and was identified in six familial patients. Four different homozygous mutations [p.Q4X, novel mutations; exons 1-2 deletion, p.V153F, p.I244S] were detected in POU1F1 gene. Central precocious puberty was firstly observed in a sporadic-male patient with homozygous POU1F1 (p.I244S) mutation. A homozygous mutation in HESX1 gene (p.R160H) was detected in one patient. This study is the first to investigate specific mutations in CPHD patients in Turkey. Complete deletion in PROP1 gene was the most common mutation encountered in patients with CPHD. We believe that the results of this study will contribute to the establishment of genetic screening strategies in Turkey, as well as to the studies on phenotype-genotype correlations and early diagnosis of CPHD patients.
Subject(s)
Homeodomain Proteins/genetics , Hypopituitarism/genetics , LIM-Homeodomain Proteins/genetics , Mutation/genetics , Transcription Factor Pit-1/genetics , Transcription Factors/genetics , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male , Mutation Rate , Pedigree , Turkey , Young AdultABSTRACT
Hypertension is one of the rare causes of peripheral facial paralysis in children. The unawareness of this association at presentation may cause serious medical errors and result in delays in the diagnosis of hypertension, which may worsen with corticosteroid therapy given for Bell's palsy. We describe a severely hypertensive child who was first seen with peripheral facial paralysis and given corticosteroid therapy in another hospital. She presented to our clinic during the second facial paralysis attack with hypertensive pontine hemorrhage.
Subject(s)
Facial Paralysis/etiology , Hypertension/complications , Cerebellopontine Angle , Cerebral Hemorrhage/etiology , Child , Female , Humans , Magnetic Resonance ImagingABSTRACT
We report an 11-year-old boy who had isolated hypoglossal nerve palsy one week after symptoms and signs of urticarial lesions. Neuroradiological examinations and other investigations for etiology of hypoglossal nerve palsy and urticaria were normal. We suggest that all patients with hypoglossal palsy must be carefully evaluated for atypical findings and etiologies.
Subject(s)
Hypoglossal Nerve Diseases/etiology , Urticaria/complications , Child , Diagnosis, Differential , Electromyography , Humans , Hypoglossal Nerve Diseases/diagnosis , Male , Neural ConductionABSTRACT
Graves' disease is the most common reason of hyperthyroidism in children. Graves' disease with accompanying functioning nodules is defined as Marine-Lenhart syndrome. This syndrome has not been described in children before. Here, a 15-year-old girl with Graves' disease and a coexisting cold nodule is presented. A thyroid scan showed diffuse uptake of Tc-99m pertechnatate in both lobes and decreased uptake in accordance with the left lobe nodule. The nodule was histologically diagnosed as benign. The patient was diagnosed with type 1 diabetes mellitus and polyglandular autoimmune syndrome during clinical follow-up. The differential diagnoses of Graves' disease with coexisting nodules should include the Marine-Lenhart syndrome. Treatment options should be determined taking this rare condition into account.
Subject(s)
Graves Disease/diagnosis , Adolescent , Antithyroid Agents/therapeutic use , Diabetes Mellitus, Type 1/complications , Female , Graves Disease/complications , Graves Disease/drug therapy , Graves Disease/radiotherapy , Humans , Iodine Radioisotopes/therapeutic use , Methimazole/therapeutic use , Polyendocrinopathies, Autoimmune/complications , SyndromeABSTRACT
BACKGROUND: The differential diagnosis of tissue passed per vagina in a young girl includes aborted pregnancy, rhabdomyosarcoma, polyp, and very rarely decidual cast. CASE: A 10-year-old girl using oral contraceptives for menorrhagia presented with a decidual cast after discontinuing the drug. Symptoms disappeared during clinical follow-up without any intervention. CONCLUSIONS: Decidual cast formation is an unusual entity of unknown origin. It's generally seen during treatment with variable contraceptives. This is the first case described with desogestrel and it occurred after discontinuing treatment.