Assessment of tissue pathology using optical polarimetry.

Optical polarimetry have been extensively used for the non-invasive assessment of biological tissues. However, the knowledge regarding differences in polarimetric signatures of different tissue pathologies is very scattered, confounding the deduction of a global trend of the polarimetric variables for healthy and pathological tissues. The purpose of this study was to bridge this gap. We conducted a rigorous online survey to collect all published studies that report the two most common polarimetric variables (i.e., depolarization and retardance) for any type of tissue pathology. A total of 101 studies describing the polarimetric assessment of tissues were collected, wherein 253 (i.e., nhuman = 149, nanimal = 104) different type of tissues were optically characterized. Most tissue samples (172/253) were investigated in ex vivo settings. The data showed 32 different types of tissues pathologies, where the most common pathology was cancer and its subtypes. The skin tissues were the most frequently explored tissues, followed by tissue samples from breast, colon, liver, and cervix. Although differences in polarimetric signatures of different tissue pathologies were summarized from the included studies, generalization of the results was hindered by the presentation of polarimetric data in a non-uniform format. The analyses presented in this study may provide an important reference for future polarimetric studies that conduct optical assessment of tissues at greater depth, particularly in the context of optical biopsy/digital staining.

Association of Working Environment and Anxiety Levels in Clinical Professionals During the COVID-19 Pandemic.

Introduction Coronavirus disease 2019 (COVID-19) is a global pandemic and has become a major life-threatening challenge. The sudden and fast spread of the COVID-19 pandemic worldwide caused a sudden increase in the workload of health care workers in parallel with the possible increase in mortality rates and the spread of this disease to a large number of people. Clinicians, who are our frontline warriors, are not only at high risk of catching COVID-19, but their mental health is also at stake. The objective of this study was to determine the prevalence of anxiety and its association with the working environment in clinical professionals during the COVID-19 pandemic. Methods This cross-sectional study collected data from 400 medical doctors through an online survey, carried out for six months. The anxiety of participants was assessed by using the Zung Self Rating anxiety scale (SAS). An anxiety index of greater than or equal to 50 was marked as anxious. Descriptive chi-square analysis and correlation analysis were used. Results This study found that out of a total, 20.1% of the participants suffered from anxiety. Anxiety was found to be positively associated with sociodemographic factors like the age of the doctor (p=0.001), their gender (p=0.000), their working environment (p=0.005), working in basic healthcare units (p=0.015), patient load per week (p=0.005), personal protective equipment (PPE) availability to doctor according to WHO guidelines (p=0.007), and patient compliance with doctors' orders (p=0.009). Conclusion We conclude that professional healthcare workers suffered from anxiety due to working conditions in the COVID-19 pandemic. Specific interventions and steps such as improving staffing and resources, policies to ensure fair distribution of working hours and rest breaks, workplace protections, work-family balance, health professional's emotional stability, and long-term benefits should be taken so as to minimize the lasting effects of these factors.