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1.

The immunology of sepsis.

van der Poll, Tom; Shankar-Hari, Manu; Wiersinga, W Joost.

Immunity ; 54(11): 2450-2464, 2021 11 09.

Article in English | MEDLINE | ID: mdl-34758337

2.

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.

Graham, Carl; Seow, Jeffrey; Huettner, Isabella; Khan, Hataf; Kouphou, Neophytos; Acors, Sam; Winstone, Helena; Pickering, Suzanne; Galao, Rui Pedro; Dupont, Liane; Lista, Maria Jose; Jimenez-Guardeño, Jose M; Laing, Adam G; Wu, Yin; Joseph, Magdalene; Muir, Luke; van Gils, Marit J; Ng, Weng M; Duyvesteyn, Helen M E; Zhao, Yuguang; Bowden, Thomas A; Shankar-Hari, Manu; Rosa, Annachiara; Cherepanov, Peter; McCoy, Laura E; Hayday, Adrian C; Neil, Stuart J D; Malim, Michael H; Doores, Katie J.

Immunity ; 54(6): 1276-1289.e6, 2021 06 08.

Article in English | MEDLINE | ID: mdl-33836142

3.

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

Pairo-Castineira, Erola; Rawlik, Konrad; Bretherick, Andrew D; Qi, Ting; Wu, Yang; Nassiri, Isar; McConkey, Glenn A; Zechner, Marie; Klaric, Lucija; Griffiths, Fiona; Oosthuyzen, Wilna; Kousathanas, Athanasios; Richmond, Anne; Millar, Jonathan; Russell, Clark D; Malinauskas, Tomas; Thwaites, Ryan; Morrice, Kirstie; Keating, Sean; Maslove, David; Nichol, Alistair; Semple, Malcolm G; Knight, Julian; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; Openshaw, Peter J M; Begg, Colin; Walsh, Timothy; Tenesa, Albert; Flores, Carlos; Riancho, José A; Rojas-Martinez, Augusto; Lapunzina, Pablo; Yang, Jian; Ponting, Chris P; Wilson, James F; Vitart, Veronique; Abedalthagafi, Malak; Luchessi, Andre D; Parra, Esteban J; Cruz, Raquel; Carracedo, Angel; Fawkes, Angie; Murphy, Lee; Rowan, Kathy.

Nature ; 617(7962): 764-768, 2023 05.

Article in English | MEDLINE | ID: mdl-37198478

4.

Genetic mechanisms of critical illness in COVID-19.

Pairo-Castineira, Erola; Clohisey, Sara; Klaric, Lucija; Bretherick, Andrew D; Rawlik, Konrad; Pasko, Dorota; Walker, Susan; Parkinson, Nick; Fourman, Max Head; Russell, Clark D; Furniss, James; Richmond, Anne; Gountouna, Elvina; Wrobel, Nicola; Harrison, David; Wang, Bo; Wu, Yang; Meynert, Alison; Griffiths, Fiona; Oosthuyzen, Wilna; Kousathanas, Athanasios; Moutsianas, Loukas; Yang, Zhijian; Zhai, Ranran; Zheng, Chenqing; Grimes, Graeme; Beale, Rupert; Millar, Jonathan; Shih, Barbara; Keating, Sean; Zechner, Marie; Haley, Chris; Porteous, David J; Hayward, Caroline; Yang, Jian; Knight, Julian; Summers, Charlotte; Shankar-Hari, Manu; Klenerman, Paul; Turtle, Lance; Ho, Antonia; Moore, Shona C; Hinds, Charles; Horby, Peter; Nichol, Alistair; Maslove, David; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; Walsh, Timothy.

Nature ; 591(7848): 92-98, 2021 03.

Article in English | MEDLINE | ID: mdl-33307546

5.

Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.

Burnap, Sean A; Ortega-Prieto, Ana Maria; Jimenez-Guardeño, Jose M; Ali, Hashim; Takov, Kaloyan; Fish, Matthew; Shankar-Hari, Manu; Giacca, Mauro; Malim, Michael H; Mayr, Manuel.

Mol Cell Proteomics ; 22(8): 100600, 2023 08.

Article in English | MEDLINE | ID: mdl-37343697

6.

Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988-2019.

Prescott, Hallie C; Harrison, David A; Rowan, Kathryn M; Shankar-Hari, Manu; Wunsch, Hannah.

Am J Respir Crit Care Med ; 209(5): 507-516, 2024 Mar 01.

Article in English | MEDLINE | ID: mdl-38259190

7.

From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations For Developing Precision Medicine in ICU.

Gordon, Anthony C; Alipanah-Lechner, Narges; Bos, Lieuwe D; Dianti, Jose; Diaz, Janet Victoria; Finfer, Simon; Fujii, Tomoko; Giamarellos-Bourboulis, Evangelos J; Goligher, Ewan C; Gong, Michelle Ng; Karakike, Eleni; Liu, Vincent; Lumlertgul, Nuttha; Marshall, John C; Menon, David K; Meyer, Nuala J; Munroe, Elizabeth S; Myatra, Sheila N; Ostermann, Marlies; Prescott, Hallie C; Randolph, Adrienne G; Schenck, Edward J; Seymour, Christopher W; Shankar-Hari, Manu; Singer, Mervyn; Smit, Marry R; Tanaka, Aiko; Taccone, Fabio Silvio; Thompson, B Taylor; Torres, Lisa K; Van der Poll, Tom; Vincent, Jean-Louis; Calfee, Carolyn S.

Am J Respir Crit Care Med ; 2024 Apr 30.

Article in English | MEDLINE | ID: mdl-38687499

8.

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.

Gordon, Anthony C; Mouncey, Paul R; Al-Beidh, Farah; Rowan, Kathryn M; Nichol, Alistair D; Arabi, Yaseen M; Annane, Djillali; Beane, Abi; van Bentum-Puijk, Wilma; Berry, Lindsay R; Bhimani, Zahra; Bonten, Marc J M; Bradbury, Charlotte A; Brunkhorst, Frank M; Buzgau, Adrian; Cheng, Allen C; Detry, Michelle A; Duffy, Eamon J; Estcourt, Lise J; Fitzgerald, Mark; Goossens, Herman; Haniffa, Rashan; Higgins, Alisa M; Hills, Thomas E; Horvat, Christopher M; Lamontagne, Francois; Lawler, Patrick R; Leavis, Helen L; Linstrum, Kelsey M; Litton, Edward; Lorenzi, Elizabeth; Marshall, John C; Mayr, Florian B; McAuley, Daniel F; McGlothlin, Anna; McGuinness, Shay P; McVerry, Bryan J; Montgomery, Stephanie K; Morpeth, Susan C; Murthy, Srinivas; Orr, Katrina; Parke, Rachael L; Parker, Jane C; Patanwala, Asad E; Pettilä, Ville; Rademaker, Emma; Santos, Marlene S; Saunders, Christina T; Seymour, Christopher W; Shankar-Hari, Manu.

N Engl J Med ; 384(16): 1491-1502, 2021 04 22.

Article in English | MEDLINE | ID: mdl-33631065

9.

Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes.

Antcliffe, David Benjamin; Mi, Yuxin; Santhakumaran, Shalini; Burnham, Katie L; Prevost, A Toby; Ward, Josie K; Marshall, Timothy J; Bradley, Claire; Al-Beidh, Farah; Hutton, Paula; McKechnie, Stuart; Davenport, Emma E; Hinds, Charles J; O'Kane, Cecilia M; McAuley, Daniel Francis; Shankar-Hari, Manu; Gordon, Anthony C; Knight, Julian C.

Thorax ; 79(6): 515-523, 2024 May 20.

Article in English | MEDLINE | ID: mdl-38471792

10.

Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).

Mehta, Puja; Samanta, Romit J; Wick, Katherine; Coll, Rebecca C; Mawhinney, Thea; McAleavey, Patrick G; Boyle, Andrew J; Conlon, John; Shankar-Hari, Manu; Rogers, Angela; Calfee, Carolyn S; Matthay, Michael A; Summers, Charlotte; Chambers, Rachel Clare; McAuley, Daniel Francis; O'Kane, Cecilia M.

Thorax ; 79(3): 227-235, 2024 Feb 15.

Article in English | MEDLINE | ID: mdl-38148147

11.

Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells.

Miller, Muska; Melis, Miranda J; Miller, James R C; Kleyman, Anna; Shankar-Hari, Manu; Singer, Mervyn.

Crit Care Med ; 52(4): 596-606, 2024 04 01.

Article in English | MEDLINE | ID: mdl-38483219

12.

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

Pairo-Castineira, Erola; Rawlik, Konrad; Bretherick, Andrew D; Qi, Ting; Wu, Yang; Nassiri, Isar; McConkey, Glenn A; Zechner, Marie; Klaric, Lucija; Griffiths, Fiona; Oosthuyzen, Wilna; Kousathanas, Athanasios; Richmond, Anne; Millar, Jonathan; Russell, Clark D; Malinauskas, Tomas; Thwaites, Ryan; Morrice, Kirstie; Keating, Sean; Maslove, David; Nichol, Alistair; Semple, Malcolm G; Knight, Julian; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; Openshaw, Peter J M; Begg, Colin; Walsh, Timothy; Tenesa, Albert; Flores, Carlos; Riancho, José A; Rojas-Martinez, Augusto; Lapunzina, Pablo; Yang, Jian; Ponting, Chris P; Wilson, James F; Vitart, Veronique; Abedalthagafi, Malak; Luchessi, Andre D; Parra, Esteban J; Cruz, Raquel; Carracedo, Angel; Fawkes, Angie; Murphy, Lee; Rowan, Kathy.

Nature ; 619(7971): E61, 2023 Jul.

Article in English | MEDLINE | ID: mdl-37433877

13.

Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review.

Munroe, Elizabeth S; Hyzy, Robert C; Semler, Matthew W; Shankar-Hari, Manu; Young, Paul J; Zampieri, Fernando G; Prescott, Hallie C.

Am J Respir Crit Care Med ; 207(10): 1283-1299, 2023 05 15.

Article in English | MEDLINE | ID: mdl-36812500

14.

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).

Gaughan, Erin E; Quinn, Tom M; Mills, Andrew; Bruce, Annya M; Antonelli, Jean; MacKinnon, Alison C; Aslanis, Vassilios; Li, Feng; O'Connor, Richard; Boz, Cecilia; Mills, Ross; Emanuel, Philip; Burgess, Matthew; Rinaldi, Giulia; Valanciute, Asta; Mills, Bethany; Scholefield, Emma; Hardisty, Gareth; Findlay, Emily Gwyer; Parker, Richard A; Norrie, John; Dear, James W; Akram, Ahsan R; Koch, Oliver; Templeton, Kate; Dockrell, David H; Walsh, Timothy S; Partridge, Stephen; Humphries, Duncan; Wang-Jairaj, Jie; Slack, Robert J; Schambye, Hans; Phung, De; Gravelle, Lise; Lindmark, Bertil; Shankar-Hari, Manu; Hirani, Nikhil; Sethi, Tariq; Dhaliwal, Kevin.

Am J Respir Crit Care Med ; 207(2): 138-149, 2023 01 15.

Article in English | MEDLINE | ID: mdl-35972987

15.

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial.

Gorman, Ellen A; Rynne, Jennifer; Gardiner, Hannah J; Rostron, Anthony J; Bannard-Smith, Jonathan; Bentley, Andrew M; Brealey, David; Campbell, Christina; Curley, Gerard; Clarke, Mike; Dushianthan, Ahilanadan; Hopkins, Phillip; Jackson, Colette; Kefela, Kallirroi; Krasnodembskaya, Anna; Laffey, John G; McDowell, Cliona; McFarland, Margaret; McFerran, Jamie; McGuigan, Peter; Perkins, Gavin D; Silversides, Jonathan; Smythe, Jon; Thompson, Jacqui; Tunnicliffe, William S; Welters, Ingeborg D M; Amado-Rodríguez, Laura; Albaiceta, Guillermo; Williams, Barry; Shankar-Hari, Manu; McAuley, Daniel F; O'Kane, Cecilia M.

Am J Respir Crit Care Med ; 208(3): 256-269, 2023 08 01.

Article in English | MEDLINE | ID: mdl-37154608

16.

Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex.

Patone, Martina; Mei, Xue W; Handunnetthi, Lahiru; Dixon, Sharon; Zaccardi, Francesco; Shankar-Hari, Manu; Watkinson, Peter; Khunti, Kamlesh; Harnden, Anthony; Coupland, Carol A C; Channon, Keith M; Mills, Nicholas L; Sheikh, Aziz; Hippisley-Cox, Julia.

Circulation ; 146(10): 743-754, 2022 09 06.

Article in English | MEDLINE | ID: mdl-35993236

17.

Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials.

Saha, Rohit; Pham, Tài; Sinha, Pratik; Maddali, Manoj V; Bellani, Giacomo; Fan, Eddy; Summers, Charlotte; Douiri, Abdel; Rubenfeld, Gordon D; Calfee, Carolyn S; Laffey, John Gerard; McAuley, Daniel Francis; Shankar-Hari, Manu.

Thorax ; 78(10): 990-1003, 2023 10.

Article in English | MEDLINE | ID: mdl-37495364

18.

Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials.

Moore, Andrew R; Pienkos, Shaun M; Sinha, Pratik; Guan, Jiazhen; O'Kane, Cecilia M; Levitt, Joseph E; Wilson, Jennifer G; Shankar-Hari, Manu; Matthay, Michael A; Calfee, Carolyn S; Baron, Rebecca M; McAuley, Daniel F; Rogers, Angela J.

Crit Care Med ; 51(12): e269-e274, 2023 12 01.

Article in English | MEDLINE | ID: mdl-37695136

19.

Comparison of systemic inflammatory profiles in COVID-19 and community-acquired pneumonia patients: a prospective cohort study.

Ibáñez-Prada, Elsa D; Fish, Matthew; Fuentes, Yuli V; Bustos, Ingrid G; Serrano-Mayorga, Cristian C; Lozada, Julian; Rynne, Jennifer; Jennings, Aislinn; Crispin, Ana M; Santos, Ana Maria; Londoño, John; Shankar-Hari, Manu; Reyes, Luis Felipe.

Respir Res ; 24(1): 60, 2023 Feb 22.

Article in English | MEDLINE | ID: mdl-36814234

20.

Phase 2 randomised placebo-controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID-19 hospitalised patients in Delhi.

Wadhwa, Bharti; Malhotra, Vikas; Kerai, Sukhyanti; Husain, Farah; Pandey, Nalini Bala; Saxena, Kirti N; Singh, Vinay; Quinn, Tom M; Li, Feng; Gaughan, Erin; Shankar-Hari, Manu; Mills, Bethany; Antonelli, Jean; Bruce, Annya; Finlayson, Keith; Moore, Anne; Dhaliwal, Kevin; Edwards, Christopher.

BMC Infect Dis ; 23(1): 326, 2023 May 15.

Article in English | MEDLINE | ID: mdl-37189034

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