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1.

Mechanisms and disease consequences of nonalcoholic fatty liver disease.

Loomba, Rohit; Friedman, Scott L; Shulman, Gerald I.

Cell ; 184(10): 2537-2564, 2021 05 13.

Article in English | MEDLINE | ID: mdl-33989548

2.

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Wang, Lifeng; Sinnott-Armstrong, Nasa; Wagschal, Alexandre; Wark, Abigail R; Camporez, Joao-Paulo; Perry, Rachel J; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T; Soukas, Alexander; Avruch, Joseph; Fried, Susan K; Hauner, Hans; Sadreyev, Ruslan I; Shulman, Gerald I; Claussnitzer, Melina; Näär, Anders M.

Cell ; 183(3): 684-701.e14, 2020 10 29.

Article in English | MEDLINE | ID: mdl-33058756

3.

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry, Rachel J; Wang, Yongliang; Cline, Gary W; Rabin-Court, Aviva; Song, Joongyu D; Dufour, Sylvie; Zhang, Xian Man; Petersen, Kitt Falk; Shulman, Gerald I.

Cell ; 172(1-2): 234-248.e17, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29307489

4.

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi, Kfir; Lin, Hua; Tavares, Clint D J; Dominy, John E; Camporez, Joao Paulo; Perry, Rachel J; Schilling, Roger; Rines, Amy K; Lee, Jaemin; Hickey, Marc; Bennion, Melissa; Palmer, Michelle; Nag, Partha P; Bittker, Joshua A; Perez, José; Jedrychowski, Mark P; Ozcan, Umut; Gygi, Steve P; Kamenecka, Theodore M; Shulman, Gerald I; Schreiber, Stuart L; Griffin, Patrick R; Puigserver, Pere.

Cell ; 169(1): 148-160.e15, 2017 03 23.

Article in English | MEDLINE | ID: mdl-28340340

5.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry, Rachel J; Camporez, João-Paulo G; Kursawe, Romy; Titchenell, Paul M; Zhang, Dongyan; Perry, Curtis J; Jurczak, Michael J; Abudukadier, Abulizi; Han, Myoung Sook; Zhang, Xian-Man; Ruan, Hai-Bin; Yang, Xiaoyong; Caprio, Sonia; Kaech, Susan M; Sul, Hei Sook; Birnbaum, Morris J; Davis, Roger J; Cline, Gary W; Petersen, Kitt Falk; Shulman, Gerald I.

Cell ; 160(4): 745-758, 2015 Feb 12.

Article in English | MEDLINE | ID: mdl-25662011

6.

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

Cohen, Paul; Levy, Julia D; Zhang, Yingying; Frontini, Andrea; Kolodin, Dmitriy P; Svensson, Katrin J; Lo, James C; Zeng, Xing; Ye, Li; Khandekar, Melin J; Wu, Jun; Gunawardana, Subhadra C; Banks, Alexander S; Camporez, João Paulo G; Jurczak, Michael J; Kajimura, Shingo; Piston, David W; Mathis, Diane; Cinti, Saverio; Shulman, Gerald I; Seale, Patrick; Spiegelman, Bruce M.

Cell ; 156(1-2): 304-16, 2014 Jan 16.

Article in English | MEDLINE | ID: mdl-24439384

7.

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21.

Han, Myoung Sook; Perry, Rachel J; Camporez, João-Paulo; Scherer, Philipp E; Shulman, Gerald I; Gao, Guangping; Davis, Roger J.

Genes Dev ; 35(1-2): 133-146, 2021 01 01.

Article in English | MEDLINE | ID: mdl-33334822

8.

Mechanisms for insulin resistance: common threads and missing links.

Samuel, Varman T; Shulman, Gerald I.

Cell ; 148(5): 852-71, 2012 Mar 02.

Article in English | MEDLINE | ID: mdl-22385956

9.

IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.

Wang, Qian; Li, Dehai; Cao, Guangchao; Shi, Qiping; Zhu, Jing; Zhang, Mingyue; Cheng, Hao; Wen, Qiong; Xu, Hao; Zhu, Leqing; Zhang, Hua; Perry, Rachel J; Spadaro, Olga; Yang, Yunfan; He, Shengqi; Chen, Yong; Wang, Baocheng; Li, Guangqiang; Liu, Zonghua; Yang, Caixian; Wu, Xiaoli; Zhou, Libing; Zhou, Qinghua; Ju, Zhenyu; Lu, Hongyun; Xin, Yongjie; Yang, Xiaoyong; Wang, Cunchuan; Liu, Yong; Shulman, Gerald I; Dixit, Vishwa Deep; Lu, Ligong; Yang, Hengwen; Flavell, Richard A; Yin, Zhinan.

Nature ; 600(7888): 314-318, 2021 12.

Article in English | MEDLINE | ID: mdl-34819664

10.

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis.

Perry, Rachel J; Zhang, Dongyan; Guerra, Mateus T; Brill, Allison L; Goedeke, Leigh; Nasiri, Ali R; Rabin-Court, Aviva; Wang, Yongliang; Peng, Liang; Dufour, Sylvie; Zhang, Ye; Zhang, Xian-Man; Butrico, Gina M; Toussaint, Keshia; Nozaki, Yuichi; Cline, Gary W; Petersen, Kitt Falk; Nathanson, Michael H; Ehrlich, Barbara E; Shulman, Gerald I.

Nature ; 579(7798): 279-283, 2020 03.

Article in English | MEDLINE | ID: mdl-32132708

11.

Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.

Sakuma, Ikki; Gaspar, Rafael C; Luukkonen, Panu K; Kahn, Mario; Zhang, Dongyan; Zhang, Xuchen; Murray, Sue; Golla, Jaya Prakash; Vatner, Daniel F; Samuel, Varman T; Petersen, Kitt Falk; Shulman, Gerald I.

Proc Natl Acad Sci U S A ; 120(52): e2312666120, 2023 Dec 26.

Article in English | MEDLINE | ID: mdl-38127985

12.

Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis.

Luukkonen, Panu K; Sakuma, Ikki; Gaspar, Rafael C; Mooring, Meghan; Nasiri, Ali; Kahn, Mario; Zhang, Xian-Man; Zhang, Dongyan; Sammalkorpi, Henna; Penttilä, Anne K; Orho-Melander, Marju; Arola, Johanna; Juuti, Anne; Zhang, Xuchen; Yimlamai, Dean; Yki-Järvinen, Hannele; Petersen, Kitt Falk; Shulman, Gerald I.

Proc Natl Acad Sci U S A ; 120(4): e2217543120, 2023 Jan 24.

Article in English | MEDLINE | ID: mdl-36669104

13.

Mechanisms of Insulin Action and Insulin Resistance.

Petersen, Max C; Shulman, Gerald I.

Physiol Rev ; 98(4): 2133-2223, 2018 10 01.

Article in English | MEDLINE | ID: mdl-30067154

14.

CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.

Kumamoto, Yosuke; Camporez, Joao Paulo G; Jurczak, Michael J; Shanabrough, Marya; Horvath, Tamas; Shulman, Gerald I; Iwasaki, Akiko.

Immunity ; 45(3): 583-596, 2016 09 20.

Article in English | MEDLINE | ID: mdl-27566941

15.

The integrative biology of type 2 diabetes.

Roden, Michael; Shulman, Gerald I.

Nature ; 576(7785): 51-60, 2019 12.

Article in English | MEDLINE | ID: mdl-31802013

16.

Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice.

Lee, Hui-Young; Jang, Hye Rim; Li, Hui; Samuel, Varman T; Dudek, Karrie D; Osipovich, Anna B; Magnuson, Mark A; Sklar, Jeffrey; Shulman, Gerald I.

Proc Natl Acad Sci U S A ; 119(49): e2213628119, 2022 12 06.

Article in English | MEDLINE | ID: mdl-36442127

17.

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.

LaMoia, Traci E; Butrico, Gina M; Kalpage, Hasini A; Goedeke, Leigh; Hubbard, Brandon T; Vatner, Daniel F; Gaspar, Rafael C; Zhang, Xian-Man; Cline, Gary W; Nakahara, Keita; Woo, Seungwan; Shimada, Atsuhiro; Hüttemann, Maik; Shulman, Gerald I.

Proc Natl Acad Sci U S A ; 119(10): e2122287119, 2022 03 08.

Article in English | MEDLINE | ID: mdl-35238637

18.

Distinct subcellular localisation of intramyocellular lipids and reduced PKCÎµ/PKCÎ¸ activity preserve muscle insulin sensitivity in exercise-trained mice.

Gaspar, Rafael C; Lyu, Kun; Hubbard, Brandon T; Leitner, Brooks P; Luukkonen, Panu K; Hirabara, Sandro M; Sakuma, Ikki; Nasiri, Ali; Zhang, Dongyan; Kahn, Mario; Cline, Gary W; Pauli, José Rodrigo; Perry, Rachel J; Petersen, Kitt F; Shulman, Gerald I.

Diabetologia ; 66(3): 567-578, 2023 03.

Article in English | MEDLINE | ID: mdl-36456864

19.

O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding.

Nakamoto, Akiko; Ohashi, Natsuko; Sugawara, Lucia; Morino, Katsutaro; Ida, Shogo; Perry, Rachel J; Sakuma, Ikki; Yanagimachi, Tsuyoshi; Fujita, Yukihiro; Ugi, Satoshi; Kume, Shinji; Shulman, Gerald I; Maegawa, Hiroshi.

Am J Physiol Endocrinol Metab ; 325(1): E46-E61, 2023 07 01.

Article in English | MEDLINE | ID: mdl-37224467

20.

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

Gillum, Matthew P; Zhang, Dongyan; Zhang, Xian-Man; Erion, Derek M; Jamison, Rachel A; Choi, Cheolsoo; Dong, Jianying; Shanabrough, Marya; Duenas, Hillary R; Frederick, David W; Hsiao, Jennifer J; Horvath, Tamas L; Lo, Chun Min; Tso, Pat; Cline, Gary W; Shulman, Gerald I.

Cell ; 135(5): 813-24, 2008 Nov 28.

Article in English | MEDLINE | ID: mdl-19041747

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