ABSTRACT
Dou Ke Jian(The Key of Smallpox) was written by Zhu Xun in the late Ming dynasty,collated and published by Zhu Fengtai in the Qing dynasty.It was rarely studied in China ,but have a far-reaching influence in Japan.By comparing with other works about smallpox and refering to the Japanese Ikeda family's Doukejian Huitong, Doukejian Siheng, Doukejian Shanzhengbuzhu completed on the basis of Dou Ke Jian,this paper systematically reviews the author's life, compilation and publication background, main content, academic characteristics and value, and influence on later generations.The views advocated in this book, such as "toxin hidden in the spleen meridians, attaching importance to qi and blood", "distinguishing between the exterior and interior, deficiency and excess, and take the lips and tongue as the key" have important reference value for the treatment of infectious diseases in later generations.