Seroprevalence of antibodies against to SARS-CoV 2 in umbilical cord blood in two hospital centers in Córdoba and Sucre, Colombia.

INTRODUCTION: Pregnant women continue to be vulnerable to COVID-19, and their immunosuppressed state could put them at greater risk of developing more severe forms of the disease. In Colombia and Latin America, there are few studies on the immune response of the newborn against SARS-CoV-2. AIM: To determine the prevalence of SARS-CoV-2 infection in umbilical cord blood in two hospital centers in Córdoba and Sucre. METHODS: Between March and June 2021, a prospective descriptive cross-sectional study was carried out. Two hospitals from the departments of Córdoba and Sucre, located in the Northwest Caribbean area of Colombia, participated. Three hundred sixty umbilical cord blood samples were taken at the two hospitals. A commercial ELISA was performed to detect total IgG, IgM, and IgA antibodies against the N protein of SARS-CoV-2. The ethics committee approved the study of the participating institutions. RESULTS: Of 3.291 women who gave birth in the hospital centers included in the study, 360 (11%) participated. Complete clinical data were obtained for 223 women. The mean age of the women was 24 years (range, 15-42). 29.4% (106/360) of the umbilical cord samples had total antibodies against SARS-CoV-2. Pregnant women did not have blood samples taken. 58% of the women were asymptomatic. There was no association between umbilical cord samples, clinical, epidemiological characteristics, and serological response to antibodies to SARS-CoV-2 (p > 0.05). CONCLUSIONS: The prevalence of umbilical cord blood samples was 29.4% for total SARS-CoV-2 antibodies. The study provides essential aspects for the epidemiological approach to neonates infected with SARS-CoV-2.

Natalidad y fecundidad, Colombia, 2001 / Nataly and Fecundity, Colombia, 2001

Se presenta la natalidad, la fecundidad los nacimientos vivos en Colombia en el año 2001 con base en la totalidad de los registros de nacidos vivos del Departamento Administrativo Nacional de Estadisticas (DANE)(724.236). La población de Colombia, calculada a mitad de periodo, se dividio en ocho categorias de municipios de acuerdo con el tamaño poblacional, segun la ley 617/2001. No se presentaron diferencias importantes entre las variables afines a las caracteristicas del recien nacido por categorias de municipios. En las caracteristicas de acuerdo con dichas categorias. Los nacidos vivos presentaron en su mayoria condiciones de vitalidad. Se calculo una tasa cruda de natalidad, de 16,84 nacimientos por cada mil habitantes y una tasa de fecundidad de 62,08 nacimientos por cada mil mujeres en edad reproductiva. Se observo que la natalidad y la fecundidad difieren de acuerdo con la estructura poblacional y que estarian influenciadas por factores externos, tales como: la estructura del sistema de salud y las condiciones sociales, culturales y economicas, entre otras. Se recomienda retroalimentar la información que permita la captación de los indicadores de una manera continua.