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1.

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).

Proal, Amy D; VanElzakker, Michael B; Aleman, Soo; Bach, Katie; Boribong, Brittany P; Buggert, Marcus; Cherry, Sara; Chertow, Daniel S; Davies, Helen E; Dupont, Christopher L; Deeks, Steven G; Eimer, William; Ely, E Wesley; Fasano, Alessio; Freire, Marcelo; Geng, Linda N; Griffin, Diane E; Henrich, Timothy J; Iwasaki, Akiko; Izquierdo-Garcia, David; Locci, Michela; Mehandru, Saurabh; Painter, Mark M; Peluso, Michael J; Pretorius, Etheresia; Price, David A; Putrino, David; Scheuermann, Richard H; Tan, Gene S; Tanzi, Rudolph E; VanBrocklin, Henry F; Yonker, Lael M; Wherry, E John.

Nat Immunol ; 24(10): 1616-1627, 2023 10.

Article in English | MEDLINE | ID: mdl-37667052

2.

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFß-mediated checkpoints.

Yin, Zhuoran; Rosenzweig, Neta; Kleemann, Kilian L; Zhang, Xiaoming; Brandão, Wesley; Margeta, Milica A; Schroeder, Caitlin; Sivanathan, Kisha N; Silveira, Sebastian; Gauthier, Christian; Mallah, Dania; Pitts, Kristen M; Durao, Ana; Herron, Shawn; Shorey, Hannah; Cheng, Yiran; Barry, Jen-Li; Krishnan, Rajesh K; Wakelin, Sam; Rhee, Jared; Yung, Anthony; Aronchik, Michael; Wang, Chao; Jain, Nimansha; Bao, Xin; Gerrits, Emma; Brouwer, Nieske; Deik, Amy; Tenen, Daniel G; Ikezu, Tsuneya; Santander, Nicolas G; McKinsey, Gabriel L; Baufeld, Caroline; Sheppard, Dean; Krasemann, Susanne; Nowarski, Roni; Eggen, Bart J L; Clish, Clary; Tanzi, Rudolph E; Madore, Charlotte; Arnold, Thomas D; Holtzman, David M; Butovsky, Oleg.

Nat Immunol ; 24(11): 1839-1853, 2023 Nov.

Article in English | MEDLINE | ID: mdl-37749326

3.

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Suh, Jaehong; Romano, Donna M; Nitschke, Larissa; Herrick, Scott P; DiMarzio, Britt A; Dzhala, Volodymyr; Bae, Jun-Seok; Oram, Mary K; Zheng, Yuejiao; Hooli, Basavaraj; Mullin, Kristina; Gennarino, Vincenzo A; Wasco, Wilma; Schmahmann, Jeremy D; Albers, Mark W; Zoghbi, Huda Y; Tanzi, Rudolph E.

Cell ; 178(5): 1159-1175.e17, 2019 08 22.

Article in English | MEDLINE | ID: mdl-31442405

4.

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.

Margeta, Milica A; Yin, Zhuoran; Madore, Charlotte; Pitts, Kristen M; Letcher, Sophia M; Tang, Jing; Jiang, Shuhong; Gauthier, Christian D; Silveira, Sebastian R; Schroeder, Caitlin M; Lad, Eleonora M; Proia, Alan D; Tanzi, Rudolph E; Holtzman, David M; Krasemann, Susanne; Chen, Dong Feng; Butovsky, Oleg.

Immunity ; 55(9): 1627-1644.e7, 2022 09 13.

Article in English | MEDLINE | ID: mdl-35977543

5.

Author Correction: SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).

Proal, Amy D; VanElzakker, Michael B; Aleman, Soo; Bach, Katie; Boribong, Brittany P; Buggert, Marcus; Cherry, Sara; Chertow, Daniel S; Davies, Helen E; Dupont, Christopher L; Deeks, Steven G; Eimer, William; Ely, E Wesley; Fasano, Alessio; Freire, Marcelo; Geng, Linda N; Griffin, Diane E; Henrich, Timothy J; Iwasaki, Akiko; Izquierdo-Garcia, David; Locci, Michela; Mehandru, Saurabh; Painter, Mark M; Peluso, Michael J; Pretorius, Etheresia; Price, David A; Putrino, David; Scheuermann, Richard H; Tan, Gene S; Tanzi, Rudolph E; VanBrocklin, Henry F; Yonker, Lael M; Wherry, E John.

Nat Immunol ; 24(10): 1778, 2023 Oct.

Article in English | MEDLINE | ID: mdl-37723351

6.

Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.

McAlpine, Cameron S; Park, Joseph; Griciuc, Ana; Kim, Eunhee; Choi, Se Hoon; Iwamoto, Yoshiko; Kiss, Máté G; Christie, Kathleen A; Vinegoni, Claudio; Poller, Wolfram C; Mindur, John E; Chan, Christopher T; He, Shun; Janssen, Henrike; Wong, Lai Ping; Downey, Jeffrey; Singh, Sumnima; Anzai, Atsushi; Kahles, Florian; Jorfi, Mehdi; Feruglio, Paolo Fumene; Sadreyev, Ruslan I; Weissleder, Ralph; Kleinstiver, Benjamin P; Nahrendorf, Matthias; Tanzi, Rudolph E; Swirski, Filip K.

Nature ; 595(7869): 701-706, 2021 07.

Article in English | MEDLINE | ID: mdl-34262178

7.

Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data.

Hahn, Georg; Prokopenko, Dmitry; Hecker, Julian; Lutz, Sharon M; Mullin, Kristina; Sejour, Leinal; Hide, Winston; Vlachos, Ioannis; DeSantis, Stacia; Tanzi, Rudolph E; Lange, Christoph.

Brief Bioinform ; 25(4)2024 May 23.

Article in English | MEDLINE | ID: mdl-38836403

8.

A comparison between similarity matrices for principal component analysis to assess population stratification in sequenced genetic data sets.

Lee, Sanghun; Hahn, Georg; Hecker, Julian; Lutz, Sharon M; Mullin, Kristina; Hide, Winston; Bertram, Lars; DeMeo, Dawn L; Tanzi, Rudolph E; Lange, Christoph; Prokopenko, Dmitry.

Brief Bioinform ; 24(1)2023 01 19.

Article in English | MEDLINE | ID: mdl-36585781

9.

Î³-Secretase Modulator BPN15606 Reduced Aß42 and Aß40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

Chen, Xu-Qiao; Becker, Ann; Albay, Ricardo; Nguyen, Phuong D; Karachentsev, Dmitry; Roberts, Amanda J; Rynearson, Kevin D; Tanzi, Rudolph E; Mobley, William C.

Ann Neurol ; 2024 May 15.

Article in English | MEDLINE | ID: mdl-38747498

10.

Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease.

Yang, Hyun-Sik; Yau, Wai-Ying Wendy; Carlyle, Becky C; Trombetta, Bianca A; Zhang, Can; Shirzadi, Zahra; Schultz, Aaron P; Pruzin, Jeremy J; Fitzpatrick, Colleen D; Kirn, Dylan R; Rabin, Jennifer S; Buckley, Rachel F; Hohman, Timothy J; Rentz, Dorene M; Tanzi, Rudolph E; Johnson, Keith A; Sperling, Reisa A; Arnold, Steven E; Chhatwal, Jasmeer P.

Brain ; 147(6): 2158-2168, 2024 Jun 03.

Article in English | MEDLINE | ID: mdl-38315899

11.

Iron-export ferroxidase activity of ß-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

Duce, James A; Tsatsanis, Andrew; Cater, Michael A; James, Simon A; Robb, Elysia; Wikhe, Krutika; Leong, Su Ling; Perez, Keyla; Johanssen, Timothy; Greenough, Mark A; Cho, Hyun-Hee; Galatis, Denise; Moir, Robert D; Masters, Colin L; McLean, Catriona; Tanzi, Rudolph E; Cappai, Roberto; Barnham, Kevin J; Ciccotosto, Giuseppe D; Rogers, Jack T; Bush, Ashley I.

Cell ; 142(6): 857-67, 2010 Sep 17.

Article in English | MEDLINE | ID: mdl-20817278

12.

Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a Î³-Secretase Modulator.

Chen, Xu-Qiao; Sawa, Mariko; Becker, Ann; Karachentsev, Dmitry; Zuo, Xinxin; Rynearson, Kevin D; Tanzi, Rudolph E; Mobley, William C.

Ann Neurol ; 94(2): 245-258, 2023 08.

Article in English | MEDLINE | ID: mdl-37042072

13.

On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.

Lee, Sanghun; Hecker, Julian; Hahn, Georg; Mullin, Kristina; Lutz, Sharon M; Tanzi, Rudolph E; Lange, Christoph; Prokopenko, Dmitry.

Alzheimers Dement ; 20(5): 3397-3405, 2024 May.

Article in English | MEDLINE | ID: mdl-38563508

14.

Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models.

Zhang, Siyi; Bai, Ping; Lei, Dan; Liang, Yingxia; Zhen, Sherri; Bakiasi, Grisilda; Pang, Hao; Choi, Se Hoon; Wang, Changning; Tanzi, Rudolph E; Zhang, Can.

J Biol Chem ; 298(4): 101794, 2022 04.

Article in English | MEDLINE | ID: mdl-35248531

15.

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPß levels in cerebrospinal fluid and 2D/3D cell culture models.

Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Koncarevic, Sasa; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, Annakaisa; Hiltunen, Mikko.

Neurobiol Dis ; 182: 106140, 2023 06 15.

Article in English | MEDLINE | ID: mdl-37120095

16.

Adult neurogenesis in Alzheimer's disease.

Choi, Se Hoon; Tanzi, Rudolph E.

Hippocampus ; 33(4): 307-321, 2023 04.

Article in English | MEDLINE | ID: mdl-36748337

17.

Bioluminescence Imaging with Functional Amyloid Reservoirs in Alzheimer's Disease Models.

Yang, Jing; Ding, Weihua; Zhu, Biyue; Zhen, Sherri; Kuang, Shi; Yang, Jun; Zhang, Can; Wang, Peng; Yang, Fan; Yang, Liuyue; Yin, Wei; Tanzi, Rudolph E; Shen, Shiqian; Ran, Chongzhao.

Anal Chem ; 95(38): 14261-14270, 2023 09 26.

Article in English | MEDLINE | ID: mdl-37712902

18.

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.

Prokopenko, Dmitry; Lee, Sanghun; Hecker, Julian; Mullin, Kristina; Morgan, Sarah; Katsumata, Yuriko; Weiner, Michael W; Fardo, David W; Laird, Nan; Bertram, Lars; Hide, Winston; Lange, Christoph; Tanzi, Rudolph E.

Mol Psychiatry ; 27(4): 1963-1969, 2022 04.

Article in English | MEDLINE | ID: mdl-35246634

19.

Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.

Lathe, Richard; Schultek, Nikki M; Balin, Brian J; Ehrlich, Garth D; Auber, Lavinia Alberi; Perry, George; Breitschwerdt, Edward B; Corry, David B; Doty, Richard L; Rissman, Robert A; Nara, Peter L; Itzhaki, Ruth; Eimer, William A; Tanzi, Rudolph E.

Alzheimers Dement ; 19(11): 5209-5231, 2023 11.

Article in English | MEDLINE | ID: mdl-37283269

20.

A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Alzheimer's Disease Treatment.

Kuang, Shi; Zhu, Biyue; Zhang, Jing; Yang, Fan; Wu, Bo; Ding, Weihua; Yang, Liuyue; Shen, Shiqian; Liang, Seven H; Mondal, Prasenjit; Kumar, Mohanraja; Tanzi, Rudolph E; Zhang, Can; Chao, Hui; Ran, Chongzhao.

Angew Chem Int Ed Engl ; 62(45): e202312519, 2023 11 06.

Article in English | MEDLINE | ID: mdl-37721455

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