Subject(s)
Carcinoma, Squamous Cell/surgery , Herpes Zoster/etiology , Mohs Surgery/adverse effects , Nose Neoplasms/surgery , Skin Neoplasms/surgery , Surgical Wound Infection/etiology , Aged, 80 and over , Antiviral Agents/therapeutic use , Female , Herpes Zoster/diagnosis , Herpes Zoster/drug therapy , Humans , Surgical Wound Infection/diagnosis , Surgical Wound Infection/drug therapy , Valacyclovir/therapeutic useABSTRACT
Gianotti-Crosti syndrome (GCS) is a viral-associated eruption that most commonly occurs in children aged 15 months to 2 years. It consists of monomorphic red-brown to pink papules and vesicles distributed symmetrically on the cheeks, extensor surface of the extremities, and buttocks. The eruption usually spontaneously resolves over the course of 10 to 60 days. We report the rare case of GCS in an adult. An otherwise healthy 20-year-old woman presented with a pruritic eruption of 2 weeks' duration on the dorsal aspect of her hands and feet, elbows, and knees. The patient received oral corticosteroids prior to presentation to our clinic with some improvement. A biopsy revealed histopathologic findings consistent with a diagnosis of GCS. The patient's aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were elevated. Over the course of the next 2 months, the patient's skin findings completely resolved with normalization of liver function tests. The clinical and histologic correlation was consistent with GCS in an adult. This condition may not be as rare in adults as previously thought. Clinicians should keep GCS in their differential diagnosis when examining adult patients.
Subject(s)
Acrodermatitis/diagnosis , Acrodermatitis/drug therapy , Anti-Inflammatory Agents/therapeutic use , Administration, Topical , Female , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Glucocorticoids/therapeutic use , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Humans , Treatment Outcome , Young AdultABSTRACT
BACKGROUND: Patients with psoriasis often inquire about complementary and alternative medicine in an effort to do everything possible to control the disease. OBJECTIVE: We sought to review the clinical trial literature regarding complementary and alternative medicine for the treatment of psoriasis. METHODS: We conducted qualitative systematic review of randomized, clinical trials. RESULTS: Although many randomized controlled trials were found, both the results and the quality of the studies varied. LIMITATIONS: The main limitations were the relatively low quality of studies (as assessed by Jadad scores), lack of inclusion of unpublished studies, and the fact that only one author determined inclusion of studies and assignment of Jadad scores. CONCLUSION: There is a large body of literature in regard to complementary and alternative medicine for the treatment of psoriasis. More work is necessary before these modalities should be recommended to our patients.
Subject(s)
Complementary Therapies , Psoriasis/therapy , Randomized Controlled Trials as Topic , HumansABSTRACT
Stress is known to play a role in the course of many skin diseases. We report here a case of erythema annulare centrifugum (EAC) that appeared to be associated with stressors in the patient's life. On multiple occasions, EAC appeared with these episodes and cleared upon their resolution without medical treatment. The patient was otherwise healthy and had no known previously reported associations for this condition.
Subject(s)
Erythema/etiology , Stress, Psychological/complications , Adult , Biopsy , Erythema/diagnosis , Erythema/pathology , Erythema/psychology , Humans , Male , Recurrence , Stress, Psychological/physiopathologyABSTRACT
BACKGROUND: Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress. METHODS: Skh mice were exposed to carcinogenic doses of ultraviolet light (UV). The stressed group was subjected to the close proximity of fox urine as a source of stress from the presence of the odor of their natural predator, while the control group remained stress free. RESULTS: A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first tumor appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21. CONCLUSION: These results suggest that stress plays a role in potentiating cutaneous carcinogenesis.
Subject(s)
Skin Neoplasms/etiology , Stress, Physiological/complications , Ultraviolet Rays/adverse effects , Animals , Chronic Disease , Disease Models, Animal , Disease-Free Survival , Female , Mice , Mice, Hairless , Neoplasms, Radiation-Induced/etiologySubject(s)
Antipsychotic Agents/therapeutic use , Schizophrenia, Paranoid/diagnosis , Schizophrenia, Paranoid/drug therapy , Skin Diseases, Parasitic/diagnosis , Aged , Antipsychotic Agents/adverse effects , Antipsychotic Agents/classification , Aripiprazole , Basal Ganglia Diseases/chemically induced , Basal Ganglia Diseases/diagnosis , Benzodiazepines/therapeutic use , Clozapine/therapeutic use , Diagnosis, Differential , Female , Humans , Metabolic Syndrome/chemically induced , Middle Aged , Olanzapine , Pain/etiology , Pain/prevention & control , Patient Compliance , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/drug therapy , Piperazines/therapeutic use , Quinolones/therapeutic use , Schizophrenia, Paranoid/complications , Sleep Wake Disorders/chemically inducedABSTRACT
BACKGROUND: Erythema ab igne is a rare condition with a carcinogenic potential produced by chronic exposure to a heat source. CASE DESCRIPTION: We present the first case of rapid-onset erythema ab igne in the setting of a dental practice. CLINICAL IMPLICATION: Physicians and dentists should be aware of this disease following short-term local application of heat.
Subject(s)
Erythema/etiology , Facial Dermatoses/etiology , Hyperthermia, Induced/adverse effects , Postoperative Care/adverse effects , Tooth Extraction , Adult , Female , Gingival Diseases/etiology , Gingival Diseases/therapy , Humans , Molar, Third/surgery , Tooth Extraction/adverse effects , Tooth Socket , Tooth, Impacted/therapyABSTRACT
BACKGROUND: Persistent cutaneous infections with Mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials. Due to the rarity of this infection, there are few data comparing the different treatment alternatives. METHODS: We report a patient with culture-proven M. marinum who was treated with two different second-generation tetracyclines. RESULTS: Our patient failed a 4-week trial of doxycycline, but responded rapidly to minocycline. CONCLUSION: This case suggests that, despite a similar mechanism, pharmacokinetics, and even sensitivity, these two agents may differ in their effectiveness against strains of M. marinum.