Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-Vaginitis.

Background and Objectives: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. Materials and Methods: A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C). Participants received vaginal therapy with Plurigin Ovules for three months. Vaginal health parameters were assessed at baseline (T0) and after six months (T1) using various diagnostic tests and analyzed with appropriate statistical tests. Results: Significant improvement in cervico-vaginitis was observed in all three groups. At T1, 87.7% patients of Group A, 66.7% of Group B, and 71.5% of Group C achieved infection resolution (all p < 0.05). Positive colposcopy results decreased across all groups (p < 0.001). Positive vaginal swabs and altered vaginal pH decreased in group A and C (p < 0.001). Positive HPV tests decreased in Group B (p < 0.001). Positive Pap tests and clinical examinations decreased significantly across all groups (p < 0.001). The odds ratios were calculated to reveal the significant associations between these diagnostic outcomes. The therapy was well-tolerated, and no major adverse events were reported. Conclusion: Plurigin Ovules exhibited promising therapeutic outcomes in the three cervico-vaginitis conditions studied. Bacterial cervico-vaginitis showed the most significant improvement, followed by fungal and viral cervico-vaginitis. These findings emphasize the potential of Plurigin Ovules as an effective therapeutic option for cervico-vaginal inflammation and infection, highlighting its role in promoting re-epithelialization and reducing inflammatory processes in the cervix and vagina.

Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review.

Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral tissue defects to blood vessels, muscle, and fibrous tissue regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due to their unique characteristics and potential to differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs in different aspects of soft tissue regeneration, including their application in craniofacial and oral soft tissue regeneration, nerve regeneration, blood vessel regeneration, muscle regeneration, and fibrous tissue regeneration. By examining the latest research findings and clinical advancements, this article aims to provide insights into the current state of MSC-based therapies in soft tissue regenerative medicine.

Overcrowding and clinical risk in Emergency Departments. A model for the reduction in NEDOCS: preliminary results.

Overcrowding in Emergency Departments represents one of the main concerns in effective hospital management today. In order to reduce this phenomenon, this study experimented with a new organizational model that exploited available resources, without incurring additional costs. Through the redistribution of hospital beds, it was possible to reduce access blocks in the Emergency Department of the test hospital. The observational period of this study was of 120 days, and daily surveys of crowding were performed at predetermined intervals. The measurement of overcrowding was calculated utilizing the National Emergency Department Overcrowding Score. The findings reveal a significant reduction in overcrowding due to an increase of only 6 beds in the Emergency Department. Currently, it is known that the principle cause of overcrowding is attributed to a lack of hospital beds for inpatients. Numerous studies have shown that through the lengthening of inpatient hospitalizations it is possible to improve crowding levels in Emergency Department. This findings of this study robustly demonstrate that a small increase in the number of available beds available in emergency department leads to a decrease in all variables of the NEDOCS, and in particular, that of the severely and dangerous overcrowding score.

Aneurysms of the gastroduodenal artery: a case report.

Aneurysms of the gastroduodenal artery are the rarest of all splanchnic artery aneurysms. A case of gastroduodenal artery aneurysm diagnosed preoperatively and successfully managed surgically is described. A 68-year-old woman was admitted to our institution as a result of recurrent epigastric pain. Arteriography of the coeliac trunk and of the upper mesenteric artery showed a coeliac axis occluded at the origin and a voluminous round aneurysmatic formation of the gastroduodenal artery measuring approx. 3 cm. Such lesions may be asymptomatic and initially pass unnoticed or may appear only on rupturing with a profile of haemoperitoneum. The preoperative diagnosis is difficult: in many cases only non-specific signs such as pain, jaundice or upper digestive tract haemorrhage are present. Selective arteriography, in this case, permitted the definitive diagnosis of a gastroduodenal aneurysm, as well as establishing its size and morphology and the vascular pattern of the lesions, all of which was of great assistance in selecting the surgical strategies to be adopted. The operation consisted in the proximal and distal ligation of the gastroduodenal artery and in resection of the aneurysm after preparation of the portal vein, the common hepatic artery and the VBP. We maintain that, because of the risk of rupture of the aneurysm, which so often has a fatal profile, an aggressive surgical approach is both justifiable and advisable.